期刊
NATURE MEDICINE
卷 22, 期 2, 页码 128-134出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.4036
关键词
-
资金
- National Cancer Center
- US National Cancer Institute [R01CA172152, R01CA113794]
- Garrett B. Smith Foundation
- Cure AT/RT Now foundation
- Avalanna Fund
- Miles for Mary
Recent genomic studies have resulted in an emerging understanding of the role of chromatin regulators in the development of cancer. EZH2, a histone methyl transferase subunit of a Polycomb repressor complex, is recurrently mutated in several forms of cancer and is highly expressed in numerous others. Notably, both gain-of-function and loss-of-function mutations occur in cancers but are associated with distinct cancer types. Here we review the spectrum of EZH2-associated mutations, discuss the mechanisms underlying EZH2 function, and synthesize a unifying perspective that the promotion of cancer arises from disruption of the role of EZH2 as a master regulator of transcription. We further discuss EZH2 inhibitors that are now showing early signs of promise in clinical trials and also additional strategies to combat roles of EZH2 in cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据