期刊
NATURE GENETICS
卷 48, 期 8, 页码 927-+出版社
NATURE PORTFOLIO
DOI: 10.1038/ng.3596
关键词
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资金
- Japan Society for the Promotion of Science [26252001]
- Council for Science, Technology and Innovation (CSTI)
- Cross-Ministerial Strategic Innovation Promotion Program (SIP)
- Technologies for Creating Next-Generation Agriculture, Forestry and Fisheries (funding agency: Bio-oriented Technology Research Advancement Institution, NARO)
- [16J08722]
- Grants-in-Aid for Scientific Research [16J08722, 26252001, 15H04436] Funding Source: KAKEN
A genome-wide association study ( GWAS) can be a powerful tool for the identification of genes associated with agronomic traits in crop species, but it is often hindered by population structure and the large extent of linkage disequilibrium. In this study, we identified agronomically important genes in rice using GWAS based on whole-genome sequencing, followed by the screening of candidate genes based on the estimated effect of nucleotide polymorphisms. Using this approach, we identified four new genes associated with agronomic traits. Some genes were undetectable by standard SNP analysis, but we detected them using gene-based association analysis. This study provides fundamental insights relevant to the rapid identification of genes associated with agronomic traits using GWAS and will accelerate future efforts aimed at crop improvement.
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