期刊
NATURE METHODS
卷 13, 期 12, 页码 1009-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.4025
关键词
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资金
- NIH [GM079205]
- 4D Nucleome Program [R01 GM114190, U54 DK107980]
We present Micro-C XL, an improved method for analysis of chromosome folding at mononucleosome resolution. Using long crosslinkers and isolation of insoluble chromatin, Micro-C XL increases signal-to-noise ratio. Micro-C XL maps of budding and fission yeast genomes capture both short-range chromosome fiber features such as chromosomally interacting domains and higher order features such as centromere clustering. Micro-C XL provides a single assay to interrogate chromosome folding at length scales from the nucleosome to the full genome.
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