4.6 Review

Intravenous Immunoglobulin in Kawasaki Disease-Evolution and Pathogenic Mechanisms

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pediatrics

Inositol-Triphosphate 3-Kinase C and DNA Methylation Involvement in NLRP3 Inflammasome Activation in Kawasaki Disease

Meng-Lei Ji et al.

Summary: This study evaluated the expression of ITPKC and NLRP3 in children with Kawasaki disease (KD) and investigated the relationship between serum pro-inflammatory cytokines triggered by NLRP3 and inflammatory indices. The study also examined the methylation level in the ITPKC promoter in children with KD. The results showed that DNA methylation modifies ITPKC promoter activity and is involved in NLRP3 inflammasome activation in children with KD.

INDIAN JOURNAL OF PEDIATRICS (2023)

Editorial Material Pediatrics

Role of Inflammasomes in Kawasaki Disease COMMENT

Anju Gupta

INDIAN JOURNAL OF PEDIATRICS (2023)

Article Pediatrics

Therapeutic Window of Intravenous Immunoglobulin (IVIG) and its correlation with IVIG-resistant in Kawasaki Disease: a retrospective study

Jiang Hui Cai et al.

Summary: This study investigated the optimal timing of initial intravenous immunoglobulin (IVIG) treatment in Kawasaki disease (KD) patients. It was found that IVIG therapy within 7 days of illness is more effective for reducing the risk of coronary artery abnormalities compared to treatment after 7 days.

JORNAL DE PEDIATRIA (2023)

Article Immunology

Intravenous Immunoglobulin Therapy Restores the Quantity and Phenotype of Circulating Dendritic Cells and CD4+ T Cells in Children With Acute Kawasaki Disease

Nana Wang et al.

Summary: This study found that the quantity and phenotypes of immune cells were altered in patients with Kawasaki disease, and intravenous immunoglobulin therapy could restore these changes. These findings are important for understanding the immunomodulatory actions of intravenous immunoglobulin in the treatment of Kawasaki disease.

FRONTIERS IN IMMUNOLOGY (2022)

Article Cardiac & Cardiovascular Systems

Stratified therapy for Kawasaki disease using a new scoring system to predict the response to a lower dose of intravenous immunoglobulin therapy

Misa Matsuura et al.

Summary: The study showed that stratified therapies for patients with Kawasaki disease based on a new scoring system can achieve satisfactory results, with no significant differences in treatment response rates and coronary artery lesion rates among different risk groups.

CARDIOLOGY IN THE YOUNG (2022)

Article Rheumatology

Low- versus high-concentration intravenous immunoglobulin for children with Kawasaki disease in the acute phase

Takanori Suzuki et al.

Summary: This study compared the outcomes of low- and high-concentration IVIG preparations for children with KD, finding a difference in IVIG resistance but no significant difference in coronary artery abnormalities between the two groups. Prospective studies adjusting for IVIG administration duration and observation period are needed to confirm the results.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2022)

Article Pediatrics

High-Concentration Intravenous Immunoglobulin May Influence the Course of Fever and Rate of Reported Treatment Resistance in Children With Kawasaki Disease: A Single-Center Retrospective Analysis

Seung Beom Han et al.

Summary: This study found a significant association between 10% IVIG therapy and increased IVIG resistance, but the increase in IVIG resistance in patients with fever patterns consistent with IVIG resistance seemed to be a result of using high-concentration IVIG rather than worsening KD.

PEDIATRIC DRUGS (2022)

Article Immunology

Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulin

Jorge Adrian Masso-Silva et al.

Summary: The pathogenesis of lung injury in COVID-19 is not fully understood, but it has been found that neutrophils and neutrophil extracellular traps (NETs) play a role in the severity of the disease. Targeting the pro-inflammatory functions of neutrophils may help reduce lung injury in COVID-19 and ARDS. Experiments showed that IVIG can inhibit NET production and reduce reactive oxygen species generation.

FRONTIERS IN IMMUNOLOGY (2022)

Article Cardiac & Cardiovascular Systems

Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease

Yasutaka Nakashima et al.

Summary: Through lipidomics analysis of 105 KD patients and 65 disease controls, the study found that oxidized phospholipids are associated with the development of coronary arteritis in KD, playing a significant role in its pathogenesis.

CARDIOVASCULAR RESEARCH (2021)

Article Pediatrics

Randomized trial of different initial intravenous immunoglobulin regimens in Kawasaki disease

Lan He et al.

Summary: The study demonstrated that a single dose of 1g/kg IVIG is a cost-effective treatment option for KD patients with similar efficacy to 2g/kg IVIG. There were no significant differences in fever resolution time, incidence of coronary artery lesions, changes in laboratory data, total fever days, and length of hospital stay among the three groups during the study period. Patients in Group C had the lowest total dose of IVIG and hospitalization expenses compared to the other two groups.

PEDIATRICS INTERNATIONAL (2021)

Article Pediatrics

Infliximab versus second intravenous immunoglobulin for treatment of resistant Kawasaki disease in the USA (KIDCARE): a randomised, multicentre comparative effectiveness trial

Jane C. Burns et al.

Summary: Infliximab is a safe and effective treatment for patients with IVIG-resistant Kawasaki disease, showing higher rate of fever resolution and shorter hospital stay compared to second IVIG infusion.

LANCET CHILD & ADOLESCENT HEALTH (2021)

Article Immunology

High Dose Intravenous IgG Therapy Modulates Multiple NK Cell and T Cell Functions in Patients With Immune Dysregulation

Sarah M. McAlpine et al.

Summary: IVIG treatment has multiple effects on NK cell subsets and CD4(+) T cells, promoting resolution of inflammation in patients with immune dysregulation.

FRONTIERS IN IMMUNOLOGY (2021)

Article Pediatrics

Efficacy and safety associated with the infusion speed of intravenous immunoglobulin for the treatment of Kawasaki disease: a randomized controlled trial

Saori Fukui et al.

Summary: The efficacy and safety of administering IVIG over 12 hours were found to be similar to those administered over 24 hours, with no significant differences in fever duration, coronary artery abnormalities, or changes in inflammatory markers between the two groups. The increase of serum immunoglobulin G from baseline level was greater in the 24-hour group compared to the 12-hour group.

PEDIATRIC RHEUMATOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease

Fumiya Anzai et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients

Zhouping Wang et al.

CARDIOVASCULAR THERAPEUTICS (2020)

Review Cardiac & Cardiovascular Systems

Antibodies and Immunity During Kawasaki Disease

Mark Daniel Hicar

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

Article Pediatrics

Identifying Downregulation of Autophagy Markers in Kawasaki Disease

Fu-Chen Huang et al.

CHILDREN-BASEL (2020)

Review Pediatrics

Aetiological Significance of Infectious Stimuli in Kawasaki Disease

Akihiro Nakamura et al.

FRONTIERS IN PEDIATRICS (2019)

Article Rheumatology

The role of echocardiography in Kawasaki disease

Brian W. McCrindle et al.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2018)

Article Pediatrics

Effect of i.v. immunoglobulin in the first 4 days of illness in Kawasaki disease

Yusuke Shiozawa et al.

PEDIATRICS INTERNATIONAL (2018)

Review Immunology

Adverse Effects of Immunoglobulin Therapy

Yi Guo et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Allergy

An introduction to immunology and immunopathology

Jean S. Marshall et al.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Predicting Coronary Artery Aneurysms in Kawasaki Disease at a North American Center: An Assessment of Baseline z Scores

Mary Beth F. Son et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)

Review Immunology

Kawasaki disease: a matter of innate immunity

T. Hara et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2016)

Article Pediatrics

Kawasaki Disease in India - Lessons Learnt Over the Last 20 Years

Surjit Singh et al.

INDIAN PEDIATRICS (2016)

Article Pediatrics

Variability in Response to Intravenous Immunoglobulin in the Treatment of Kawasaki Disease

Mallory L. Downie et al.

JOURNAL OF PEDIATRICS (2016)

Article Cardiac & Cardiovascular Systems

Coronary Artery Aneurysms in Kawasaki Disease: Risk Factors for Progressive Disease and Adverse Cardiac Events in the US Population

Kevin G. Friedman et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

Article Immunology

Regulatory T cell microRNA expression changes in children with acute Kawasaki disease

F-F. Ni et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2014)

Article Immunology

Immune-monitoring in Kawasaki disease patients treated with infliximab and intravenous immunoglobulin

J. C. Burns et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2013)

Article Pediatrics

DC-SIGN gene promoter variants and IVIG treatment response in Kawasaki disease

Michael A. Portman et al.

PEDIATRIC RHEUMATOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Role of Activating FcγR Gene Polymorphisms in Kawasaki Disease Susceptibility and Intravenous Immunoglobulin Response

Sadeep Shrestha et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2012)

Review Immunology

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

Daolin Tang et al.

IMMUNOLOGICAL REVIEWS (2012)

Letter Allergy

Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki disease

Christine Deffert et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Effectiveness of Medium-Dose Intravenous Immunoglobulin (1 g/kg) in the Treatment of Kawasaki Disease

Joong-Seok Yeo et al.

Korean Circulation Journal (2010)

Review Microbiology

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

Trine H. Mogensen

CLINICAL MICROBIOLOGY REVIEWS (2009)

Article Cardiac & Cardiovascular Systems

Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease

Tohru Kobayashi et al.

CIRCULATION (2006)

Article Pediatrics

CD25+ CD4+ regulatory T cells in patients with Kawasaki disease

K Furuno et al.

JOURNAL OF PEDIATRICS (2004)

Article Cardiac & Cardiovascular Systems

Prognostic impact of vascular leakage in acute Kawasaki disease

M Terai et al.

CIRCULATION (2003)

Article Immunology

Delayed apoptosis of circulating neutrophils in Kawasaki disease

H Tsujimoto et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2001)

Review Medicine, General & Internal

Advances in immunology: Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin.

MD Kazatchkine et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)