Oxygen Requirement in Overweight/Obese Kidney Transplant Recipients with COVID-19: An Observational Cohort Study

Introduction: Obesity is one of the components of the cardiometabolic syndrome that contributes to COVID-19 progression and mortality. Immunosuppressed individuals are at greater risk of the COVID-19 burden. Therefore, we sought to investigate the impact of the combination of overweight/obesity and kidney transplant on oxygen (O-2) requirements in the COVID-19 setting. Methods: Retrospective analysis of 284 kidney transplant recipients (KTRs) from March/2020 to August/2020 in a single center. We investigated the risk factors associated with O-2 requirements in overweight/obese KTRs. Results: Overall, 65.1% had a BMI (body mass index) & GE; 25 kg/m(2), 52.4% were male, the mean age was 53.3 & PLUSMN; 11 years old, 78.4% had hypertension, and 41.1% had diabetes mellitus. BMI was an independent risk factor for O-2 requirements (OR = 1.07, p = 0.02) alongside age, lymphopenia, and hyponatremia. When overweight/obese KTRs were older, smokers, they presented higher levels of lactate dehydrogenase (LDH), and lower levels of estimated glomerular filtration rate (eGFR), lymphocytes, and sodium at admission, and they needed O-2 more often. Conclusion: Being overweight/obese is associated with greater O-2 requirements in KTRs, in particular in older people and smokers, with worse kidney allograft functions, more inflammation, and lower sodium levels. Therefore, the early identification of factors that predict a worse outcome in overweight/obese KTRs affected by COVID-19 contributes to risk stratification and therapeutic decisions.

Automated summary

Obesity is a component of the cardiometabolic syndrome that worsens the progression and mortality of COVID-19. In this study, the impact of overweight/obesity and kidney transplant on oxygen requirements in COVID-19 patients was investigated. The results showed that obesity was an independent risk factor for oxygen requirements in overweight/obese kidney transplant recipients, particularly in older individuals and smokers.