4.6 Article

Overcoming Challenges in Chemical Glycosylation to Achieve Innovative Vaccine Adjuvants Possessing Enhanced TLR4 Activity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

Alessio Romerio et al.

Summary: In this study, a new series of small-molecule TLR4 agonists (the FP20 series) with increased chemical stability and a more efficient synthesis method were developed based on previously developed TLR4 ligands (the FP18 series). The FP20 series showed selective activity as TLR4 agonists, but with a different mechanism of action compared to the FP18 series. Computational studies suggested that the 3D shape of the FP20 series allows for binding to the MD-2 pocket. Additionally, FP20 displayed promising adjuvant activity in mouse vaccination experiments.

JOURNAL OF MEDICINAL CHEMISTRY (2023)

Article Biochemistry & Molecular Biology

Expanding the scope of stereoselective ?-galactosylation using glycosyl chlorides

Melanie Shadrick et al.

Summary: This study presents a stereoselective synthesis of alpha-galactosides using galactosyl chlorides as glycosyl donors under the catalytic system of Ag2SO4 and Bi(OTf)3.

BIOORGANIC & MEDICINAL CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

A Streamlined Regenerative Glycosylation Reaction: Direct, Acid-Free Activation of Thioglycosides

Samira Escopy et al.

Summary: This research describes a direct conversion of thioglycosides using a regenerative approach, bypassing the need for bromide intermediates and heavy-metal-based promoters. The reaction conditions are mild, with only 1 equiv. NIS and catalytic HOFox needed under neutral conditions.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

Review Biotechnology & Applied Microbiology

Vaccines and vaccination: history and emerging issues

Veysel Kayser et al.

Summary: Prophylactic vaccines play a crucial role in preventing infectious diseases, with historically fearsome diseases like polio and smallpox now rare due to vaccination efforts. Most vaccines are administered to healthy individuals as a preventive measure, but there have been ethically questionable practices in vaccine testing throughout history.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

Article Chemistry, Organic

Bismuth(iii) triflate as a novel and efficient activator for glycosyl halides†

Hayley B. Steber et al.

Summary: The discovery of Bi(OTf)(3) as an effective catalyst for glycosyl halides activation allows for fast reactions with low catalyst amount and environmental friendliness.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

A Highly Efficient Glycosidation of Glycosyl Chlorides by Using Cooperative Silver(I) Oxide-Triflic Acid Catalysis

Scott A. Geringer et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

Review Immunology

The continued advance of vaccine adjuvants - 'we can work it out'

Derek T. O'Hagan et al.

SEMINARS IN IMMUNOLOGY (2020)

Article Chemistry, Multidisciplinary

Koenigs-Knorr Glycosylation Reaction Catalyzed by Trimethylsilyl Trifluoromethanesulfonate

Yashapal Singh et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

Review Chemistry, Medicinal

Recent clinical trends in Toll-like receptor targeting therapeutics

Muhammad Ayaz Anwar et al.

MEDICINAL RESEARCH REVIEWS (2019)

Review Chemistry, Multidisciplinary

One-Pot Protection, Glycosylation, and Protection-Glycosylation Strategies of Carbohydrates

Suvarn S. Kulkarni et al.

CHEMICAL REVIEWS (2018)

Review Medicine, General & Internal

Understanding modern-day vaccines: what you need to know

Volker Vetter et al.

ANNALS OF MEDICINE (2018)

Review Biochemistry & Molecular Biology

The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling

Florent Cochet et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Common side reactions of the glycosyl donor in chemical glycosylation

Helle M. Christensen et al.

CARBOHYDRATE RESEARCH (2015)

Review Chemistry, Multidisciplinary

Chemistry of Lipid A: At the Heart of Innate Immunity

Antonio Molinaro et al.

CHEMISTRY-A EUROPEAN JOURNAL (2015)

Review Biochemistry & Molecular Biology

Key roles of adjuvants in modern vaccines

Steven G. Reed et al.

NATURE MEDICINE (2013)

Article Multidisciplinary Sciences

TRIF Is Required for TLR4 Mediated Adjuvant Effects on T Cell Clonal Expansion

Siva K. Gandhapudi et al.

PLOS ONE (2013)

Review Chemistry, Organic

Ritter Reaction: Recent Catalytic Developments

Amandine Guerinot et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2012)

Review Cell Biology

Toll-Like Receptor Signaling Pathways-Therapeutic Opportunities

Jiankun Zhu et al.

MEDIATORS OF INFLAMMATION (2010)

Article Multidisciplinary Sciences

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

Beom Seok Park et al.

NATURE (2009)

Article Multidisciplinary Sciences

CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages

Claudia Oliva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Biochemistry & Molecular Biology

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

C. R. Casella et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Article Biochemistry & Molecular Biology

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran

Ho Min Kim et al.

Article Multidisciplinary Sciences

The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4

Veronica Mata-Haro et al.

SCIENCE (2007)

Review Biochemistry & Molecular Biology

Bacterial lipopolysaccharides and innate immunity

C Alexander et al.

JOURNAL OF ENDOTOXIN RESEARCH (2001)