期刊
ANTIOXIDANTS
卷 12, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/antiox12071400
关键词
ulcerative colitis; macromolecular extract; purslane; oxidative stress; small molecular extract; gut microbiota; Portulaca oleracea L
This study investigated the therapeutic effects of purslane macromolecular (POEM) and small molecular extracts (POES) on ulcerative colitis (UC) and found that POEM alleviated UC by regulating antioxidant capacity and gut microbiota, while the major alleviatory effect of POES was primarily related to the regulation of antioxidant capacity. These findings provide a theoretical basis for the development of purslane as a functional food.
Purslane, a common wild vegetable, contains active substances with various biological functions. However, its effects have been under-investigated in ulcerative colitis (UC). Therefore, this study investigated the therapeutic effects of purslane macromolecular (POEM) and small molecular extracts (POES) on dextran sulfate sodium (DSS)-induced UC in mice. Membrane separation was used to obtain extracts of different molecular weights, and their compositional differences were compared using liquid chromatography-mass spectrometry (LC/MS). POEM contained more proteins and polysaccharides, whereas POES contained more organic acids and alkaloids. These differences in composition were directly responsible for the different degrees of remission of the alleviated UC in model mice. POEM may alleviate UC by regulating the antioxidant capacity and the gut microbiota, whereas the major alleviatory effect of POES was primarily related to the regulation of antioxidant capacity. The POEM and POES effects identified in this study provide a theoretical basis for the development of purslane as a functional food.
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