期刊
BIOMOLECULES
卷 13, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/biom13101550
关键词
myo-inositol; phosphoinositides; phosphatidylinositol; phosphatidylinositol phosphate; myotubular myopathy; X-linked myotubular myopathy; neurodegenerative disorders; carcinogenesis
Myo-inositol and its derivatives play important roles in intracellular processes and mutations can lead to various disorders. This review provides an in-depth analysis of the influence of phosphatidylinositols and their phosphates on diseases, emphasizing the need for further research on myo-inositol.
Myo-inositol belongs to one of the sugar alcohol groups known as cyclitols. Phosphatidylinositols are one of the derivatives of Myo-inositol, and constitute important mediators in many intracellular processes such as cell growth, cell differentiation, receptor recycling, cytoskeletal organization, and membrane fusion. They also have even more functions that are essential for cell survival. Mutations in genes encoding phosphatidylinositols and their derivatives can lead to many disorders. This review aims to perform an in-depth analysis of these connections. Many authors emphasize the significant influence of phosphatidylinositols and phosphatidylinositols' phosphates in the pathogenesis of myotubular myopathies, neurodegenerative disorders, carcinogenesis, and other less frequently observed diseases. In our review, we have focused on three of the most often mentioned groups of disorders. Inositols are the topic of many studies, and yet, there are no clear results of successful clinical trials. Analysis of the available literature gives promising results and shows that further research is still needed.
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