Ceftazidime-Avibactam as Osteomyelitis Therapy: A Miniseries and Review of the Literature

Bone and joint infections (BJIs) caused by multidrug-resistant gram-negative bacteria are becoming a concern due to limited therapeutic options. Although not approved for these indications, an ever-growing amount of evidence supports the efficacy and safety of ceftazidime-avibactam as a therapy for osteomyelitis and prosthetic joint infections. Here, we present three cases of difficult-to-treat resistant Pseudomonas aeruginosa osteomyelitis that were successfully treated with ceftazidime-avibactam alone or in combination therapy with fosfomycin and amikacin. Ceftazidime-avibactam was prescribed at a daily dose of 2.5 g every 8 h for 42 days in all cases. One potential drug-related adverse effect was observed, i.e., Clostridioides difficile infection, which occurred after fourteen days of treatment with ceftazidime-avibactam.

Automated summary

BJIs caused by multidrug-resistant gram-negative bacteria are becoming a concern. Ceftazidime-avibactam has shown efficacy and safety in treating osteomyelitis and prosthetic joint infections, despite not being approved for these indications. This study presents three successful cases of resistant Pseudomonas aeruginosa osteomyelitis treated with ceftazidime-avibactam alone or in combination therapy.