Analytical Method Optimization of Tetrodotoxin and Its Contamination in Gastropods

Article Chemistry, Medicinal

An Updated Review of Tetrodotoxin and Its Peculiarities

Panagiota Katikou et al.

Summary: Tetrodotoxin is a potent marine toxin found in various marine and terrestrial organisms. Its toxic effects and the lack of an antidote make TTX poisoning a significant global health concern.

MARINE DRUGS (2022)

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Article Food Science & Technology

Simultaneous Determination of Tetrodotoxin in the Fresh and Heat-Processed Aquatic Products by High-Performance Liquid Chromatography-Tandem Mass Spectrometry

Hongli Ye et al.

Summary: Tetrodotoxin (TTX) was detected in both fresh and heat-processed aquatic products using high-performance liquid chromatography-tandem mass spectrometry. A sensitive determination method was established based on optimized parameters, featuring a good linear relationship (R-2 = 0.9998) between signal and TTX concentration, a wide detection range (0.2-100 ng/g), and a low detection limit (0.2 ng/g). The accuracy and reliability of the method were confirmed by spiked assays with recoveries of 90.5-107.2%. This developed method was successfully applied to the determination of TTX in various fresh and heat-processed aquatic products.

FOODS (2022)

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Review Agriculture, Multidisciplinary

Tetrodotoxin and Its Analogues in Food: Recent Updates on Sample Preparation and Analytical Methods Since 2012

Cong Hu et al.

Summary: This review summarizes the recent advances in the detection methods of Tetrodotoxin (TTX) and its analogues. The focus of current research is on sample preparation and analytical techniques, with the introduction of several state-of-the-art technologies. The review provides valuable insights for the future development of TTX detection methods.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Biochemical Research Methods

Simple and fast determination of tetrodotoxin in human plasma based on hydrophilic-interaction/ion-exchange mixed-mode solid phase extraction combined with liquid chromatography-tandem mass spectroscopy

Liang Xin et al.

Summary: In this study, a simple, fast, and sensitive LC-MS/MS method was developed and validated for measuring tetrodotoxin (TTX) in human plasma. Different solid phase extraction (SPE) carriers with different functional groups were compared, and the Siphila i HILIX SPE plate with multi-carboxyl groups was selected for better extraction recovery of TTX. The method avoids the evaporation and ultrafiltration processes, making it simple, time-saving, and effective for analyzing TTX in plasma.

JOURNAL OF CHROMATOGRAPHY A (2022)

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Article Food Science & Technology

First occurrence of tetrodotoxins in bivalve mollusks from Northern Adriatic Sea (Italy)

Paola Bordin et al.

Summary: Tetrodotoxins are a potent neurotoxin with potentially fatal effects if ingested by humans. Recently, significant amounts of tetrodotoxins were detected in mussels collected in a specific area of the Northern Adriatic Sea in Italy, with the highest concentration ever found in mollusks in Europe.

FOOD CONTROL (2021)

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Article Chemistry, Medicinal

Distribution of Tetrodotoxin in Pacific Oysters (Crassostrea gigas)

Monika Dhanji-Rapkova et al.

Summary: A potent and heat-stable toxin, TTX, accumulates in various marine bivalve species, including Pacific oysters, with the highest concentrations found in the digestive gland. TTX levels vary significantly between different geographical locations and within populations of oysters, suggesting high variability in toxin distribution.

MARINE DRUGS (2021)

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Article Food Science & Technology

High Levels of Tetrodotoxin (TTX) in Trumpet Shell Charonia lampas from the Portuguese Coast

Pedro Reis Costa et al.

Summary: The study found that trumpet shell marine snails may contain high levels of TTX, with toxin levels below safety limits in the edible portion, highlighting the importance of proper evisceration by consumers to ensure food safety.

TOXINS (2021)

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Article Biochemical Research Methods

Simultaneous determination of ten paralytic shellfish toxins and tetrodotoxin in scallop and short-necked clam by ion-pair solid-phase extraction and hydrophilic interaction chromatography with tandem mass spectrometry

Naoki Ochi

Summary: A simple and effective clean-up procedure was developed for the simultaneous determination of ten paralytic shellfish toxins and tetrodotoxin in scallop and short-necked clam samples. The method showed minimal matrix effects and allowed quantification of the toxins through simple external calibration.

JOURNAL OF CHROMATOGRAPHY A (2021)

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Review Food Science & Technology

A Global Retrospective Study on Human Cases of Tetrodotoxin (TTX) Poisoning after Seafood Consumption

Lisa Guardone et al.

FOOD REVIEWS INTERNATIONAL (2020)

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Article Biochemical Research Methods

Determination of ibotenic acid and muscimol in plasma by liquid chromatography-triple quadrupole mass spectrometry with bimolecular dansylation

Xiao-min Xu et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2020)

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Article Food Science & Technology

Multi-Toxin Quantitative Analysis of Paralytic Shellfish Toxins and Tetrodotoxins in Bivalve Mollusks with Ultra-Performance Hydrophilic Interaction LC-MS/MS-An In-House Validation Study

Fadillah Putri Patria et al.

TOXINS (2020)

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Article Food Science & Technology

First Detection of Tetrodotoxin in Bivalves and Gastropods from the French Mainland Coasts

Vincent Hort et al.

TOXINS (2020)

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Article Chemistry, Analytical

Ultrahigh-Performance Hydrophilic Interaction Liquid Chromatography with Tandem Mass Spectrometry Method for the Determination of Paralytic Shellfish Toxins and Tetrodotoxin in Mussels, Oysters, Clams, Cockles, and Scallops: Collaborative Study

Andrew D. Turner et al.

JOURNAL OF AOAC INTERNATIONAL (2020)

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Article Chemistry, Analytical

A gold nanoparticle-based lateral flow immunosensor for ultrasensitive detection of tetrodotoxin

Yue Li et al.

ANALYST (2020)

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Review Environmental Sciences

Tetrodotoxin in marine bivalves and edible gastropods: A mini-review

Laura Biessy et al.

CHEMOSPHERE (2019)

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Article Chemistry, Applied

Rapid analysis of paralytic shellfish toxins and tetrodotoxins by liquid chromatography-tandem mass spectrometry using a porous graphitic carbon column

Veronica Rey et al.

FOOD CHEMISTRY (2018)

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Article Chemistry, Analytical

Development and validation of a maleimide-based enzyme-linked immunosorbent assay for the detection of tetrodotoxin in oysters and mussels

Laia Reverte et al.

TALANTA (2018)

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Article Environmental Sciences

Analysis and Evaluation of Tetrodotoxin in Coastal Aquatic Products of Zhejiang Province

Chengcheng Han et al.

JOURNAL OF COASTAL RESEARCH (2018)

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Article Chemistry, Analytical

Development and Single-Laboratory Validation of a Liquid Chromatography Tandem Mass Spectrometry Method for Quantitation of Tetrodotoxin in Mussels and Oysters

Andrew D. Turner et al.

JOURNAL OF AOAC INTERNATIONAL (2017)

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Article Chemistry, Analytical

Rapid in vivo determination of tetrodotoxin in pufferfish (Fugu) muscle by solid-phase microextraction coupled to high-performance liquid chromatography tandem mass spectrometry

Le Chen et al.

TALANTA (2017)

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Article Food Science & Technology

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Paula Abal et al.

TOXINS (2017)

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Article Food Science & Technology

Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods

Helle Katrine Knutsen et al.

EFSA JOURNAL (2017)

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Article Chemistry, Applied

LC-MS/MS method for the determination of tetrodotoxin (TTX) on a triple quadruple mass spectrometer

Vaishali Bane et al.

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2016)

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Article Pharmacology & Pharmacy

Development and validation of a high-throughput online solid phase extraction - Liquid chromatography - Tandem mass spectrometry method for the detection of tetrodotoxin in human urine

Rebecca Coleman et al.

TOXICON (2016)

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Article Chemistry, Applied

A rapid method for tetrodotoxin (TTX) determination by LC-MS/MS from small volumes of human serum, and confirmation of pufferfish poisoning by TTX monitoring

Kazunari Tsujimura et al.

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2015)

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Article Agriculture, Multidisciplinary

Immunoaffinity Chromatography Purification and Ultrahigh Performance Liquid Chromatography Tandem Mass Spectrometry Determination of Tetrodotoxin in Marine Organisms

Xiaojun Zhang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2015)

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Article Chemistry, Analytical

Study of the matrix effects of tetrodotoxin and its content in cooked seafood by liquid chromatography with triple quadrupole mass spectrometry

Xiao-min Xu et al.

JOURNAL OF SEPARATION SCIENCE (2015)

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Review Chemistry, Medicinal

Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses

Jorge Lago et al.

MARINE DRUGS (2015)

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Article Chemistry, Applied

Toxin composition and toxicity dynamics of marine gastropod Nassarius spp. collected from Lianyungang, China

X. Luo et al.

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2012)

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Article Medicine, Legal

Determination and validation of tetrodotoxin in human whole blood using hydrophilic interaction liquid chromatography-tandem mass spectroscopy and its application

Hwang Eui Cho et al.

FORENSIC SCIENCE INTERNATIONAL (2012)

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Article Pharmacology & Pharmacy

Separation, identification and quantification of tetrodotoxin and its analogs by LC-MS without calibration of individual analogs

Xiao-Wu Chen et al.

TOXICON (2011)

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Article Biochemical Research Methods

Screening of tetrodotoxin in puffers using gas chromatography-mass spectrometry

Che Nin Man et al.

JOURNAL OF CHROMATOGRAPHY A (2010)

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Article Chemistry, Medicinal

LC/MS Analysis of Tetrodotoxin and Its Deoxy Analogs in the Marine Puffer Fish Fugu niphobles from the Southern Coast of Korea, and in the Brackishwater Puffer Fishes Tetraodon nigroviridis and Tetraodon biocellatus from Southeast Asia

Jun-Ho Jang et al.

MARINE DRUGS (2010)

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Article Pharmacology & Pharmacy

Detection of tetrodotoxin from the grey side-gilled sea slug - Pleurobranchaea maculata, and associated dog neurotoxicosis on beaches adjacent to the Hauraki Gulf, Auckland, New Zealand

Paul McNabb et al.

TOXICON (2010)

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Article Chemistry, Analytical

First toxicity report of tetrodotoxin and 5,6,11-trideoxyTTX in the trumpet shell Charonia lampas lampas in Europe

Paula Rodriguez et al.

ANALYTICAL CHEMISTRY (2008)

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Article Biochemical Research Methods

Tetrodotoxin poisoning evidenced by solid-phase extraction combining with liquid chromatography-tandem mass spectrometry

Hsiao-Chin Jen et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2008)

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Article Pharmacology & Pharmacy

Identification and quantification of tetrodotoxin in the marine gastropod Nassarius by LC-MS

Hong-Nan Huang et al.

TOXICON (2008)

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Article Pharmacology & Pharmacy

Toxin-screening and identification of bacteria isolated from highly toxic marine gastropod Nassarius semiplicatus

Xiao-Jie Wang et al.

TOXICON (2008)

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Article Chemistry, Applied

Occurrence of tetrodotoxin and paralytic shellfish poisons in a gastropod implicated in food poisoning in southern Taiwan

H.-C. Jen et al.

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2007)

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Analytical Method Optimization of Tetrodotoxin and Its Contamination in Gastropods

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