4.6 Review

Systematic Literature Review of the Epidemiological Characteristics of Pneumococcal Disease Caused by the Additional Serotypes Covered by the 20-Valent Pneumococcal Conjugate Vaccine

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MICROORGANISMS
卷 11, 期 7, 页码 -

出版社

MDPI
DOI: 10.3390/microorganisms11071816

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20-valent pneumococcal conjugate vaccine; invasive pneumococcal disease; proportion; incidence; severity; antimicrobial non-susceptibility; PCV20; PCV15; Streptococcus pneumoniae

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Higher valency pneumococcal conjugate vaccines (PCV15 and PCV20) have been developed to tackle the disease burden caused by non-vaccine serotypes. This review provides an overview of the epidemiological characteristics of serotypes beyond PCV13, analyzing their association with different diseases and their antimicrobial non-susceptibility. The findings can contribute to informed decision-making regarding the choice and use of higher valency PCVs.
Higher valency pneumococcal conjugate vaccines (PCV15 and PCV20) have been developed to address the disease burden of current non-vaccine serotypes. This review describes the epidemiological characteristics of serotypes beyond PCV13 (serotypes 8, 10A, 11A, 12F, 15B/C, 22F, and 33F; PCV20nonPCV13 serotypes). Peer-reviewed studies published between 1 January 2010 (the year PCV13 became available) and 18 August 2020 were systematically reviewed (PROSPERO number: CRD42021212875). Data describing serotype-specific outcomes on disease proportions, incidence, severity, and antimicrobial non-susceptibility were summarized for individual and aggregate PCV20nonPCV13 serotypes by age group and by type and duration of pediatric PCV immunization program. Of 1168 studies, 127 (11%) were included in the analysis. PCV20nonPCV13 serotypes accounted for 28% of invasive pneumococcal disease (IPD), although the most frequent serotypes differed between children (10A, 15B/C) and adults (8, 12F, 22F). In children, serotype 15B/C tended to be more frequently associated with pneumococcal meningitis and acute otitis media; in adults, serotype 8 was more frequently associated with pneumonia and serotype 12F with meningitis. Serotypes 10A and 15B/C in children and 11A and 15B/C in adults were often associated with severe IPD. Serotype 15B/C was also among the most frequently identified penicillin/macrolide non-susceptible PCV20nonPCV13 serotypes. These results could inform decision making about higher valency PCV choice and use.

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