☆ 4.6 Review

MiRNAs and Their Role in Venous Thromboembolic Complications

DIAGNOSTICS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Hematology

Erythrocytosis, thrombocytosis, and rate of recurrent thromboembolic event—A population based cohort study

Anneli Enblom Larsson et al.

Summary: Management strategies for reducing the risk of thromboembolic complications in polycythemia vera and essential thrombocythemia are well established, but for other conditions with elevated blood values, there is no consensus on treatment and follow-up. This retrospective cohort study of 3931 adult patients in Sweden found that elevated blood values are common in patients with thromboembolic events and the risk of recurrence and restricted mean survival time is highest in patients with unexplained thrombocytosis and secondary erythrocytosis. This highlights the importance of identifying and managing the underlying condition.

EUROPEAN JOURNAL OF HAEMATOLOGY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Downregulation of miR-125a-5p Promotes Endothelial Progenitor Cell Migration and Angiogenesis and Alleviates Deep Vein Thrombosis in Mice Via Upregulation of MCL-1

Jingfan Yu et al.

Summary: This study aimed to investigate the effect of miR-125a-5p on endothelial progenitor cells (EPCs) in deep vein thrombosis (DVT). It was found that upregulation of miR-125a-5p suppressed EPC migration and angiogenesis, while promoting apoptosis. Downregulation of miR-125a-5p had the opposite effect. Furthermore, miR-125a-5p inhibited the PI3K/AKT pathway. Cellular experiments showed that MCL-1 was regulated by miR-125a-5p. Animal experiments demonstrated that downregulation of miR-125a-5p inhibited thrombus formation and enhanced EPC homing, thereby alleviating DVT.

MOLECULAR BIOTECHNOLOGY (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19

Jessica Gambardella et al.

Summary: We hypothesized that exosomal microRNAs may play a role in the development of thromboembolic complications in COVID-19. We isolated circulating exosomes from COVID-19 patients and categorized them based on D-dimer levels. We found that exosomal miR-145 and miR-885 were significantly correlated with D-dimer levels. Furthermore, human endothelial cells treated with serum from COVID-19 patients showed reduced release of miR-145 and miR-885, increased apoptosis, and impaired angiogenetic properties compared to cells treated with non-COVID-19 serum.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)

添加到收藏夹

Article Emergency Medicine

Managing Pulmonary Embolism

Lauren M. Westafer et al.

ANNALS OF EMERGENCY MEDICINE (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

MicroRNA-126 Regulates Thrombosis Through Endothelial Progenitor Cells

Qian Xiao et al.

Summary: Thrombosis is a common problem with severe consequences. Endothelial progenitor cells (EPCs) have potential as thrombosis therapy due to their angiogenesis-promoting, thrombus-relieving, and anticoagulant functions. miRNA-126, highly enriched in EPCs and endothelial cells, regulates EPC functions through various pathways and cytokines. This review aims to clarify the role of miR-126 in thrombosis through regulation of EPCs, providing insights for alternative thrombotic disease therapies.

DNA AND CELL BIOLOGY (2023)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Epidemiology and prevention of venous thromboembolism

Pamela L. Lutsey et al.

Summary: Venous thromboembolism is an under-appreciated vascular disease with significant health disparities in incidence and outcomes. In addition to understanding the epidemiological characteristics and risk factors of this disease, attention should also be given to prevention measures and reducing disparities.

NATURE REVIEWS CARDIOLOGY (2023)

添加到收藏夹

Article Hematology

Long non-coding RNA crnde promotes deep vein thrombosis by sequestering miR-181a-5p away from thrombogenic Pcyox1l

Xin He et al.

Summary: In this study, the involvement of the lncRNA Crnde/miR-181a-5p/Pcyox1l axis in thrombus formation in deep vein thrombosis was investigated. It was found that Crnde competitively binds to miR-181a-5p and inhibits its expression, leading to increased expression of Pcyox1l and aggravation of thrombus formation.

THROMBOSIS JOURNAL (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Overexpression of MiR-181c-5p Attenuates Human Umbilical Vascular Endothelial Cell Injury in Deep Vein Thrombosis by Targeting FOS

Fei Yang et al.

Summary: DVT is the third most common cardiovascular disease. miR-181c-5p can improve endothelial cell injury and thrombosis-related factor expression by regulating the FOS gene.

INTERNATIONAL HEART JOURNAL (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Small-Extracellular-Vesicle-Derived miRNA Profile Identifies miR-483-3p and miR-326 as Regulators in the Pathogenesis of Antiphospholipid Syndrome (APS)

Cristina Sole et al.

Summary: Primary antiphospholipid syndrome (PAPS) is an autoimmune disease characterized by recurrent thrombosis and obstetric morbidity. In this study, we found that circulating small extracellular vesicles (sEVs) were increased in PAPS patients, mainly originating from activated platelets. These sEVs contained specific miRNAs, including miR-483-3p and miR-326, which were associated with endothelial cell proliferation and monocyte activation, respectively. Our findings suggest that miRNA-derived sEVs play a role in the pathogenesis of APS.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Article Surgery

MiR-128-3p promotes the progression of deep venous thrombosis through binding SIRT1

Jinan Han et al.

Summary: This study investigated the effect of microRNA-128-3p (miR-128-3p) on deep venous thrombosis (DVT). Cell experiments were conducted using the MTT assay, Transwell chamber method, and flow cytometry technique. The study revealed a potential connection between miR-128-3p and SIRT1, and demonstrated that miR-128-3p was upregulated in patients with DVT, making it a significant biomarker for distinguishing DVT patients.

PHLEBOLOGY (2023)

添加到收藏夹

Review Medicine, Research & Experimental

Pathophysiology of deep vein thrombosis

Simon Navarrete et al.

Summary: Deep venous thrombosis is a common and multifactorial disease that leads to morbidity and mortality. The mechanisms underlying deep venous thrombosis are not fully understood, but recent research has shed light on the role of venous flow, endothelium, platelets, leukocytes, and the interaction between inflammation and hemostasis.

CLINICAL AND EXPERIMENTAL MEDICINE (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

MiR-34a-3p suppresses pulmonary vascular proliferation in acute pulmonary embolism rat by targeting DUSP1

Yang Li et al.

Summary: MiR-34a-3p expression is down-regulated in APE patients and can inhibit the increase of mPAP and thickening of pulmonary arterial walls in APE rats, it can suppress PASMC proliferation by negatively regulating DUSP1 expression.

BIOSCIENCE REPORTS (2022)

添加到收藏夹

Article Medicine, General & Internal

Combination of circulating miR-125a-5p, miR-223-3p and D-dimer as a novel biomarker for deep vein thrombosis

Luoluo Xu et al.

Summary: In this study, differential expression of circulating miRNAs in plasma of DVT patients was identified. The miRNAs miR-125a-5p and miR-223-3p showed significant changes and can be potential biomarkers for the diagnosis and treatment of DVT. Combining these miRNAs with the classic biomarker D-dimer improved the efficiency of diagnosing DVT.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2022)

添加到收藏夹

Article Surgery

Metformin Inhibits Multiple Myeloma Serum-induced Endothelial Cell Thrombosis by Down-Regulating miR-532

Lixia Gao et al.

Summary: The study found that metformin could inhibit MM-induced HUVEC thrombosis, suggesting it may serve as a novel antithrombotic approach for multiple myeloma patients.

ANNALS OF VASCULAR SURGERY (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Upregulated miR-206 Aggravates Deep Vein Thrombosis by Regulating GJA1-Mediated Autophagy of Endothelial Progenitor Cells

Yan Li et al.

Summary: miR-206 knockdown upregulates GJA1 to inhibit autophagy of EPCs and then promote EPC proliferation, migration, and angiogenesis, thereby enhancing EPC homing to thrombi and facilitating thrombus resolution.

CARDIOVASCULAR THERAPEUTICS (2022)

添加到收藏夹

Article Cell Biology

Resveratrol Ameliorates Deep Vein Thrombosis-Induced Inflammatory Response Through Inhibiting HIF-1α/NLRP3 Pathway

Jianwen Fei et al.

Summary: This study aimed to investigate the effect of resveratrol (Res) on deep vein thrombosis (DVT) and explore its mechanism. The results showed that Res effectively ameliorated DVT in rats by inhibiting the HIF-1 alpha/NLRP3 pathway. This provides a novel therapeutic strategy for DVT treatment.

INFLAMMATION (2022)

添加到收藏夹

Review Respiratory System

Chronic Thromboembolic Pulmonary Hypertension

Krittika Teerapuncharoen et al.

Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a long-term complication of pulmonary embolism (PE), and delay in diagnosis and treatment is associated with poor outcomes. High clinical suspicion and accurate interpretation of relevant imaging examinations are crucial for diagnosing CTEPH.

LUNG (2022)

添加到收藏夹

Article Hematology

Inhibition of Hypoxia-Inducible Factor Prolyl-Hydroxylase Modulates Platelet Function

Wei Gu et al.

THROMBOSIS AND HAEMOSTASIS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

MicroRNA 449a can Attenuate Protective Effect of Urokinase Against Pulmonary Embolism

Ran Zhu et al.

Summary: Acute pulmonary embolism (APE) is a disabling disease with high incidence and mortality rates. D-Dimer lacks specificity for assessing APE, necessitating the identification of additional diagnostic and prognostic biomarkers. This study identified a group of miRNAs that are differentially expressed in the presence of APE, and showed that urokinase-type plasminogen activator (uPA) can modulate the expression of these miRNAs. These findings have important implications for the treatment and prognosis prediction of APE patients.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Oncology

Circulating miRNAs as Diagnostic and Prognostic Biomarkers in High-Grade Gliomas

Jianing Wu et al.

Summary: This study found that circulating miR-181a/b, miR-410, and miR-155 could be useful diagnostic and prognostic biomarkers for high-grade gliomas.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Article Hematology

Upregulation of HIF-1α contributes to complement activation in transplantation-associated thrombotic microangiopathy

Jiaqian Qi et al.

Summary: This study found that levels of hypoxia-inducible factor-1 alpha (HIF-1 alpha) were significantly higher in patients with transplantation-associated thrombotic microangiopathy (TA-TMA) compared to controls. Upregulation of HIF-1 alpha led to an increase in membrane-bound complement C3 and dysfunction of endothelial cells. Increasing HIF-1 alpha in mice led to complement activation, thrombocytopenia, anemia, and increased lactate dehydrogenase (LDH) levels, mimicking the TA-TMA phenotype. The study suggests that HIF-1 alpha may play a role in the development of TA-TMA by inhibiting the transcription of complement factor H (CFH).

BRITISH JOURNAL OF HAEMATOLOGY (2022)

添加到收藏夹

Review Emergency Medicine

Diagnosis and Management of Pulmonary Embolism

Terren Trott et al.

EMERGENCY MEDICINE CLINICS OF NORTH AMERICA (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Thrombosis-related circulating miR-16-5p is associated with disease severity in patients hospitalised for COVID-19

Ceren Eyileten et al.

Summary: By utilizing bioinformatic and co-expression analysis, this study identified and validated miRNAs associated with thrombosis in COVID-19 patients, which can serve as potential diagnostic and prognostic biomarkers for disease severity. The findings contribute to our understanding of the pathogenesis of COVID-19 and the identification of novel predictive markers.

RNA BIOLOGY (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

MicroRNA-342-3p loaded by human umbilical cord mesenchymal stem cells-derived exosomes attenuates deep vein thrombosis by downregulating EDNRA

Zhiyu Pan et al.

Summary: This study investigated the role of microRNA (miR)-342-3p transferred by human umbilical cord mesenchymal stem cell (hucMSCs)-derived exosomes (exos) in deep vein thrombosis (DVT). The researchers found that upregulated miR-342-3p could alleviate DVT and promote angiogenesis in vitro. This discovery provides a novel direction for the treatment of DVT.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2022)

添加到收藏夹

Article Medical Laboratory Technology

Clinical Significance of miRNA-145 and-126 in Chronic Obstructive Pulmonary Disease with Pulmonary Embolism

Asmaa Nafady et al.

Summary: In COPD patients, lower levels of miRNA-145 and higher levels of miRNA-126 are associated with worse diagnosis of pulmonary embolism (PE).

CLINICAL LABORATORY (2022)

添加到收藏夹

Article Medicine, General & Internal

let-7b-5p suppresses the proliferation and migration of pulmonary artery smooth muscle cells via down-regulating IGF1

Yadi Zhang et al.

Summary: let-7b-5p inhibits the proliferation and migration of PDGF-induced PASMCs by modulating IGF1.

CLINICS (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Suppression of long intergenic non-protein coding RNA 1123 constrains lower extremity deep vein thrombosis via microRNA-125a-3p to target interleukin 1 receptor type 1

Baocai Yang et al.

Summary: This study revealed the mechanism by which LINC01123 inhibits LEDVT through targeting IL1R1 via miR-125a-3p.

BIOENGINEERED (2022)

添加到收藏夹

Article Medical Laboratory Technology

Peripheral Blood Levels of miR-448 and SIRT1 in Patients with Deep Venous Thrombosis and Their Relationship

Pu Wang et al.

Summary: This study aimed to investigate the changes in peripheral blood levels of miR-448 and silent information regulator 1 (SIRT1) in patients with deep venous thrombosis (DVT) and analyze their relationship. The results showed that serum SIRT1 protein level was lower and miR-448 expression in peripheral blood mononuclear cells (PBMCs) was higher in DVT patients compared to non-DVT patients. MiR-448 inhibits SIRT1 expression through binding to SIRT1 mRNA 3'-UTR with complementary bases, thus promoting DVT formation through inflammatory response. The combination of miR-448 and SIRT1 has a high predictive value for the occurrence of DVT.

CLINICAL LABORATORY (2022)

添加到收藏夹

Article Cell & Tissue Engineering

The Endoplasmic Reticulum-Stressed Head and Neck Squamous Cell Carcinoma Cells Induced Exosomal miR-424-5p Inhibits Angiogenesis and Migration of Humanumbilical Vein Endothelial Cells Through LAMC1-Mediated Wnt/β-Catenin Signaling Pathway

Zeyu Wang et al.

Summary: This study reveals that ER-stressed HNSCC cell-induced exosomal miR-424-5p inhibits angiogenesis and migration of HUVEC cells through the LAMC1-mediated Wnt/beta-catenin signaling pathway.

CELL TRANSPLANTATION (2022)

添加到收藏夹

Article Medical Laboratory Technology

Endothelial Nitric Oxide Synthase Gene Polymorphisms Increase Risk of Deep Vein Thrombosis by Altering Homocysteine Levels

Mohammad S. Akhter et al.

Summary: The study investigates the association between endothelial nitric oxide gene polymorphisms and deep vein thrombosis. The results demonstrate that the 894G/T and 2479G/A polymorphisms are associated with lower levels of nitric oxide and higher levels of homocysteine, which may increase the risk of deep vein thrombosis.

CLINICAL LABORATORY (2022)

添加到收藏夹

Article Medical Laboratory Technology

Expression and diagnostic value of circulating miRNA-190 and miRNA-197 in patients with pulmonary thromboembolism

XiaoTing Zhou et al.

Summary: The study showed that the expression levels of plasma miRNA-190 and miRNA-197 in patients with PTE were significantly higher than in the MI and healthy control groups, suggesting their potential as noninvasive diagnostic markers for PTE. Combining miRNA-190, miRNA-197, and D-dimer levels improved the diagnostic power for PTE.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

添加到收藏夹

Article Clinical Neurology

Circulating miR-126 as a Potential Non-invasive Biomarker for Intracra-nial Aneurysmal Rupture: A Pilot Study

Jianing Wu et al.

Summary: The study measured circulating miR-126 levels at different time points, finding higher levels in UIAs patients compared to healthy controls, and a substantial increase from day 1 to day 7 in aSAH patients, peaking on day 7. miR-126 showed high diagnostic value and could serve as a biomarker for detecting IAs and preventing high-risk ruptures.

CURRENT NEUROVASCULAR RESEARCH (2021)

添加到收藏夹

Review Hematology

The Role of Epigenetics in the Regulation of Hemostatic Balance

Elisa Danese et al.

Summary: Epigenetics is now seen as fundamental in developmental biology, with evidence suggesting its key role in primary and secondary hemostasis. Epigenetic alterations, like DNA methylation and histone modifications, may impact platelet functions, drug responsiveness, and protein production relevant to blood clotting and fibrinolysis. Understanding these mechanisms could lead to new therapeutic targets and tests for assessing bleeding or thrombosis risk.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2021)

添加到收藏夹

Article Genetics & Heredity

Analysis of MicroRNAs Associated With Carotid Atherosclerotic Plaque Rupture With Thrombosis

Peng Nie et al.

Summary: The study revealed that plaque rupture and thrombus formation peaked at 8 weeks post-surgery and decreased thereafter. MiR-322-5p and miR-206-3p may be associated with the formation of atherosclerotic plaques, while miR-466h-5p may promote plaque rupture via apoptosis-related pathways.

FRONTIERS IN GENETICS (2021)

添加到收藏夹

Article Cell Biology

Curcumin protects against inflammation and lung injury in rats with acute pulmonary embolism with the involvement of microRNA-21/PTEN/NF-κB axis

Dean Liang et al.

Summary: The study demonstrated that Curcumin inhibited lung injury and inflammation in acute pulmonary embolism (APE) rats by modulating the miR-21/PTEN/NF-kappa B axis.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Expression of miR-93-5p as a Potential Predictor of the Severity of Chronic Thromboembolic Pulmonary Hypertension

Juanni Gong et al.

Summary: The study identified an association between miR-93-5p expression and the severity of CTEPH, suggesting its potential as a predictor for high-risk CTEPH.

BIOMED RESEARCH INTERNATIONAL (2021)

添加到收藏夹

Article Surgery

Role and Mechanism of mir-5189-3p in Deep Vein Thrombosis of Lower Extremities

Jing Lu et al.

Summary: The study found that miR-5189-3p may play a role in DVT by inhibiting apoptosis and promoting thrombus organization through the Notch signaling pathway. MiR-5189-3p could be a potential target for DVT treatment.

ANNALS OF VASCULAR SURGERY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Resistance exercise affects catheter-related thrombosis in rats through miR-92a-3p, oxidative stress and the MAPK/NF-κB pathway

Cui Wen et al.

Summary: The research showed that resistance exercise intervention can decrease the expression level of miR-92a-3p, repair oxidative stress injury, and prevent the formation of CRT.

BMC CARDIOVASCULAR DISORDERS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

MiR-296-5p ameliorates deep venous thrombosis by inactivating S100A4

Zhichang Pan et al.

Summary: miR-296-5p may inhibit deep venous thrombosis formation by suppressing S100A4 expression, suggesting that both miR-296-5p and S100A4 could be potential therapeutic targets and diagnostic markers for deep venous thrombosis.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Circulating Plasma miRNA and Clinical/Hemodynamic Characteristics Provide Additional Predictive Information About Acute Pulmonary Thromboembolism, Chronic Thromboembolic Pulmonary Hypertension and Idiopathic Pulmonary Hypertension

Alexandre Todorovic Fabro et al.

Summary: This study identified five circulating plasma miRNAs in common with APTE, CTEPH, and IPAH, and found upregulation of miR-let-7i-5p in APTE and IPAH, as well as upregulation of miRNA-320a in CTEPH and IPAH. Target gene analysis revealed genes regulated by these miRNAs, influencing pulmonary arterial adventitial fibroblasts, pulmonary artery endothelial cells, and pulmonary artery smooth muscle cells. Abnormal remodeling in APTE might lead to CTEPH, while imbalances in pulmonary artery cellular phenotype could differentiate IPAH from CTEPH.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Point-of-Care Testing for D-Dimer in the Diagnosis of Venous Thromboembolism in Primary Care: A Narrative Review

Christopher P. Price et al.

Summary: VTE is a significant cause of mortality and disability, and utilizing POCT D-dimer in primary care has the potential to reduce hospital referrals for imaging confirmatory investigation, resulting in cost savings and clinical benefits. Collaborating with local laboratories for harmonization of D-dimer methods and quality assurance is essential for improving VTE diagnosis.

CARDIOLOGY AND THERAPY (2021)

添加到收藏夹

Article Behavioral Sciences

Plasma D-dimer predicts poor outcome and mortality after spontaneous intracerebral hemorrhage

Qi Zhou et al.

Summary: The elevated plasma D-dimer level after spontaneous ICH is associated with poor functional outcome and mortality. This suggests that the elevated D-dimer level has a predictive value for the outcome and mortality in patients with spontaneous ICH.

BRAIN AND BEHAVIOR (2021)

添加到收藏夹

Review Hematology

Methods to Investigate miRNA Function: Focus on Platelet Reactivity

Alix Garcia et al.

Summary: miRNAs, small noncoding RNAs regulating protein production, play crucial roles in cell function and are considered biomarkers in diseases. Development of techniques has led to models dedicated to miRNA study, and plasma samples are accessible for clinical trials. Extraction, purification techniques, and normalization procedures are important for comparing miRNA levels in populations and over time.

THROMBOSIS AND HAEMOSTASIS (2021)

添加到收藏夹

Article Clinical Neurology

Circulating MicroRNAs as Potential Noninvasive Biomarkers of Spontaneous Intracerebral Hemorrhage

Ilgiz Gareev et al.

WORLD NEUROSURGERY (2020)

添加到收藏夹

Article Surgery

Downregulation of miR-103a-3p Contributes to Endothelial Progenitor Cell Dysfunction in Deep Vein Thrombosis Through PTEN Targeting

Peng Zhang et al.

ANNALS OF VASCULAR SURGERY (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Platelet Function in Cardiovascular Disease: Activation of Molecules and Activation by Molecules

Elahe Khodadi

CARDIOVASCULAR TOXICOLOGY (2020)

添加到收藏夹

Article Oncology

Tissue factor activity on microvesicles from cancer patients

Fanny Ender et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2020)

添加到收藏夹

Article Hematology

IL (Interleukin)-6 Contributes to Deep Vein Thrombosis and Is Negatively Regulated by miR-338-5p

Yunhong Zhang et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

添加到收藏夹

Review Medicine, Research & Experimental

The current state of MiRNAs as biomarkers and therapeutic tools

Ilgiz Gareev et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Inflammatory Factors Induce Thrombosis through the miR-146b-3p/p38MAPK/COX-2 Pathway

Zhengjia Su et al.

BIOMED RESEARCH INTERNATIONAL (2020)

添加到收藏夹

Editorial Material Medicine, General & Internal

Chronic Obstructive Pulmonary Disease

Wassim W. Labaki et al.

ANNALS OF INTERNAL MEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Let-7b-5p is involved in the response of endoplasmic reticulum stress in acute pulmonary embolism through upregulating the expression of stress-associated endoplasmic reticulum protein 1

Ting-wei Liu et al.

IUBMB LIFE (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

miR-374b-5p is increased in deep vein thrombosis and negatively targets IL-10

Yunhong Zhang et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

添加到收藏夹

Review Medicine, General & Internal

Pulmonary Hypertension: A Brief Guide for Clinicians

Stacy A. Mandras et al.

MAYO CLINIC PROCEEDINGS (2020)

添加到收藏夹

Article Anatomy & Morphology

MiR-143-3p targets ATG2B to inhibit autophagy and promote endothelial progenitor cells tube formation in deep vein thrombosis

Wangao Zhang et al.

TISSUE & CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p

Mingyi Qu et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Respiratory System

The Predictive Value of microRNA-134 and microRNA-1233 for the Early Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Acute Pulmonary Embolism

Ling Peng et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Current Management of Acute Pulmonary Embolism

Carlos R. Martinez Licha et al.

ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY (2020)

添加到收藏夹

Review Cell Biology

MicroRNAs as potential regulators of platelet function and bleeding diatheses

Ascension M. De Los Reyes-Garcia et al.

PLATELETS (2019)

添加到收藏夹

Article Hematology

The D-dimer assay

Eric D. Johnson et al.

AMERICAN JOURNAL OF HEMATOLOGY (2019)

添加到收藏夹

Review Medicine, General & Internal

Deep vein thrombosis: update on diagnosis and management

Paul C. Kruger et al.

MEDICAL JOURNAL OF AUSTRALIA (2019)

添加到收藏夹

Article Cell Biology

MiR-205 promotes endothelial progenitor cell angiogenesis and deep vein thrombosis recanalization and resolution by targeting PTEN to regulate Akt/autophagy pathway and MMP2 expression

Li-Li Sun et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

添加到收藏夹

Editorial Material Hematology

MicroRNAs: A New Understanding of Platelet Physiology and Pathology

Christian Schulte et al.

THROMBOSIS AND HAEMOSTASIS (2019)

添加到收藏夹

Article Medical Laboratory Technology

Resistin Promotes Thrombosis in Rats with Deep Vein Thrombosis via Up-Regulating MMP-2, MMP-9, and PAI-1

Yang Din et al.

CLINICAL LABORATORY (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

MiR-411 suppressed vein wall fibrosis by downregulating MMP-2 via targeting HIF-1α

Peng Ai et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

microRNAs regulate nitric oxide release from endothelial cells by targeting NOS3

Ji-zheng Qin et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2018)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Chronic Thromboembolic Pulmonary Hypertension

Christopher J. Mullin et al.

HEART FAILURE CLINICS (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Combination of Circulating miRNA-320a/b and D-Dimer Improves Diagnostic Accuracy in Deep Vein Thrombosis Patients

Zhiyun Jiang et al.

MEDICAL SCIENCE MONITOR (2018)

添加到收藏夹

Article Hematology

Large-scale identification of functional microRNA targeting reveals cooperative regulation of the hemostatic system

J. Nourse et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effect of miR-495 on lower extremity deep vein thrombosis through the TLR4 signaling pathway by regulation of IL1R1 (Publication with Expression of Concern. See vol. 42, pg. 1, 2022)

Ke-Cheng Tang et al.

BIOSCIENCE REPORTS (2018)

添加到收藏夹

Review Medical Laboratory Technology

D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications

Julien Favresse et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Plasma Levels of microRNA-221 (miR-221) are Increased in Patients with Acute Pulmonary Embolism

Tingwei Liu et al.

MEDICAL SCIENCE MONITOR (2018)

添加到收藏夹

Article Peripheral Vascular Disease

Diagnostic value of circulating microRNA-27a/b in patients with acute pulmonary embolism

Qian Wang et al.

INTERNATIONAL ANGIOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Hematopoietic Deficiency of miR-223 Attenuates Thrombosis in Response to Photochemical Injury in Mice

Hui Wang et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Dermatology

Plasma MMP and TIMP evaluation in patients with deep venous thrombosis: could they have a predictive role in the development of post-thrombotic syndrome?

Stefano de Franciscis et al.

INTERNATIONAL WOUND JOURNAL (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Serum microRNA-1233 is a specific biomarker for diagnosing acute pulmonary embolism

Thorsten Kessler et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Upregulation of miR-483-3p contributes to endothelial progenitor cells dysfunction in deep vein thrombosis patients via SRF

Lingshang Kong et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2016)

添加到收藏夹

Article Hematology

Diagnostic potential of plasma microRNA signatures in patients with deep-vein thrombosis

Xiao Wang et al.

THROMBOSIS AND HAEMOSTASIS (2016)

添加到收藏夹

Article Hematology

MiR-28-3p as a potential plasma marker in diagnosis of pulmonary embolism

Xin Zhou et al.

THROMBOSIS RESEARCH (2016)

添加到收藏夹

Article Hematology

Downregulation of let-7e-5p contributes to endothelial progenitor cell dysfunction in deep vein thrombosis via targeting FASLG

Lingshang Kong et al.

THROMBOSIS RESEARCH (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Deep vein thrombosis is accurately predicted by comprehensive analysis of the levels of microRNA-96 and plasma D-dimer

Xuesheng Xie et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Hyperglycaemia-induced reciprocal changes in miR-30c and PAI-1 expression in platelets

Mao Luo et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Cell & Tissue Engineering

Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia

Ahmed Saad et al.

STEM CELL RESEARCH & THERAPY (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

A panel of microRNAs as a new biomarkers for the detection of deep vein thrombosis

Jizheng Qin et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

MicroRNA-223 inhibits tissue factor expression in vascular endothelial cells

Sufang Li et al.

ATHEROSCLEROSIS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Differentially Expressed Plasma MicroRNAs and the Potential Regulatory Function of Let-7b in Chronic Thromboembolic Pulmonary Hypertension

Lijuan Guo et al.

PLOS ONE (2014)

添加到收藏夹

Article Hematology

Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression

Olof Gidlof et al.

BLOOD (2013)

添加到收藏夹

Article Cell Biology

MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion

Ge Yu et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2013)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

MicroRNA expression profile of pulmonary artery smooth muscle cells and the effect of let-7d in chronic thromboembolic pulmonary hypertension

Lei Wang et al.

PULMONARY CIRCULATION (2013)

添加到收藏夹

Article Endocrinology & Metabolism

miR-93/106b and Their Host Gene, MCM7, Are Differentially Expressed in Leiomyomas and Functionally Target F3 and IL-8

Tsai-Der Chuang et al.

MOLECULAR ENDOCRINOLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

MicroRNA-19 (miR-19) Regulates Tissue Factor Expression in Breast Cancer Cells

Xiaoxi Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

添加到收藏夹

Article Hematology

Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome

R. Teruel et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)

添加到收藏夹

Article Medicine, Research & Experimental

MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism

Junjie Xiao et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2011)

添加到收藏夹

Article Hematology

Regulation of fibrinogen production by microRNAs

Alexandre Fort et al.

BLOOD (2010)

添加到收藏夹

Article Genetics & Heredity

Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphic fibrinogen alpha gene

Zhiyong Chen et al.

HUMAN GENETICS (2010)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.