Application of seaweed polysaccharide in bone tissue regeneration

Regeneration is a complex process influenced by many independent or combined factors, including inflammation, proliferation, and tissue remodeling. The ocean, the most extensive resource on Earth, is rich in Seaweed. With increasing research in recent years, researchers have discovered that seaweed polysaccharides have various pharmacological effects, including a particular efficacy in promoting bone tissue regeneration. However, the application of this material in the field of bone tissue engineering is very limited. However, there are few studies on the polysaccharide at home and abroad, and little is known about its potential application value in bone repair. In addition, the bioavailability of the seaweed polysaccharide is also low, and there are still many problems to be solved. For example, the ease of solubility of fucoidan in water is a key issue that restricts its practical application. In this review, we summarize the applications and mechanisms of seaweed polysaccharides in bone healing. We also propose to combine seaweed polysaccharides with novel technologies through different types of preparations, hydrogels, scaffolds, and 3D printing to improve their use in tissue healing and regeneration.

Automated summary

Applications and mechanisms of seaweed polysaccharides in bone healing are summarized in this review. The potential application value of seaweed polysaccharides in bone repair is still not well understood due to limited research. The low bioavailability of seaweed polysaccharides and the issue of solubility of fucoidan in water pose challenges for practical application. The combination of seaweed polysaccharides with novel technologies, including hydrogels, scaffolds, and 3D printing, is proposed to improve their use in tissue healing and regeneration.