☆ 4.6 Review

Indeterminate Thyroid Nodules: From Cytology to Molecular Testing

DIAGNOSTICS (2023)

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Summary: The TP53 gene plays a crucial role in cell proliferation control and signaling regulation. TP53 mutation is associated with the malignant transformation of thyroid cells and tumor progression. This study found that the expression of p53 in cytology samples was correlated with malignant pathology diagnosis. p53 may be a useful marker for distinguishing thyroid follicular lesions.

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Down-regulation of miR-7-5p and miR-548ar-5p predicts malignancy in indeterminate thyroid nodules negative for BRAF and RAS mutations

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Carla Colombo et al.

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