☆ 4.6 Article

In vitro activity of new combinations of β-lactam and β-lactamase inhibitors against the Mycobacterium tuberculosis complex

MICROBIOLOGY SPECTRUM (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Multidisciplinary Sciences

Premature termination of transcription is shaped by Rho and translated uORFS in Mycobacterium tuberculosis

Alexandre D'Halluin et al.

Summary: Little is known about transcription elongation versus termination in Mycobacterium tuberculosis. This study found that the majority of transcription termination in M.TB is premature and associated with translated regions. Computational predictions and analysis suggest that Rho-dependent transcription termination dominates all transcription termination sites. The study also suggests that tightly coupled translation may suppress Rho-dependent termination.

ISCIENCE (2023)

添加到收藏夹

Article Critical Care Medicine

Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis The COMRADE Randomized, Phase 2A Clinical Trial

Veronique De Jager et al.

Summary: This study aimed to evaluate the efficacy of different doses of meropenem, with or without rifampin, in the treatment of tuberculosis. The study found that a total daily dose of 6 g of meropenem had stronger bactericidal activity compared to a lower dose of 3 g. However, the tolerability of intravenous meropenem was poor, raising concerns about its utility in second-line regimens.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

添加到收藏夹

Article Medicine, General & Internal

Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection

Paul B. Eckburg et al.

Summary: This study demonstrated the noninferiority of orally administered tebipenem pivoxil hydrobromide compared to intravenous ertapenem in the treatment of complicated urinary tract infection and acute pyelonephritis, with similar safety profiles.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

添加到收藏夹

Article Biology

Pervasive translation in Mycobacterium tuberculosis

Carol Smith et al.

Summary: Most bacterial ORFs are identified by automated prediction algorithms, but the algorithms often fail to identify ORFs lacking canonical features. In this study, ribosome profiling is used to identify actively translated ORFs in Mycobacterium tuberculosis. The study reveals the pervasive translation of previously undescribed ORFs, particularly short ones encoding proteins of <= 50 amino acids. The data suggest that the translation of short ORFs in M. tuberculosis serves as a source for evolving new functional proteins.

ELIFE (2022)

添加到收藏夹

Article Microbiology

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

Shuqi Li et al.

Summary: This study utilized a CRISPR interference chemical-genetics platform to uncover various drug resistant mechanisms in Mycobacterium tuberculosis (Mtb) and identified a potential new drug for treating tuberculosis.

NATURE MICROBIOLOGY (2022)

添加到收藏夹

Article Microbiology

Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing

Francisco Olivenca et al.

Summary: This study reveals the differential phenotypes of M. tuberculosis to beta-lactam antibiotics and finds that highly drug-resistant sublineages are more susceptible to beta-lactams. This provides an important strategy for directing beta-lactams to treat specific sublineages of M. tuberculosis infections.

MICROBIOLOGY SPECTRUM (2022)

添加到收藏夹

Article Respiratory System

Susceptibility of β-Lactam Antibiotics and Genetic Mutation of Drug-Resistant Mycobacterium tuberculosis Isolates in Korea

Sanghee Park et al.

Summary: This study investigated the susceptibility of drug-resistant Mycobacterium tuberculosis to amoxicillin-clavulanate and meropenem-clavulanate. The MIC values were determined, and a mutation related to beta-lactam antibiotic susceptibility was identified. These findings provide important insights for treating drug-resistant TB.

TUBERCULOSIS AND RESPIRATORY DISEASES (2022)

添加到收藏夹

Article Cell Biology

A snapshot of translation in Mycobacterium tuberculosis during exponential growth and nutrient starvation revealed by ribosome profiling

Elizabeth B. Sawyer et al.

Summary: Research found that a large proportion of mRNA transcripts expressed in M. tuberculosis lack canonical bacterial translation initiation signals, which has important implications for fine-tuning of translation. Under conditions of nutrient starvation, patterns of ribosome recruitment vary, suggesting that regulation of translation in this pathogen is more complex than originally thought.

CELL REPORTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Conserved residues Glu37 and Trp229 play an essential role in protein folding of β-lactamase

Aleksandra Chikunova et al.

Summary: In class A β-lactamases, the conservation of two residues (Glu37 and Trp229) plays a crucial role in the folding process rather than in the structural and catalytic aspects of the enzyme. These conserved residues are essential for protein resistance and folding.

FEBS JOURNAL (2021)

添加到收藏夹

Article Microbiology

Role of Epistasis in Amikacin, Kanamycin, Bedaquiline, and Clofazimine Resistance in Mycobacterium tuberculosis Complex

Roger Vargas et al.

Summary: Antibiotic resistance among bacterial pathogens is a major global health threat, with Mycobacterium tuberculosis complex having the highest resistance rates globally. By analyzing over 31,000 MTBC genomes, it was demonstrated that certain mutations may not confer resistance independently and might require multiple mutations to act together. Understanding the association between specific mutations and resistance through genome analysis can help improve drug susceptibility testing.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

添加到收藏夹

Article Microbiology

Collateral Sensitivity to β-Lactam Drugs in Drug-Resistant Tuberculosis Is Driven by the Transcriptional Wiring of BlaI Operon Genes

A. S. Trigos et al.

Summary: The evolution of resistance to one antimicrobial can result in enhanced sensitivity to another, known as collateral sensitivity, which opens new therapeutic possibilities for patients infected with pathogens unresponsive to classical treatments. Recent studies have found beta-lactam sensitivity in strains resistant to classical drug therapy, suggesting potential for the use of beta-lactams for tuberculosis treatment. Molecular analyses have shown regulatory links between genes involved in beta-lactam sensitivity and drug resistance, supporting continued exploration of beta-lactams for drug-resistant tuberculosis strains.

MSPHERE (2021)

添加到收藏夹

Article Infectious Diseases

Antimicrobial susceptibility testing of Mycobacterium tuberculosis complex isolates - the EUCAST broth microdilution reference method for MIC determination

Thomas Schon et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

添加到收藏夹

Correction Biochemistry & Molecular Biology

IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era (vol 37, pg 1530, 2020)

Bui Quang Minh et al.

MOLECULAR BIOLOGY AND EVOLUTION (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Improved metagenomic analysis with Kraken 2

Derrick E. Wood et al.

GENOME BIOLOGY (2019)

添加到收藏夹

Article Infectious Diseases

MIC-based dose adjustment: facts and fables

Johan W. Mouton et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)

添加到收藏夹

Article Microbiology

The Inoculum Effect in the Era of Multidrug Resistance: Minor Differences in Inoculum Have Dramatic Effect on MIC Determination

Kenneth P. Smith et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Have we realized the full potential of β-lactams for treating drug-resistant TB?

Elizabeth Story-Roller et al.

IUBMB LIFE (2018)

添加到收藏夹

Article Infectious Diseases

Variation of MIC measurements: the contribution of strain and laboratory variability to measurement precision

Johan W. Mouton et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates

Fu Li et al.

BIOMED RESEARCH INTERNATIONAL (2018)

添加到收藏夹

Article Multidisciplinary Sciences

MTBseq: a comprehensive pipeline for whole genome sequence analysis of Mycobacterium tuberculosis complex isolates

Thomas Andreas Kohl et al.

PEERJ (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Non-classical transpeptidases yield insight into new antibacterials

Pankaj Kumar et al.

NATURE CHEMICAL BIOLOGY (2017)

添加到收藏夹

Article Microbiology

Non-pncA Gene-Mutated but Pyrazinamide-Resistant Mycobacterium tuberculosis: Why Is That?

Jim Werngren et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2017)

添加到收藏夹

Article Genetics & Heredity

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

Abigail L. Manson et al.

NATURE GENETICS (2017)

添加到收藏夹

Article Microbiology

Mutation in an Unannotated Protein Confers Carbapenem Resistance in Mycobacterium tuberculosis

Pankaj Kumar et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)

添加到收藏夹

Article Microbiology

In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Multidrug-Resistant Mycobacterium tuberculosis Isolates

Dan Zhang et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

添加到收藏夹

Article Medicine, General & Internal

Paradoxical Hypersusceptibility of Drug-resistant Mycobacterium tuberculosis to β-lactam Antibiotics

Keira A. Cohen et al.

EBIOMEDICINE (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Carbapenems to Treat Multidrug and Extensively Drug-Resistant Tuberculosis: A Systematic Review

Giovanni Sotgiu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

添加到收藏夹

Article Microbiology

Meropenem-Clavulanic Acid Has High In Vitro Activity against Multidrug-Resistant Mycobacterium tuberculosis

L. Davies Forsman et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

添加到收藏夹

Article Genetics & Heredity

Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape

Scarlet S. Shell et al.

PLOS GENETICS (2015)

添加到收藏夹

Article Microbiology

In Vitro Susceptibility of Mycobacterium tuberculosis Isolates to an Oral Carbapenem Alone or in Combination with β-Lactamase Inhibitors

Yasuhiro Horita et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

A robust SNP barcode for typing Mycobacterium tuberculosis complex strains

Francesc Coll et al.

NATURE COMMUNICATIONS (2014)

添加到收藏夹

Article Respiratory System

Efficacy and safety of meropenem-clavulanate added to linezolid-containing regimens in the treatment of MDR-/XDR-TB

Saverio De Lorenzo et al.

EUROPEAN RESPIRATORY JOURNAL (2013)

添加到收藏夹

Letter Medicine, General & Internal

Whole-Genome Sequencing for Rapid Susceptibility Testing of M-tuberculosis

Claudio U. Koeser et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

添加到收藏夹

Article Cell Biology

Genome-wide Mapping of Transcriptional Start Sites Defines an Extensive Leaderless Transcriptome in Mycobacterium tuberculosis

Teresa Cortes et al.

CELL REPORTS (2013)

添加到收藏夹

Article Infectious Diseases

Clinical use of the meropenem-clavulanate combination for extensively drug-resistant tuberculosis

M. C. Payen et al.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2

Sabri B. Erdemli et al.

STRUCTURE (2012)

添加到收藏夹

Review Microbiology

Carbapenems: Past, Present, and Future

Krisztina M. Papp-Wallace et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

Jean-Emmanuel Hugonnet et al.

SCIENCE (2009)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Molecular cloning, overexpression and biochemical characterization of hypothetical β-lactamases of Mycobacterium tuberculosis H37Rv

K. M. Nampoothiri et al.

JOURNAL OF APPLIED MICROBIOLOGY (2008)

添加到收藏夹

Article Microbiology

The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation

Marie Lavollay et al.

JOURNAL OF BACTERIOLOGY (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

Irreversible inhibition of the mycobacterium tuberculosis β-lactarnase by clavulanate

Jean-Emmanuel Hugonnet et al.

BIOCHEMISTRY (2007)

添加到收藏夹

Review Pharmacology & Pharmacy

Comparative review of the carbapenems

George G. Zhanel et al.

DRUGS (2007)

添加到收藏夹

Article Microbiology

Genetic analysis of the β-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to β-lactam antibiotics

AR Flores et al.

MICROBIOLOGY-SGM (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.