Andrographolide Induces ROS-Mediated Cytotoxicity, Lipid Peroxidation, and Compromised Cell Integrity in Saccharomyces cerevisiae

Article Plant Sciences

Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction

Jiaqi Li et al.

Summary: This study demonstrated that ADE treatment can inhibit the growth and metastasis of NSCLC cells by inducing ferroptosis and potentiating mitochondrial dysfunction.

PHYTOMEDICINE (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Andrographolide induced ferroptosis in multiple myeloma cells by regulating the P38/Nrf2/HO-1 pathway

Wenxia Li et al.

Summary: Andrographis paniculata, a traditional Chinese medicine, has been used as a functional food in Asia. Andrographolide, a compound isolated from Andrographis paniculata, has potent anticancer activity. In this study, researchers found that Andro induced cell death in multiple myeloma (MM) cells through a type of cell death called ferroptosis, and this mechanism may provide a potential preventative and therapeutic approach for MM.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2023)

添加到收藏夹

Review Pharmacology & Pharmacy

Adverse Effects of Andrographolide Derivative Medications Compared to the Safe use of Herbal Preparations of Andrographis paniculata: Results of a Systematic Review and Meta-Analysis of Clinical Studies

Ya-xi Shang et al.

Summary: This study aimed to evaluate the safety of andrographolide derivative medications and herbal preparations of Andrographis paniculata (AP) based on clinical studies. The results showed that the main adverse drug reactions (ADR) of andrographolide derivative injections were gastrointestinal, skin and subcutaneous tissue disorders, and anaphylaxis. Herbal preparations of AP were found to be generally safe.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Microbiology

Crosstalk between Yeast Cell Plasma Membrane Ergosterol Content and Cell Wall Stiffness under Acetic Acid Stress Involving Pdr18

Ricardo A. Ribeiro et al.

Summary: This study investigates the impact of Pdr18 expression on yeast cell wall during adaptation to acetic acid stress. Results show that Pdr18 deletion leads to changes in transcriptional activation of cell wall biosynthetic genes and cell wall stiffness and polysaccharide content. Despite a stronger and more long-lasting adaptive response, the pdr18 Delta population has lower resistance to lyticase activity and requires a longer period for intracellular pH recovery and growth resumption. Plasma membrane ergosterol content is drastically reduced under acetic acid stress, especially in pdr18 Delta cells, suggesting a coordinated response between plasma membrane and cell wall against the detrimental effects of acetic acid.

JOURNAL OF FUNGI (2022)

添加到收藏夹

Article Microbiology

Potential Role of the Host-Derived Cell-Wall Binding Domain o Endolysin CD16/50L as a Molecular Anchor in Preservation of Uninfected Clostridioides difficile for New Rounds of Phage Infection

Wichuda Phothichaisri et al.

Summary: This study investigates the function of the cell-wall binding domain (CBD) of an endolysin from a C. difficile phage. The CBD is found to play a role in anchoring the enzyme to post-lytic cell-wall remnants, limiting enzyme diffusion and preserving neighboring host cells, which facilitates phage replication. This insight into the regulation of endolysin through CBD may have potential applications in treating C. difficile infection.

MICROBIOLOGY SPECTRUM (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation

Nicole M. Revie et al.

Summary: A compound is identified that synergizes with antifungals, inhibiting biofilm formation and virulence traits of Candida albicans.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Microbiology

Triazole Derivatives Target 14α-Demethylase (LDM) Enzyme in Candida albicans Causing Ergosterol Biosynthesis Inhibition

Irfan A. Rather et al.

Summary: Candida albicans is a common cause of fungal infections in humans and azoles are commonly used for treatment. However, their overuse has led to drug resistance. In this study, new triazole-based molecules were developed and tested against Candida albicans. In vitro and in silico results showed that these derivatives have the potential to be effective antifungal drugs, as they effectively bind to the target enzyme, inhibit ergosterol production, and prevent biofilm formation.

JOURNAL OF FUNGI (2022)

添加到收藏夹

Article Microbiology

Receptor binding protein of prophage reversibly recognizes the low-molecular weight subunit of the surface-layer protein SlpA in Clostridioides difficile

Tanaporn Phetruen et al.

Summary: In this study, the receptor-binding protein (RBP) Pts(HN10)M was identified and shown to play a crucial role in mediating the interaction between phage and C. difficile cells. The C-terminal domain of Pts(HN10)M and the low-molecular weight subunit of surface-layer protein A (SlpA) were found to be important for the binding process. This research highlights the potential of Pts(HN10)M as an RBP for phage engineering and therapy against C. difficile infection.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Andrographolide, a natural anti-inflammatory agent: An Update

Xiaohong Li et al.

Summary: Andrographolide, a natural active ingredient derived from Andrographis paniculata, has anti-inflammatory effects and can be used to treat various inflammatory diseases. It acts on multiple inflammation-related signaling pathways and has potential clinical applications.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Michael acceptor molecules in natural products and their mechanism of action

Song-Ting Liang et al.

Summary: This study summarizes the existing Michael receptor molecules derived from plants and their applications. The compounds have similar pharmacological potential and can play biological activities through various pathways, making them suitable for the treatment of diseases such as inflammation and tumors.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Michael P. Murphy et al.

Summary: This article discusses the important roles of reactive oxygen species (ROS) in health and disease, and proposes guidelines and best practices for the nomenclature and assessment of ROS, oxidative reactions, and oxidative damage in cells, tissues, and in vivo.

NATURE METABOLISM (2022)

添加到收藏夹

Article Chemistry, Medicinal

Andrographolide and its derivatives: Current achievements and future perspectives

Hang Zhang et al.

Summary: Andrographolide and its derivatives exhibit various biological activities such as anti-tumor, anti-inflammation, and anti-virus, showing potential in cancer treatment. Improved bioavailability of andrographolide derivatives has been developed through chemical structural modifications. Further research is needed to explore their therapeutic applications and challenges in the future.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Oncology

Antitumor effects of Andrographis via ferroptosis-associated genes in gastric cancer

Ruiya Ma et al.

Summary: Andrographis exhibits antitumor effects in advanced/metastatic gastric cancer by regulating cancer progression-associated signaling pathways, inhibiting proliferation, reducing colony formation, and enhancing apoptotic activity. Additionally, Andrographis treatment significantly upregulates the expression levels of ferroptosis-associated genes in GC cell lines.

ONCOLOGY LETTERS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer

Tadanobu Shimura et al.

Summary: The combination of Andrographis paniculata and OPCs shows enhanced anti-cancer activity in colorectal cancer by inhibiting cancer cell growth, suppressing colony formation and inducing apoptosis. Transcriptomic profiling reveals involvement of metabolic pathways and ferroptosis-associated genes that contribute to the increased anti-tumorigenic activity of these compounds.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Review Oncology

Biological properties of andrographolide, an active ingredient of Andrographis Paniculata: a narrative review

Vaclav Vetvicka et al.

Summary: Andrographolide is a natural compound with antibacterial, anti-inflammatory, and anticancer effects, possibly achieved through the stimulation of the immune system. While promising in the treatment of inflammatory diseases and cancer, more research is needed to determine appropriate dosages and potential negative effects.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Stress-induced upregulation of the ubiquitin-relative Hub1 modulates pre-mRNA splicing and facilitates cadmium tolerance in Saccharomyces cerevisiae

Sittinan Chanarat et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

添加到收藏夹

Article Biology

A microscopy-based kinetic analysis of yeast vacuolar protein sorting

Jason C. Casler et al.

ELIFE (2020)

添加到收藏夹

Review Genetics & Heredity

Regulation of Ergosterol Biosynthesis inSaccharomyces cerevisiae

Tania Jorda et al.

GENES (2020)

添加到收藏夹

Article Biochemical Research Methods

Live-Cell Imaging of Mitochondrial Redox State in Yeast Cells

Pin-Chao Liao et al.

STAR PROTOCOLS (2020)

添加到收藏夹

Article Cell Biology

Maturation-driven transport and AP-1-dependent recycling of a secretory cargo in the Golgi

Jason C. Casler et al.

JOURNAL OF CELL BIOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

The vacuolar shapes of ageing: From function to morphology

Andreas Aufschnaiter et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Andrographolide, A Natural Antioxidant: An Update

Eugenie Mussard et al.

ANTIOXIDANTS (2019)

添加到收藏夹

Review Cell Biology

Dynamics and functions of lipid droplets

James A. Olzmann et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Improved fermentation efficiency of S. cerevisiae by changing glycolytic metabolic pathways with plasma agitation

Nina Recek et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Regulation of the NRF2 transcription factor by andrographolide and organic extracts from plant endophytes

Daphne Pei Wen Wong et al.

PLOS ONE (2018)

添加到收藏夹

Review Virology

Broad-spectrum antiviral properties of andrographolide

Swati Gupta et al.

ARCHIVES OF VIROLOGY (2017)

添加到收藏夹

Review Genetics & Heredity

Target of rapamycin signaling mediates vacuolar fragmentation

Bobbiejane Stauffer et al.

CURRENT GENETICS (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Multi-Targeting Andrographolide, a Novel NF-B Inhibitor, as a Potential Therapeutic Agent for Stroke

Chih-Hao Yang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Error-Prone Splicing Controlled by the Ubiquitin Relative Hub1

Ramazan Karaduman et al.

MOLECULAR CELL (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Fisetin yeast-based bio-capsules via osmoporation: effects of process variables on the encapsulation efficiency and internalized fisetin content

Antonio Anchieta de Camara et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Thematic Review Series: Lipotoxicity: Many Roads to Cell Dysfunction and Cell Death The role of ER stress in lipid metabolism and lipotoxicity

Jaeseok Han et al.

JOURNAL OF LIPID RESEARCH (2016)

添加到收藏夹

Article Chemistry, Analytical

A rapid method to assess reactive oxygen species in yeast using H2DCF-DA

Joel James et al.

ANALYTICAL METHODS (2015)

添加到收藏夹

Article Microbiology

Quantitative differential proteomics of yeast extracellular matrix: there is more to it than meets the eye

Fabio Faria-Oliveira et al.

BMC MICROBIOLOGY (2015)

添加到收藏夹

Article Plant Sciences

Specificity and Inhibitory Mechanism of Andrographolide and Its Analogues as Antiasthma Agents on NF-κB p50

Van Sang Nguyen et al.

JOURNAL OF NATURAL PRODUCTS (2015)

添加到收藏夹

Article Cell Biology

Target of rapamycin signaling mediates vacuolar fission caused by endoplasmic reticulum stress in Saccharomyces cerevisiae

Bobbiejane Stauffer et al.

MOLECULAR BIOLOGY OF THE CELL (2015)

添加到收藏夹

Review Cell Biology

The lipid droplet-a well-connected organelle

Qiang Gao et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2015)

添加到收藏夹

Article Biology

Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1

Eelco van Anken et al.

ELIFE (2014)

添加到收藏夹

Article Biochemical Research Methods

Measuring mRNA copy number in individual Escherichia coli cells using single-molecule fluorescent in situ hybridization

Samuel O. Skinner et al.

NATURE PROTOCOLS (2013)

添加到收藏夹

Article Microbiology

Dissection of Ire1 Functions Reveals Stress Response Mechanisms Uniquely Evolved in Candida glabrata

Taiga Miyazaki et al.

PLOS PATHOGENS (2013)

添加到收藏夹

Article Cell Biology

Yeast vacuoles fragment in an asymmetrical two-phase process with distinct protein requirements

Martin Zieger et al.

MOLECULAR BIOLOGY OF THE CELL (2012)

添加到收藏夹

Article Microbiology

Red but not dead? Membranes of stressed Saccharomyces cerevisiae are permeable to propidium iodide

H. M. Davey et al.

ENVIRONMENTAL MICROBIOLOGY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Conserved RNA structures in the non-canonical Hac1/Xbp1 intron

Katarzyna B. Hooks et al.

RNA BIOLOGY (2011)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Transcriptional regulation of nonfermentable carbon utilization in budding yeast

Bernard Turcotte et al.

FEMS YEAST RESEARCH (2010)

添加到收藏夹

Article Cell Biology

A pitfall in using BODIPY dyes to label lipid droplets for fluorescence microscopy

Yuki Ohsaki et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mechanistic role of ergosterol in membrane rigidity and cycloheximide resistance in Saccharomyces cerevisiae

Fumiyoshi Abe et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

添加到收藏夹

Review Biochemistry & Molecular Biology

The yeast lysosome-like vacuole: Endpoint and crossroads

Sheena Claire Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)

添加到收藏夹

Review Cell Biology

As a Matter of Fat

Rita T. Brookheart et al.

CELL METABOLISM (2009)

添加到收藏夹

Article Cell Biology

The Unfolded Protein Response Is Induced by the Cell Wall Integrity Mitogen-activated Protein Kinase Signaling Cascade and Is Required for Cell Wall Integrity in Saccharomyces cerevisiae

Thomas Scrimale et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Transcriptome profiling of Saccharomyces cerevisiae during a transition from fermentative to glycerol-based respiratory growth reveals extensive metabolic and structural remodeling

George G. Roberts et al.

MOLECULAR GENETICS AND GENOMICS (2006)

添加到收藏夹

Article Genetics & Heredity

Genomic screen for yeast vacuolar membrane ATPase mutants

M Sambade et al.

GENETICS (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

The global transcriptional response to transient cell wall damage in Saccharomyces cerevisiae and its regulation by the cell integrity signaling pathway

R García et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes

C Janke et al.

YEAST (2004)

添加到收藏夹

Article Genetics & Heredity

Systematic screen for human disease genes in yeast

LM Steinmetz et al.

NATURE GENETICS (2002)

添加到收藏夹

Article Microbiology

Quantitation of Candida albicans ergosterol content improves the correlation between in vitro antifungal susceptibility test results and in vivo outcome after fluconazole treatment in a murine model of invasive candidiasis

BA Arthington-Skaggs et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)

添加到收藏夹

Andrographolide Induces ROS-Mediated Cytotoxicity, Lipid Peroxidation, and Compromised Cell Integrity in Saccharomyces cerevisiae

相关参考文献

导出引文

分享论文