期刊
SUSTAINABLE CHEMISTRY AND PHARMACY
卷 35, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scp.2023.101193
关键词
RGE; BBD-RSM; DDQ; TCNQ; Computational; Analytical eco-scale score
Spectrophotometric and computational methods were used to determine RGE in pharmaceutical formulations. Charge-transfer interaction of RGE is significant for its receptor-effective mechanisms. A reliable charge-transfer-based spectrophotometric evaluation method for RGE in its pharmaceutical formulation was developed. Rating: 7/10
Spectrophotometric and computational methods were recognized to determine remogliflozin etabonate (RGE) in pharmaceutical formulations. Remogliflozin's charge-transfer interaction is significant in pursuing its receptor-effective mechanisms. It helps develop a trustworthy charge-transfer-based spectrophotometric evaluation for remogliflozin with 2, 3-dichloro 5, 6-dicyano 1, 4-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) in its pharmaceutical for-mulation. The spectrophotometric studies were performed at 445 and 750 nm against the reagent reference for the RGE-DDQ and RGE-TCNQ complexes. The optimization was accomplished by occupying the response surface methodology (RSM) combined with Box-Behnken design (BBD) which included three independent parameters: RGE concentration, DDQ concentration and reac-tion time. The energy differences associated with the charge transfer band formation were inves-tigated at room temperature. The molar absorptivity and formation constant were attained by employing the Benesi-Hildebrand plot. The method was validated per the International Confer-ence on Harmonization (ICH) guidelines. The current investigation's linearity was within the range of 10-25 and 5-20 & mu;g/mL, respectively, for the RGE-DDQ and RGE-TCNQ complexes. The formation constant (K) and Gibbs free energy (& UDelta;G & DEG;) were found to be 4.58 x 101, 4.55 x 102 L mol-1 and - 2.13 x 103, - 3.6 x 103 k J mol-1, respectively. The results were re-producible with the analysis completed with pharmaceutical dosage samples. The proposed method's greenness profile was determined by applying the Eco-scale protocol. In the forced degradation findings, the degradation amount was within 5-20% as per the ICH guidelines. The extracted RGE was characterized using FTIR spectroscopy and supported with simulated vibra-tional IR, NMR and UV-visible spectroscopy. The electronic and spectral properties of RGE were examined, and the findings will be useful for further research on RGE.
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