☆ 4.7 Review

Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response-Toward an Actionable Strategy for Anti-Aging

BIOMOLECULES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Medicine, Research & Experimental

BCAA insufficiency leads to premature ovarian insufficiency via ceramide-induced elevation of ROS

Xiao Guo et al.

Summary: Premature ovarian insufficiency (POI) is characterized by early menopause before the age of 40, accompanied by elevated follicle-stimulating hormone levels. A study has shown a potential correlation between POI and metabolic disorders, particularly in underweight individuals. Metabolomics analysis has identified BCAA insufficiency-related metabolic disorders in POI patients, and a low BCAA diet has replicated the metabolic, endocrine, ovarian, and reproductive changes associated with POI in mice. Further research has revealed that BCAA insufficiency-induced POI is associated with abnormal activation of the ceramide-reactive oxygen species (ROS) axis and impaired ovarian granulosa cell function. Dietary supplementation of BCAA has been found to prevent ROS-induced POI in female mice, suggesting potential therapeutic options for POI.

EMBO MOLECULAR MEDICINE (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cellular Modulators of the NRF2/KEAP1 Signaling Pathway in Prostate Cancer

Giovanni Tossetta et al.

Summary: Prostate cancer is the second most common malignancy in men worldwide, and can be treated through surgery, radiotherapy and hormone therapy. Oxidative stress is involved in cancer occurrence and development, and the NRF2/KEAP1 pathway is affected by reactive oxygen species. This review analyzes the current literature on NRF2/KEAP1 pathway regulation and its potential as a therapeutic target in prostate cancer cells.

FRONTIERS IN BIOSCIENCE-LANDMARK (2023)

添加到收藏夹

Review Neurosciences

Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury

P. M. Abdul-Muneer

Summary: This review discusses the potential and feasibility of using nuclear factor erythroid 2-related factor 2 (Nrf2) as a therapeutic target to minimize the devastating effects of brain injury. The review summarizes the different sources of oxidative stress and their impact on blood-brain barrier dysfunction, mitochondrial damage, and changes in various inflammatory molecules associated with central nervous system injury. The potential effectiveness of the Nrf2 transcription factor in reducing oxidative stress-mediated secondary damage after CNS injury is explained, and evidence of Nrf2's role in activating antioxidant genes is provided. The review recognizes the scope of Nrf2 in developing therapeutic interventions for various pathophysiological conditions associated with CNS injury-induced free radical/inflammatory signaling. Nrf2 has widespread applications in basic and clinical neuroscience for understanding and treating disorders related to free radical/inflammatory signaling, including neurological diseases.

JOURNAL OF INTEGRATIVE NEUROSCIENCE (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Acute Oxidative Stress Can Paradoxically Suppress Human NRF2 Protein Synthesis by Inhibiting Global Protein Translation

Kaitlin M. Pensabene et al.

Summary: This study found that the activation of the NRF2/ARE pathway by H2O2 can be limited by the inhibition of NRF2 protein synthesis. In addition, global protein synthesis is also inhibited. The use of a manganese porphyrin antioxidant and a diphenol can rescue this inhibition.

ANTIOXIDANTS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

The role of mitochondrial reactive oxygen species in insulin resistance

Anita Ayer et al.

Summary: This review examines the evidence linking mitochondrial reactive oxygen species with insulin resistance, highlighting their potential role in the development of this condition. However, limitations in current research methods and the lack of data connecting mitochondrial reactive oxygen species with cytosolic insulin signaling pathways present significant obstacles to proving this mechanistic link. Future studies are needed to provide stronger evidence on the relationship between mitochondrial reactive oxygen species and insulin resistance, potentially paving the way for new therapeutic strategies.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

添加到收藏夹

Article Nutrition & Dietetics

Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis

Jinwang Li et al.

Summary: Sulforaphane (SFA) has the potential to improve lipid metabolism, inhibit lipid accumulation and apoptosis, making it a potential candidate for preventing and treating nonalcoholic fatty liver disease (NAFLD).

NUTRIENTS (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation

Sharon Baumel-Alterzon et al.

Summary: By manipulating Nrf2 levels, researchers have discovered the importance of managing reactive oxygen species in regulating beta-cell mass, highlighting Nrf2 as an exciting therapeutic target for expanding and protecting beta-cell mass in diabetes.

DIABETES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of NRF2 in Ovarian Cancer

Giovanni Tossetta et al.

Summary: This review summarizes the role of NRF2 in ovarian cancer, focusing on its function in drug resistance, natural and synthetic modulators of NRF2, and its protective function in normal ovarian preservation.

ANTIOXIDANTS (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis

Ya Zhang et al.

Summary: Sulforaphane extracted from high-risk diet can improve insulin resistance by increasing glucose uptake and insulin signaling.

BIOMEDICINE & PHARMACOTHERAPY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

Froukje Vanweert et al.

Summary: This study used NaPB to lower plasma BCAA levels in patients with T2D and found that it improved peripheral insulin sensitivity, muscle mitochondrial oxidative capacity, and whole-body insulin-stimulated carbohydrate oxidation while reducing plasma BCAA and glucose levels.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives

Daniela Maria Tanase et al.

Summary: Diabetes mellitus is a debilitating chronic disease with increasing prevalence worldwide. Diabetic Kidney Disease is a major complication of diabetes, caused by mechanisms such as hyperglycemia, inflammation, and oxidative stress. NRF2-inducing strategies show potential in the treatment of Diabetic Kidney Disease, but limitations such as lack of large-scale clinical trials hinder their clinical use.

BIOMOLECULES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Nrf2 Modulation in Breast Cancer

Somayyeh Ghareghomi et al.

Summary: ROS play a crucial role in cellular processes, with Keap1-Nrf2 pathway acting as a master antioxidant mechanism. While activation of Nrf2 benefits cells in early stages by reducing ROS levels, hyperactivation can support the survival of healthy and cancer cells against oxidative stress and treatments. Understanding the dual role of Nrf2 in cancer cells can be important in cancer treatment strategies.

BIOMEDICINES (2022)

添加到收藏夹

Review Endocrinology & Metabolism

Nrf2: The Master and Captain of Beta Cell Fate

Sharon Baumel-Alterzon et al.

Summary: Prolonged hyperglycemia is harmful to pancreatic beta cells, and Nrf2 plays a crucial role in protecting these cells from oxidative stress. Modulating Nrf2 activity is a promising therapeutic approach for the treatment of diabetes.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

The pivotal role of Nrf2 activators in adipocyte biology

A. S. Annie-Mathew et al.

Summary: Adipose tissue plays a crucial role in maintaining metabolic homeostasis, but overnutrition can lead to abnormal increase in adipocytes, causing obesity and other chronic complications. Oxidative stress is closely involved in the pathogenesis of obesity, and the Nrf2 signaling pathway plays a significant role in regulating oxidative and inflammatory responses. Researchers are currently seeking novel compounds to modulate Nrf2 activity for the management of adipogenesis and obesity.

PHARMACOLOGICAL RESEARCH (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

Chrysovalantou E. Xirouchaki et al.

Summary: ROS generated by NOX4 in skeletal muscle play a crucial role in promoting muscle function, maintaining redox balance, and preventing the development of insulin resistance. Reductions in NOX4 levels in skeletal muscle contribute to insulin resistance development, affecting exercise capacity and antioxidant defense mechanisms.

SCIENCE ADVANCES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance

Jan Gojda et al.

Summary: The human gut microbiota is an active ecosystem that has evolved in symbiosis with the human host, playing a role in the metabolism of compounds like branched-chain amino acids and impacting insulin resistance development. Dietary modulation of gut microbiota BCAA metabolism could be a promising approach in preventing and treating insulin resistance related conditions.

BIOMOLECULES (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Sphingolipids as a Culprit of Mitochondrial Dysfunction in Insulin Resistance and Type 2 Diabetes

Kamila Roszczyc-Owsiejczuk et al.

Summary: Insulin resistance is a complex pathological condition caused by abnormal cellular and metabolic responses to insulin, often associated with obesity and high-fat diets. The accumulation of bioactive lipids in insulin-sensitive tissues, particularly ceramides and other sphingolipids, plays a significant role in inhibiting insulin signaling pathway and contributing to the development of insulin resistance and type 2 diabetes (T2D). Studies have shown that sphingolipids also negatively affect mitochondrial function, which may further exacerbate the insulin resistance in T2D subjects.

FRONTIERS IN ENDOCRINOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Exercise-Stimulated ROS Sensitive Signaling Pathways in Skeletal Muscle

Jessica Bouviere et al.

Summary: Physical exercise induces acute and adaptative responses at the cellular and systemic levels through the modulation of various signaling pathways in skeletal muscle. Antioxidants can blunt these adaptations, highlighting the crucial role of ROS in exercise. Understanding the balance between beneficial and harmful effects of ROS during and after exercise is a challenging question in exercise biology.

ANTIOXIDANTS (2021)

添加到收藏夹

Review Cell Biology

The aetiology and molecular landscape of insulin resistance

David E. James et al.

Summary: Insulin resistance is an early manifestation of various human diseases, including type 2 diabetes and cardiovascular disease, caused by a combination of genetic and environmental factors. Recent research has highlighted the important role of adipose tissue in the development of insulin resistance by releasing lipids and other factors that disrupt insulin action in other organs. Identifying the targets involved in this unified insulin resistance pathway is crucial for developing new treatments for insulin resistance-related diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

添加到收藏夹

Review Physiology

The Role of Skeletal Muscle in The Pathogenesis of Altered Concentrations of Branched-Chain Amino Acids (Valine, Leucine, and Isoleucine) in Liver Cirrhosis, Diabetes, and Other Diseases

Milan Holecek

Summary: The article discusses the dominant role of skeletal muscle in the catabolism of branched-chain amino acids (BCAAs) and the pathogenesis of their altered levels in liver cirrhosis and diabetes. It also highlights inconsistent alterations in BCAA levels in disorders with systemic inflammatory response syndrome (SIRS), due to contradictory effects on muscles. Further studies are needed to clarify the role of BCAA metabolism alterations and the potential outcomes of BCAA supplementation in specific diseases.

PHYSIOLOGICAL RESEARCH (2021)

添加到收藏夹

Article Cell Biology

SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis

Elma Zaganjor et al.

Summary: This study provides a temporal analysis of adipocyte differentiation, uncovering early metabolic events that stimulate transcriptional reprogramming.

CELL REPORTS (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Effects of Aging on Cardiac Oxidative Stress and Transcriptional Changes in Pathways of Reactive Oxygen Species Generation and Clearance

Farhan Rizvi et al.

Summary: Age-related heart diseases contribute to increased morbidity and mortality, with evidence suggesting that mitochondria play a key role in increased ROS generation. Studies on adult and aged rats, as well as adults and elderly humans, show higher ROS production in elderly cardiomyocytes and cardiac tissue, indicating a commonality in mitochondrial dysfunction and oxidative stress in aging hearts. Network analysis highlights potential targets for aging-related ROS pathways in both rat and human hearts.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

添加到收藏夹

Review Chemistry, Medicinal

Nrf2 in adipocytes

Zhendi Wang et al.

ARCHIVES OF PHARMACAL RESEARCH (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

Eduardo Balsa et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Endocrinology & Metabolism

β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice

Frank K. Huynh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Role of the Nrf2 Signaling in Obesity and Insulin Resistance

Shiri Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Pathophysiology of Type 2 Diabetes Mellitus

Unai Galicia-Garcia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Modulating NRF2 in Disease: Timing Is Everything

Matthew Dodson et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)

添加到收藏夹

Review Nutrition & Dietetics

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control

Shuya Kasai et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2019)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

Branched-chain amino acids in disease

Phillip J. White et al.

SCIENCE (2019)

添加到收藏夹

Review Physiology

Heterogeneity of Metabolic Defects in Type 2 Diabetes and Its Relation to Reactive Oxygen Species and Alterations in Beta-Cell Mass

Andris Elksnis et al.

FRONTIERS IN PHYSIOLOGY (2019)

添加到收藏夹

Article Endocrinology & Metabolism

TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle

Jin-Ho Koh et al.

DIABETES (2019)

添加到收藏夹

Article Nutrition & Dietetics

Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis

Wendi Teng et al.

NUTRIENTS (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

Meiyi Zhou et al.

DIABETES (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

Bhagirath Chaurasia et al.

SCIENCE (2019)

添加到收藏夹

Review Nutrition & Dietetics

The Paradox of Coenzyme Q10 in Aging

M. Elena Diaz-Casado et al.

NUTRIENTS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Redox regulation by NRF2 in aging and disease

Cody J. Schmidlin et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

添加到收藏夹

Review Cell Biology

Adipogenesis and metabolic health

Alexandra L. Ghaben et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice

Dionysios Chartoumpekis et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

Plamena R. Angelova et al.

FEBS LETTERS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

Daniel J. Fazakerley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

添加到收藏夹

Article Biology

Mitochondrial CoQ deficiency is a common driver of mitochondria! oxidants and insulin resistance

Daniel J. Fazakerley et al.

ELIFE (2018)

添加到收藏夹

Article Food Science & Technology

β-Cryptoxanthin ameliorates metabolic risk factors by regulating NF-κB and Nrf2 pathways in insulin resistance induced by high-fat diet in rodents

Kazim Sahin et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice

Joao Paulo Camporez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

添加到收藏夹

Review Physiology

Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease

Filippo Scialo et al.

FRONTIERS IN PHYSIOLOGY (2017)

添加到收藏夹

Article Endocrinology & Metabolism

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

Hui-Young Lee et al.

DIABETES (2017)

添加到收藏夹

Article Endocrinology & Metabolism

Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice

Naoto Nagata et al.

DIABETES (2017)

添加到收藏夹

Article Cell Biology

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

Kristin A. Anderson et al.

CELL METABOLISM (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

Courtney R. Green et al.

NATURE CHEMICAL BIOLOGY (2016)

添加到收藏夹

Article Cell Biology

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

Paul M. Titchenell et al.

CELL METABOLISM (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

A 3-methylcrotonyl-CoA carboxylase deficient human skin fibroblast transcriptome reveals underlying mitochondrial dysfunction and oxidative stress

L. Zandberg et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism

Akira Uruno et al.

MOLECULAR AND CELLULAR BIOLOGY (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

Carles Lerin et al.

MOLECULAR METABOLISM (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Rising levels of atmospheric oxygen and evolution of Nrf2

Ranko Gacesa et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

Rachel J. Perry et al.

CELL (2015)

添加到收藏夹

Review Nutrition & Dietetics

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria

Ken Itoh et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2015)

添加到收藏夹

Article Medicine, Research & Experimental

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

Joshua W. Knowles et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

添加到收藏夹

Article Endocrinology & Metabolism

Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice

Kun Lian et al.

DIABETES (2015)

添加到收藏夹

Review Endocrinology & Metabolism

Branched-chain amino acids in metabolic signalling and insulin resistance

Christopher J. Lynch et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

Amit R. Majithia et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Adipose Deficiency of Nrf2 in ob/ob Mice Results in Severe Metabolic Syndrome

Peng Xue et al.

DIABETES (2013)

添加到收藏夹

Article Endocrinology & Metabolism

Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach

Cristina Menni et al.

DIABETES (2013)

添加到收藏夹

Article Endocrinology & Metabolism

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

Jialin Xu et al.

DIABETES (2012)

添加到收藏夹

Article Genetics & Heredity

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Robert A. Scott et al.

NATURE GENETICS (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet Induced Insulin Resistance

Yun Sok Lee et al.

DIABETES (2011)

添加到收藏夹

Article Medicine, Research & Experimental

Ceramides as modulators of cellular and whole-body metabolism

Benjamin T. Bikman et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

添加到收藏夹

Article Endocrinology & Metabolism

The genetics of type 2 diabetes: what have we learned from GWAS?

Liana K. Billings et al.

YEAR IN DIABETES AND OBESITY (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

Ken Itoh et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

添加到收藏夹

Article Endocrinology & Metabolism

Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling

Sarah L. Gray et al.

ENDOCRINOLOGY (2010)

添加到收藏夹

Review Geriatrics & Gerontology

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

Michael Ristow et al.

EXPERIMENTAL GERONTOLOGY (2010)

添加到收藏夹

Article Medicine, Research & Experimental

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Ethan J. Anderson et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

添加到收藏夹

Article Pharmacology & Pharmacy

Sphingolipids Function as Downstream Effectors of a Fungal PAQR

Nancy Y. Villa et al.

MOLECULAR PHARMACOLOGY (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Insulin resistance is a cellular antioxidant defense mechanism

Kyle L. Hoehn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

添加到收藏夹

Article Cell Biology

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis

Sudha B. Biddinger et al.

CELL METABOLISM (2008)

添加到收藏夹

Editorial Material Cell Biology

Selective versus total insulin resistance: A pathogenic paradox

Michael S. Brown et al.

CELL METABOLISM (2008)

添加到收藏夹

Article Endocrinology & Metabolism

Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance

K. Sreekumaran Nair et al.

DIABETES (2008)

添加到收藏夹

Article Pharmacology & Pharmacy

NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet

Yuji Tanaka et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

添加到收藏夹

Review Endocrinology & Metabolism

Is mitochondrial dysfunction a cause of insulin resistance?

Nigel Turner et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2008)

添加到收藏夹

Article Medicine, General & Internal

Global transcript profiles of fat in monozygotic twins discordant for BMI:: Pathways behind acquired obesity

Kirsi H. Pietilainen et al.

PLOS MEDICINE (2008)

添加到收藏夹

Article Endocrinology & Metabolism

Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism

Pengxiang She et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury

Jacqui M. Marzec et al.

FASEB JOURNAL (2007)

添加到收藏夹

Article Genetics & Heredity

Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants

Raquel Moreno-Loshuertos et al.

NATURE GENETICS (2006)

添加到收藏夹

Article Multidisciplinary Sciences

Reactive oxygen species have a causal role in multiple forms of insulin resistance

N Houstis et al.

NATURE (2006)

添加到收藏夹

Article Medicine, General & Internal

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

KF Petersen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

添加到收藏夹

Article Multidisciplinary Sciences

Mitochondrial dysfunction in the elderly: Possible role in insulin resistance

KF Petersen et al.

SCIENCE (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.