期刊
NATURE METHODS
卷 14, 期 1, 页码 49-52出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.4079
关键词
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资金
- NIH [32GM113406, AI20566, GM047467, GM075879, AI037581]
- Human Frontiers Science program
- HHMI
- TUM Institute for Advanced Study
- European Commission
- CIPSM excellence cluster
- DFG [SFB1035]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI037581, R21AI020566, R01AI020566, R37AI020566] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [F32GM113406, P01GM047467, R01GM075879] Funding Source: NIH RePORTER
We engineered covalently circularized nanodiscs (cNDs) which, compared with standard nanodiscs, exhibit enhanced stability, defined diameter sizes and tunable shapes. Reconstitution into cNDs enhanced the quality of nuclear magnetic resonance spectra for both VDAC-1, a beta-barrel membrane protein, and the G-protein-coupled receptor NTR1, an alpha-helical membrane protein. In addition, we used cNDs to visualize how simple, nonenveloped viruses translocate their genomes across membranes to initiate infection.
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