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Association between Impaired Ketogenesis and Metabolic-Associated Fatty Liver Disease

BIOMOLECULES (2023)

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Summary: A comprehensive meta-analysis was conducted to assess the global and regional prevalence, incidence, and mortality of non-alcoholic fatty liver disease (NAFLD). The results showed that the global prevalence of NAFLD is 30% and increasing, highlighting the need for urgent and comprehensive strategies to raise awareness and address NAFLD on local, regional, and global levels.

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Summary: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide, with a prevalence of approximately 30%. Its prevalence varies depending on comorbidities and is expected to increase due to the rising obesity rates. NAFLD is a major cause of chronic liver diseases, including cirrhosis and hepatocellular carcinoma (HCC). This article provides a brief overview of NAFLD's definition and classification based on current knowledge.

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Impaired ketogenesis is associated with metabolic-associated fatty liver disease in subjects with type 2 diabetes

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Summary: Non-alcoholic fatty liver disease (NAFLD), resulting from excessive fat accumulation in the liver, is the most common chronic liver disease. NAFL can progress to non-alcoholic steatohepatitis (NASH) and eventually lead to severe liver diseases. The pathogenesis of NAFLD involves disruptions in lipid and glucose metabolism.

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Summary: The study investigated the association between spontaneous fasting ketonuria and liver fibrosis in NAFLD patients without prediabetes and diabetes mellitus. Results showed that patients with ketonuria were younger, had lower levels of glucose and insulin resistance, and had an inverse association with liver fibrosis compared to patients without ketonuria. The presence of ketonuria in these patients may have favorable metabolic effects.

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