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Expression of Proteins, Glycoproteins, and Transcripts in the Guts of Fasting, Fed, and Trypanosoma cruzi-Infected Triatomines: A Systematic Review

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PATHOGENS
卷 12, 期 9, 页码 -

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MDPI
DOI: 10.3390/pathogens12091124

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triatomine; proteins; transcripts; glycoproteins; Trypanosoma cruzi; gut; intestine; Chagas disease; vectors

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Chagas disease is caused by Trypanosoma cruzi, a hemoflagellate protozoan, which is mainly transmitted through contact with infected triatomine bug feces. The interaction between the vector and parasite in the digestive tract of the bug plays a crucial role in the replication and differentiation processes of T. cruzi, potentially affecting its infectivity for vertebrate hosts. A systematic review was conducted to analyze information on transcripts, proteins, and glycoproteins in the guts of fasting, fed, and T. cruzi-infected triatomines from 2000 to 2022, and the findings from 55 original research articles were compiled.
Chagas disease is caused by the hemoflagellate protozoan Trypanosoma cruzi. The main transmission mechanism for the parasite in endemic areas is contact with the feces of an infected triatomine bug. Part of the life cycle of T. cruzi occurs in the digestive tract of triatomines, where vector and parasite engage in a close interaction at a proteomic-molecular level. This interaction triggers replication and differentiation processes in the parasite that can affect its infectivity for the vertebrate host. With the aim of compiling and analyzing information from indexed publications on transcripts, proteins, and glycoproteins in the guts of fasting, fed, and T. cruzi-infected triatomines in the period 2000-2022, a systematic review was conducted following the PRISMA guidelines. Fifty-five original research articles retrieved from PubMed and ScienceDirect were selected; forty-four papers reported 1-26,946 transcripts, and twenty-one studies described 1-2603 peptides/proteins.

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