☆ 4.6 Review

A Puzzling Mast Cell Trilogy: Anaphylaxis, MCAS, and Mastocytosis

DIAGNOSTICS (2023)

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Article Allergy

Mast Cell Activation Syndromes: Comparison Between Two Scoring Models to Predict for Mast Cell Clonality

Tiago Azenha Rama et al.

Summary: This study compared the performance of REMAs and NICAS in the diagnosis of MC clonality. The results showed that REMAs had higher accuracy and rates of correctly classified patients compared to NICAS, especially in male patients, those with systemic mastocytosis, and those with anaphylaxis featuring urticaria, cardiovascular symptoms, and/or presyncope. It is recommended to combine REMAs and blood detection of KITD816V to improve classification efficiency.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2023)

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Article Allergy

Management of Mediator Symptoms, Allergy, and Anaphylaxis in Mastocytosis

Theo Gulen

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2023)

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Review Biochemistry & Molecular Biology

Secretory and Membrane-Associated Biomarkers of Mast Cell Activation and Proliferation

Roberta Parente et al.

Summary: Mast cells (MCs) are immune cells that play a significant role in allergic and inflammatory diseases, releasing pro-inflammatory mediators. MC disorders, including mastocytosis and MC activation syndromes, are heterogeneous conditions characterized by abnormal MC proliferation and hyperactivity. The diagnosis of MC disorders is challenging due to the transient and unspecific symptoms and the similarity with other diseases. Tryptase is currently used as a biomarker for MC activation, but there is a need for further research to identify more reliable biomarkers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Allergy

Increased Excretion of Mast Cell Mediator Metabolites During Mast Cell Activation Syndrome

Joseph H. Butterfield

Summary: This study found that the ratios of acute/baseline levels of urinary mediator metabolites in MCAS patients were around 1.3 when there was a 20% plus 2 ng/mL increase in serum tryptase. This suggests that an acute increase of 1.3 or higher in these mediators can be useful for confirming a diagnosis of MCAS.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2023)

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Article Medicine, General & Internal

Thymic stromal lymphopoietin (TSLP) is a substrate for tryptase in patients with mastocytosis

Simone Marcella et al.

Summary: Mastocytosis is a heterogeneous disease characterized by uncontrolled proliferation and increased density of mast cells. In this study, it was found that serum concentrations of Thymic stromal lymphopoietin (TSLP) were lower in patients with mastocytosis compared to healthy donors. TSLP was found to be a substrate for human mast cell tryptase, indicating a novel connection between these mediators in mastocytosis.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2023)

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Article Allergy

Increased TIM-3 and galectin-9 serum levels in patients with advanced systemic mastocytosis

Martina Konantz et al.

Summary: This study found that serum levels of TIM-3 and galectin-9 are increased in patients with advanced systemic mastocytosis. Additionally, TIM-3 and galectin-9 are expressed in bone marrow infiltrates in mastocytosis. These findings suggest that TIM-3 and galectin-9 could be explored as diagnostic markers and potential therapeutic targets in systemic mastocytosis, particularly in advanced forms.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2023)

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Article Medicine, General & Internal

Diagnostic Evaluation of Hypersensitivity Reactions to Antibiotics in a Large Cohort of Mastocytosis Patients

Jesper Jarkvist et al.

Summary: This study investigates the prevalence and clinical features of hypersensitivity reactions to antibiotics in mastocytosis patients. The results suggest a similar prevalence of antibiotic hypersensitivity in these patients compared to the general population, and antibiotics appear to rarely cause anaphylaxis in this population. Therefore, mastocytosis patients without a history of antibiotic hypersensitivity may be safely treated with these drugs.

DIAGNOSTICS (2023)

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Article Allergy

Anaphylaxis Definition, Epidemiology, Diagnostic Challenges, Grading System

Adriana G. Bagos-Estevez et al.

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2022)

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Article Allergy

Anaphylaxis and Mast Cell Disorders

Theo Gulen et al.

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2022)

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Letter Allergy

Mast cells derived from systemic mastocytosis exhibit an increased responsiveness to hyperosmolarity

Katarina Lyberg et al.

ALLERGY (2022)

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Article Allergy

Hereditary alpha tryptasemia is not associated with specific clinical phenotypes

Madeleine B. Chollet et al.

Summary: This study found that the prevalence of H alpha T in a random biorepository population was 7.5% and in patients with mastocytosis was 18%. There were no differences in clinical symptomology or medical history between individuals with H alpha T and controls. Elevated baseline serum tryptase was the only consistent phenotypic marker for H alpha T in this study.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Tyrosine kinase inhibitors for the treatment of indolent systemic mastocytosis: Are we there yet?

Cem Akin et al.

Summary: Indolent systemic mastocytosis (ISM) is the most common form of systemic mastocytosis, and many patients experience symptoms related to mast cell mediators. Conventional medication may effectively control symptoms in some patients, but there is a subset of patients who do not respond to these treatments. Tyrosine kinase inhibitors directed against specific gene mutations may be an alternative option for these patients.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Review Allergy

Global Classification of Mast Cell Activation Disorders: An ICD-10-CM-Adjusted Proposal of the ECNM-AIM Consortium

Peter Valent et al.

Summary: Mast cell activation (MCA) is a common physiological pathological phenomenon that occurs in many diseases. In some patients, there is no obvious underlying disease or trigger for MCA. When symptoms are severe, systemic, and recurrent, and accompanied by an increase in serum tryptase level or other mediators of mast cells, it may be diagnosed as mast cell activation syndrome (MCAS).

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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Review Allergy

Nontryptase Urinary and Hematologic Biomarkers of Mast Cell Expansion and Mast Cell Activation: Status 2022

J. H. Butterfield

Summary: Quantification of urinary metabolites can improve diagnosis and management of patients with systemic mastocytosis and mast cell activation syndrome. It provides a more accurate and targeted approach for diagnosis and treatment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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Article Allergy

Mastocytosis presenting with mast cell-mediator release-associated symptoms elicited by cyclo oxygenase inhibitors: prevalence, clinical, and laboratory features

Tiago Azenha Rama et al.

Summary: This study aimed to determine the tolerance and clinical features of mastocytosis patients to NSAIDs. The results showed that the majority of patients tolerated the drugs, and the incidence of hypersensitivity reactions was lower than previously estimated. Disease features and evaluation of drug tolerance history are important for assessing the risk of reactions in patients.

CLINICAL AND TRANSLATIONAL ALLERGY (2022)

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Article Oncology

Clinical Outcomes of Adults with Systemic Mastocytosis: A 15-Year Multidisciplinary Experience

Johanna Ungerstedt et al.

Summary: This retrospective study analyzed the clinical outcomes of patients with mastocytosis and found that the most common variant was indolent mastocytosis. The study also determined the prevalence of mastocytosis in the region and found that patients with indolent mastocytosis had better overall survival.

CANCERS (2022)

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Article Allergy

Non-steroidal anti-inflammatory drug-induced anaphylaxis infrequent in 388 patients with mastocytosis: A two-center retrospective cohort study

Patrizia Bonadonna et al.

Summary: A study found that patients with mastocytosis have an approximately 4-fold increased prevalence of hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) compared to the general population. However, most reactions were limited to the skin and severe hypersensitivity reactions were infrequent. Patients with a known tolerance to NSAIDs can continue using these medications without special precautions, while those with a prior reaction should undergo a thorough allergy work-up.

FRONTIERS IN ALLERGY (2022)

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Article Hematology

Hereditary α tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis

Georg Greiner et al.

Summary: The study showed that in patients with mastocytosis, those with HαT had higher levels of tryptase and were more likely to experience hymenoptera venom hypersensitivity reactions and severe cardiovascular mediator-related symptoms/anaphylaxis. This suggests that HαT could be a novel emerging robust biomarker in mastocytosis.

BLOOD (2021)

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Article Allergy

Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1

Jonathan J. Lyons et al.

Summary: This study revealed that genotypes have a significant impact on the severity of anaphylaxis in humans, particularly in association with H alpha T. The prevalence of H alpha T was higher in healthy individuals and controls with nonatopic disease, and it was particularly prominent in systemic mastocytosis and idiopathic anaphylaxis, suggesting it as a potential risk factor for severe allergic reactions.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Severity grading system for acute allergic reactions: A multidisciplinary Delphi study

Timothy E. Dribin et al.

Summary: This study aimed to develop a severity grading system for acute allergic reactions in order to distinguish between different levels of severity, making it intuitive and straightforward for clinical care and research purposes.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Allergy

Idiopathic Anaphylaxis: a Perplexing Diagnostic Challenge for Allergists

Theo Gulen et al.

Summary: The systematic review aims to present proposed theories of pathogenesis for idiopathic anaphylaxis (IA), discuss its classification, diagnostic approach, and management. Recent findings show that IA represents a major diagnostic challenge and certain conditions such as mastocytosis and red meat allergy may overlap with its symptomatology. Patients with IA should always carry an epinephrine autoinjector for prompt treatment and prophylaxis.

CURRENT ALLERGY AND ASTHMA REPORTS (2021)

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Review Biochemistry & Molecular Biology

Genetic Regulation of Tryptase Production and Clinical Impact: Hereditary Alpha Tryptasemia, Mastocytosis and Beyond

Bettina Sprinzl et al.

Summary: Tryptase, mainly produced by tissue mast cells, has been linked to specific diseases such as systemic mastocytosis and severe Hymenoptera venom-induced anaphylaxis, due to genetic variations in the TPSAB1 gene. Hereditary alpha tryptasemia, caused by TPSAB1 gene copy number gains, can result in elevated serum tryptase levels and should be considered in patients with symptomatic SM, severe anaphylaxis, or MCAS during diagnosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Allergy

Distinct plasma biomarkers confirm the diagnosis of mastocytosis and identify increased risk of anaphylaxis

Theo Gulen et al.

Summary: This study identified a group of potential biomarkers in plasma that could be used to predict patients with mastocytosis at increased risk of anaphylaxis. In addition to known markers, four novel proteins were discovered, providing important value in screening and identifying patients with this condition.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Oncology

A Multidisciplinary Diagnostic Approach Reveals a Higher Prevalence of Indolent Systemic Mastocytosis: 15-Years' Experience of the GISM Network

Roberta Zanotti et al.

Summary: By utilizing a multidisciplinary approach, the Interdisciplinary Group for Study of Mastocytosis in Verona has identified a higher prevalence of systemic mastocytosis (SM) than expected, with a significant increase in the diagnosis of indolent SM. Timely diagnosis of SM is crucial for discovering and treating underdiagnosed osteoporosis, especially in males. Osteoporosis and Hymenoptera venom allergy are major factors leading to the diagnosis of CMD in adults.

CANCERS (2021)

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Review Allergy

Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review

Theo Gulen et al.

Summary: Research on mast cell activation and syndromes has advanced in recent years, but there is ongoing debate about diagnostic and classification criteria, highlighting the importance of applying consensus criteria to ensure accurate diagnosis and treatment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Hematology

Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus Proposal

Peter Valent et al.

Summary: Mastocytosis is a hematologic neoplasm characterized by the expansion and accumulation of neoplastic mast cells in various organs. Recent developments necessitate updates and refinements in the classification and diagnostic criteria of MC neoplasms. Adjustments in the classification of CM and SM, refinements in diagnostic criteria of SM variants, and updated criteria for MCAS were proposed for better diagnostic evaluation and prognostication.

HEMASPHERE (2021)

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Article Allergy

Venom immunotherapy in patients with clonal mast cell disorders: IgG4 correlates with protection

Jesper Jarkvist et al.

ALLERGY (2020)

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Review Allergy

Omalizumab in the treatment of adult patients with mastocytosis: A systematic review

Fatma Jendoubi et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2020)

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Article Allergy

PIONEER: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent or Smoldering Systemic Mastocytosis (SM) With Symptoms Inadequately Controlled by Standard Therapy

Cem Akin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Letter Allergy

MRGPRX2 signaling and skin test results

John M. Kelso

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Article Allergy

PGE2 deficiency predisposes to anaphylaxis by causing mast cell hyperresponsiveness

Shruti Rastogi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

Midostaurin improves quality of life and mediator-related symptoms in advanced systemic mastocytosis

Karin Hartmann et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Review Allergy

Hymenoptera venom-induced anaphylaxis and hereditary alpha-tryptasemia

Michael P. O'Connell et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

Hereditary Alpha-Tryptasemia: UK Prevalence and Variability in Disease Expression

Rebecca C. Robey et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Article Allergy

Low Frequency of IgE-Mediated Food Hypersensitivity in Mastocytosis

Jesper Jarkvist et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Article Allergy

Persistent, refractory, and biphasic anaphylaxis: A multidisciplinary Delphi study

Timothy E. Dribin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Review Medicine, Research & Experimental

Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts

Peter Valent et al.

THERANOSTICS (2020)

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Article Allergy

Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome

Peter Valent et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

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Editorial Material Allergy

Anaphylaxis Management: Time to Re-Evaluate the Role of Corticosteroids

Dianne E. Campbell

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

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Review Allergy

Why the 20%+2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activation and Mast Cell Activation Syndrome

Peter Valent et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2019)

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Article Allergy

A distinct biomolecular profile identifies monoclonal mast cell disorders in patients with idiopathic anaphylaxis

Melody C. Carter et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Allergy

Omalizumab prevents anaphylaxis and improves symptoms in systemic mastocytosis: Efficacy and safety observations

S. Broesby-Olsen et al.

ALLERGY (2018)

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Article Allergy

The pathophysiology of anaphylaxis

Laurent L. Reber et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Allergy

Risk Factor Analysis of Anaphylactic Reactions in Patients With Systemic Mastocytosis

Theo Gulen et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2017)

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Review Allergy

Fatal Anaphylaxis: Mortality Rate and Risk Factors

Paul J. Turner et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2017)

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Review Allergy

Pharmacotherapy of mast cell disorders

Theo Guelen et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Allergy

Assessment of in vivo mast cell reactivity in patients with systemic mastocytosis

T. Gulen et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2017)

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Review Medicine, General & Internal

Mastocytosis: the puzzling clinical spectrum and challenging diagnostic aspects of an enigmatic disease

T. Gulen et al.

JOURNAL OF INTERNAL MEDICINE (2016)

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Article Emergency Medicine

Appropriateness of epinephrine use in ED patients with anaphylaxis

Damian V. Baalmann et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2016)

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Article Allergy

Anaphylaxis in children and adolescents: The European Anaphylaxis Registry

Linus B. Grabenhenrich et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

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Article Genetics & Heredity

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

Jonathan J. Lyons et al.

NATURE GENETICS (2016)

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Article Medicine, General & Internal

Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis

Jason Gotlib et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Letter Allergy

α-Gal-a new clue for anaphylaxis in mastocytosis

Sophie Roenneberg et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2016)

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Article Allergy

Prospective Validation of the NIAID/FAAN Criteria for Emergency Department Diagnosis of Anaphylaxis

Caitlin E. Loprinzi Brauer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2016)

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Article Allergy

Drug hypersensitivity in clonal mast cell disorders: ENDA/EAACI position paper

P. Bonadonna et al.

ALLERGY (2015)

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Letter Allergy

Systemic mastocytosis presenting as IgE-mediated food-induced anaphylaxis: A report of two cases

Alicia Prieto-Garcia et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2015)

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Article Medicine, General & Internal

Recognition and First-Line Treatment of Anaphylaxis

Phillip L. Lieberman

AMERICAN JOURNAL OF MEDICINE (2014)

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Article Allergy

Emergency department diagnosis and treatment of anaphylaxis: a practice parameter

Ronna L. Campbell et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2014)

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Article Hematology

Epidemiology of systemic mastocytosis in Denmark

Sarah S. Cohen et al.

BRITISH JOURNAL OF HAEMATOLOGY (2014)

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Article Allergy

High prevalence of anaphylaxis in patients with systemic mastocytosis - a single-centre experience

T. Gulen et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2014)

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Review Allergy

Risk factors and management of severe life-threatening anaphylaxis in patients with clonal mast cell disorders

P. Valent

CLINICAL AND EXPERIMENTAL ALLERGY (2014)

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Article Allergy

The presence of mast cell clonality in patients with unexplained anaphylaxis

T. Gulen et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2014)

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Article Allergy

Anaphylaxis in America: The prevalence and characteristics of anaphylaxis in the United States

Robert A. Wood et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Letter Allergy

Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities

Jonathan J. Lyons et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Review Cell Biology

Mast Cell Function: A New Vision of an Old Cell

Elaine Zayas Marcelino da Silva et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2014)

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Article Medicine, General & Internal

Flushing, fatigue, and recurrent anaphylaxis: a delayed diagnosis of mastocytosis

Theo Gülen et al.

LANCET (2014)

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Review Allergy

Mast Cell Activation Disorders

Cem Akin

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2014)

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Article Allergy

Non-steroidal anti-inflammatory drug hypersensitivity: association with elevated basal serum tryptase?

Cornelia S. Seitz et al.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2014)

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Review Allergy

The epidemiology of anaphylaxis in Europe: a systematic review

S. S. Panesar et al.

ALLERGY (2013)

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Article Allergy

Clonal Mast Cell Activation Syndrome with Anaphylaxis to Sulfites

Liliana Cifuentes et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2013)

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Article Allergy

Prevalence of Atopy and Respiratory Allergic Diseases in the Elderly SAPALDIA Population

Brunello Wuethrich et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2013)

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Letter Allergy

Prevalence of indolent systemic mastocytosis in a Dutch region

Jasper J. van Doormaal et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Article Allergy

Higher mast cell load decreases the risk of Hymenoptera venom-induced anaphylaxis in patients with mastocytosis

Bjorn van Anrooij et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Article Allergy

Low incidence and high remission of allergic sensitization among adults

Katja Warm et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Allergy

Evaluation of National Institute of Allergy and Infectious Diseases/Food Allergy and Anaphylaxis Network criteria for the diagnosis of anaphylaxis in emergency department patients

Ronna L. Campbell et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Anesthesiology

Case Report: Perioperative immediate hypersensitivity involves not only allergy but also mastocytosis

Valerie Renauld et al.

CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE (2011)

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Review Immunology

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

Stephen J. Galli et al.

NATURE IMMUNOLOGY (2011)

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Review Immunology

Mechanisms underlying the localisation of mast cells in tissues

Sarah J. Collington et al.

TRENDS IN IMMUNOLOGY (2011)

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Article Immunology

Regulation of Mast Cell Responses in Health and Disease

Alasdair M. Gilfillan et al.

CRITICAL REVIEWS IN IMMUNOLOGY (2011)

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Review Hematology

How I treat patients with advanced systemic mastocytosis

Peter Valent et al.

BLOOD (2010)

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Review Allergy

Anaphylaxis and Mast Cell Disease: What Is the Risk?

Cem Akin

CURRENT ALLERGY AND ASTHMA REPORTS (2010)

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Review Immunology

Mast cells in allergy and infection: Versatile effector and regulatory cells in innate and adaptive immunity

Stephen J. Galli et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2010)

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Article Allergy

Clinical, biological, and molecular characteristics of clonal mast cell disorders presenting with systemic mast cell activation symptoms

Ivan Alvarez-Twose et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Article Allergy

Mast cell activation syndrome: Proposed diagnostic criteria

Cem Akin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Article Immunology

Amplification mechanisms for the enhancement of antigen-mediated mast cell activation

Alasdair M. Gilfillan et al.

IMMUNOLOGIC RESEARCH (2009)

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Article Allergy

Mechanisms of mast cell signaling in anaphylaxis

Dean D. Metcalfe et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

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Article Allergy

Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels

Patrizia Bonadonna et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

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Article Anesthesiology

Anaphylactoid reaction to intravenous contrast in patient with systemic mastocytosis

T. N. Weingarten et al.

ANAESTHESIA AND INTENSIVE CARE (2009)

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Article Allergy

Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients

K. Brockow et al.

ALLERGY (2008)

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Review Allergy

Understanding the mechanisms of anaphylaxis

Richard D. Peavy et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2008)

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Article Allergy

The etiology and incidence of anaphylaxis in Rochester, Minnesota: A report from the Rochester Epidemiology Project

Wyatt W. Decker et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)

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Article Dermatology

Mast cells: Versatile regulators of inflammation, tissue remodeling, host defense and homeostasis

Stephen J. Galli et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2008)

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Article Medicine, General & Internal

Trends in national incidence, lifetime prevalence and adrenaline prescribing for anaphylaxis in England

Aziz Sheikh et al.

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE (2008)

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Article Allergy

Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain:: a study of the Spanish network on mastocytosis (REMA)

D. Gonzalez de Olano et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2007)

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Article Hematology

Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with idiopathic anaphylaxis

Cem Akin et al.

BLOOD (2007)

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Article Allergy

Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: Monoclonal mast cell activation syndrome

Karoline Sonneck et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2007)

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Article Allergy

Diagnostic value of tryptase in anaphylaxis and mastocytosis

Lawrence B. Schwartz

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2006)

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Review Allergy

Mast cell mediators in allergic inflammation and mastocytosis

Mariana Castells

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2006)

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Article Emergency Medicine

Second Symposium on the Definition and Management of Anaphylaxis:: Summary report -: Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium

HA Sampson et al.

ANNALS OF EMERGENCY MEDICINE (2006)

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Review Allergy

The role of genetics in the development of asthma and atopy

MN Blumenthal

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2005)

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Letter Medicine, General & Internal

Treatment of systemic mast-cell disease with cladribine

A Tefferi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

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