期刊
NATURE GENETICS
卷 48, 期 7, 页码 817-+出版社
NATURE PORTFOLIO
DOI: 10.1038/ng.3583
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资金
- Medical Research Council (MRC) [MC_PC_12010]
- National Institute for Health Research (NIHR)
- ERC [617306]
- European Research Council (ERC) [617306] Funding Source: European Research Council (ERC)
- MRC [G1000861, MC_PC_12010] Funding Source: UKRI
- Medical Research Council [G1000861, MC_qA137853, MC_PC_12010] Funding Source: researchfish
The UK Biobank (UKB) has recently released genotypes on 152,328 individuals together with extensive phenotypic and lifestyle information. We present a new phasing method, SHAPEIT3, that can handle such biobank-scale data sets and results in switch error rates as low as similar to 0.3%. The method exhibits O(NlogN) scaling with sample size N, enabling fast and accurate phasing of even larger cohorts.
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