期刊
NATURE MEDICINE
卷 22, 期 12, 页码 1392-1401出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.4238
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资金
- US National Institutes of Health (NIH) [R00 DK087923, R01 HL121570]
- Lawrence Ellison Foundation
- Damon Runyon Cancer Research Foundation
- Edward Evans Foundation
- Taub Foundation for MDS research
Together with recent advances in the processing and culture of human tissue, bioengineering, xenotransplantation and genome editing, Induced pluripotent stem cells (iPSCs) present a range of new opportunities for the study of human cancer. Here we discuss the main advantages and limitations of iPSC modeling, and how the method intersects with other patient-derived models of cancer, such as organoids, organson- chips and patient-derived xenografts (PDXs). We highlight the opportunities that iPSC models can provide beyond those offered by existing systems and animal models and present current challenges and crucial areas for future improvements toward wider adoption of this technology.
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