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Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds

ANTIOXIDANTS (2023)

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Summary: Pregnancy and childbirth can lead to oxidative stress, which may negatively impact the fetus and labor. Monitoring oxidative stress parameters can help assess risk and newborn health in pregnancy. This study examined oxidative stress in mother-child pairs during physiological labor. Results showed lower total antioxidant status (TAS), glutathione peroxidase (GPx) activity, and zinc (Zn) concentration in maternal blood compared to umbilical cord blood, while superoxide dismutase (SOD) activity and copper (Cu) concentration were higher in maternal blood. Manganese (Mn) concentration was similar in both blood samples. The findings suggest depletion of redox reserves in women's blood during labor.

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Article Biochemistry & Molecular Biology

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Mexican traditional medicines for women's reproductive health

Paulina Cabada-Aguirre et al.

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Article Biochemistry & Molecular Biology

Preeclampsia Affects Lipid Metabolism and HDL Function in Mothers and Their Offspring

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Review Biochemistry & Molecular Biology

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Summary: Dietary patterns, specifically those containing bioactive food compounds such as polyphenols, unsaturated fatty acids, and probiotics, show promise in preventing and treating obesity-induced inflammation. These compounds modulate the secretion of inflammatory molecules, regulate gene expression, and modify signaling pathways involved in the inflammatory response. However, further research is needed to determine optimal strategies for their intake, and global education is necessary to promote the advantages of consuming bioactive food compounds and combat unhealthy dietary patterns.

ANTIOXIDANTS (2023)

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Article Biochemistry & Molecular Biology

The Association of Physical Activity and Sedentary Behavior with Maternal and Cord Blood Anti-Oxidative Capacity and HDL Functionality: Findings of DALI Study

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Differential expression of lipid metabolic genes in hypercholesterolemic rabbit placenta predisposes the offspring to develop atherosclerosis in early adulthood

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High maternal adiposity during pregnancy programs an imbalance in the lipidome and predisposes to diet-induced hepatosteatosis in the offspring

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Article Multidisciplinary Sciences

Inflammation and decreased cardiovagal modulation are linked to stress and depression at 36th week of pregnancy in gestational diabetes mellitus

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Summary: Stress and depression were found to be present in gestational diabetes mellitus (GDM). While inflammation and oxidative stress are associated with depression, there have been no reports on the link between cardiometabolic risks (CMR) and stress and depression in GDM. A study on normal pregnant women and women with GDM at 36 weeks of gestation showed that the study group had higher perceived stress scores, depression scores, Indian diabetic risk scores, and Edinburgh postnatal depression scores, as well as lower cardiovascular metabolic risks, oxidative stress, inflammation, and endothelial dysfunction.

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Article Endocrinology & Metabolism

Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)

Gabriele Mocciaro et al.

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Summary: The HDL proteome, identified through various studies using different methodologies across multiple laboratories, provides valuable insights into HDL function. Known functions of consensus HDL proteins extend beyond traditional roles in lipid transport, pointing towards involvement in innate immunity, inflammation, cell adhesion, hemostasis, protease regulation, as well as vitamin and metal binding. Further research is needed to address significant issues identified in these studies.

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Pregnancy and Reproductive Risk Factors for Cardiovascular Disease in Women

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Summary: In addition to conventional risk factors, women also face sex-specific risk factors for cardiovascular disease. Key stages of a woman's reproductive history, such as early and late menarche, polycystic ovary syndrome, infertility, adverse pregnancy outcomes, and absence of breastfeeding, are associated with increased future cardiovascular disease risk. The menopause transition period also represents an accelerated cardiovascular disease risk, with timing, mechanism, and symptoms of menopause playing a role. Differences in conventional risk factors explain some, but not all, of the observed associations between reproductive history and cardiovascular disease; further research is needed to understand hormonal effects and unique sex-specific mechanisms. A history of reproductive risk factors provides an opportunity for comprehensive screening, refinement of risk assessment, and implementation of prevention strategies to optimize women's long-term cardiometabolic health.

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Summary: Gestational diabetes mellitus (GDM) refers to abnormal glucose tolerance that occurs during pregnancy and is associated with higher infant birthweight, as well as future maternal and offspring cardiometabolic disease. The prevalence of GDM is increasing globally due to factors such as rising obesity rates in women of reproductive age and revised diagnostic criteria. Although there is a lack of international consensus on the diagnosis of GDM, it is important to recognize it as an early risk factor for type 2 diabetes and cardiovascular disease, considering its long-term complications for both mothers and offspring.

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Article Nutrition & Dietetics

Cross-Sectional Associations between HDL Structure or Function, Cell Membrane Fatty Acid Composition, and Inflammation in Elderly Adults

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Article Obstetrics & Gynecology

Foetal umbilical cord brain-derived neurotrophic factor (BDNF) levels in pregnancy with gestational diabetes mellitus

Melike Geyik Bayman et al.

Summary: The aim of this study was to investigate the impact of gestational diabetes mellitus (GDM) on brain-derived neurotrophic factor (BDNF) levels in foetal umbilical cord blood. The study found that GDM had no effect on cord blood BDNF levels, but cord blood BDNF values were higher in female infants and in patients using insulin for GDM.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2022)

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Review Biochemistry & Molecular Biology

Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes

Anju Singh et al.

Summary: Oxidative stress is a metabolic dysfunction caused by the imbalance between reactive oxygen species production and the body's antioxidant defense system. It is closely related to the development of various noncommunicable diseases. Diabetes mellitus, especially type 2 diabetes, is significantly influenced by oxidative stress, which plays a crucial role in insulin signaling pathways.

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Review Medicine, General & Internal

Clinical tools and biomarkers to predict preeclampsia

Teresa M. MacDonald et al.

Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.

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Review Cardiac & Cardiovascular Systems

Pregnancy-related acute myocardial infarction: a review of the recent literature

Andrea Carlo Merlo et al.

Summary: Pregnancy-related acute myocardial infarction is a rare but potentially life-threatening cardiovascular event, mainly caused by risk factors such as increased maternal age. Despite improvements in diagnosis and treatment, early recognition and management remain crucial, with attention to the harmful effects of ionizing radiation on the fetus.

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Review Immunology

Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity

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Summary: Metabolic and immune adaptation are important features of pregnancy. The field of immunometabolism explores how cellular metabolism influences immune cell function, and it may play a crucial role in immune plasticity during pregnancy. Obesity, a metabolic disorder, can modify immunometabolism and lead to adverse pregnancy outcomes. Further research on the interactions between metabolism, immunoinflammation, and pregnancy outcomes is needed.

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First description of Lotmaria passim and Crithidia mellificae haptomonad stages in the honeybee hindgut

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INTERNATIONAL JOURNAL FOR PARASITOLOGY (2022)

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Review Nutrition & Dietetics

Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review

Simon C. Langley-Evans et al.

Summary: The global prevalence of overweight and obesity in pregnancy is increasing, posing significant challenges for pregnancy and delivery management. Overweight and obese women are more likely to experience complications during pregnancy, which can pose a threat to the lives of both mothers and babies. Studies have shown that appropriate dietary interventions can help control weight gain and reduce the risk of pregnancy complications.

JOURNAL OF HUMAN NUTRITION AND DIETETICS (2022)

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Review Cell Biology

Ginger for Healthy Ageing: A Systematic Review on Current Evidence of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties

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Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis

Yali Dai et al.

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RENAL FAILURE (2022)

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Review Nutrition & Dietetics

An Overview of Obesity, Cholesterol, and Systemic Inflammation in Preeclampsia

Morgan C. Alston et al.

Summary: Preeclampsia, a state of inflammation during pregnancy, is a significant cause of maternal and fetal morbidity and mortality. Women with obesity have an increased risk of developing preeclampsia, likely due to impaired placental development. Inflammatory cytokines from maternal adipose tissue and circulating cholesterol have been linked to adverse outcomes associated with preeclampsia.

NUTRIENTS (2022)

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Review Biochemistry & Molecular Biology

HDL as Bidirectional Lipid Vectors: Time for New Paradigms

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Review Nutrition & Dietetics

The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders

Mirjana Nacka-Aleksic et al.

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NUTRIENTS (2022)

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Review Biochemistry & Molecular Biology

Foetal lipoprotein oxidation and preeclampsia

La Gil-Acevedo et al.

Summary: Preeclampsia is a pregnancy-specific syndrome with unknown causes. Lipid metabolism is altered in preeclampsia, leading to risks for both the mother and the fetus. Lipoperoxidation is the main process of lipid damage, generating toxic substances that cause reduced vasodilation and endothelial dysfunction. Neonates of mothers with preeclampsia are at increased risk of cardiovascular diseases, mental retardation, and metabolic diseases.

LIPIDS IN HEALTH AND DISEASE (2022)

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Review Nutrition & Dietetics

Functional bioactive compounds in ginger, turmeric, and garlic

Christiana Oluwatoyin Ajanaku et al.

Summary: Nutrition plays a crucial role in promoting individual health and has led to a global shift from pharmaceuticals to nutraceuticals due to the high cost and side effects associated with pharmaceutical consumption. This report reviews the bioactive compounds in ginger, turmeric, and garlic as potential natural therapeutics for cancer and heart-related diseases, discussing their analytical profiles, functional activities, and possible recommendations for disease treatment using these nutraceuticals.

FRONTIERS IN NUTRITION (2022)

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Article Obstetrics & Gynecology

Maternal lipid levels in early pregnancy as a predictor of childhood lipid levels: a prospective cohort study

Maria C. Adank et al.

Summary: Maternal lipid levels in early pregnancy are positively associated with childhood lipid levels in offspring, independent of maternal BMI and diet. This suggests that gestational lipid levels can be used as an early predictor of children's long-term health.

BMC PREGNANCY AND CHILDBIRTH (2022)

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Review Endocrinology & Metabolism

The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis

Dinara Afrose et al.

Summary: This study conducted a systematic review and meta-analysis to determine the most reliable oxidative stress biomarkers in preeclampsia. Ischemia-modified albumin (IMA), uric acid (UA), and malondialdehyde (MDA) were identified as the most promising biomarkers associated with preeclampsia. IMA showed the best diagnostic potential.

BIOLOGY OF SEX DIFFERENCES (2022)

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Review Infectious Diseases

Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects

Natalia Vaou et al.

Summary: This study is a critical review of the current scientific literature on the combined effects of plant-derived extracts/bioactive compounds, with a focus on antimicrobial synergistic or antagonistic combinations. It discusses the challenges and future perspectives surrounding combination effects and the utilization of bioactive compounds from medicinal plant extracts as antimicrobials. The understanding of the interactions between medicinal plant-derived bioactive compounds will lead to the development of new combination antimicrobial therapies.

ANTIBIOTICS-BASEL (2022)

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Review Nutrition & Dietetics

Polyphenol Intake in Pregnant Women on Gestational Diabetes Risk and Neurodevelopmental Disorders in Offspring: A Systematic Review

Blanca Salinas-Roca et al.

Summary: This review examines the effects of polyphenol intake during pregnancy through supplements or polyphenol-rich foods on gestational diabetes mellitus (GDM) and fetal neurodevelopment. The findings suggest a positive relationship between polyphenol intake and the prevention and control of cardiometabolic complications during pregnancy, such as GDM. Additionally, GDM is associated with a higher risk of neurodevelopmental disorders in the offspring.

NUTRIENTS (2022)

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Review Medicine, General & Internal

Association of gestational diabetes mellitus with overall and type specific cardiovascular and cerebrovascular diseases: systematic review and meta-analysis

Wenhui Xie et al.

Summary: The study found that women with a history of gestational diabetes have an increased risk of cardiovascular and cerebrovascular diseases as well as venous thromboembolism, and this risk cannot be solely attributed to conventional cardiovascular risk factors or subsequent diabetes.

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Review Immunology

Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring

Merve Denizli et al.

Summary: This article discusses the potential impact of maternal obesity on fetal health. Cytokines and inflammatory status produced by obese mothers during pregnancy may result in fetal programming and increased risks of chronic illnesses such as neuropsychiatric disorders, metabolic diseases, and malignancies.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Review Chemistry, Medicinal

A Comprehensive Study of Therapeutic Applications of Chamomile

Amit Sah et al.

Summary: Chamomile has a long history of traditional medicinal uses. Recent developments have established its role as a therapeutic agent in various areas such as anti-inflammatory, antioxidant, analgesic, antimicrobial, hepatoprotective, anti-allergic, anticancer, and anti-hypertensive agent. However, its role in the treatment of CNS disorders and metabolic syndromes is not well-known.

PHARMACEUTICALS (2022)

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Article Cell Biology

Folate derivatives, 5-methyltetrahydrofolate and 10-formyltetrahydrofolate, protect BEAS-2B cells from high glucose-induced oxidative stress and inflammation

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Summary: Folate and its active derivatives have antioxidant and anti-inflammatory potential, protecting cells from oxidative stress and inflammation caused by high glucose. Active folate derivatives may be a suitable alternative to alleviate inflammatory injury.

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Article Cell Biology

Yeast Fermentate Prebiotic Ameliorates Allergic Asthma, Associating with Inhibiting Inflammation and Reducing Oxidative Stress Level through Suppressing Autophagy

Subo Gong et al.

Summary: The research showed that YFP may exert antiasthmatic effects by inhibiting airway allergic inflammation and oxidative stress level through suppressing autophagy.

MEDIATORS OF INFLAMMATION (2021)

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Review Nutrition & Dietetics

Impact of Maternal Obesity on the Metabolism and Bioavailability of Polyunsaturated Fatty Acids during Pregnancy and Breastfeeding

Daniela Alvarez et al.

Summary: Maternal health is crucial for the supply of essential fatty acids to offspring, and maternal obesity can alter the fatty acid profile, leading to increased risks of obesity and other health issues in the offspring.

NUTRIENTS (2021)

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Review Biochemistry & Molecular Biology

Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia

Paul Guerby et al.

Summary: Preeclampsia is a pregnancy disease exclusive to humans, characterized by gestational hypertension, proteinuria, oxidative stress, and imbalance between NO and ROS production, possibly due to placental abnormalities and oxidative stress.

REDOX BIOLOGY (2021)

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Article Pharmacology & Pharmacy

Attenuation of baroreflex sensitivity and heart rate variability is linked to reduced levels of nitric oxide in pregnant women having risks of developing gestational hypertension

Kuzhanthaivelu Karthiga et al.

Summary: The study showed that decreased BRS and SVI are associated with a reduction in NO levels, which may be linked to CV risks in GH.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2021)

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Review Cell Biology

The Role of Oxidative Stress and Antioxidant Balance in Pregnancy

Tarique Hussain et al.

Summary: Oxidative stress disrupts the balance between reactive oxygen species and antioxidants in the body, affecting various developmental processes during pregnancy. Excessive oxidative stress can lead to reproductive failure and pregnancy complications, highlighting the importance of maintaining oxidative and antioxidant balance at different stages of pregnancy.

MEDIATORS OF INFLAMMATION (2021)

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Article Medicine, Research & Experimental

Antepartum and postpartum changes in adipokines, endothelial dysfunction, inflammatory markers and other biochemical parameters in preeclamptic women: A prospective observational cohort study

Amany Yasseen Talab et al.

Summary: This study found that patients with preeclampsia exhibited more severe lipid metabolism disorder and oxidative stress, with significantly higher levels of resistin and vaspin in the serum. Additionally, the levels of these adipokines significantly decreased four weeks postpartum.

JOURNAL OF APPLIED BIOMEDICINE (2021)

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Review Biochemistry & Molecular Biology

The Wonderful Activities of the Genus Mentha: Not Only Antioxidant Properties

Majid Tafrihi et al.

Summary: Medicinal plants like mint have diverse health benefits, including antioxidant, anti-obesity, antimicrobial properties, and especially notable anticancer activities. Mint-derived compounds, such as essential oils, show cytotoxic effects on cancer cells and also exhibit antibacterial activities against various strains.

MOLECULES (2021)

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Article Obstetrics & Gynecology

Is GDF-15 level associated with gestational diabetes mellitus and adverse perinatal outcomes?

Kadriye Yakut et al.

Summary: This study found that patients with GDM have higher levels of serum GDF-15, which is associated with disease risk. The results suggest that GDF-15 may serve as a diagnostic biomarker for GDM, but further research is needed to explore its correlation with perinatal outcomes.

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY (2021)

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Review Biodiversity Conservation

Actualized inventory of medicinal plants used in traditional medicine in Oaxaca, Mexico

Cruz-Perez Alejandra Lucia et al.

Summary: Oaxaca is a diverse state in Mexico with deep traditional knowledge of medicinal plants among different ethnic groups. Over a thousand medicinal plants were documented, mainly treating digestive and genitourinary system illnesses. The importance of recognizing and respecting traditional knowledge and the role of medicinal plants in the conservation of biodiversity is highlighted.

JOURNAL OF ETHNOBIOLOGY AND ETHNOMEDICINE (2021)

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Article Obstetrics & Gynecology

A prospective cohort study providing insights for markers of adverse pregnancy outcome in older mothers

Samantha C. Lean et al.

Summary: This study revealed that smoking is associated with adverse pregnancy outcome in older women, while multiparity can decrease the likelihood of adverse outcomes. In older mothers with adverse outcomes, oxidative stress markers were increased, and levels of maternal circulating placental hormones were reduced.

BMC PREGNANCY AND CHILDBIRTH (2021)

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Article Multidisciplinary Sciences

Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes

Jingjing Li et al.

Summary: Subclinical hypothyroidism (SCH) in pregnancy is associated with disturbed lipid metabolism. Using nontargeted lipidomics, researchers found significant differences in lipid profiles between pregnant women with SCH and healthy pregnant women. Several lipid metabolites show potential as biomarkers for SCH pathogenesis, while correlation analyses reveal associations between specific lipids and inflammatory markers. Further investigation into lipid molecules like sphingomyelin (SM), phosphatidylethanolamine (PE), and phosphatidylinositol (PI) may offer insights into reducing adverse pregnancy outcomes.

SCIENTIFIC REPORTS (2021)

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Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus

Aranzazu Bocanegra et al.

Summary: This review discusses the applications of algae and their components in Type-2 diabetes mellitus, emphasizing the mechanisms involved. Studies involving whole algae, algal extracts, or isolated compounds in various conditions, including in vitro experiments and human studies, were analyzed. The review also highlights the potential effects of algae on modulating carbohydrate digestion and absorption, blood glucose levels, and insulin resistance.

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Article Peripheral Vascular Disease

Association between serum beta-human chorionic gonadotropin and inflammation, oxidative stress in pregnancy-induced hypertension

Ruijuan Wang et al.

Summary: The aberrant increase of circulating β-human chorionic gonadotropin (?-HCG) at early stages of pregnancy is associated with predicting gestational hypertension. Inflammatory and oxidative stress markers play a significant role in severe pregnancy-induced hypertension during the perinatal stage.

MICROVASCULAR RESEARCH (2021)

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Review Nutrition & Dietetics

Dietary Strategies to Improve Cardiovascular Health: Focus on Increasing High-Density Lipoprotein Functionality

Julia T. Stadler et al.

Summary: Cardiovascular disease is a major global health issue with increasing incidence. Lifestyle modifications, particularly dietary changes, play a crucial role in preventing and managing cardiovascular disease. The Mediterranean diet, rich in beneficial components like extra virgin olive oil, has been shown to improve HDL function and reduce the risk of cardiovascular disease.

FRONTIERS IN NUTRITION (2021)

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Review Cell Biology

Effects of Traditional Chinese Medication-Based Bioactive Compounds on Cellular and Molecular Mechanisms of Oxidative Stress

Bo Liang et al.

Summary: Oxidative stress is the imbalance between oxidation and antioxidation in the body, leading to excessive production of oxygen free radicals that cannot be removed, causing damage to cells and tissues. Traditional Chinese medications contain various antioxidant bioactive compounds, studying their mechanisms is important for disease treatment.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Chemistry, Medicinal

Potential Mechanism of S. baicalensis on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics

Ping-Yuan Ge et al.

Summary: S. baicalensis modulates lipid metabolism through pathways such as steroid biosynthesis, sphingolipid metabolism, the PPAR signaling pathway, and glycerolipid metabolism. Metabolomics studies indicate that cholesterol metabolism and sphingolipid metabolism are the most relevant pathways associated with the effects of S. baicalensis.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Review Nutrition & Dietetics

Functional Food and Bioactive Compounds on the Modulation of the Functionality of HDL-C: A Narrative Review

Karla Paulina Luna-Castillo et al.

Summary: Cardiovascular diseases (CVD) are a major cause of mortality worldwide, with high-density lipoprotein cholesterol (HDL-C) playing a crucial role in its prevention. Maintaining healthy levels of HDL-C is important, but ensuring the functionality of this particle is key. Functional foods and dietary compounds like extra virgin olive oil and nuts can improve HDL functionality. Further research is needed to better understand the association between diet and HDL functionality.

NUTRIENTS (2021)

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Review Nutrition & Dietetics

Are Pregnant Women Who Are Living with Overweight or Obesity at Greater Risk of Developing Iron Deficiency/Anaemia?

Anna A. Wawer et al.

Summary: Low-grade inflammation often present in individuals with obesity can affect iron uptake and metabolism, increasing the risk of iron deficiency and iron-deficiency anemia. Pregnant women are particularly vulnerable to these risks. Therefore, closer monitoring of iron status and weight gain is recommended for pregnant women living with obesity.

NUTRIENTS (2021)

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Article Endocrinology & Metabolism

Accelerated developmental adipogenesis programs adipose tissue dysfunction and cardiometabolic risk in offspring born to dams with metabolic dysfunction

Anna Mikolajczak et al.

Summary: This study demonstrated that accelerated adipogenesis during the perinatal period predisposes offspring to hypertrophic adipocyte dysfunction later in life, compromising the buffering function of subcutaneous fat depot.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021)

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Review Biochemistry & Molecular Biology

Sphingolipids in HDL - Potential markers for adaptation to pregnancy?

Patamat Patanapirunhakit et al.

Summary: Plasma HDL plays a protective role in vascular function during healthy pregnancy but not in preeclampsia. Specific sphingolipids like S1P and ceramide in HDL are potentially important in cardiovascular disease and pregnancy, with evidence suggesting their role in vascular protection in healthy pregnancy but not in preeclampsia.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2021)

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Review Biochemistry & Molecular Biology

Effect of Endogenic and Exogenic Oxidative Stress Triggers on Adverse Pregnancy Outcomes: Preeclampsia, Fetal Growth Restriction, Gestational Diabetes Mellitus and Preterm Birth

Eun Hui Joo et al.

Summary: Oxidative stress, caused by the imbalance between ROS production and detoxification ability, is associated with pregnancy complications. Maintaining normal placental function and vascular network is crucial for a healthy pregnancy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Gastroenterology & Hepatology

Maternal obesity increases the risk and severity of NAFLD in offspring

Hannes Hagstrom et al.

Summary: This study revealed a strong association between maternal obesity and future NAFLD in offspring among young individuals in Sweden. Adjustment for socio-economic and metabolic factors did not change this finding, suggesting maternal obesity as an independent risk factor for NAFLD in offspring.

JOURNAL OF HEPATOLOGY (2021)

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Article Endocrinology & Metabolism

Gestational Weight Gain Influences the Adipokine-Oxidative Stress Association during Pregnancy

Juan Mario Solis Paredes et al.

Summary: This study investigated the association between adipokines and oxidative stress markers in pregnant women and found that gestational weight gain influenced this association. Women with excessive gestational weight gain had lower adiponectin levels and a positive association between leptin and oxidative markers, suggesting that mechanisms regulating adipokine production and oxidative stress in pregnant women are influenced by excessive adipose tissue accumulation.

OBESITY FACTS (2021)

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Review Cell Biology

The Role of Oxidative Stress in Hypertensive Disorders of Pregnancy (Preeclampsia, Gestational Hypertension) and Metabolic Disorder of Pregnancy (Gestational Diabetes Mellitus)

Wendy N. Phoswa et al.

Summary: The review highlights the role of oxidative stress in hypertensive disorders of pregnancy and gestational diabetes mellitus. Oxidative stress leads to inadequate placental perfusion in conditions like preeclampsia and gestational hypertension, causing maternal inflammatory response. In gestational diabetes mellitus, over secretion of insulin results in lipid peroxidation and prevents glucose transportation in body tissues. More research is needed to understand the genetic differences and improve diagnostic procedures for these conditions.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Environmental Sciences

Bioactive Compounds of Porcine Hearts and Aortas May Improve Cardiovascular Disorders in Humans

Irina Chernukha et al.

Summary: The study focused on the biological effects of a pate made of pork hearts and aortas on middle-aged adults' lipid profile. Results showed that consumption of this meat product helped reduce total cholesterol and low-density lipoprotein cholesterol levels in the experimental group participants.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Biochemistry & Molecular Biology

Peripheral Blood Mononuclear Cells Oxidative Stress and Plasma Inflammatory Biomarkers in Adults with Normal Weight, Overweight and Obesity

Margalida Monserrat-Mesquida et al.

Summary: The study found that inflammatory biomarkers increased in the plasma and PBMCs of obese patients, while antioxidant enzyme activities also increased with BMI, providing useful biomarkers for monitoring the progression and reversal of obesity.

ANTIOXIDANTS (2021)

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Article Endocrinology & Metabolism

High Concentration of Medium-Sized HDL Particles and Enrichment in HDL Paraoxonase 1 Associate With Protection From Vascular Complications in People With Long-standing Type 1 Diabetes

Tomas Vaisar et al.

DIABETES CARE (2020)

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Article Endocrinology & Metabolism

Maternal Exposure to Environmental Disruptors and Sexually Dimorphic Changes in Maternal and Neonatal Oxidative Stress

Muraly Puttabyatappa et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

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Article Medicine, Research & Experimental

Maternal diet intervention before pregnancy primes offspring lipid metabolism in liver

Yi Zhou et al.

LABORATORY INVESTIGATION (2020)

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Article Endocrinology & Metabolism

Gestational Diabetes Mellitus in a Tertiary Care Hospital of Kolkata, India: Prevalence, Pathogenesis and Potential Disease Biomarkers

Jayita Basu et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2020)

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Review Biochemistry & Molecular Biology

The Role and Function of HDL in Patients with Chronic Kidney Disease and the Risk of Cardiovascular Disease

Jacek Rysz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Pharmacology & Pharmacy

Anatomical and physiological alterations of pregnancy

Jamil M. Kazma et al.

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2020)

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Review Endocrinology & Metabolism

Dyslipidemia in Type 1 Diabetes: A Masked Danger

Bruno Verges

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2020)

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Review Nutrition & Dietetics

Nutraceuticals and Hypertensive Disorders in Pregnancy: The Available Clinical Evidence

Silvia Fogacci et al.

NUTRIENTS (2020)

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Article Nutrition & Dietetics

Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes

Gabriele Piuri et al.

NUTRIENTS (2020)

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Review Biochemistry & Molecular Biology

The Pharmacological Activity of Camellia sinensis (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review

Marta Sanchez et al.

BIOMOLECULES (2020)

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Review Cell Biology

Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

Habib Yaribeygi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Biochemistry & Molecular Biology

Biomarkers of placental redox imbalance in pregnancies with preeclampsia and consequent perinatal outcomes

Raphaela Costa Ferreira et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Article Medical Laboratory Technology

Proteome profiling of gestational diabetes mellitus at 16-18 weeks revealed by LC-MS/MS

Xiaoting Liu et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Biochemistry & Molecular Biology

Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits

Alan Dorantes-Morales et al.

MOLECULES (2020)

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Review Immunology

Preterm birth and sustained inflammation: consequences for the neonate

Alexander Humberg et al.

SEMINARS IN IMMUNOPATHOLOGY (2020)

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Review Immunology

Pathogenesis of preterm birth: bidirectional inflammation in mother and fetus

Ella Shana Green et al.

SEMINARS IN IMMUNOPATHOLOGY (2020)

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Review Medicine, General & Internal

Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review

Kelvin Okoth et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Review Environmental Sciences

Associations of Dietary Bioactive Compounds with Maternal Adiposity and Inflammation in Gestational Diabetes: An Update on Observational and Clinical Studies

Dustin W. Davis et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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Article Biochemistry & Molecular Biology

Placental Adaptive Changes to Protect Function and Decrease Oxidative Damage in Metabolically Healthy Maternal Obesity

Celeste Santos-Rosendo et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

Panax quinquefolius (North American Ginseng) Polysaccharides as Immunomodulators: Current Research Status and Future Directions

Rajarshi Ghosh et al.

MOLECULES (2020)

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Review Endocrinology & Metabolism

Nutrition and Metabolic Adaptations in Physiological and Complicated Pregnancy: Focus on Obesity and Gestational Diabetes

Sara Parrettini et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Review Biochemistry & Molecular Biology

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Shokoh Parham et al.

ANTIOXIDANTS (2020)

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Article Medicine, Research & Experimental

Structure-function relationships of HDL in diabetes and coronary heart disease

Mathias Cardner et al.

JCI INSIGHT (2020)

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Article Nursing

Mexican Traditional Medicine: Application of a Traditional and Complementary Medicine System to Improve Opioid Use Treatment in Latinos

Tanya R. Sorrell

JOURNAL OF HOLISTIC NURSING (2020)

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Article Obstetrics & Gynecology

Changes in circulating levels of carboxymethyllysine, soluble receptor for advanced glycation end products (sRAGE), and inflammation markers in women during normal pregnancy

Claudia V. Quintanilla-Garcia et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2019)

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Review Urology & Nephrology

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

Elizabeth A. Phipps et al.

NATURE REVIEWS NEPHROLOGY (2019)

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Review Cardiac & Cardiovascular Systems

HDL and Reverse Cholesterol Transport Basic Mechanisms and Their Roles in Vascular Health and Disease

Mireille Ouimet et al.

CIRCULATION RESEARCH (2019)

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Article Nutrition & Dietetics

Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome

Diego Estrada-Luna et al.

NUTRIENTS (2019)

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Article Biotechnology & Applied Microbiology

Assessment of relationship between serum vascular adhesion protein-1 (VAP-1) and gestational diabetes mellitus

Burcu Dincgez Cakmak et al.

BIOMARKERS (2019)

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Article Nutrition & Dietetics

A Dietary Intervention of Bioactive Enriched Foods Aimed at Adults at Risk of Metabolic Syndrome: Protocol and Results from PATHWAY-27 Pilot Study

Achim Bub et al.

NUTRIENTS (2019)

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Article Peripheral Vascular Disease

Maternal Gestational Diabetes Is Associated With Offspring's Hypertension

Jun Lu et al.

AMERICAN JOURNAL OF HYPERTENSION (2019)

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Article Biochemistry & Molecular Biology

Key Clinical Factors Predicting Adipokine and Oxidative Stress Marker Concentrations among Normal, Overweight and Obese Pregnant Women Using Artificial Neural Networks

Mario Solis-Paredes et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Endocrinology & Metabolism

Is gestational diabetes mellitus in obese women predicted by oxidative damage in red blood cells?

Guadalupe Leon-Reyes et al.

GYNECOLOGICAL ENDOCRINOLOGY (2018)

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Review Biochemistry & Molecular Biology

Oxidative Stress in Preeclampsia and Placental Diseases

Rajaa Aouache et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Biochemistry & Molecular Biology

Oxidative modifications of foetal LDL-c and HDL-c lipoproteins in preeclampsia

G. Leon-Reyes et al.

LIPIDS IN HEALTH AND DISEASE (2018)

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Article Biochemistry & Molecular Biology

F-2-isoprostanes and fatty acids profile in early pregnancy complicated by pre-existing diabetes

Andrea Taschereau-Charron et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2018)

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Article Obstetrics & Gynecology

Inflammatory and Oxidative Responses in Pregnancies With Obesity and Periodontal Disease

Marta Zambon et al.

REPRODUCTIVE SCIENCES (2018)

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Article Multidisciplinary Sciences

Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function

Dominique Mannaerts et al.

PLOS ONE (2018)

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Review Endocrinology & Metabolism

A novel and compact review on the role of oxidative stress in female reproduction

Jiayin Lu et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2018)

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Article Nutrition & Dietetics

A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal-Infant Dyads between a Nigerian and a United States Population

Caleb Cave et al.

NUTRIENTS (2018)

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Article Biochemistry & Molecular Biology

HDL-Mediated Lipid Influx to Endothelial Cells Contributes to Regulating Intercellular Adhesion Molecule (ICAM)-1 Expression and eNOS Phosphorylation

Monica Munoz-Vega et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Biochemistry & Molecular Biology

Current Therapies Focused on High-Density Lipoproteins Associated with Cardiovascular Disease

Diego Estrada-Luna et al.

MOLECULES (2018)

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Article Rheumatology

Musculoskeletal pain and symptoms in pregnancy: a descriptive study

Serdar Kesikburun et al.

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2018)

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Article Medicine, Research & Experimental

Interrelationship Between Markers of Oxidative Stress, Inflammation and Hematological Parameters Among Preeclamptic Nigerian Women

Oloruntoba Ayodele Ekun et al.

MEDICAL SCIENCE MONITOR BASIC RESEARCH (2018)

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Article Endocrinology & Metabolism

Role of serum levels of irisin and oxidative stress markers in pregnant women with and without gestational diabetes

Betul Usluogullari et al.

GYNECOLOGICAL ENDOCRINOLOGY (2017)

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Article Nutrition & Dietetics

Dietary epigallocatechin 3-gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double-blind randomised controlled trial

H. Zhang et al.

JOURNAL OF HUMAN NUTRITION AND DIETETICS (2017)

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Article Optics

Streaking of 43-attosecond soft-X-ray pulses generated by a passively CEP-stable mid-infrared driver

Thomas Gaumnitz et al.

OPTICS EXPRESS (2017)

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Review Medicine, General & Internal

Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child

Patrick M. Catalano et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Review Medicine, General & Internal

Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child

Patrick M. Catalano et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Article Multidisciplinary Sciences

Effects of vaspin on pancreatic β cell secretion via PI3K/Akt and NF-κB signaling pathways

Shiwei Liu et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

Maternal Gestational Diabetes Mellitus increases placental and foetal lipoprotein-associated Phospholipase A2 which might exert protective functions against oxidative stress

Carolin Schliefsteiner et al.

SCIENTIFIC REPORTS (2017)

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Review Medicine, General & Internal

Antioxidative activity of high-density lipoprotein (HDL): Mechanistic insights into potential clinical benefit

Fernando Brites et al.

BBA CLINICAL (2017)

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Review Cardiac & Cardiovascular Systems

HDL functionality in type 1 diabetes

Shiva Ganjali et al.

ATHEROSCLEROSIS (2017)

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Review Integrative & Complementary Medicine

The use of traditional medicine in maternity care among African women in Africa and the diaspora: a systematic review

Zewdneh Shewamene et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

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Review Immunology

The unique immunological and microbial aspects of pregnancy

Gil Mor et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Review Immunology

Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes

Zakia Sultana et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2017)

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Article Obstetrics & Gynecology

Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies

Kelly K. Ferguson et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Mediterranean Diet Improves High-Density Lipoprotein Function in High-Cardiovascular-Risk Individuals A Randomized Controlled Trial

Alvaro Hernaez et al.

CIRCULATION (2017)

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Article Immunology

Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates

Maria Hernandez-Trejo et al.

BMC IMMUNOLOGY (2017)

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Review Biochemistry & Molecular Biology

Immunometabolism: Cellular Metabolism Turns Immune Regulator

Roisin M. Loftus et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Article Biochemistry & Molecular Biology

Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein Interaction

Xiaodong Gu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Review Cardiac & Cardiovascular Systems

Dysfunctional HDL and atherosclerotic cardiovascular disease

Robert S. Rosenson et al.

NATURE REVIEWS CARDIOLOGY (2016)

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Article Immunology

Oxidized lipoproteins are associated with markers of inflammation and immune activation in HIV-1 infection

Theodoros Kelesidis et al.

AIDS (2016)

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Review Obstetrics & Gynecology

Inflammation in Complicated Pregnancy and Its Outcome

Ram R. Kalagiri et al.

AMERICAN JOURNAL OF PERINATOLOGY (2016)

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Article Pharmacology & Pharmacy

Decreased baroreflex sensitivity is linked to sympathovagal imbalance, low-grade inflammation, and oxidative stress in pregnancy-induced hypertension

M. Subha et al.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2016)

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Article Nutrition & Dietetics

Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women with gestational diabetes mellitus and lowered the incidence of large-for-gestational-age newborns

Li-Jia Yuan et al.

CLINICAL NUTRITION (2016)

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Article Endocrinology & Metabolism

Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes

J. Martino et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

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Article Biochemistry & Molecular Biology

Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution

Nicholas J. Woudberg et al.

LIPIDS IN HEALTH AND DISEASE (2016)

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Article Biochemistry & Molecular Biology

Comparison of Anti-Oxidant and Anti-Inflammatory Effects between Fresh and Aged Black Garlic Extracts

Yi Yeong Jeong et al.

MOLECULES (2016)

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Article Medicine, General & Internal

Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies

Emily Bartsch et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

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Article Medicine, General & Internal

Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies

Emily Bartsch et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

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Article Infectious Diseases

Oxidative stress markers in saliva and periodontal disease status: modulation during pregnancy and postpartum

Pinar Gumus et al.

BMC INFECTIOUS DISEASES (2015)

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Article Immunology

Interleukin-1 family cytokines and their regulatory proteins in normal pregnancy and pre-eclampsia

J. H. Southcombe et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2015)

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Article Medical Laboratory Technology

HIF1A and MIF as potential predictive mRNA biomarkers of pre-eclampsia: a longitudinal prospective study in high risk population

Silvia Galbiati et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2015)

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Article Nutrition & Dietetics

Association between magnesium status, oxidative stress and inflammation in preeclampsia: A case-control study

Vivianne de Sousa Rocha et al.

CLINICAL NUTRITION (2015)

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Article Biochemistry & Molecular Biology

Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL

Shobini Jayaraman et al.

JOURNAL OF LIPID RESEARCH (2015)

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Article Developmental Biology

Oxidative stress as common trait of endothelial dysfunction in chorionic arteries from fetuses with IUGR and LGA

D. Schneider et al.

PLACENTA (2015)

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Article Multidisciplinary Sciences

Oxidized Low-Density Lipoprotein Contributes to Atherogenesis via Co-activation of Macrophages and Mast Cells

Chong Chen et al.

PLOS ONE (2015)

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Article Biochemistry & Molecular Biology

Abdominal obesity and gestational diabetes: the interactive role of magnesium

Ebrahim Mostafavi et al.

MAGNESIUM RESEARCH (2015)

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Review Physiology

Redox-Dependent Anti-Inflammatory Signaling Actions of Unsaturated Fatty Acids

Meghan Delmastro-Greenwood et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 76 (2014)

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Article Hematology

Olive Oil Polyphenols Enhance High-Density Lipoprotein Function in Humans A Randomized Controlled Trial

Alvaro Hernaez et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

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Review Cardiac & Cardiovascular Systems

Cardiovascular Risk, Lipids and Pregnancy: Preeclampsia and the Risk of Later Life Cardiovascular Disease

Francesca Charlton et al.

HEART LUNG AND CIRCULATION (2014)

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Article Obstetrics & Gynecology

Obesity during pregnancy alters maternal oxidant balance and micronutrient status

S. Sen et al.

JOURNAL OF PERINATOLOGY (2014)

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Article Developmental Biology

Oxidative stress and maternal obesity: Feto-placental unit interaction

N. Malti et al.

PLACENTA (2014)

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Article Multidisciplinary Sciences

Effects of Poly-Bioactive Compounds on Lipid Profile and Body Weight in a Moderately Hypercholesterolemic Population with Low Cardiovascular Disease Risk: A Multicenter Randomized Trial

Rosa Sola et al.

PLOS ONE (2014)

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Article Obstetrics & Gynecology

Oxidative stress and immunological alteration in women with preeclampsia

Danilla Michelle Costa e Silva et al.

HYPERTENSION IN PREGNANCY (2013)

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Review Biochemistry & Molecular Biology

Thematic Review Series: High Density Lipoprotein Structure, Function, and Metabolism Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond

Amy S. Shah et al.

JOURNAL OF LIPID RESEARCH (2013)

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Article Obstetrics & Gynecology

Obesity during pregnancy and fetal iron status: is Hepcidin the link?

M. C. Dao et al.

JOURNAL OF PERINATOLOGY (2013)

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Review Medicine, General & Internal

Prevalence of complementary and alternative medicine (CAM) use by the general population: a systematic review and update

P. E. Harris et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2012)

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Article Pediatrics

Elevated Acetoacetate and Monocyte Chemotactic Protein-1 Levels in Cord Blood of Infants of Diabetic Mothers

Dalibor Kurepa et al.

NEONATOLOGY (2012)

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Article Cell Biology

Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study

Fabiana C. B. Bernardi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2012)

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Review Oncology

Potential Anticancer Properties of Grape Antioxidants

Kequan Zhou et al.

JOURNAL OF ONCOLOGY (2012)

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Review Pharmacology & Pharmacy

Molecular Mechanisms Regulating the Vascular Prostacyclin Pathways and Their Adaptation during Pregnancy and in the Newborn

Batoule H. Majed et al.

PHARMACOLOGICAL REVIEWS (2012)

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Article Obstetrics & Gynecology

Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood

Cristina Catarino et al.

JOURNAL OF PREGNANCY (2012)

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Article Obstetrics & Gynecology

Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy

Jennifer A. Hutcheon et al.

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