☆ 4.6 Review

Periprosthetic Joint Infection Diagnosis: A Narrative Review

ANTIBIOTICS-BASEL (2023)

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Editorial Material Infectious Diseases

Acute paronychia: An atypical presentation of Monkeypox infection

Joana Vieitez Frade et al.

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA (2023)

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Article Infectious Diseases

A multicentre evaluation and expert recommendations of use of the newly developed BioFire Joint Infection polymerase chain reaction panel

Kordo Saeed et al.

Summary: This study evaluated the performance of the BioFire Joint Infection Panel (BJIP) for the diagnosis of septic arthritis and compared it to routine culture. The BJIP showed a higher agreement rate with culture results, detecting more positive cases and providing additional microbial information. A multidisciplinary team agreed that the BJIP could be used in patient management and potentially impact treatment choices.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2023)

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Article Immunology

Targeted Versus Shotgun Metagenomic Sequencing-based Detection of Microorganisms in Sonicate Fluid for Periprosthetic Joint Infection Diagnosis

Hyo Lim Hong et al.

Summary: This study compared the performance of 16S rRNA gene-based targeted metagenomic sequencing (tNGS) and shotgun metagenomic sequencing (sNGS) in detecting and identifying pathogens in sonicate fluid from failed total hip arthroplasty (THA) and total knee arthroplasty (TKA). The study found that tNGS had a higher positive percent agreement with sonicate fluid culture compared to sNGS, and detected potential pathogens in culture-negative PJIs. The study concludes that tNGS is a potential diagnostic tool for identifying PJI pathogens in sonicate fluid, with similar performance characteristics to sNGS.

CLINICAL INFECTIOUS DISEASES (2023)

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Review Infectious Diseases

Use of C-reactive protein to guide the antibiotic therapy in hospitalized patients: a systematic review and meta-analysis

Raphael Figuiredo Dias et al.

Summary: This meta-analysis examined the benefits and risks of CRP-guided protocols to guide antibiotic therapy in hospitalized patients. The results showed that CRP-guided protocols can decrease the duration of antibiotic therapy without increasing mortality or infection relapse rates.

BMC INFECTIOUS DISEASES (2023)

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Article Orthopedics

The Impact of a Dedicated Multidisciplinary Team Approach for Prosthetic Joint Infections of the Lower Limb

James D. Sires et al.

Summary: In this retrospective study, the authors reviewed the cases of 71 patients with prosthetic joint infections of the hip or knee and reported on the early outcomes of their dedicated multidisciplinary team. The results showed improved cure rates after the establishment of the team, although the differences were not statistically significant. The authors suggest further research to identify modifiable risk factors and improve outcomes for these patients.

INDIAN JOURNAL OF ORTHOPAEDICS (2023)

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Review Orthopedics

Higher sensitivity and accuracy of synovial next-generation sequencing in comparison to culture in diagnosing periprosthetic joint infection: a systematic review and meta-analysis

Ashraf T. Hantouly et al.

Summary: This meta-analysis compared the diagnostic parameters of synovial next-generation sequencing (NGS) and cultures in diagnosing periprosthetic joint infections (PJI). The results showed that NGS has potential in diagnosing hip and knee PJIs due to its high sensitivity, specificity, and accuracy. However, the sensitivity and specificity reported by the studies varied according to the time of synovial sampling.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2023)

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Review Pharmacology & Pharmacy

Prosthetic Joint Infections: Biofilm Formation, Management, and the Potential of Mesoporous Bioactive Glass as a New Treatment Option

Dana Almasri et al.

Summary: Infection of prosthetic joints is a major challenge after total joint arthroplasty, caused by difficult-to-treat bacterial colonies. Local delivery of antibiotics can be a solution, impacting patients' health and reducing healthcare costs. This review focuses on prosthetic joint infections, discussing development, management, and diagnosis. The use of biodegradable and highly compatible bioactive glass, specifically mesoporous bioactive glass, is explored as a potential alternative treatment for infections after joint replacement surgeries, due to its ability to deliver biomolecules, stimulate bone growth, and treat infections.

PHARMACEUTICS (2023)

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Article Immunology

Genomic characterization of beta-haemolytic streptococci isolated from prosthetic joint infections

Niklas Lowbeer et al.

Summary: Prosthetic joint infection (PJI) is a growing concern due to the increasing number of arthroplasty surgeries, and the genetic features and characteristics of Streptococcal PJIs are largely unknown. This study conducted whole-genome sequencing on Streptococcus dysgalactiae, Streptococcus agalactiae, and S. pyogenes isolates from PJIs in Sweden. The results showed genetic diversity among S. dysgalactiae and S. agalactiae, with distinct differences in antimicrobial resistance (AMR) between the two species.

APMIS (2023)

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Article Surgery

Case report: Be alert to herpes zoster after total knee arthroplasty

Zhanqi Wei et al.

Summary: An 88-year-old woman experienced severe pain in the right knee and above three weeks after undergoing right total knee arthroplasty (TKA). The pain could not be effectively controlled with empirical treatment. It was later discovered that the cause of the pain was herpes zoster (HZ), which is extremely rare in patients after TKA.

FRONTIERS IN SURGERY (2023)

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Article Microbiology

Prosthetic joint infection caused by an atypical gram-negative bacilli: Odoribacter splanchnicus

Yuri Lara-Taranchenko et al.

Summary: Prosthetic joint infection (PJI) after total hip arthroplasty is a serious complication. This case report describes the diagnosis and treatment of an 82-year-old woman with hip PJI caused by Odoribacter splanchnicus, a rare microorganism not previously reported as a cause of PJI. The patient underwent radical debridement, prosthetic withdrawal, spacer introduction, and antibiotic bitherapy with ciprofloxacin and metronidazole.

ANAEROBE (2023)

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Article Infectious Diseases

A case of cat bite associated Pasteurella multocida prosthetic joint infection

Jamila Ranavaya et al.

Summary: Cases of Pasteurella multocida related joint infections are often late in onset, but with the increase in prosthetic joints should be considered, especially in knee infections. Often thought of in relation to animal bites, these infections are further transmitted by nasal secretions, scratches, and licking behavior. We present a case of Pasteurella multocida joint infection in a patient who initially presented with Enterococcus faecalis bacteremia, which obscured the clinical picture due to a cat bite. This case serves as a good reminder for the importance of antibiotic prophylaxis in patients with cat bites and prostheses and highlights the need for clinicians to consider P. multocida in their differential diagnosis.

IDCASES (2023)

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Article Infectious Diseases

Heterogeneity of Staphylococcus epidermidis in prosthetic joint infections: time to reevaluate microbiological criteria?

Micael Widerstrom et al.

Summary: Prosthetic joint infection (PJI) is challenging to diagnose due to the presence of CoNS diversity, particularly in cases involving multiple S. epidermidis isolates with varying antibiotic susceptibility patterns. Larger systematic studies are needed to determine the implications of this diversity for microbiological diagnostics and patient outcomes.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2022)

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Review Biochemistry & Molecular Biology

Biofilm and Small Colony Variants-An Update on Staphylococcus aureus Strategies toward Drug Resistance

Henan Guo et al.

Summary: The overuse of antibiotics leading to drug-resistance and multidrug-resistance has become a major concern. Staphylococcus aureus, as a representative of drug-resistant pathogens, can cause a variety of infections and adapt to diverse environments through phenotypic changes like biofilm and SCVs. This article reviews the development of drug-resistance, explores classical mechanisms, and focuses on the non-classical resistance mechanisms triggered by biofilm and SCVs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Orthopedics

Diagnosis and Treatment of Culture-Negative Periprosthetic Joint Infection

Graham S. Goh et al.

Summary: Identifying the causative organisms in periprosthetic joint infection (PJI) is a challenging task, with traditional culture methods being criticized for their limitations, resulting in a clinical entity known as "culture-negative PJI." As biofilm infections become more prevalent and difficult to culture, the field of clinical microbiology has shifted from culture-based to molecular-based methods. These novel techniques show promise in addressing culture-negative PJI and revolutionizing the microbiology laboratory.

JOURNAL OF ARTHROPLASTY (2022)

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Article Orthopedics

Usefulness of a Multiplex PCR Assay for the Diagnosis of Prosthetic Joint Infections in the Routine Setting

Alvaro Aunon et al.

Summary: This study evaluated the usefulness of multiplex PCR assay in the diagnosis of prosthetic joint infections. The results showed that this technique is a valuable tool for diagnosing bone and joint infections and can provide guidance for treatment, especially for patients at high risk of culture-negative infections and those with a high suspicion of infection.

ORTHOPAEDIC SURGERY (2022)

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Review Orthopedics

Fungal periprosthetic joint infection: Rare but challenging problem

Emanuele Chisari et al.

Summary: Periprosthetic joint infection (PJI) is a challenging complication following total joint arthroplasty, with bacterial species being the main cause and fungal infections being less common but more complex. The diagnosis and treatment of fungal PJI are challenging due to the absence of a consistent algorithm. Next-generation sequencing has provided an opportunity to isolate infective organisms in culture-negative PJI cases.

CHINESE JOURNAL OF TRAUMATOLOGY (2022)

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Article Infectious Diseases

Microbiology of hip and knee periprosthetic joint infections: a database study

Don Bambino Geno Tai et al.

Summary: This study identified the most common microorganisms associated with periprosthetic joint infection (PJI), with coagulase-negative Staphylococcus species being the predominant group. Factors such as joint age, presence of a sinus tract, and type of arthroplasty (primary or revision) were found to influence the microbiology of PJI.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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Article Infectious Diseases

Preoperative and perioperative risk factors, and risk score development for prosthetic joint infection due to Staphylococcus aureus: a multinational matched case-control study

Reinaldo Espindola et al.

Summary: This study aims to identify preoperative and perioperative risk factors associated with post-surgical Staphylococcus aureus prosthetic joint infections (PJI) and develop risk-scoring systems. Independent risk factors have been found and predictive scores have been developed for implementation of specific preventive measures.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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Review Microbiology

Enhancing Diagnostics in Orthopedic Infections

Eibhlin Higgins et al.

Summary: This minireview discusses the importance of accurate diagnosis of orthopedic infection and explores various microbiological and nonmicrobiological methods for pathogen detection. It also introduces systemic and localized assays to assess host response for maximizing diagnostic yield.

JOURNAL OF CLINICAL MICROBIOLOGY (2022)

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Article Immunology

Outcome and Failure Analysis of 132 Episodes of Hematogenous Periprosthetic Joint Infections-A Cohort Study

Nora Renz et al.

Summary: This study evaluated 132 episodes of hematogenous periprosthetic joint infection in 110 patients treated at a single institution from 2010 to 2019. The study found a high persistence/relapse-free survival rate of 84%, but new hematogenous infections caused by the same or new pathogens occurred frequently, reducing treatment success rate to 62% after 4 years of follow-up. The outcomes were similar for different pathogens, but worse in cases treated with prosthesis retention compared to multistage exchange.

OPEN FORUM INFECTIOUS DISEASES (2022)

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Article Immunology

Clinical Profile of Monomicrobial Corynebacterium Hip and Knee Periprosthetic Joint Infections

Hussam Tabaja et al.

Summary: Corynebacterium PJIs present a therapeutic challenge due to limited antimicrobial options and undefined optimal surgical interventions. Vancomycin and linezolid remain the most reliable treatment agents. DAIR may be attempted for acute PJI, but verification of durable chronic suppression options will be critical for this approach.

OPEN FORUM INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Orthopaedic Implant-Associated Staphylococcal Infections: A Critical Reappraisal of Unmet Clinical Needs Associated with the Implementation of the Best Antibiotic Choice

Milo Gatti et al.

Summary: Infections associated with orthopaedic implants are a major health concern, and the treatment requires consideration of antimicrobial therapy and drug selection. Novel long-acting lipoglycopeptides, particularly dalbavancin, may represent the best antibiotic choice, and the implementation of a multidisciplinary taskforce and close cooperation between microbiologists and clinicians are essential for providing optimal care.

ANTIBIOTICS-BASEL (2022)

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Review Orthopedics

Prosthetic joint infection of the hip and knee due to Mycobacterium species: A systematic review

Asep Santoso et al.

Summary: This study analyzed cases of hip and knee prosthetic joint infection (PJI) caused by Mycobacterium sp over the past 30 years. It found that at least 17 different species of Mycobacterium can be responsible for PJI in these joints. While Mycobacterium tuberculosis is the most common pathogen, non-tuberculous mycobacteria (NTM) should also be considered as an emerging cause of hip and knee PJI.

WORLD JOURNAL OF ORTHOPEDICS (2022)

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Article Infectious Diseases

Streptococcal and Staphylococcus aureus prosthetic joint infections: are they really different?

Yousra Kherabi et al.

Summary: This study analyzed the outcome of streptococcal and methicillin-susceptible Staphylococcus aureus (MSSA) prosthetic joint infections (PJIs). The results showed that streptococcal PJI patients had higher reinfection-free survival rates after different treatment strategies, particularly after debridement, antibiotics, and implant retention (DAIR) and prolonged suppressive antibiotic therapy (SAT).

BMC INFECTIOUS DISEASES (2022)

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Article Cell & Tissue Engineering

The role of Staphylococcus aureus small colony variants in intraosseous invasion and colonization in periprosthetic joint infection

Y. Cai et al.

Summary: This study aimed to investigate the role of Staphylococcus aureus small colony variants (SCVs) in intraosseous invasion and colonization in patients with periprosthetic joint infection (PJI). The results showed that SCVs have a greater ability to invade and colonize bone, and there are significant differences in gene expression profiles between chronic and acute PJI. These findings are important for understanding the pathogenesis of chronic infections.

BONE & JOINT RESEARCH (2022)

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Review Orthopedics

Viral infections in orthopedics: A systematic review and classification proposal

Konstantinos Sidiropoulos et al.

Summary: Evidence suggests that viral infections can cause moderate to severe arthritis and osteitis. Pre-existing risk factors such as rheumatologic diseases contribute to higher disease severity and longer symptom duration.

WORLD JOURNAL OF ORTHOPEDICS (2022)

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Article Medicine, General & Internal

Microbiological Profiles of Patients with Periprosthetic Joint Infection of the Hip or Knee

Frank Sebastian Froeschen et al.

Summary: This study analyzed the causative pathogens of periprosthetic joint infections (PJI) and found that coagulase-negative staphylococci were the most common pathogens, with a majority being resistant to oxacillin. Vancomycin may provide the highest antimicrobial coverage for empirical therapy in cases of unknown pathogens.

DIAGNOSTICS (2022)

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Review Biology

An Overview of Biofilm Formation-Combating Strategies and Mechanisms of Action of Antibiofilm Agents

Syeda Tasmia Asma et al.

Summary: Biofilm formation on surfaces by microbial colonization is a global health issue that causes infections and provides resistance to treatment. Effective anti-biofilm strategies are necessary to reduce healthcare problems associated with biofilms.

LIFE-BASEL (2022)

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Article Infectious Diseases

Staphylococcus lugdunensis prosthetic joint infection: A multicentric cohort study

Yannick Herry et al.

Summary: This study describes the management and outcome of Staphylococcus lugdunensis prosthetic joint infection (PJI). Surgical management plays a pivotal role in the treatment of this difficult-to-treat infection.

JOURNAL OF INFECTION (2022)

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Review Orthopedics

Reliable Diagnostic Tests and Thresholds for Preoperative Diagnosis of Non-Inflammatory Arthritis Periprosthetic Joint Infection: A Meta-analysis and Systematic Review

Haozheng Tang et al.

Summary: This study aimed to evaluate and unify diagnostic criteria for periprosthetic joint infection (PJI) and found that laboratory-based synovial alpha-defensin and synovial calprotectin are the two best independent preoperative diagnostic tests for PJI. A cut off of 70% for synovial PMN% and tighter cut-offs for synovial WBC and serum CRP could have a better diagnostic accuracy for non-IA patients with chronic PJI.

ORTHOPAEDIC SURGERY (2022)

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Article Infectious Diseases

Pasteurella multocida in total knee prosthetic joint infection caused by cat scratches and bites in a liver transplant recipient

Chiu-Yu Shih et al.

Summary: Pasteurella multocida, a pathogen typically causing zoonotic infections, rarely leads to prosthetic joint infection. However, we present the first case of a prosthetic joint infection caused by this pathogen in a patient who underwent liver transplantation. Physicians should be vigilant, especially in immunosuppressed patients.

IDCASES (2022)

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Review Orthopedics

Diagnosing Periprosthetic Joint Infection: a Scoping Review

Aaron Gazendam et al.

Summary: The purpose of this review is to provide an updated understanding of the current tests used for the diagnosis of periprosthetic joint infection (PJI) in total knee and hip arthroplasty. Despite the increasing number of diagnostic methods, diagnosing PJI remains challenging. A combination of clinical, serum, and synovial tests, as well as microbiologic and histologic examinations, are commonly used for diagnosis. Novel molecular and imaging studies may be beneficial for cases with uncertain diagnosis. Recently proposed stepwise diagnostic algorithms have shown high sensitivity and specificity. However, the lack of definitive tests to rule out infection makes the diagnosis of PJI challenging.

CURRENT REVIEWS IN MUSCULOSKELETAL MEDICINE (2022)

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Article Orthopedics

Automated Detection of Periprosthetic Joint Infections and Data Elements Using Natural Language Processing

Sunyang Fu et al.

Summary: The study aimed to develop a natural language processing (NLP) algorithm to replicate manual chart review for periprosthetic joint infection (PJI) data elements. Through training and testing samples comparison, the results showed that the algorithm achieved high accuracy and effectiveness in extracting PJI-related data, and has the potential to play an important role in automating data collection.

JOURNAL OF ARTHROPLASTY (2021)

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Article Orthopedics

Factors affecting outcome in the treatment of streptococcal periprosthetic joint infections: results from a single-centre retrospective cohort study

Octavian Andronic et al.

Summary: This study reported and analyzed the factors affecting the outcome of streptococcal periprosthetic joint infections. It was found that DAIR was the most common surgical treatment method.

INTERNATIONAL ORTHOPAEDICS (2021)

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Article Orthopedics

Anatomic Landmark-Guided Hip Aspiration in the Diagnosis of Periprosthetic Joint Infection

Rui Li et al.

Summary: The study evaluated the use of anatomic landmarks for hip aspiration to detect periprosthetic joint infection (PJI), finding that this method provided satisfactory detection results for PJI.

ORTHOPEDICS (2021)

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Article Orthopedics

Next-generation sequencing not superior to culture in periprosthetic joint infection diagnosis

B. J. Kildow et al.

Summary: This study compared the diagnostic accuracy of different methods for periprosthetic joint infection (PJI) and found that Next-generation sequencing (NGS) did not provide superior sensitivity or specificity compared to culture, with sensitivity of 60.9% and specificity of 89.9%.

BONE & JOINT JOURNAL (2021)

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Review Infectious Diseases

Think Twice before Prescribing Antibiotics for That Swollen Knee: The Influence of Antibiotics on the Diagnosis of Periprosthetic Joint Infection

Graham S. Goh et al.

Summary: The use of antibiotics may affect the diagnostic accuracy of periprosthetic joint infection (PJI), particularly in microbiological cultures and biomarkers. Future research should focus on patients who have received antibiotics before specimen collection.

ANTIBIOTICS-BASEL (2021)

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Article Orthopedics

Synovial fluid IL-1β appears useful for the diagnosis of chronic periprosthetic joint infection

Hai Wang et al.

Summary: The study demonstrates the valuable role of synovial fluid IL-1 beta in diagnosing chronic PJI, with the combined measurement of IL-1 beta and PMN% leading to increased specificity.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

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Article Orthopedics

An update about molecular biology techniques to detect orthopaedic implant-related infections

Jaime Esteban et al.

Summary: Despite different criteria for diagnosing prosthetic joint infections, identifying the causing microorganism through molecular biology techniques is crucial for guiding treatment. Multiplex polymerase chain reaction methods demonstrate high specificity and sensitivity in clinical cases, and next-generation metagenomics may further enhance sensitivity while maintaining specificity. Molecular biology techniques are expected to significantly transform current microbiological diagnosis of PJI in the next five years.

EFORT OPEN REVIEWS (2021)

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Article Infectious Diseases

Outcomes and Risk Factors in Prosthetic Joint Infections by multidrug-resistant Gram-negative Bacteria: A Retrospective Cohort Study

Raquel Bandeira da Silva et al.

Summary: This study identified independent risk factors associated with multidrug-resistant GNB prosthetic joint infection, including revision arthroplasty, postoperative hematoma, previous orthopaedic infection, and early infection. Extensively drug-resistant GNB and comorbidities were independently associated with higher treatment failure rates in MDR-GNB PJI.

ANTIBIOTICS-BASEL (2021)

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Article Orthopedics

Next generation sequencing for pathogen detection in periprosthetic joint infections

Pier F. Indelli et al.

Summary: Next generation sequencing (NGS) is a promising tool for rapid diagnosis of periprosthetic joint infections (PJI), offering the potential to detect pathogens and antimicrobial resistance genes quickly. While revolutionary, NGS technologies still require further clinical evidence before becoming widely adopted for PJI diagnosis.

EFORT OPEN REVIEWS (2021)

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Review Infectious Diseases

The road to success of coagulase-negative staphylococci: clinical significance of small colony variants and their pathogenic role in persistent infections

Agnieszka Bogut et al.

Summary: Bacterial small colony variants are naturally occurring microbial subpopulations with distinctive phenotypic and pathogenic traits. They tend to persist intracellularly, displaying antibiotic resistance and reduced virulence factor expression, contributing to chronic infections. Despite their clinical significance, studies on the formation mechanisms and impact of CoNS SCVs in the infectious process are scarce compared to S. aureus SCVs.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2021)

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Article Immunology

Staphylococcus epidermidis small colony variants, clinically significant quiescent threats for patients with prosthetic joint infection

Diana Fernandez-Rodriguez et al.

Summary: This study found a relatively high proportion of Staphylococcus epidermidis small colony variants in prosthetic joint infections, which were associated with difficulties in achieving remission. Small colony variants showed higher resistance rates to trimethoprim/sulfamethoxazole and lower resistance rates to levofloxacin.

MICROBES AND INFECTION (2021)

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Review Biochemistry & Molecular Biology

Serum Inflammatory Biomarkers in the Diagnosis of Periprosthetic Joint Infections

Irene K. Sigmund et al.

Summary: Accurate preoperative diagnosis of periprosthetic joint infections (PJIs) can be challenging, serum parameters such as CRP and ESR are commonly used to distinguish septic from aseptic failure, while novel serum biomarkers are being investigated to find a more specific and accurate diagnostic tool.

BIOMEDICINES (2021)

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Article Orthopedics

Screening for Periprosthetic Joint Infections With ESR and CRP: The Ideal Cutoffs

Joshua S. Bingham et al.

JOURNAL OF ARTHROPLASTY (2020)

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Article Orthopedics

Diagnosis and Prevention of Periprosthetic Joint Infections

Creighton C. Tubb et al.

JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS (2020)

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Article Infectious Diseases

Can metagenomic next-generation sequencing identify the pathogens responsible for culture-negative prosthetic joint infection?

Chaoxin Wang et al.

BMC INFECTIOUS DISEASES (2020)

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Article Orthopedics

Is Procalcitonin (PCT) a reliable biomarker for preoperative diagnosing of low grade periprosthetic joint infection? A prospective study

Andre Busch et al.

BMC MUSCULOSKELETAL DISORDERS (2020)

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Article Infectious Diseases

Comparison of broad-range polymerase chain reaction and metagenomic next-generation sequencing for the diagnosis of prosthetic joint infection

Chao-xin Wang et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Review Microbiology

Regulatory Mechanisms and Promising Applications of Quorum Sensing-Inhibiting Agents in Control of Bacterial Biofilm Formation

Lantian Zhou et al.

FRONTIERS IN MICROBIOLOGY (2020)

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ARTHROSCOPIC EVALUATION AND TREATMENT OF COMPLICATIONS THAT ARISE FOLLOWING PROSTHETIC SHOULDER ARTHROPLASTY

David B. Parker et al.

JBJS REVIEWS (2020)

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Article Orthopedics

Comparison between the Staphylococci aureus and coagulase-negative staphylococci infected total joint arthroplasty treated by two-stage revision: A retrospective study with two year minimum follow-up

Zhisen Gao et al.

JOURNAL OF ORTHOPAEDIC SCIENCE (2019)

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Article Orthopedics

Hip and Knee Section, Fungal Periprosthetic Joint Infection, Diagnosis and Treatment: Proceedings of International Consensus on Orthopedic Infections

Katherine Belden et al.

JOURNAL OF ARTHROPLASTY (2019)

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Article Orthopedics

Hip and Knee Section, Diagnosis, Pathogen Isolation, Culture: Proceedings of International Consensus on Orthopedic Infections

Matthew P. Abdel et al.

JOURNAL OF ARTHROPLASTY (2019)

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Article Orthopedics

Hip and Knee Section, Diagnosis, Algorithm: Proceedings of International Consensus on Orthopedic Infections

Mahmoud Abdel Karim et al.

JOURNAL OF ARTHROPLASTY (2019)

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Article Orthopedics

General Assembly, Diagnosis, Pathogen Isolation - Culture Matters: Proceedings of International Consensus on Orthopedic Infections

Tiziana Ascione et al.

JOURNAL OF ARTHROPLASTY (2019)

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Article Orthopedics

Next-Generation Sequencing vs Culture-Based Methods for Diagnosing Periprosthetic Joint Infection After Total Knee Arthroplasty: A Cost-Effectiveness Analysis

Michael T. Torchia et al.

JOURNAL OF ARTHROPLASTY (2019)

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Review Orthopedics

A standardized interdisciplinary algorithm for the treatment of prosthetic joint infections OUTCOME IN A CENTRALIZED AND SPECIALIZED DEPARTMENT

D. Karczewski et al.

BONE & JOINT JOURNAL (2019)

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Trisha N. Peel

FRONTIERS IN MICROBIOLOGY (2019)

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Diagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements A Systematic Review

Alberto Carli et al.

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Antibiotics versus biofilm: an emerging battleground in microbial communities

Divakar Sharma et al.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2019)

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The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms

Natividad Benito et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Article Orthopedics

Use of Natural Language Processing Tools to Identify and Classify Periprosthetic Femur Fractures

Meagan E. Tibbo et al.

JOURNAL OF ARTHROPLASTY (2019)

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Article Orthopedics

Use of Natural Language Processing Algorithms to Identify Common Data Elements in Operative Notes for Total Hip Arthroplasty

Cody C. Wyles et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2019)

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Article Infectious Diseases

Microbiology of polymicrobial prosthetic joint infection

Laure Flurin et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2019)

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Article Infectious Diseases

Culturing periprosthetic tissue in blood culture bottles results in isolation of additional microorganisms

Wouter van den Bijllaardt et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2019)

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Article Infectious Diseases

Enterococcal periprosthetic joint infection: clinical and microbiological findings from an 8-year retrospective cohort study

Nora Renz et al.

BMC INFECTIOUS DISEASES (2019)

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Article Orthopedics

Total Hip Arthroplasty in Human Immunodeficiency Viruse-Positive Patients: A Concise Follow-Up at 10 to 14 Years

David Novikov et al.

JOURNAL OF ARTHROPLASTY (2019)

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Article Medicine, General & Internal

Post-total knee arthroplasty herpes zoster activation

Mantu Jain et al.

BMJ CASE REPORTS (2019)

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Article Infectious Diseases

The prognosis of streptococcal prosthetic bone and joint infections depends on surgical management-A multicenter retrospective study

Rafael Mahieu et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2019)

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Article Orthopedics

Low sensitivity of α-defensin (Synovasure) test for intraoperative exclusion of prosthetic joint infection

Ruben Scholten et al.

ACTA ORTHOPAEDICA (2018)

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Article Microbiology

Periprosthetic joint infection caused by anaerobes. Retrospective analysis reveals no need for prolonged cultivation time if sensitive supplemented growth media are used

Heime Rieber et al.

ANAEROBE (2018)

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Review Orthopedics

Does the Alpha-defensin Immunoassay or the Lateral Flow Test Have Better Diagnostic Value for Periprosthetic Joint Infection? A Systematic Review

Hannah K. Eriksson et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2018)

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Article Infectious Diseases

Synovial fluid multiplex PCR is superior to culture for detection of low-virulent pathogens causing periprosthetic joint infection

Christian Morgenstern et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2018)

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Article Infectious Diseases

Combination of conventional culture, vial culture, and broad-range PCR of sonication fluid for the diagnosis of prosthetic joint infection

Antonios Stylianakis et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2018)

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Article Public, Environmental & Occupational Health

Species and antimicrobial susceptibility testing of coagulase-negative staphylococci in periprosthetic joint infections

J. Lourtet-Hascoet et al.

EPIDEMIOLOGY AND INFECTION (2018)

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Article Infectious Diseases

Prosthetic valve endocarditis caused by Propionibacterium species: a national registry-based study of 51 Swedish cases

Fredrik Lindell et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2018)

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Review Orthopedics

Diagnostic accuracy of interleukin-6 and procalcitonin in patients with periprosthetic joint infection: a systematic review and meta-analysis

Jung-Ro Yoon et al.

INTERNATIONAL ORTHOPAEDICS (2018)

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Article Orthopedics

The 2018 Definition of Periprosthetic Hip and Knee Infection: An Evidence-Based and Validated Criteria

Javad Parvizi et al.

JOURNAL OF ARTHROPLASTY (2018)

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Article Microbiology

Histopathological Diagnosis of Prosthetic Joint Infection: Does a Threshold of 23 Neutrophils Do Better than Classification of the Periprosthetic Membrane in a Prospective Multicenter Study?

Pascale Bemer et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2018)

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Article Multidisciplinary Sciences

Meta-analysis of sonication prosthetic fluid PCR for diagnosing periprosthetic joint infection

Kan Liu et al.

PLOS ONE (2018)

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Review Virology

Together Forever: Bacterial-Viral Interactions in Infection and Immunity

Zhenda Shi et al.

VIRUSES-BASEL (2018)

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Editorial Material Orthopedics

Delayed Infection in a Patient After Total Hip Arthroplasty

Manasi Bohra et al.

JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY (2018)

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Review Multidisciplinary Sciences

Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention

Zohra Khatoon et al.

HELIYON (2018)

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Article Orthopedics

How Reliable Is the Alpha-defensin Immunoassay Test for Diagnosing Periprosthetic Joint Infection? A Prospective Study

Tommaso Bonanzinga et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2017)

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Article Orthopedics

Serum D-Dimer Test Is Promising for the Diagnosis of Periprosthetic Joint Infection and Timing of Reimplantation

Alisina Shahi et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2017)

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Article Orthopedics

Rapidly growing non-tuberculous mycobacteria infection of prosthetic knee joints: A report of two cases

Manyoung Kim et al.

KNEE (2017)

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Article Orthopedics

Synovial calprotectin A POTENTIAL BIOMARKER TO EXCLUDE A PROSTHETIC JOINT INFECTION

M. Wouthuyzen-Bakker et al.

BONE & JOINT JOURNAL (2017)

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Article Orthopedics

Qualitative α-defensin test (Synovasure) for the diagnosis of periprosthetic infection in revision total joint arthroplasty

I. K. Sigmund et al.

BONE & JOINT JOURNAL (2017)

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Article Infectious Diseases

Rapidly-growing mycobacterial infection: a recognized cause of early-onset prosthetic joint infection

Anupop Jitmuang et al.

BMC INFECTIOUS DISEASES (2017)

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Review Surgery

HUMAN IMMUNODEFICIENCY VIRUS INFECTION AND HIP AND KNEE ARTHROPLASTY

Dimitrios Dimitriou et al.

JBJS REVIEWS (2017)

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Review Critical Care Medicine

Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy

Ashitha L. Vijayan et al.

JOURNAL OF INTENSIVE CARE (2017)

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Article Infectious Diseases

Time trends in the aetiology of prosthetic joint infections: a multicentre cohort study

N. Benito et al.

CLINICAL MICROBIOLOGY AND INFECTION (2016)

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Review Orthopedics

Alpha-defensin-novel synovial fluid biomarker for the diagnosis of periprosthetic joint infection

Jakrapun Pupaibool et al.

INTERNATIONAL ORTHOPAEDICS (2016)

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Review Medicine, General & Internal

Periprosthetic joint infection

Bhaveen H. Kapadia et al.

LANCET (2016)

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Review Infectious Diseases

Prosthetic joint infections secondary to rapidly growing mycobacteria: Two case reports and a review of the literature

Michael W. Henry et al.

INFECTIOUS DISEASES (2016)

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Article Orthopedics

Safety and efficacy of arthroscopy in the setting of shoulder arthroplasty

Sebastian Heaven et al.

CURRENT REVIEWS IN MUSCULOSKELETAL MEDICINE (2016)

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Article Microbiology

Antibiotic susceptibility of Propionibacterium acnes isolated from orthopaedic implant-associated infections

Jasmine Khassebaf et al.

ANAEROBE (2015)

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Article Microbiology

First Experience of a Multicenter External Quality Assessment of Molecular 16S rRNA Gene Detection in Bone and Joint Infections

Chloe Plouzeau et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2015)

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Article Infectious Diseases

Characteristics of prosthetic joint infections due to Enterococcus sp and predictors of failure: a multi-national study

E. Tornero et al.

CLINICAL MICROBIOLOGY AND INFECTION (2014)

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Review Microbiology

Prosthetic Joint Infection

Aaron J. Tande et al.

CLINICAL MICROBIOLOGY REVIEWS (2014)

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Article Orthopedics

Diagnosing Periprosthetic Joint Infection: Has the Era of the Biomarker Arrived?

Carl Deirmengian et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2014)

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Letter Orthopedics

Definition of Periprosthetic Joint Infection

Javad Parvizi et al.

JOURNAL OF ARTHROPLASTY (2014)

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Review Orthopedics

CURRENT CONCEPTS REVIEW Culture-Negative Periprosthetic Joint Infection

Javad Parvizi et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2014)

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Article Microbiology

Evaluation of 16S rRNA Gene PCR Sensitivity and Specificity for Diagnosis of Prosthetic Joint Infection: a Prospective Multicenter Cross-Sectional Study

Pascale Bemer et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2014)

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Article Infectious Diseases

Advantages of sonication fluid culture for the diagnosis of prosthetic joint infection

Maria Eugenia Portillo et al.

JOURNAL OF INFECTION (2014)

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Review Medicine, General & Internal

Clinical presentation and treatment of orthopaedic implant-associated infection

W. Zimmerli

JOURNAL OF INTERNAL MEDICINE (2014)

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Article Biotechnology & Applied Microbiology

Sensitivities, Specificities, and Predictive Values of Microbiological Culture Techniques for the Diagnosis of Prosthetic Joint Infection

Robert W. Jordan et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Article Immunology

Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of America

Douglas R. Osmon et al.

CLINICAL INFECTIOUS DISEASES (2013)

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Article Microbiology

Comparison of molecular and culture method in diagnosis of prosthetic joint infection

Mitja Rak et al.

FEMS MICROBIOLOGY LETTERS (2013)

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Article Orthopedics

Should Draining Wounds and Sinuses Associated With Hip and Knee Arthroplasties Be Cultured?

Matthew W. Tetreault et al.

JOURNAL OF ARTHROPLASTY (2013)

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Article Orthopedics

Antimicrobial Peptides and Proinflammatory Cytokines in Periprosthetic Joint Infection

Hans Gollwitzer et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2013)

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Article Microbiology

PCR-Based Diagnosis of Prosthetic Joint Infection

Xinhua Qu et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2013)

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Article Microbiology

Rapid Molecular Microbiologic Diagnosis of Prosthetic Joint Infection

Charles Cazanave et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2013)

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Article Hematology

Role of Fibrinolysis in Sepsis

Satoshi Gando

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2013)

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Article Orthopedics

Prolonged incubation time does not increase sensitivity for the diagnosis of implant-related infection using samples prepared by sonication of the implants

J. Esteban et al.

Bone & Joint Journal (2013)

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Review Engineering, Biomedical

Epidemiology and new developments in the diagnosis of prosthetic joint infection

Stephane Corvec et al.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2012)

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Article Orthopedics

Revision Total Knee Arthroplasty: Infection Should Be Ruled Out in All Cases

Mohammad R. Rasouli et al.

JOURNAL OF ARTHROPLASTY (2012)

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Article Microbiology

Prosthetic Joint Infection Diagnosis Using Broad-Range PCR of Biofilms Dislodged from Knee and Hip Arthroplasty Surfaces Using Sonication

Eric Gomez et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2012)

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Article Orthopedics

Post-traumatic bone and/or joint limb infections due to Clostridium spp.

A. Ibnoulkhatib et al.

ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH (2012)

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Article Orthopedics

Diagnosis of Periprosthetic Joint Infection: The Utility of a Simple Yet Unappreciated Enzyme

ORTHOPEDICS (2012)

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Article Orthopedics

New Definition for Periprosthetic Joint Infection: From the Workgroup of the Musculoskeletal Infection Society

Javad Parvizi et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2011)

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Article Orthopedics

Prior Use of Antimicrobial Therapy is a Risk Factor for Culture-negative Prosthetic Joint Infection

Davud Malekzadeh et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2010)

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Article Orthopedics

Synovial Fluid Biomarkers for Periprosthetic Infection

Carl Deirmengian et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2010)

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Article Orthopedics

Inflammatory Blood Laboratory Levels as Markers of Prosthetic Joint Infection A Systematic Review and Meta-Analysis

Elie Berbari et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2010)

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Article Microbiology

Escherichia coli Variants in Periprosthetic Joint Infection: Diagnostic Challenges with Sessile Bacteria and Sonication

Parham Sendi et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2010)

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Article Orthopedics

Microbiological, Clinical, and Surgical Features of Fungal Prosthetic Joint Infections: A Multi-Institutional Experience

Khalid Azzam et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2009)

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Article Biochemistry & Molecular Biology

Interleukin (IL) 1β induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IκB kinase α pathway targeting activator protein-1

Catherine M. Cahill et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Microbiology

Characterization of small-colony variants of Enterococcus faecalis isolated from chickens with amyloid arthropathy

Andreas Petersen et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2008)

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Article Medicine, General & Internal

Sonication of removed hip and knee prostheses for diagnosis of infection

Andrej Trampuz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Review Microbiology

Anaerobes: Antibiotic resistance, clinical significance, and the role of susceptibility testing

David W. Hecht

ANAEROBE (2006)

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Review Medicine, General & Internal

Current concepts: Prosthetic-joint infections

W Zimmerli et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

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Review Microbiology

Bacterial biofilms: An emerging link to disease pathogenesis

MR Parsek et al.

ANNUAL REVIEW OF MICROBIOLOGY (2003)

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Article Orthopedics

Evaluation of preoperative cultures before second-stage reimplantation of a total knee prosthesis complicated by infection - A comparison-group study

MA Mont et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2000)

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