Role of Non-Coding RNAs in TGF-β Signalling in Glioma

Brain tumours and Gliomas, in particular, are among the primary causes of cancer mortality worldwide. Glioma diagnosis and therapy have not significantly improved despite decades of efforts. Autocrine TGF-beta signalling promotes glioma proliferation, invasion, epithelial-to-mesenchymal transition (EMT), and drug resistance. Non-coding RNAs such as miRNA, lncRNA, and circRNAs have emerged as critical transcriptional and post-transcriptional regulators of TGF-beta pathway components in glioma. Here, we summarize the complex regulatory network among regulatory ncRNAs and TGF-beta pathway during Glioma pathogenesis and discuss their role as potential therapeutic targets for Gliomas.

Automated summary

This article summarizes the complex regulatory network between non-coding RNAs and the TGF-beta pathway during glioma pathogenesis, and discusses their role as potential therapeutic targets for gliomas.