☆ 4.7 Review

Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review

BIOMOLECULES (2023)

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Article Oncology

Lenalidomide treatment for recurrent adult T-cell leukemia/lymphoma after allogeneic hematopoietic cell transplantation

Takashi Tanaka et al.

Summary: This study retrospectively evaluated the efficacy and safety of lenalidomide in patients with recurrent adult T-cell leukemia/lymphoma after allogeneic hematopoietic cell transplantation. The results showed that lenalidomide may improve survival and administering lenalidomide before mogamulizumab treatment may enhance efficacy.

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Article Virology

Advances in the treatment of HTLV-1-associated adult T-cell leukemia lymphoma

Adrienne A. Phillips

Summary: Adult T-cell leukemia/lymphoma (ATLL) is a refractory hematologic malignancy associated with HTLV-1 infection. The oncogenic viral genes Tax and Hbz are implicated in the oncogenesis of ATLL. Current therapies have poor outcomes, with allogeneic hematopoietic stem cell transplant being the only curative treatment option. Ongoing research efforts are needed to improve survival rates and develop better therapeutic approaches for ATLL.

CURRENT OPINION IN VIROLOGY (2023)

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Article Immunology

Epidemiological Evidence of Nosocomial and Zoonotic Transmission of Human T-Cell Leukemia Virus-1 in a Large Survey in a Rural Population of Central Africa

Jill Lea Ramassamy et al.

Summary: This study investigated the prevalence of HTLV-1 and associated risk factors in a rural population in Cameroon. The results suggest both iatrogenic and zoonotic transmission of HTLV-1 in Cameroon. Further research is needed to assess the risk of nosocomial transmission and guide the implementation of preventive measures.

JOURNAL OF INFECTIOUS DISEASES (2023)

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Article Oncology

Live attenuated VZV vaccination induces antitumor immunity in ATLL patients

Tatsuro Jo et al.

Summary: This study investigated whether vaccination with live attenuated varicella-zoster virus (VZV) can activate HTLV-1 Tax-specific cellular immune response in patients with ATLL. The results showed that after VZV vaccination, there was a significant increase in HTLV-1 Tax-specific CTLs percentage in aggressive-type ATLL patients.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2023)

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Article Hematology

Current and emerging therapeutic strategies in adult T-cell leukemia-lymphoma

Hiroo Katsuya

Summary: Adult T-cell leukemia-lymphoma (ATL) is a heterogeneous disease with different clinical subtypes. Aggressive ATL requires more intensive treatments and allogeneic hematopoietic stem cell transplantation can be a potential cure. Recent advances in reduced-intensity conditioning regimens and the availability of new drugs have significantly improved the therapeutic strategies for aggressive ATL. This article provides an overview of these recent advances.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2023)

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Review Biochemistry & Molecular Biology

How Can We Prevent Mother-to-Child Transmission of HTLV-1?

Kazuo Itabashi et al.

Summary: The perception of HTlV-1 infection as a silent disease has shifted, as it is now believed to have various effects. It causes ATL, an aggressive cancer, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Mother-to-child transmission of HTLV-1 primarily occurs through breastfeeding, but short-term breastfeeding does not increase transmission rate compared to artificial nutrition. Therefore, clinical applications of antiretroviral drugs and immunotherapy are urgently needed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Oncology

Role of tumor microenvironment in cancer progression and therapeutic strategy

Qingjing Wang et al.

Summary: Cancer is now recognized as a disease influenced by the tumor microenvironment (TME) rather than just a cellular and genetic disorder. Significant progress has been made in understanding the complexity of the TME and its impact on various anticancer therapies, particularly immunotherapies. Immunotherapy has shown promising therapeutic effects in treating solid tumors and hematological malignancies by leveraging the body's immune system to target and eliminate cancer cells. Recent advancements include the use of PD-1 and PD-L1 inhibitors, CAR-T cell therapy, and tumor vaccines. The TME plays a crucial role in tumor development, progression, and metastasis, making it an important focus for cancer immunotherapy research.

CANCER MEDICINE (2023)

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Macrophages in immunoregulation and therapeutics

Shanze Chen et al.

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SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

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Review Microbiology

Clinical and Public Health Implications of Human T-Lymphotropic Virus Type 1 Infection

Nicolas Legrand et al.

Summary: Human T-lymphotropic virus type 1 (HTLV-1) is a global viral infection that affects an estimated 5 to 10 million people and can lead to severe and potentially fatal diseases. The infection is geographically concentrated, with high prevalence in specific regions and populations. Despite screening in high-income countries, there is a lack of public health measures to prevent HTLV-1 infection. This review emphasizes the need for further research and collaboration to improve prevention, management, and awareness of HTLV-1 infection.

CLINICAL MICROBIOLOGY REVIEWS (2022)

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Review Virology

HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread

Svetlana Kalinichenko et al.

Summary: So far, only HIV and HTLV-1 have been recognized as pathogenic retroviruses for humans. These viruses primarily infect CD4+ T lymphocytes and are transmitted between individuals through various modes of transmission.

VIRUSES-BASEL (2022)

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Article Hematology

Beneficial impact of first-line mogamulizumab-containing chemotherapy in adult T-cell leukaemia-lymphoma

Takafumi Shichijo et al.

Summary: This retrospective study analyzed the clinical outcomes of 39 transplant-ineligible patients with untreated aggressive ATL. The results showed that first-line Mog-containing treatment can significantly improve overall survival compared to chemotherapy alone, even in elderly patients.

BRITISH JOURNAL OF HAEMATOLOGY (2022)

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Prediction of the risk for graft versus host disease after allogeneic hematopoietic stem cell transplantation in patients treated with mogamulizumab

Yuhei Kamada et al.

Summary: In this study, it was found that ATL patients who received Mog treatment before or after allo-HSCT had a higher risk of developing severe GVHD and CMV enteritis, leading to death. The use of Mog also suppressed Treg numbers, and measuring Mog concentration and Treg numbers at the time of allo-HSCT may predict the risk of GVHD.

LEUKEMIA & LYMPHOMA (2022)

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Article Oncology

HTLV-1 Tax-specific memory cytotoxic T lymphocytes in long-term survivors of aggressive-type adult T-cell leukemia/lymphoma

Tatsuro Jo et al.

Summary: This study investigated the characteristics of long-term survivors with Adult T-cell leukemia/lymphoma (ATLL) and found that Tax-specific memory CTLs may eradicate ATLL cells and prevent ATLL relapse in the long term, possibly in conjunction with anticancer agents. Strong activation of cellular immunity, such as infection with herpes virus, appears to be necessary to induce a large number of Tax-specific CTLs.

CANCER MEDICINE (2022)

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Review Immunology

Functional and Pathogenic Roles of Retroviral Antisense Transcripts

Kosuke Toyoda et al.

Summary: This review discusses the mechanisms by which endogenous retroviruses utilize functional RNAs to evade host immune surveillance and their impact on disease pathogenesis.

FRONTIERS IN IMMUNOLOGY (2022)

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Clinical and Laboratory Outcomes in HIV-1 and HTLV-1/2 Coinfection: A Systematic Review

Iris Montano-Castellon et al.

Summary: This systematic review examined the clinical outcomes in individuals co-infected with HIV-1 and HTLV-1/HTLV-2. The results showed that co-infected patients had shorter survival, higher mortality rate, and faster disease progression compared to those with mono-infections. Additionally, co-infected patients were more likely to have certain diseases and neurological manifestations. The findings highlight the urgent need for prevention, control measures, and comprehensive care for individuals with HIV-1 and HTLV-1/HTLV-2 co-infections.

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HTLV-2 Enhances CD8+ T Cell-Mediated HIV-1 Inhibition and Reduces HIV-1 Integrated Proviral Load in People Living with HIV-1

Maria Abad-Fernandez et al.

Summary: Individuals coinfected with HIV-1 and HTLV-2 exhibit slower CD4(+) T cell depletion, natural control of HIV-1, and lower mortality rates. The infection may benefit by increasing CD8(+) T cell-mediated HIV-1 inhibition and cytolytic factors, leading to lower HIV-1 viral load.

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HTLV-1 Coinfection among Patients Attending a Large HIV Treatment Centre in Trinidad

Robert Jeffrey Edwards et al.

Summary: Studies have shown that HIV-1/HTLV-1 coinfected patients tend to have higher CD4+ counts than HIV singly infected patients. This study conducted chart reviews at a large HIV Clinic in Trinidad to determine the prevalence of HIV-1/HTLV-1 coinfection and compare the CD4+ counts and opportunistic infections among coinfected patients and HIV-1 singly infected patients. The results showed that coinfected patients had higher HIV-1 viral loads and a higher rate of opportunistic infections compared to singly infected patients, indicating a worse prognosis.

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Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia

Hiba El Hajj et al.

Summary: This review explores the interplay between HTLV-1 and its associated pathologies, as well as the crucial role of the host immune system in controlling HTLV-1-associated diseases and treatment response. It focuses on the viral oncoproteins Tax and HBZ in evading the host innate immune response and provides an overview of the function of innate immunity in preclinical and clinical settings.

FRONTIERS IN IMMUNOLOGY (2022)

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Co-Infection and Cancer: Host-Pathogen Interaction between Dendritic Cells and HIV-1, HTLV-1, and Other Oncogenic Viruses

Tania H. Mulherkar et al.

Summary: Dendritic cells play a crucial role in the infections of HIV-1 and HTLV-1 and are associated with neurodegenerative diseases and cancer. Infected dendritic cells can transmit the infection to other cells and contribute to the development of neurodegenerative diseases. Current vaccines and therapies targeting host-pathogen interactions can be applied to patients with these diseases.

VIRUSES-BASEL (2022)

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Review Virology

HTLV-1's Foxy Strategy for Survival and Transmission

Yusuke Higuchi et al.

Summary: Human T-cell leukemia virus type 1 (HTLV-1) possesses multiple strategies, such as minimizing Tax production and transforming infected cell phenotype with HBZ, to evade host immune surveillance and promote infected cell proliferation.

FRONTIERS IN VIROLOGY (2022)

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Review Infectious Diseases

Human T-cell lymphotropic virus type-1: a lifelong persistent infection, yet never truly silent

Ashley Hirons et al.

Summary: HTLV-1 has a significant global burden, especially in certain communities, with a lack of effective treatments and vaccines currently available.

LANCET INFECTIOUS DISEASES (2021)

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Article Biochemistry & Molecular Biology

Involvement of EZH2 inhibition in lenalidomide and pomalidomide-mediated growth suppression in HTLV-1-infected cells

Nobuyo Kondo et al.

Summary: The immunomodulatory imide drugs show antitumor effects in T-cell leukemia/lymphoma caused by HTLV-1 by reducing key protein expression and affecting histone modification levels. The mechanism underlying the antitumor effects of IMiDs involves a reduction of EZH2 expression.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Review Oncology

Adult T-Cell Leukemia: a Comprehensive Overview on Current and Promising Treatment Modalities

Rita Hleihel et al.

Summary: ATL is a highly aggressive and chemo-resistant malignancy caused by HTLV-1 retrovirus. Current treatments have limitations and the prognosis remains poor. Targeted therapies focusing on HTLV-1 viral replication and regulatory proteins, as well as host antiviral immunity, show promise in treating ATL.

CURRENT ONCOLOGY REPORTS (2021)

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Review Oncology

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Haixiang Shen et al.

Summary: High expression of CD68+ TAMs and M2-TAMs are risk factors for poor prognosis in ccRCC patients. TAMs' high density is associated with advanced clinicopathological features in ccRCC. TAMs could be potential biomarkers for prognosis and novel targets for immunotherapy in ccRCC.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Mother-to-Child Transmission of Human T-Cell Leukemia Virus Type 1: Mechanisms and Nutritional Strategies for Prevention

Kazuo Itabashi et al.

Summary: Mother-to-child transmission of HTLV-1 is a major cause of adult T-cell leukemia, with Japan implementing antibody screening for pregnant women in 2010. Short-term breastfeeding (<= 3 months) has been shown to prevent MTCT effectively, while prolonged breastfeeding increases the risk.

CANCERS (2021)

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Article Oncology

Real-World Data on Adult T-Cell Leukemia/Lymphoma in Latin America: A Study From the Grupo de Estudio Latinoamericano de Linfoproliferativos

Luis Malpica et al.

Summary: This study analyzed patients with ATLL in 11 Latin American countries between 1995 and 2019 and found that most patients were from Peru, Chile, Argentina, and Colombia. The median survival times for acute, lymphomatous, chronic, and smoldering forms were reported, with acute type having the shortest median survival. Progression-free survival rates were also reported for different treatment options in different ATLL subtypes.

JCO GLOBAL ONCOLOGY (2021)

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Review Hematology

Tumor microenvironment of adult T-cell leukemia/lymphoma

Mai Takeuchi et al.

Summary: Adult T-cell leukemia/lymphoma (ATLL) is a malignancy caused by human T-cell leukemia virus type 1, with aggressive ATLL being refractory to conventional chemotherapy and having a poor prognosis. Better therapeutic approaches, including cancer immunotherapy, are needed to improve survival and prognosis. The genetic landscape of ATLL shows frequent genetic alterations in genes associated with immune surveillance, and clinicopathological investigations reveal complex tumor immunity mechanisms in ATLL.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY (2021)

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Article Medicine, Research & Experimental

HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma

Benjy J. Y. Tan et al.

Summary: This study used single-cell sequencing to investigate the differentiation and malignant transformation of T cells infected with HTLV-1. The results showed that HTLV-1-infected cells in an activated state can further transform into ATL cells, which are clonally expanded and highly activated. Additionally, ATL cells exhibit Treg signatures, indicating immune escape mechanisms at the single-cell level.

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Single-Cell Analysis of the Multicellular Ecosystem in Viral Carcinogenesis by HTLV-1

Junji Koya et al.

Summary: The study comprehensively dissected cellular and molecular alterations in HTLV-1 infection, revealing insights into clonal evolution and immune landscape. It not only sheds light on premalignant clonal expansion in viral carcinogenesis, but also helps devise novel diagnostic and therapeutic strategies for HTLV-1-related disorders.

BLOOD CANCER DISCOVERY (2021)

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Tumor-infiltrating lymphocytes in the immunotherapy era

Sterre T. Paijens et al.

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CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Masao Matsuoka et al.

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Jun-ichirou Yasunaga

FRONTIERS IN MICROBIOLOGY (2020)

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Eriko Yanagida et al.

HEMATOLOGICAL ONCOLOGY (2020)

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Kunihiro Tsukasaki et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Adult T-cell leukemia/lymphoma incidence rate in French Guiana: a prospective cohort of women infected with HTLV-1

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Takashi Ishida et al.

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Indolent, waxing and waning cutaneous presentation of HTLV-1-associated adult T-cell leukemia/lymphoma in an HIV-1-positive patient

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HAEMATOLOGICA (2017)

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HTLV-1 Tax activates HIV-1 transcription in latency models

Victor Emmanuel Viana Geddes et al.

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HAEMATOLOGICA (2017)

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HTLV-1 is predominantly sexually transmitted in Salvador, the city with the highest HTLV-1 prevalence in Brazil

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PLOS ONE (2017)

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CANCER SCIENCE (2017)

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Multicenter Phase II Study of Lenalidomide in Relapsed or Recurrent Adult T-Cell Leukemia/Lymphoma: ATLL-002

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Kenji Sugata et al.

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Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T cell leukaemia/lymphoma in a pilot study

Youko Suehiro et al.

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Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan

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Defucosylated Humanized Anti-CCR4 Monoclonal Antibody KW-0761 as a Novel Immunotherapeutic Agent for Adult T-cell Leukemia/Lymphoma

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HLA Class I Binding of HBZ Determines Outcome in HTLV-1 Infection

Aidan MacNamara et al.

PLOS PATHOGENS (2010)

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Article Hematology

Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders

Kazuko Azakami et al.

BLOOD (2009)

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Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting

Kunihiro Tsukasaki et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

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Article Biotechnology & Applied Microbiology

HBZ is an immunogenic protein, but not a target antigen for human T-cell leukemia virus type 1-specific cytotoxic T lymphocytes

Koichiro Suemori et al.

JOURNAL OF GENERAL VIROLOGY (2009)

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Review Pharmacology & Pharmacy

Lenalidomide in the treatment of multiple myeloma: a review

X. Armoiry et al.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2008)

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Adult T-cell leukaemia/lymphoma

E. Matutes

JOURNAL OF CLINICAL PATHOLOGY (2007)

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Article Public, Environmental & Occupational Health

Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis

Eduardo Gotuzzo et al.

REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH (2007)

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Article Biochemistry & Molecular Biology

A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27

Sabine Plancoulaine et al.

HUMAN MOLECULAR GENETICS (2006)

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Article Biochemistry & Molecular Biology

The HTLV-I p30 interferes with TLR4 signaling and modulates the release of pro- and anti-inflammatory cytokines from human macrophages

Abhik Datta et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells

Y Satou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Review Oncology

Tumor immunity against adult T-cell leukemia

M Kannagi et al.

CANCER SCIENCE (2005)

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Review Immunology

Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis

EM Carvalho et al.

PARASITE IMMUNOLOGY (2004)

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Article Oncology

Graft-versus-tax response in adult T-cell leukemia patients after hematopoietic stem cell transplantation

N Harashima et al.

CANCER RESEARCH (2004)

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Article Biochemistry & Molecular Biology

Involvement of IL-2/IL-2R system activation by parasite antigen in polyclonal expansion of CD4+25+ HTLV-1-infected T-cells in human carriers of both HTLV-1 and S-stercoralis

M Satoh et al.

ONCOGENE (2002)

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The contribution of NF-κB activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors

T Portis et al.

BLOOD (2001)

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Article Immunology

HLA-A26, HLA-B4002, HLA-B4006, and HLA-B4801 alleles predispose to adult T cell leukemia:: The limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8+ cytotoxic T lymphocytes

S Yashiki et al.

AIDS RESEARCH AND HUMAN RETROVIRUSES (2001)

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Article Virology

Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12I protein

JM Johnson et al.

JOURNAL OF VIROLOGY (2001)

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Article Biochemistry & Molecular Biology

High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis

AS Gabet et al.

ONCOGENE (2000)

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