期刊
NATURE GENETICS
卷 48, 期 12, 页码 1462-1472出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3698
关键词
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资金
- ERC Consolidator Grant SOCIOGENOME [615603]
- Dutch Science Foundation (NWO) grant (VIDI grant) [452-10-012]
- UK ESRC/NCRM SOCGEN grant [ES/N011856/1]
- European Union [320116]
- Wellcome Trust ISSF
- John Fell Fund
- Swedish Research Council [2015-03657, 421-2013-1061, 537-2014-371]
- Swedish Heart-Lung Foundation [20140543]
- US National Science Foundation (EAGER: 'Workshop for the Formation of a Social Science Genetic Association Consortium')
- National Institutes of Health Office of Behavioral and Social Science Research
- Ragnar Soderberg Foundation [E9/11]
- Jan Wallander and Tom Hedelius Foundation
- ERC [647648 EdGe]
- Pershing Square Fund of the Foundations of Human Behavior
- NIA/NIH [P01-AG005842, P01-AG005842-20S2, P30-AG012810, T32-AG000186-23, R01-AG042568-02]
- ESRC [ES/N011856/1] Funding Source: UKRI
- MRC [MC_UU_12013/3, MC_UU_12013/1, MC_PC_U127561128, MC_UU_12015/2, MR/N01104X/1, MC_UU_12015/1, MR/J012165/1, MC_U106179472, G1001799] Funding Source: UKRI
- Swedish Research Council [2015-03657] Funding Source: Swedish Research Council
- British Heart Foundation [RG/15/12/31616] Funding Source: researchfish
- Economic and Social Research Council [ES/N011856/1] Funding Source: researchfish
- Lundbeck Foundation [R163-2013-16235] Funding Source: researchfish
- Medical Research Council [MR/N01104X/1, G9815508, MC_U106179471, G1001799, MR/K026992/1, MR/J012165/1, MC_U106179472, MC_UU_12015/1, MC_UU_12015/2, MC_PC_U127561128, 1201677, MC_UU_12013/1, MC_UU_12013/3, MC_PC_13048] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0507-10228, NF-SI-0514-10027] Funding Source: researchfish
- Novo Nordisk Fonden [NNF12OC1016374, NNF15OC0016362, NNF14OC0010513, NNF13OC0005785] Funding Source: researchfish
- European Research Council (ERC) [615603] Funding Source: European Research Council (ERC)
The genetic architecture of human reproductive behavior age at first birth (AFB) and number of children ever born (NEB) has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
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