期刊
NATURE METHODS
卷 13, 期 8, 页码 639-650出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3929
关键词
-
资金
- CRUK [C47594/A16267, C14303/A17197]
- European Commission [CIG FP7-PEOPLE-2013-CIG-630729]
- EPSRC-CRUK Cancer Imaging Centre in Cambridge and Manchester [C197/A16465]
- King's College London
- University College London Comprehensive Cancer Imaging Centre Cancer Research UK
- Medical Research Council, UK
- Department of Health, UK
- European Union (project FAMOS FP7 ICT) [317744]
- Engineering and Physical Sciences Research Council
- Cancer Research UK [16267, 16465, 21142] Funding Source: researchfish
Photoacoustic imaging (PAI) is an emerging tool that bridges the traditional depth limits of ballistic optical imaging and the resolution limits of diffuse optical imaging. Using the acoustic waves generated in response to the absorption of pulsed laser light, it provides noninvasive images of absorbed optical energy density at depths of several centimeters with a resolution of similar to 100 mu m. This versatile and scalable imaging modality has now shown potential for molecular imaging, which enables visualization of biological processes with systemically introduced contrast agents. Understanding the relative merits of the vast range of contrast agents available, from small-molecule dyes to gold and carbon nanostructures to liposome encapsulations, is a considerable challenge. Here we critically review the physical, chemical and biochemical characteristics of the existing photoacoustic contrast agents, highlighting key applications and present challenges for molecular PAI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据