☆ 4.6 Article

Natural Shikonin Potentially Alters Intestinal Flora to Alleviate Acute Inflammation

MICROORGANISMS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Cardiac & Cardiovascular Systems

The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease

Rima Mohsen Chakaroun et al.

Summary: In this Review, the authors summarize the evidence for gut microbiome alterations in cardiometabolic and cardiovascular diseases and the rationale and potential benefit of targeting the gut microbiota and its metabolites for prevention and treatment. The gut microbiota has been shown to play a causal role in CVD through specific microbiota-host metabolites, and perturbations of the gut microbial community have been consistently observed in CVD. However, there are still challenges in translating this knowledge into clinical interventions.

NATURE REVIEWS CARDIOLOGY (2023)

添加到收藏夹

Review Plant Sciences

Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches

Qiang Sun et al.

Summary: Shikonin, a major phytochemical component of Lithospermum erythrorhizon, shows promising therapeutic effects on various diseases by regulating multiple signaling pathways. However, its pharmacokinetics reveal low oral bioavailability and potential toxicological effects, such as nephrotoxicity and skin allergies. Clinical trials validating its pharmacodynamics and pharmacokinetics are limited, with potential for pharmaceutical innovation to develop shikonin-based drugs for clinical use.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Natural Compound Shikonin Induces Apoptosis and Attenuates Epithelial to Mesenchymal Transition in Radiation-Resistant Human Colon Cancer Cells

Kristina Shilnikova et al.

Summary: The study demonstrated that shikonin has anti-proliferative, apoptotic-inducing, and migration-inhibiting effects on radiation-resistant human colon carcinoma cells through multiple mechanisms, which could potentially overcome the obstacle of radiation resistance in colorectal cancer treatment.

BIOMOLECULES & THERAPEUTICS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Shikonin Derivatives Inhibit Inflammation Processes and Modulate MAPK Signaling in Human Healthy and Osteoarthritis Chondrocytes

Birgit Lohberger et al.

Summary: This study investigated the effects of shikonin derivatives on inflammation, MMP expression, and MAPK signaling in healthy and osteoarthritis chondrocytes. The results demonstrate that shikonin can reduce the inflammatory response and affect downstream regulation, potentially providing a therapeutic approach for osteoarthritis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Contrasting Health Effects of Bacteroidetes and Firmicutes Lies in Their Genomes: Analysis of P450s, Ferredoxins, and Secondary Metabolite Clusters

Bridget Valeria Zinhle Nkosi et al.

Summary: This study reveals the distinct characteristics of gene pools in the Bacteroidetes and Firmicutes bacterial groups, particularly in terms of bacterial families, ferredoxins, and secondary metabolites. These differences may contribute to the contrasting health effects of these two bacterial groups on the host.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Chemistry, Medicinal

Curcumin regulates the homeostasis of Th17/Treg and improves the composition of gut microbiota in type 2 diabetic mice with colitis

Qiu-Ping Xiao et al.

Summary: The study found that curcumin effectively alleviated ulcerative colitis complicated by diabetes, achieving this by modulating immune responses and the composition of the intestinal microbiota.

PHYTOTHERAPY RESEARCH (2022)

添加到收藏夹

Article Geriatrics & Gerontology

Gut microbiota may be involved in Alzheimer's disease pathology by dysregulating pyrimidine metabolism in APP/PS1 mice

Min Feng et al.

Summary: Through studying AD mice, it was found that the gut microbiota may be associated with the development of cognitive impairment in AD through dysregulation of pyrimidine metabolism. Bacillus firmus, Rikenella, Clostridium sp. Culture-27, and deoxyuridine may serve as important biological markers for AD.

FRONTIERS IN AGING NEUROSCIENCE (2022)

添加到收藏夹

Article Immunology

Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer

Hongyan Lin et al.

Summary: This study identified SK and acetyl-SK, especially SK, as potential preventive agents for CAC through regulating both gut microbes and pathways involved in inflammation and cancer such as Wnt/β-catenin signaling pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Review Chemistry, Medicinal

Crosstalk between traditional Chinese medicine-derived polysaccharides and the gut microbiota: A new perspective to understand traditional Chinese medicine

Bingjie Yue et al.

Summary: This article discusses the extraction and pharmacological effects of traditional Chinese medicine polysaccharides, the functions of the gut microbiota, and the interactions between polysaccharides and the gut microbiota. It elucidates the mechanisms of how polysaccharides modulate host physiology via the gut microbiota.

PHYTOTHERAPY RESEARCH (2022)

添加到收藏夹

Article Nutrition & Dietetics

Arenga pinnata Resistant Starch Modulate Gut Microbiota and Ameliorate Intestinal Inflammation in Aged Mice

Minhong Ren et al.

Summary: This study compared the regulatory effects of Arenga pinnata retrograded starch (APRS), Arenga pinnata starch (APS), and whole Arenga pinnata flour (APF) on gut microbiota and improvement of intestinal inflammation in aged mice. The results showed that APS had the greatest impact on gut microbiota composition, while APF had the greatest effect on improving intestinal inflammation.

NUTRIENTS (2022)

添加到收藏夹

Review Nutrition & Dietetics

Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges

Jing Yan et al.

Summary: Diet plays a crucial role in regulating gut microbiota and the course of inflammatory bowel disease (IBD), with certain dietary patterns found to be effective in achieving clinical remission of IBD.

NUTRIENTS (2022)

添加到收藏夹

Review Immunology

The science behind TCM and Gut microbiota interaction-their combinatorial approach holds promising therapeutic applications

Wenrui Xia et al.

Summary: The trend of using herbal medicine as an alternative treatment is increasing globally, but there is insufficient pharmacologic information available for orally taken medicines. Traditional Chinese medicine (TCM) researchers are studying the interaction between herbal medicine and gut microbiome to better understand TCM pharmacology and enhance its efficacy and bioavailability.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

添加到收藏夹

Review Microbiology

Human gut microbiota in health and disease: Unveiling the relationship

Muhammad Afzaal et al.

Summary: The human gut contains a complex microbial community, which forms a connecting axis with other organs and plays a vital role in host-microbe interactions. Dysbiosis of the gut microbiota is linked to various human diseases. Understanding the role of gut microbiota in health and disease is crucial for maintaining health and treating diseases.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹

Article Oncology

Wenzi Jiedu Recipe ameliorates colorectal cancer by remodeling the gut microbiota and tumor microenvironment

Wenli Qiu et al.

Summary: WJR has shown significant anti-CRC effects by regulating gut microbiota and increasing the proportion of CD8+ T cells and the expression of immune-associated cytokines IL-10, IFN-gamma, and TNF-alpha.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Review Oncology

Antitumor effects of Chinese herbal medicine compounds and their nano-formulations on regulating the immune system microenvironment

Kexiang Sun et al.

Summary: Traditional Chinese medicine (TCM), including herbal medicine, acupuncture, and meditation, has a wide range of applications in China. It has been used to control tumor growth, reduce suffering, improve quality of life, and prolong the life span of cancer patients. Herbal medicine can be used in conjunction with radiotherapy and chemotherapy or as an adjuvant to strengthen the immune effect of anticancer vaccines. In addition, the combination of active ingredients of herbal medicine and modern nanotechnology can alter the tumor immune microenvironment.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Article Ecology

Disruption of Firmicutes and Actinobacteria abundance in tomato rhizosphere causes the incidence of bacterial wilt disease

Sang-Moo Lee et al.

Summary: The study showed that enrichment of protective microbiota in the rhizosphere facilitates disease suppression, while disruption of protective rhizobacteria can increase the incidence of disease. Artificial disruption of Gram-positive bacteria in rhizosphere soil resulted in higher occurrence of bacterial wilt in tomatoes. Identification of specific Gram-positive bacteria species in healthy rhizosphere soil contributed to plant immunity activation and enhanced plant disease resistance.

ISME JOURNAL (2021)

添加到收藏夹

Review Plant Sciences

Effect of traditional Chinese medicine on gut microbiota in adults with type 2 diabetes: A systematic review and meta-analysis

Yujiao Zheng et al.

Summary: Recent studies have shown the significant role of gut microbiota in the development of type 2 diabetes mellitus (T2DM) and the potential therapeutic effect of traditional Chinese medicine (TCM) on T2DM. This systematic review included five randomized controlled trials (RCTs) on TCM interventions targeting gut microbiota in T2DM patients, showing statistically significant improvements in HbA1c, fasting blood glucose, postprandial blood glucose, insulin resistance, and beta-cell function. While TCM was found to modulate gut microbiota and improve glucose metabolism, further studies are needed to explore its effects on inflammation.

PHYTOMEDICINE (2021)

添加到收藏夹

Article Plant Sciences

Uncovering the antitumor effects and mechanisms of Shikonin against colon cancer on comprehensive analysis

Yang Chen et al.

Summary: Shikonin demonstrates significant antitumor potency in colon cancer by affecting cell cycle and inducing apoptosis. Transcriptomics and metabolomics analysis reveal perturbed pathways related to purine metabolism, arginine biosynthesis, pyrimidine metabolism, urea cycle, and amino acid metabolism. The up-regulated expression of proteins vital for arginine biosynthesis is validated, and the genes participating in purine metabolism and arginine biosynthesis are further determined by RT-qPCR.

PHYTOMEDICINE (2021)

添加到收藏夹

Article Oncology

Altered Gut Microbiota Associated With Hemorrhage in Chronic Radiation Proctitis

Liangzhe Liu et al.

Summary: This study compared the gut microbiota of CRP patients with and without hematochezia, revealing differential dysbiosis patterns and suggesting potential involvement of radiation-induced inflammation in mineral absorption and arachidonic acid metabolism. The findings provide new insights into the altered composition and function of gut microbiota in patients with hematochezia, indicating the potential use of probiotics and prebiotics for CRP assessment and treatment.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Gut-microbiota-targeted diets modulate human immune status

Hannah C. Wastyk et al.

Summary: This study investigated the effects of plant-based fiber and fermented foods on the human microbiome and immune system, finding that a high-fiber diet increased glycan-degrading carbohydrate active enzymes while a high-fermented-food diet increased microbiome diversity and decreased inflammatory markers. The data suggest that coupling dietary interventions with immune and microbiome profiling can provide personalized and populationwide insights, with fermented foods potentially valuable in countering decreased microbiome diversity and increased inflammation in industrialized societies.

CELL (2021)

添加到收藏夹

Article Plant Sciences

Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS

Tian Lan et al.

Summary: The study demonstrated that shikonin could inhibit the metabolism of ambrisentan. Further research is needed to verify whether similar interactions occur in humans and whether this interaction has clinical significance.

PHARMACEUTICAL BIOLOGY (2021)

添加到收藏夹

Article Plant Sciences

Total flavonoids from Anchusa italica Retz. Improve cardiac function and attenuate cardiac remodeling post myocardial infarction in mice

Shoubao Wang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

添加到收藏夹

Article Plant Sciences

Comparative Proteomic Analysis of Lithospermum erythrorhizon Reveals Regulation of a Variety of Metabolic Enzymes Leading to Comprehensive Understanding of the Shikonin Biosynthetic Pathway

Kojiro Takanashi et al.

PLANT AND CELL PHYSIOLOGY (2019)

添加到收藏夹

Article Oncology

Shikonin derivatives for cancer prevention and therapy

Joelle C. Boulos et al.

CANCER LETTERS (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Gut microbiota, a new frontier to understand traditional Chinese medicines

Wuwen Feng et al.

PHARMACOLOGICAL RESEARCH (2019)

添加到收藏夹

Article Plant Sciences

Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb

Huang-he Yu et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

The gut microbiota and colon cancer

Wendy S. Garrett

SCIENCE (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Pharmacological properties and derivatives of shikonin-A review in recent years

Chuanjie Guo et al.

PHARMACOLOGICAL RESEARCH (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

ER-mediated anti-tumor effects of shikonin on breast cancer

Yang Yang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Human gut microbiome: hopes, threats and promises

Patrice D. Cani

GUT (2018)

添加到收藏夹

Editorial Material Cell Biology

Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives

Lijuan Sun et al.

PROTEIN & CELL (2018)

添加到收藏夹

Review Cell Biology

Gut microbiota derived metabolites in cardiovascular health and disease

Zeneng Wang et al.

PROTEIN & CELL (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Shikonin exerts anti-inflammatory effects in LPS-induced mastitis by inhibiting NF-kappa B signaling pathway

Chao Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

添加到收藏夹

Article Microbiology

Gut microbiota dysbiosis contributes to the development of hypertension

Jing Li et al.

MICROBIOME (2017)

添加到收藏夹

Review Oncology

Treatment of renal cell carcinoma: Current status and future directions

Pedro C. Barata et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis

Daijie Fu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2016)

添加到收藏夹

Article Geriatrics & Gerontology

Chinese medicine treatment for menopausal symptoms in the UK health service: Is a clinical trial warranted?

Volker Scheid et al.

MATURITAS (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

An integrated metabonomics and microbiology analysis of host-microbiota metabolic interactions in rats with Coptis chinensis-induced diarrhea

Yemeng Li et al.

RSC ADVANCES (2015)

添加到收藏夹

Article Plant Sciences

Effects of Atractylodes macrocephala Koidzumi rhizome on 3T3-L1 adipogenesis and an animal model of obesity

Chang Keun Kim et al.

JOURNAL OF ETHNOPHARMACOLOGY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

J. Chen et al.

ONCOGENE (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla

Michael A. Mahowald et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

添加到收藏夹

Article Biochemical Research Methods

Encapsulation of isohexenylnaphthazarins in cyclodextrins

AN Assimopoulou et al.

BIOMEDICAL CHROMATOGRAPHY (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.