期刊
NATURE METHODS
卷 13, 期 4, 页码 366-370出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3799
关键词
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资金
- Swiss National Science Foundation [FN 310030_152724/1, FN 31003A-143914]
- SystemsX.ch
- Swiss Institute of Bioinformatics
- Leenaards Foundation
Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type- and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoters and genes. Integration with 37 genome-wide association studies (GWASs) showed that disease associated genetic variants including variants that do not reach genome-wide significance often perturb regulatory modules that are highly specific to disease-relevant cell types or tissues. Our resource opens the door to systematic analysis of regulatory programs across hundreds of human cell types and tissues (http://regulatorycircuits.org).
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