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Antimicrobial Stewardship in the Hospital Setting: A Narrative Review

期刊

ANTIBIOTICS-BASEL
卷 12, 期 10, 页码 -

出版社

MDPI
DOI: 10.3390/antibiotics12101557

关键词

stewardship; antibiotics; resistance; preauthorization; restriction; handshake; audit; feedback; de-escalation; surgical prophylaxis

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The increasing global threat of antibiotic resistance highlights the need for strategic action. Medical societies have implemented antibiotic stewardship programs within healthcare institutions to combat resistance. Multidisciplinary teams and evidence-based strategies have shown initial success in reducing resistance rates, but further research is needed for novel interventions.
The increasing global threat of antibiotic resistance, which has resulted in countless fatalities due to untreatable infections, underscores the urgent need for a strategic action plan. The acknowledgment that humanity is perilously approaching the End of the Miracle Drugs due to the unjustifiable overuse and misuse of antibiotics has prompted a critical reassessment of their usage. In response, numerous relevant medical societies have initiated a concerted effort to combat resistance by implementing antibiotic stewardship programs within healthcare institutions, grounded in evidence-based guidelines and designed to guide antibiotic utilization. Crucial to this initiative is the establishment of multidisciplinary teams within each hospital, led by a dedicated Infectious Diseases physician. This team includes clinical pharmacists, clinical microbiologists, hospital epidemiologists, infection control experts, and specialized nurses who receive intensive training in the field. These teams have evidence-supported strategies aiming to mitigate resistance, such as conducting prospective audits and providing feedback, including the innovative 'Handshake Stewardship' approach, implementing formulary restrictions and preauthorization protocols, disseminating educational materials, promoting antibiotic de-escalation practices, employing rapid diagnostic techniques, and enhancing infection prevention and control measures. While initial outcomes have demonstrated success in reducing resistance rates, ongoing research is imperative to explore novel stewardship interventions.

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