期刊
DIAGNOSTICS
卷 13, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics13152472
关键词
adaptive optics; cone dystrophy; cone-rod dystrophy; inherited retinal diseases; inherited retinal dystrophies; photoreceptors; retinal imaging; Stargardt disease
This study examines the application of adaptive optics (AO) in the assessment of patients with inherited retinal dystrophies (IRDs). AO allows for detailed observation of retinal photoreceptor structures and quantitative analysis of parameters. The study found significant differences in DM, SM, REG, and N%6 parameters between healthy and IRD-affected eyes.
Inherited retinal dystrophies (IRDs) are genetic disorders that lead to the bilateral degeneration of the retina, causing irreversible vision loss. These conditions often manifest during the first and second decades of life, and their primary symptoms can be non-specific. Diagnostic processes encompass assessments of best-corrected visual acuity, fundoscopy, optical coherence tomography, fundus autofluorescence, fluorescein angiography, electrophysiological tests, and genetic testing. This study focuses on the application of adaptive optics (AO), a non-invasive retinal examination, for the assessment of patients with IRDs. AO facilitates the high-quality, detailed observation of retinal photoreceptor structures (cones and rods) and enables the quantitative analysis of parameters such as cone density (DM), cone spacing (SM), cone regularity (REG), and Voronoi analysis (N%6). AO examinations were conducted on eyes diagnosed with Stargardt disease (STGD, N = 36), cone dystrophy (CD, N = 9), and cone-rod dystrophy (CRD, N = 8), and on healthy eyes (N = 14). There were significant differences in the DM, SM, REG, and N%6 parameters between the healthy and IRD-affected eyes (p < 0.001 for DM, SM, and REG; p = 0.008 for N%6). The mean DM in the CD, CRD, and STGD groups was 8900.39/mm2, 9296.32/mm(2), and 16,209.66/mm(2), respectively, with a significant inter-group difference (p = 0.006). The mean SM in the CD, CRD, and STGD groups was 12.37 mu m, 14.82 mu m, and 9.65 mu m, respectively, with a significant difference observed between groups ( p = 0.002). However, no significant difference was found in REG and N%6 among the CD, CRD, and STGD groups. Significant differences were found in SM and DM between CD and STGD ( p = 0.014 for SM; p = 0.003 for DM) and between CRD and STGD (p = 0.027 for SM; p = 0.003 for DM). Our findings suggest that AO holds significant potential as an impactful diagnostic tool for IRDs.
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