Clinical Significance of Plasma Leptin and Its Receptors mRNA Expression in Craniopharyngiomas: A Prospective Study

Article Chemistry, Medicinal

Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes

ThiKem Nguyen et al.

Summary: The role of cathepsin B signaling in leptin-induced hepatic cancer growth was investigated and it was found that cathepsin B plays a crucial role in activating NLRP3 inflammasomes.

ARCHIVES OF PHARMACAL RESEARCH (2023)

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Article

The Effect of Serum Leptin Concentration and Leptin Receptor Expression on Colorectal Cancer

Sylwia Chludzińska-Kasperuk et al.

International Journal of Environmental Research and Public Health (2023)

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Article Medicine, General & Internal

Effects of Craniotomy and Endoscopic Endonasal Transsphenoidal Surgery on Bodyweight in Adult-Onset Craniopharyngioma: A Single-Center Retrospective Study

Yanbin Li et al.

Summary: This study compared the effects of traditional craniotomy and endoscopic endonasal transsphenoidal surgery on adult-onset craniopharyngioma, and found that the endoscopic approach had advantages in surgical resection, hypothalamic involvement, postoperative endocrine function, and weight control.

JOURNAL OF CLINICAL MEDICINE (2023)

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Review Oncology

STAT proteins in cancer: orchestration of metabolism

Yi-Jia Li et al.

Summary: Reprogrammed metabolism is a key feature of cancer, and it involves a variety of distinct cellular metabolic pathways. This review focuses on the roles of STAT proteins, particularly STAT3, STAT5, STAT6, and STAT1, in regulating the dynamic metabolism of cancer cells, immune cells, and adipocytes in the tumor microenvironment. STAT proteins have the ability to shape different metabolic processes that regulate tumor progression and therapy resistance, including transducing signals from metabolites, cytokines, growth factors, and their receptors; defining genetic programs that control metabolism in cancer and immune cells; and regulating mitochondrial activity. Targeting STAT proteins could be a potential therapeutic strategy for altering metabolic reprogramming in cancer.

NATURE REVIEWS CANCER (2023)

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Review Oncology

Leptin signaling in breast cancer and its crosstalk with peroxisome proliferator-activated receptors α and γ

Nasim Dana et al.

Summary: Obesity affects tumor development and interacts with leptin and peroxisome proliferator-activated receptors. Studies have shown an association between obesity and various types of cancer, including breast cancer.

CLINICAL & TRANSLATIONAL ONCOLOGY (2023)

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Review Neurosciences

Monogenic Obesity Syndromes Provide Insights Into the Hypothalamic Regulation of Appetite and Associated Behaviors

I. Sadaf Farooqi

Summary: Neuronal circuits in the hypothalamus play a crucial role in the regulation of body weight and innate behaviors. Genetic disorders that disrupt these circuits can lead to hyperphagia, obesity, and maladaptive behaviors like anxiety and autism. Understanding these mechanisms is important for studying and treating clinical disorders.

BIOLOGICAL PSYCHIATRY (2022)

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Article Immunology

Adamantinomatous craniopharyngioma cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamic neurons by inducing the production of β-amyloid

Yilamujiang Ainiwan et al.

Summary: In this study, a reliable animal model of adamantinomatous craniopharyngioma (ACP) cyst fluid-induced hypothalamic injury was established. It was found for the first time that ACP cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamus, which may be related to the upregulation of the CD74-APP interaction and deposition of beta-amyloid, implying that there may be a similar mechanism between ACP cyst fluid damage to the hypothalamus and neurodegenerative diseases.

JOURNAL OF NEUROINFLAMMATION (2022)

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Review Endocrinology & Metabolism

Hypothalamic mechanisms of obesity-associated disturbance of hypothalamic-pituitary-ovarian axis

Xiaolin Chen et al.

Summary: Ovulatory disorders are common in obese women, and they are influenced by leptin and hypothalamic inflammation. This review focuses on the disturbance of hypothalamic mechanisms during obesity and suggests future research and therapeutic strategies.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2022)

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Article Pharmacology & Pharmacy

Perindopril sensitizes hepatocellular carcinoma to chemotherapy: A possible role of leptin/Wnt/β-catenin axis with subsequent inhibition of liver cancer stem cells

Sherin Zakaria et al.

Summary: This study investigates the potential role of perindopril as a chemosensitizer agent to sorafenib. The results show that perindopril decreases liver enzymes, preserves liver architecture, and significantly enhances the antineoplastic, antiangiogenic, and antimetastatic effects of sorafenib. These effects are associated with the downregulation of the leptin/Wnt/ss-catenin pathway and the overexpression of ALDH1.

SAUDI PHARMACEUTICAL JOURNAL (2022)

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Article Oncology

Integrin α6 Indicates a Poor Prognosis of Craniopharyngioma through Bioinformatic Analysis and Experimental Validation

Yanfei Jia et al.

Summary: This study identified differentially expressed genes (DEGs) associated with craniopharyngioma (CP) and found an important metabolism-related gene, ITGA6, through survival analysis, which is closely related to the overall survival of CP patients.

JOURNAL OF ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer

Roberto Buonaiuto et al.

Summary: Leptin, a hormone involved in appetite control and energy balance, can contribute to chronic inflammation and cancer development when adipose tissue expands. Leptin activates multiple cancer pathways and affects cancer immune response. High levels of leptin associated with obesity are related to breast cancer risk.

BIOMOLECULES (2022)

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Article Clinical Neurology

Endoscopic extended transsphenoidal surgery for newly diagnosed paediatric craniopharyngiomas

Mohsen Javadpour et al.

Summary: Endoscopic extended transsphenoidal surgery (EETSS) shows promising outcomes in treating newly diagnosed pediatric craniopharyngiomas, with high success rates and minimal complications observed in patients.

CHILDS NERVOUS SYSTEM (2021)

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Article Clinical Neurology

The predictive value of intraoperative visual evoked potential for visual outcome after extended endoscopic endonasal surgery for adult craniopharyngioma

Ning Qiao et al.

Summary: Intraoperative VEP monitoring during EEES for craniopharyngioma can effectively predict postoperative visual changes in adult patients. Tight adhesion and larger tumor volume are strong predictors of postoperative visual impairment.

JOURNAL OF NEUROSURGERY (2021)

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Article Medicine, General & Internal

Expression Pattern of Leptin and Its Receptors in Endometrioid Endometrial Cancer

Dariusz Boron et al.

Summary: The study investigated the expression profile of leptin-related genes in endometrial cancer patients, showing an overexpression of leptin and its receptors, particularly correlating with patient body mass index, which may contribute to the progression of cancer.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Biology