☆ 4.6 Review

Benzimidazole-Triazole Hybrids as Antimicrobial and Antiviral Agents: A Systematic Review

ANTIBIOTICS-BASEL (2023)

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Summary: This study found that triazole-pyrimidine hybrid compounds exhibit neuroprotective and anti-inflammatory properties. Several compounds showed significant anti-neuroinflammatory activity by inhibiting the production of nitric oxide and tumor necrosis factor-alpha in human microglia cells. Additionally, several compounds demonstrated promising neuroprotective activity in human neuronal cells by reducing the expression of endoplasmic reticulum chaperone BIP and apoptosis marker cleaved caspase-3.

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Review Infectious Diseases

Coumarin Triazoles as Potential Antimicrobial Agents

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Design, synthesis, spectroscopic characterization, single crystal X-ray analysis, in vitro α-amylase inhibition assay, DPPH free radical evaluation and computational studies of naphtho[2,3-d]imidazole-4,9-dione appended 1,2,3-triazoles

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)

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Rebaz Anwar Omar et al.

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Review Pharmacology & Pharmacy

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Heba E. Hashem et al.

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Review Biotechnology & Applied Microbiology

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BIOMED RESEARCH INTERNATIONAL (2022)

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Article Chemistry, Medicinal

Discovery of benzimidazole substituted 1, 2, 4-oxadiazole compounds as novel anti-HBV agents with TLR8-agonistic activities

Jingying Qiu et al.

Summary: In this study, a new series of compounds were designed as immunomodulatory anti-HBV agents. Compound 11o exhibited significant in vitro anti-HBV activity and promoted the secretion of cytokines, making it a potential immunomodulatory anti-HBV agent.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Ajay Kumar Shukla et al.

Journal of Basic and Clinical Physiology and Pharmacology (2022)

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Article Chemistry, Medicinal

Synthesis and Anti-Inflammatory Activity Evaluation of Some Benzimidazole Derivatives

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PHARMACEUTICAL CHEMISTRY JOURNAL (2022)

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Emerging impact of triazoles as anti-tubercular agent

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Article Chemistry, Multidisciplinary

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New biologically potent benzimidazole-based-triazole derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors along with molecular docking study

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Synthesis methods of 1,2,3-/1,2,4-triazoles: A review

Jinlian Dai et al.

Summary: Triazole is an important heterocycle with broad biological activities. Many drugs with a triazole structure have been developed, and the synthesis of triazole compounds has attracted much attention.

FRONTIERS IN CHEMISTRY (2022)

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Review Oncology

Repurposing of Benzimidazole Anthelmintic Drugs as Cancer Therapeutics

Bomi Song et al.

Summary: This review investigates the potential and limitations of benzimidazole anthelmintics as a cancer therapy, suggesting ways to overcome these limitations. The results demonstrate the potential of repurposing benzimidazoles for cancer treatment based on preclinical evidence, and highlight the need for further studies on anti-cancer pathways and development strategies.

CANCERS (2022)

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Article Biology

1,2,3-Triazole-Benzofused Molecular Conjugates as Potential Antiviral Agents against SARS-CoV-2 Virus Variants

Jehan Y. Al-Humaidi et al.

Summary: The study found that some synthesized compounds have high affinity for SARS-CoV-2 and the Omicron variant, preventing viral entry into host cells and reducing viral replication and infection. Among them, compound 9 showed the highest binding affinity for both viruses in vitro.

LIFE-BASEL (2022)

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Article Chemistry, Multidisciplinary

A review on biological and medicinal impact of heterocyclic compounds

Emranul Kabir et al.

Summary: Heterocyclic compounds have gained significant attention for their medical and biological uses. Research interest in these compounds is increasing due to their synthetic study and functional utility. They have a wide range of applications in pharmaceuticals, agrochemicals, and veterinary items.

RESULTS IN CHEMISTRY (2022)

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Review Chemistry, Multidisciplinary

Metal catalyzed C-H functionalization on triazole rings

Anushka Koranne et al.

Summary: This review summarizes the advancements in C-H functionalization on triazole rings, utilizing palladium or copper catalysts with various substrates to develop substituted 1,2,3- and 1,2,4-triazoles synthesis. The synthesis of these substituted compounds is necessary for pharmaceutical, medicinal, and materials chemistry perspectives.

RSC ADVANCES (2022)

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Review Chemistry, Medicinal

Structure-Activity Relationship Analysis of Benzimidazoles as Emerging Anti-Inflammatory Agents: An Overview

Ravichandran Veerasamy et al.

Summary: Many currently used anti-inflammatory drugs are becoming obsolete, prompting researchers to develop new agents such as benzimidazole derivatives which show promising therapeutic potential. These compounds exert anti-inflammatory effects by interacting with various receptors and proteins, highlighting their potential as future anti-inflammatory drugs.

PHARMACEUTICALS (2021)

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Article Microbiology

Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

Robert M. Cox et al.

Summary: Treating SARS-CoV-2-infected ferrets with nucleoside analogue MK-4482/EIDD-2801 reduced viral load and suppressed virus spread. This therapeutic approach shows promise in breaking transmission chains of the COVID-19 pandemic.

NATURE MICROBIOLOGY (2021)

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Article Chemistry, Physical

New 1,2,3-triazole containing benzimidazolone derivatives: Syntheses, crystal structures, spectroscopic characterizations, Hirshfeld surface analyses, DFT calculations, anti-corrosion property anticipation, and antibacterial activities

Asmaa Saber et al.

Summary: A new series of triazole derivatives containing a benzimidazolone moiety were synthesized using 1,3-dipolar cycloaddition and click chemistry, with their structures characterized and confirmed by spectroscopy and X-ray crystallography. The compounds showed promising anti-corrosion properties for iron and exhibited antibacterial activities against various microbial strains.

JOURNAL OF MOLECULAR STRUCTURE (2021)

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Article Biochemistry & Molecular Biology

Synthesis, Identification, Computer-Aided Docking Studies, and ADMET Prediction of Novel Benzimidazo-1,2,3-triazole Based Molecules as Potential Antimicrobial Agents

Huda R. M. Rashdan et al.

Summary: The study describes a synthetic method for producing new compounds with promising antimicrobial activity against bacterial strains. Through molecular docking studies and in vitro experiments, the synthesized compounds were found to exhibit significant potential as antimicrobial agents.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Synthesis and Pharmacological Evaluation of Novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole Derivatives as Promising Anxiolytic and Analgesic Agents

Dmitriy V. V. Maltsev et al.

Summary: A series of novel compounds were synthesized through alkylation, with compounds 2d and 3b showing significant analgesic and anxiolytic potentials in various biological activity tests. In silico analysis indicated that the high anxiolytic activity of compound 3b may be attributed to its interaction with specific receptors.

MOLECULES (2021)

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Article Chemistry, Medicinal

Furazans in Medicinal Chemistry

Ross S. Mancini et al.

Summary: The article provides a summary of the application of furazan-containing molecules in medicinal chemistry and drug development, with a focus on projects that have reached clinical or preclinical stages of development.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Synthesis, molecular docking, antibacterial, and anti-inflammatory activities of benzimidazole-containing tricyclic systems

Vinuta Kamat et al.

Summary: This study reported the synthesis of benzimidazole-containing tricyclic systems with significant antimicrobial and anti-inflammatory activities, with compound 5b showing excellent efficacy. The hydroxyl group on the aromatic ring plays an important role in biological activity, and the synthesized compounds displayed promising minimum inhibitory concentration values against tested strains. The molecular docking study showed good binding interactions against Escherichia coli, supporting the in vitro findings.

JOURNAL OF THE CHINESE CHEMICAL SOCIETY (2021)

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Article Chemistry, Multidisciplinary

Antibacterial and antiviral activities and action mechanism of flavonoid derivatives with a benzimidazole moiety

Mei Chen et al.

Summary: In this study, a class of novel benzimidazole-containing flavonoid derivatives were synthesized and exhibited promising antibacterial and antiviral activities. Compound 4e showed outstanding antibacterial activity against Rs, while compound 4n displayed remarkable curative, protective, and inactivating activities against TMV. These findings suggest that benzimidazole-containing flavonoid derivatives have potential as agricultural antibacterial and antiviral agents.

JOURNAL OF SAUDI CHEMICAL SOCIETY (2021)

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Review Chemistry, Medicinal

1,2,4-Triazoles as Important Antibacterial Agents

Malgorzata Strzelecka et al.

Summary: Compounds containing the 1,2,4-triazole ring exhibit multidirectional biological activity and significant antibacterial properties, making them promising candidates for the development of novel antimicrobial agents to combat microbial resistance issues. Further research and rational design are needed to fully harness the potential of this scaffold.

PHARMACEUTICALS (2021)

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Review Pharmacology & Pharmacy

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

Shejuti Rahman Brishty et al.

Summary: Benzimidazole derivatives, as a class of potential drugs, play an important role in the field of medicine with broad biological activity and structure-activity relationships. These compounds show a wide range of pharmacological properties from antibacterial effects to the world's most deadly diseases.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Chemistry, Multidisciplinary

Green synthesis of biologically active heterocycles of medicinal importance: a review

R. Nishanth Rao et al.

Summary: Heterocyclic moieties are essential for 80% of commercial medicines, yet many synthetic methods are not sustainable, prompting the need for eco-friendly strategies like microwave-assisted synthesis and nanoparticle-catalysed synthesis. Other sustainable methods include solvent-free synthesis, ionic liquid-supported synthesis, organic synthesis in water, sonochemical synthesis, and combinatorial synthesis.

ENVIRONMENTAL CHEMISTRY LETTERS (2021)

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Review Chemistry, Multidisciplinary

A review on 'triazoles': their chemistry, synthesis and pharmacological potentials

Deepali Dixit et al.

Summary: Triazole compounds are cyclic compounds with at least two different elements in the ring, showing versatile biological activities and being widely used in various drug classes.

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY (2021)

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Article Pharmacology & Pharmacy

Antihypertensive Effect of a Novel Angiotensin II Receptor Blocker Fluorophenyl Benzimidazole: Contribution of cGMP, Voltage-dependent Calcium Channels, and BKCa Channels to Vasorelaxant Mechanisms

Hina Iqbal et al.

Summary: The study introduces a novel angiotensin II receptor blocker FPD as an antihypertensive agent in the SHR model of hypertension. FPD effectively decreased blood pressure in SHR, relaxed superior mesenteric arteries, and inhibited angiotensin II-induced contraction by increasing tissue cGMP levels, inhibiting L-type calcium channels, and opening BKCa channels. Moreover, FPD showed good safety in toxicity evaluation and demonstrated potential as a vasorelaxant with cGMP, L-type calcium channels, and BKCa channels as putative targets.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2

Israa A. Seliem et al.

Summary: Novel small molecules with quinoline scaffolds were synthesized and assessed for their anti-SARS-CoV2 activity, with compounds 10g and 12c showing high potency and significant efficacy in comparison to reference drugs.

BIOORGANIC CHEMISTRY (2021)

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Review Chemistry, Physical

Recent Progress in Catalytic Synthesis of 1,2,3-Triazoles

Antonio De Nino et al.

Summary: This review summarizes the progress achieved in the synthesis of 1,2,3-triazoles from 2015 to today, focusing particularly on the development of new catalytic and eco-compatible approaches. The report is subdivided based on the degree of functionalization of the molecules, with emphasis on the role of the catalyst employed for each specific approach.

CATALYSTS (2021)

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Review Infectious Diseases

Synthesis of Antimicrobial Benzimidazole-Pyrazole Compounds and Their Biological Activities

Maria Marinescu

Summary: The synthesis of new compounds with antimicrobial and antiviral properties is crucial in combating the COVID-19 pandemic. Benzimidazole and pyrazole compounds possess diverse biological activities, making them important in medicinal chemistry.

ANTIBIOTICS-BASEL (2021)

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Article Chemistry, Multidisciplinary

New 1H-benzimidazole-2-yl hydrazones with combined antiparasitic and antioxidant activity

Maria A. Argirova et al.

Summary: A series of new compounds combining anthelmintic with antioxidant properties were synthesized and found to be more active than clinically used anthelmintic drugs in vitro. Two of these compounds showed the best radical scavenging ability and their antioxidant mechanisms were elucidated through DFT calculations. It was demonstrated that these compounds are capable of reacting with various free radicals.

RSC ADVANCES (2021)

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Article Medicine, General & Internal

Potential antidiabetic activity of benzimidazole derivative albendazole and lansoprazole drugs in different doses in experimental type 2 diabetic rats

Burak Dik et al.

Summary: The study revealed that albendazole and lansoprazole treatments could potentially act as drugs or in combination with antidiabetic drugs in type 2 diabetic (T2D) treatment through multiple antidiabetic mechanisms, such as AMPK and PPAR. Developing more specific substances with benzimidazole scaffold may help in creating a more effective treatment strategy.

TURKISH JOURNAL OF MEDICAL SCIENCES (2021)

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Review Pharmacology & Pharmacy

Triazole analogues as potential pharmacological agents: a brief review

Sachin Kumar et al.

Summary: This review focuses on the recent synthetic procedures of the triazole moiety, which exhibit various pharmacological activities such as antimicrobial, anticonvulsant, anti-inflammatory, analgesic, antitubercular, anthelmintic, antioxidant, antimalarial, antiviral, etc. The review highlights the current status of triazole compounds with different multitarget pharmacological activities, emphasizing their wide usage in various potential activities.

FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Benzimidazole-1,2,3-triazole hybrid molecules: synthesis and study of their interaction with G-quadruplex DNA

Padma S. Singu et al.

Summary: A series of new benzimidazole-1,2,3-triazole hybrid derivatives were synthesized via 'click' reaction, with compound 4f showing high selectivity for G-quadruplex DNA and inducing G2/M phase arrest and apoptosis. Experimental results suggest that compound 4f may be a G-quadruplex DNA groove binding molecule with potential anticancer activity.

RSC MEDICINAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Preclinical evaluation of 1,2,4-triazole-based compounds targeting voltage-gated sodium channels (VGSCs) as promising anticonvulsant drug candidates

Barbara Kapron et al.

BIOORGANIC CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Synthesis and biological evaluation of new benzimidazole-1,2,3-triazole hybrids as potential α-glucosidase inhibitors

Nafise Asemanipoor et al.

BIOORGANIC CHEMISTRY (2020)

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Article Chemistry, Medicinal

Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis-(1,2,3-triazolyl)-appended benzimidazo[1,2-a] quinoline derivatives

Andrijana Mescic Macan et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Chemistry, Medicinal

Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction

Wei-Lin Chen et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Chemistry, Physical

A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+

Amar Djemoui et al.

JOURNAL OF MOLECULAR STRUCTURE (2020)

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Article Chemistry, Medicinal

Microwave-assisted synthesis and in vitro antiproliferative activity of some novel 1,2,3-triazole-based pyrazole aldehydes and their benzimidazole derivatives

Dongamanti Ashok et al.

MEDICINAL CHEMISTRY RESEARCH (2020)

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Article Biochemistry & Molecular Biology

The Significance of Halogen Bonding in Ligand-Receptor Interactions: The Lesson Learned from Molecular Dynamic Simulations of the D4 Receptor

Rafal Kurczab et al.

MOLECULES (2020)

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Article Chemistry, Organic

Design, synthesis and biological activity evaluation of novel methyl substituted benzimidazole derivatives

Tianrong Zhang et al.

TETRAHEDRON (2020)

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Article Chemistry, Medicinal

Synthesis and antidiabetic evaluation of benzimidazole-tethered 1,2,3-triazoles

Laxmi Deswal et al.

ARCHIV DER PHARMAZIE (2020)

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Article Chemistry, Multidisciplinary

Synthesis, density functional theory study and in vitro antimicrobial evaluation of new benzimidazole Mannich bases

Maria Marinescu et al.

BMC CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Novel benzimidazole-triazole hybrids as apoptosis inducing agents in lung cancer: Design, synthesis, 18F-radiolabeling & galectin-1 inhibition studies

Nerella Sridhar Goud et al.

BIOORGANIC CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Synthesis and neuroprotective effects of novel chalcone-triazole hybrids

Pichjira Sooknual et al.

BIOORGANIC CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Structure based approach for twin-enzyme targeted benzimidazolyl-1,2,4-triazole molecular hybrids as antifungal agents

Radha Ahuja et al.

ARABIAN JOURNAL OF CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Synthesis of Benzimidazole-Based Analogs as Anti Alzheimer's Disease Compounds and Their Molecular Docking Studies

Bushra Adalat et al.

MOLECULES (2020)

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Article Chemistry, Multidisciplinary

Synthesis and Antimicrobial Activity of Novel Bis-1,2,3-triazol-1H-4-yl-substituted Aryl Benzimidazole-2-thiol Derivatives

Y. Aparna et al.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY (2020)

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Review Chemistry, Multidisciplinary

Synthesis of anti-allergic drugs

Shiyang Zhou et al.

RSC ADVANCES (2020)

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Article Chemistry, Multidisciplinary

Design, synthesis and antifungal evaluation of novel benzimidazole tertiary amine type of fluconazole analogues

Rani S. Kankate et al.

ARABIAN JOURNAL OF CHEMISTRY (2019)

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Review Chemistry, Medicinal

Triazole derivatives and their antiplasmodial and antimalarial activities

Xue-Mei Chu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives

Ulviye Acar Cevik et al.

MOLECULES (2019)

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Review Chemistry, Medicinal

Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids

Bo Zhang

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Review Chemistry, Medicinal

Antimicrobial Potential of Benzimidazole Derived Molecules

Yogita Bansal et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2019)

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Article Chemistry, Medicinal

Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors

Ismail Celik et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Article Chemistry, Physical

Design, click synthesis, anticancer screening and docking studies of novel benzothiazole-1,2,3-triazoles appended with some bioactive benzofused heterocycles

Mohamed Reda Aouad et al.

JOURNAL OF MOLECULAR STRUCTURE (2019)

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Review Chemistry, Medicinal

Recent Advances in Antiviral Benzimidazole Derivatives: A Mini Review

Afshan Kanwal et al.

PHARMACEUTICAL CHEMISTRY JOURNAL (2019)

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Review Biochemistry & Molecular Biology

1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

Khurshed Bozorov et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

A click chemistry approach for the synthesis of cyclic ureido tethered coumarinyl and 1-aza coumarinyl 1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis H37Rv and their in silico studies

Netravati Khanapurmath et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2019)

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Review Chemistry, Medicinal

Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships

Man Xu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Article Multidisciplinary Sciences

Strategies Towards the Synthesis of N2-Substituted 1,2,3-Triazoles

Rodrigo Octavio M. A. De Souza et al.

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2019)

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Article Biochemistry & Molecular Biology

Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies

Ciro Milite et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)

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Article Chemistry, Medicinal

New Application of Neomycin B-Bisbenzimidazole Hybrids as Antifungal Agents

Nishad Thamban Chandrika et al.

ACS INFECTIOUS DISEASES (2018)

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Article Chemistry, Medicinal

Synthesis of substituted fluorobenzimidazoles as inhibitors of 5-lipoxygenase and soluble epoxide hydrolase for anti-inflammatory activity

B. Nandha et al.

ARCHIV DER PHARMAZIE (2018)

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Article Biochemistry & Molecular Biology

Molecular docking simulation, synthesis and 3D pharmacophore studies of novel 2-substituted-5-nitro-benzimidazole derivatives as anticancer agents targeting VEGFR-2 and c-Met

Heba A. Ibrahim et al.

BIOORGANIC CHEMISTRY (2018)

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Article Chemistry, Medicinal

Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer

Andrea Bistrovic et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

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Article Chemistry, Physical

Synthesis, spectroscopic characterization, DFT study and antimicrobial activity of novel alkylaminopyrazole derivatives

Christina Zalaru et al.

JOURNAL OF MOLECULAR STRUCTURE (2018)

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Article Biochemistry & Molecular Biology

Conventional and microwave-assisted synthesis of new indole-tethered benzimidazole-based 1,2,3-triazoles and evaluation of their antimycobacterial, antioxidant and antimicrobial activities

Dongamanti Ashok et al.

MOLECULAR DIVERSITY (2018)

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Article Biochemistry & Molecular Biology

Synthesis and biological evaluation of novel flavone/triazole/benzimidazole hybrids and flavone/isoxazole-annulated heterocycles as antiproliferative and antimycobacterial agents

Yerrabelly Jayaprakash Rao et al.

MOLECULAR DIVERSITY (2018)

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Article Biochemistry & Molecular Biology

Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA

Andrea Bistrovic et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)

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Article Chemistry, Multidisciplinary

Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents

Fawzia Faleh Al-blewi et al.

CHEMISTRY CENTRAL JOURNAL (2018)

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Article Biochemistry & Molecular Biology

Design, Synthesis and Anticancer Screening of Novel Benzothiazole-Piperazine-1,2,3-Triazole Hybrids

Mohamed R. Aouad et al.

MOLECULES (2018)

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Article Chemistry, Multidisciplinary

Design and Synthesis of Imidazo/Benzimidazo[1,2-c]quinazoline Derivatives and Evaluation of Their Antimicrobial Activity

Nitesh Kumar Nandwana et al.

ACS OMEGA (2018)

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Article Chemistry, Physical

Density functional theory molecular modeling, chemical synthesis, and antimicrobial behaviour of selected benzimidazole derivatives

Maria Marinescu et al.

JOURNAL OF MOLECULAR STRUCTURE (2017)

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Article Chemistry, Medicinal

Novel 2-Arylbenzimidazole derivatives as multi-targeting agents to treat Alzheimer's disease

Oya Unsal-Tan et al.

MEDICINAL CHEMISTRY RESEARCH (2017)

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Article Biochemistry & Molecular Biology

New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation

Hulya Karaca Gencer et al.

MOLECULES (2017)

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Article Chemistry, Organic

Green Microwave Synthesis and Antimicrobial Evaluation of Novel Triazoles

Nadjet Rezki

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL (2017)

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Article Chemistry, Medicinal

PREDICTION AND STUDY OF ANTICONVULSANT PROPERTIES OF BENZIMIDAZOLE DERIVATIVES

P. M. Vasil'ev et al.

PHARMACEUTICAL CHEMISTRY JOURNAL (2017)

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Article Chemistry, Organic

Synthesis of new 1,2,3-triazole linked benzimidazole molecules as anti-proliferative agents

Ishani I. Sahay et al.

SYNTHETIC COMMUNICATIONS (2017)

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Article Chemistry, Multidisciplinary

Synthesis of novel benzimidazole and benzothiazole derivatives bearing a 1,2,3-triazole ring system and their acetylcholinesterase inhibitory activity

Laleh Faraji et al.

JOURNAL OF CHEMICAL RESEARCH (2017)

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Article Chemistry, Multidisciplinary

Design, synthesis and antimicrobial activities of some novel 1,3,4-thiadiazole, 1,2,4-triazole-5-thione and 1,3-thiazolan-4-one derivatives of benzimidazole

Kuldipsinh P. Barot et al.

JOURNAL OF SAUDI CHEMICAL SOCIETY (2017)

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Article Biochemistry & Molecular Biology

Synthesis, in vitro antiproliferative activity and kinase profile of new benzimidazole and benzotriazole derivatives

Konrad Chojnacki et al.

BIOORGANIC CHEMISTRY (2017)

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Article Chemistry, Medicinal

One pot Click chemistry: A three component reaction for the synthesis of 2-mercaptobenzimidazole linked coumarinyl triazoles as anti-tubercular agents

Ashish Anand et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

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Article Biochemistry & Molecular Biology

A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies

Musa Ozil et al.

BIOORGANIC CHEMISTRY (2016)

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Article Multidisciplinary Sciences

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren et al.

NATURE (2016)

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Article Pharmacology & Pharmacy

Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus

Bahaa G. M. Youssif et al.

ACTA PHARMACEUTICA (2016)

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Article Cell Biology

Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism

Ting-Lin Yen et al.

JOURNAL OF BIOMEDICAL SCIENCE (2016)

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Article Chemistry, Multidisciplinary

SYNTHESIS AND ANTIBACTERIAL EVALUATION OF SOME NOVEL MANNICH BASES OF BENZIMIDAZOLE DERIVATIVES

A. Ahmadi

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA (2016)

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Article Chemistry, Organic

Synthesis and Study of α-Glucosidase Inhibitory, Antimicrobial and Antioxidant Activities of Some Benzimidazole Derivatives Containing Triazole, Thiadiazole, Oxadiazole, and Morpholine Rings

E. Mentese et al.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS (2015)

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Article Engineering, Electrical & Electronic

Octahydroacridine thin films grown by matrix-assisted pulsed laser evaporation for non linear optical applications

Valentin Ion et al.

MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING (2015)

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Article Chemistry, Multidisciplinary

Novel benzimidazole derived naphthalimide triazoles: synthesis, antimicrobial activity and interactions with calf thymus DNA

Yun-Lei Luo et al.

SCIENCE CHINA-CHEMISTRY (2015)

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Article Chemistry, Medicinal

Benzimidazole-1,2,3-triazole Hybrid Molecules: Synthesis and Evaluation for Antibacterial/Antifungal Activity

Abdelaaziz Ouahrouch et al.

ARCHIV DER PHARMAZIE (2014)

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Article Chemistry, Medicinal

Part I. Synthesis, biological evaluation and docking studies of new 2-furylbenzimidazoles as antiangiogenic agents

Ahmed Temirak et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)

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Article Chemistry, Medicinal

Benzimidazole clubbed with triazolo-thiadiazoles and triazolo-thiadiazines: New anticancer agents

Asif Husain et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

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Article Chemistry, Medicinal

Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement

Zhigan Jiang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

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Article Chemistry, Multidisciplinary

Synthesis and Pharmacological Evaluation of Some Novel 2-Mercapto Benzimidazole Derivatives

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JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE (2013)

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Article Chemistry, Medicinal

Benzimidazole bearing oxadiazole and triazolo-thiadiazoles nucleus: Design and synthesis as anticancer agents

Asif Husain et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

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Article Multidisciplinary Sciences

Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells

James B. Stanton et al.

PLOS ONE (2012)

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Article Chemistry, Multidisciplinary

Synthesis and biological activity of some triazole-bearing benzimidazole derivatives

K. F. Ansari et al.

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY (2011)

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SAR study of clubbed [1,2,4]-triazolyl with fluorobenzimidazoles as antimicrobial and antituberculosis agents

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2009)

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Article Chemistry, Medicinal

Clubbed [1,2,3] triazoles by fluorine benzimidazole: A novel approach to H37Rv inhibitors as a potential treatment for tuberculosis

Charansingh Gill et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

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Article Biochemistry & Molecular Biology

Antiviral Activity of Benzimidazole Derivatives. I. Antiviral Activity of 1-Substituted-2-[(Benzotriazol-1/2-yl)methyl]benzimidazoles)

Michele Tonelli et al.

CHEMISTRY & BIODIVERSITY (2008)

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Article Chemistry, Medicinal

A simple approach for indexing the oral druglikeness of a compound: Discriminating druglike compounds from nondruglike ones

Dhrubajyoti Biswas et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2006)

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Article Biochemistry & Molecular Biology

Synthesis and antioxidant properties of novel benzimidazole derivatives

G Ayhan-Kilcigil et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2004)

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Article Chemistry, Medicinal

Synthesis and antioxidant properties of some novel benzimidazole derivatives on lipid peroxidation in the rat liver

C Kus et al.

ARCHIVES OF PHARMACAL RESEARCH (2004)

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Article Biochemistry & Molecular Biology

Synthesis and antimicrobial activity of some new benzimidazole derivatives

AH El-masry et al.

MOLECULES (2000)

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