相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis
Daichi Inoue et al.
GENES & DEVELOPMENT (2016)
Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution
Thi Hoang Duong Nguyen et al.
NATURE (2016)
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins
Stanley Chun-Wei Lee et al.
NATURE MEDICINE (2016)
Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages
Kerstin A. Effenberger et al.
RNA (2016)
The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
Ruixue Wan et al.
SCIENCE (2016)
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Konstantinos J. Mavrakis et al.
SCIENCE (2016)
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
Gregory V. Kryukov et al.
SCIENCE (2016)
Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
Samar Alsafadi et al.
NATURE COMMUNICATIONS (2016)
RNA splicing factors as oncoproteins and tumour suppressors
Heidi Dvinge et al.
NATURE REVIEWS CANCER (2016)
SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition
Eunhee Kim et al.
CANCER CELL (2015)
A Chemical Genetics Approach for the Functional Assessment of Novel Cancer Genes
Qianhe Zhou et al.
CANCER RESEARCH (2015)
The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond
Nicole Stopa et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2015)
An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies
Graham McClorey et al.
CURRENT OPINION IN PHARMACOLOGY (2015)
SRSF1-Regulated Alternative Splicing in Breast Cancer
Olga Anczukow et al.
MOLECULAR CELL (2015)
The architecture of the spliceosomal U4/U6.U5 tri-snRNP
Thi Hoang Duong Nguyen et al.
NATURE (2015)
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente et al.
NATURE (2015)
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
Tiffany Y. -T. Hsu et al.
NATURE (2015)
MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
Cheryl M. Koh et al.
NATURE (2015)
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
Elayne Chan-Penebre et al.
NATURE CHEMICAL BIOLOGY (2015)
Intron retention is a widespread mechanism of tumor-suppressor inactivation
Hyunchul Jung- et al.
NATURE GENETICS (2015)
Identification of recurrent regulated alternative splicing events across human solid tumors
Miri Danan-Gotthold et al.
NUCLEIC ACIDS RESEARCH (2015)
Inhibitors of CLK Protein Kinases Suppress Cell Growth and Induce Apoptosis by Modulating Pre-mRNA Splicing
Shinsuke Araki et al.
PLOS ONE (2015)
Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities
Jian Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Structure of a yeast spliceosome at 3.6-angstrom resolution
Chuangye Yan et al.
SCIENCE (2015)
Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing
Maayan Salton et al.
NATURE COMMUNICATIONS (2015)
Response to MET Inhibitors in Patients with Stage IV Lung Adenocarcinomas Harboring MET Mutations Causing Exon 14 Skipping
Paul K. Paik et al.
CANCER DISCOVERY (2015)
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
Elena Sotillo et al.
CANCER DISCOVERY (2015)
Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point
Rachel B. Darman et al.
CELL REPORTS (2015)
Widespread intron retention diversifies most cancer transcriptomes
Heidi Dvinge et al.
GENOME MEDICINE (2015)
Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3′ Splice Site Selection in SF3B1-mutated Cancers
Christopher DeBoever et al.
PLOS COMPUTATIONAL BIOLOGY (2015)
U2AF1 mutations alter splice site recognition in hematological malignancies
Janine O. Ilagan et al.
GENOME RESEARCH (2015)
Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron
V. Visconte et al.
LEUKEMIA (2015)
Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)
Raoni Pais Siqueira et al.
PLOS ONE (2015)
Pre-mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide-Herboxidiene Hybrid Analog and Related Derivatives
Chandraiah Lagisetti et al.
ACS CHEMICAL BIOLOGY (2014)
Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers
Fran Supek et al.
CELL (2014)
Molecular Therapeutic Strategies for Spinal Muscular Atrophies: Current and Future Clinical Trials
Chiara Zanetta et al.
CLINICAL THERAPEUTICS (2014)
Antisense oligonucleotides in cancer
Daniela Castanotto et al.
CURRENT OPINION IN ONCOLOGY (2014)
Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects
Jeremy M. Simon et al.
GENOME RESEARCH (2014)
A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors
D. S. Hong et al.
INVESTIGATIONAL NEW DRUGS (2014)
Comprehensive molecular profiling of lung adenocarcinoma
Eric A. Collisson et al.
NATURE (2014)
Context-dependent control of alternative splicing by RNA-binding proteins
Xiang-Dong Fu et al.
NATURE REVIEWS GENETICS (2014)
A day in the life of the spliceosome
A. Gregory Matera et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Splicing factor SRSF6 promotes hyperplasia of sensitized skin
Mads A. Jensen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Total Synthesis of 6-Deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 Cancer Cell Line
Kenzo Arai et al.
ORGANIC LETTERS (2014)
Identification of a Novel Function of CX-4945 as a Splicing Regulator
Hyeongki Kim et al.
PLOS ONE (2014)
Regulation of splicing by SR proteins and SR protein-specific kinases
Zhihong Zhou et al.
CHROMOSOMA (2013)
Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors
Ferry A. L. M. Eskens et al.
CLINICAL CANCER RESEARCH (2013)
The development and application of small molecule modulators of SF3b as therapeutic agents for cancer
Thomas R. Webb et al.
DRUG DISCOVERY TODAY (2013)
Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A
Christopher G. Hubert et al.
GENES & DEVELOPMENT (2013)
Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery
Marco Bezzi et al.
GENES & DEVELOPMENT (2013)
Optimization of Antitumor Modulators of Pre-mRNA Splicing
Chandraiah Lagisetti et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43
Xiangyang Liu et al.
JOURNAL OF NATURAL PRODUCTS (2013)
Genome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing
Shatakshi Pandit et al.
MOLECULAR CELL (2013)
Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3
Marcel Martin et al.
NATURE GENETICS (2013)
Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
J. William Harbour et al.
NATURE GENETICS (2013)
Misregulation of Pre-mRNA Alternative Splicing in Cancer
Jian Zhang et al.
CANCER DISCOVERY (2013)
Protein arginine methyltransferases and cancer
Yanzhong Yang et al.
NATURE REVIEWS CANCER (2013)
Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Marcin Imielinski et al.
CELL (2012)
Comprehensive genomic characterization of squamous cell lung cancers
Peter S. Hammerman et al.
NATURE (2012)
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
Timothy A. Graubert et al.
NATURE GENETICS (2012)
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
Victor Quesada et al.
NATURE GENETICS (2012)
The spliceosome as a target of novel antitumour drugs
Sophie Bonnal et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
Olga Anczukow et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC
Shipra Das et al.
CELL REPORTS (2012)
Evolution of SR protein and hnRNP splicing regulatory factors
Anke Busch et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2012)
Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing
Liying Fan et al.
ACS CHEMICAL BIOLOGY (2011)
Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product
Makoto Hasegawa et al.
ACS CHEMICAL BIOLOGY (2011)
Biological validation that SF3b is a target of the antitumor macrolide pladienolide
Akira Yokoi et al.
FEBS JOURNAL (2011)
Serine-arginine protein kinases: a small protein kinase family with a large cellular presence
Thomas Giannakouros et al.
FEBS JOURNAL (2011)
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
Anna Corrionero et al.
GENES & DEVELOPMENT (2011)
The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region
Eric G. Folco et al.
GENES & DEVELOPMENT (2011)
Increased levels of noisy splicing in cancers, but not for oncogene-derived transcripts
Lu Chen et al.
HUMAN MOLECULAR GENETICS (2011)
Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study
Sebahattin Cirak et al.
LANCET (2011)
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
Poulikos I. Poulikakos et al.
NATURE (2011)
Frequent pathway mutations of splicing machinery in myelodysplasia
Kenichi Yoshida et al.
NATURE (2011)
Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts
E. Papaemmanuil et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
Lili Wang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
Charles J. David et al.
NATURE (2010)
Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation
Gabriel A. Roybal et al.
NUCLEIC ACIDS RESEARCH (2010)
Small Molecule Inhibitors of Yeast Pre-mRNA Splicing
Kelly G. Aukema et al.
ACS CHEMICAL BIOLOGY (2009)
The Spliceosome: Design Principles of a Dynamic RNP Machine
Markus C. Wahl et al.
CELL (2009)
The SR protein family
Peter J. Shepard et al.
GENOME BIOLOGY (2009)
Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in Transgenic mice
Yimin Hua et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
PHF5A represents a bridge protein between splicing proteins and ATP-dependent helicases and is differentially expressed during mouse spermatogenesis
T. Rzymski et al.
CYTOGENETIC AND GENOME RESEARCH (2008)
Alternative isoform regulation in human tissue transcriptomes
Eric T. Wang et al.
NATURE (2008)
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
Qun Pan et al.
NATURE GENETICS (2008)
The splicing-factor oncoprotein SF2/ASF activates mTORC1
Rotem Karni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Splicing regulation: From a parts list of regulatory elements to an integrated splicing code
Zefeng Wang et al.
RNA (2008)
A synthetic entry to pladienolide B and FD-895
Alexander L. Mandel et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Splicing factor SF3b as a target of the antitumor natural product pladienolide
Yoshihiko Kotake et al.
NATURE CHEMICAL BIOLOGY (2007)
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Daisuke Kaida et al.
NATURE CHEMICAL BIOLOGY (2007)
Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue
Brian J. Albert et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
The gene encoding the splicing factor SF2/ASF is a proto-oncogene
Rotem Karni et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Utilization of host SR protein kinases and RNA-splicing machinery during viral replication
Takeshi Fukuhara et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Somatic mutations lead to an oncogenic deletion of Met in lung cancer
M Kong-Beltran et al.
CANCER RESEARCH (2006)
Pladienolides, new substances from culture of Streptomyces platensis Mer-11107 I.: Taxonomy, fermentation, isolation and screening
T Sakai et al.
JOURNAL OF ANTIBIOTICS (2004)
Pladienolides, new substances from culture of Streptomyces platensis Mer-11107 II.: Physico-chemical properties and structure elucidation
T Sakai et al.
JOURNAL OF ANTIBIOTICS (2004)
Pladienolides, new substances from culture of Streptomyces platensis Mer-11107 III.: In vitro and In vivo antitumor activities
Y Mizui et al.
JOURNAL OF ANTIBIOTICS (2004)
Rescue of dystrophic muscle through U7 snRNA-mediated exon skipping
A Goyenvalle et al.
SCIENCE (2004)
Manipulation of alternative splicing by a newly developed inhibitor of Clks
M Muraki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse
QL Lu et al.
NATURE MEDICINE (2003)
Differential effects of hyperphosphorylation on splicing factor SRp55
MC Lai et al.
BIOCHEMICAL JOURNAL (2003)
GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp -: 1.: Taxonomy, production, isolation, physicochemical properties and biological activities
Y Sakai et al.
JOURNAL OF ANTIBIOTICS (2002)
FR901464: Total synthesis, proof of structure, and evaluation of synthetic analogues
CF Thompson et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)