☆ 4.7 Review

The Promising Potential of Reverse Vaccinology-Based Next-Generation Vaccine Development over Conventional Vaccines against Antibiotic-Resistant Bacteria

VACCINES (2023)

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Article Immunology

A Phase II/III, Multicenter, Observer-blinded, Randomized, Non-inferiority and Safety, study of typhoid conjugate vaccine (EuTCV) compared to Typbar-TCV® in healthy 6 Months-45 years aged participants

Yeong Ok Baik et al.

Summary: The typhoid conjugate vaccine (TCV) has long-lasting protective immune response and is suitable for young children. The EuTCV displayed good immunogenicity and safety in Phase I study, leading to further evaluation in Phase II/III trials. The clinical trial conducted in healthy Filipino participants showed that EuTCV had comparable safety and immunogenicity to Typbar-TCV (R), meeting the study objectives.

VACCINE (2023)

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Review Virology

Development of Next Generation Vaccines against SARS-CoV-2 and Variants of Concern

Abdul Aziz Al-Fattah Yahaya et al.

Summary: SARS-CoV-2 has caused a global pandemic, resulting in over 673 million infections and 6.85 million deaths. The current mRNA and viral-vectored vaccines have shown good efficacy against the SARS-CoV-2 Wuhan strain, but are less effective against highly transmissible variants like Omicron. Development of next-generation vaccines is urgently needed to provide broad protection.

VIRUSES-BASEL (2023)

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Review Microbiology

Anti-Pseudomonas aeruginosa Vaccines and Therapies: An Assessment of Clinical Trials

Moamen M. M. Elmassry et al.

Summary: Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that causes high morbidity and mortality in CF and immunocompromised patients, and eradicating the bacteria is difficult due to its antibiotic resistance mechanisms and virulence factors. It is considered as one of the urgently needed targets for the development of novel antibiotics by the WHO.

MICROORGANISMS (2023)

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Review Medicine, Research & Experimental

The development of DNA vaccines against SARS-CoV-2

Kanwal Khalid et al.

Summary: The COVID-19 pandemic had a significant impact on public health and the global economy. Research efforts to develop vaccines against SARS-CoV-2 led to the administration of novel mRNA, viral vectored, and inactivated vaccines. However, emerging variants of concern have reduced the efficacy of current vaccines, highlighting the need for next-generation vaccines.

ADVANCES IN MEDICAL SCIENCES (2023)

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Editorial Material Immunology

Will the mRNA vaccine platform be the panacea for the development of vaccines against antimicrobial resistant (AMR) pathogens?

Wangxue Chen

EXPERT REVIEW OF VACCINES (2022)

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Article Biochemistry & Molecular Biology

Molecular Characterization and Designing of a Novel Multiepitope Vaccine Construct Against Pseudomonas aeruginosa

Jyotirmayee Dey et al.

Summary: In this study, a computational approach was used to design a vaccine against Pseudomonas aeruginosa infection. The vaccine, containing peptides from B-cells and T-cells, showed good immunogenic and biophysical properties. Through various experiments, the vaccine demonstrated promising efficacy in preventing Pseudomonas aeruginosa infection.

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS (2022)

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Article Medicine, General & Internal

Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021

Matthew E. Oster et al.

Summary: Based on reports in the US, the risk of myocarditis after receiving mRNA-based COVID-19 vaccines was increased, especially among adolescent males and young men, particularly after the second dose. This risk should be considered in the context of the benefits of COVID-19 vaccination.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Medicine, General & Internal

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J. L. Murray et al.

Summary: Antimicrobial resistance (AMR) poses a significant threat to global human health, and this study provides the most comprehensive estimates of AMR burden to date. By estimating deaths and disability-adjusted life-years (DALYs) associated with bacterial AMR in 204 countries and territories in 2019, the study highlights the impact of resistance and the leading pathogen-drug combinations contributing to it.

LANCET (2022)

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Article Infectious Diseases

Safety and immunogenicity of the Vi-DT typhoid conjugate vaccine in healthy volunteers in Nepal: an observer-blind, active-controlled, randomised, non-inferiority, phase 3 trial

Ganesh Kumar Rai et al.

Summary: The Vi-DT vaccine showed non-inferiority compared to Vi-TT vaccine and demonstrated lot-to-lot equivalence. This suggests that the Vi-DT vaccine is safe and effective, and could be a viable option for global typhoid vaccination efforts once prequalified by the WHO.

LANCET INFECTIOUS DISEASES (2022)

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Editorial Material Urology & Nephrology

Outer membrane vesicle vaccines for Neisseria gonorrhoeae

Evgeny A. Semchenko et al.

Summary: Multidrug-resistant Neisseria gonorrhoeae is a global health issue, and the development of a vaccine is crucial for effective control. The use of outer membrane vesicle vaccines shows promise in preventing N. gonorrhoeae infection.

NATURE REVIEWS UROLOGY (2022)

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Review Immunology

The Candidate Antigens to Achieving an Effective Vaccine against Staphylococcus aureus

Hamid Reza Jahantigh et al.

Summary: Staphylococcus aureus is an opportunistic pathogen that poses a serious threat to human health due to its antibiotic resistance. The development of a prophylactic vaccine against this pathogen is crucial but has faced challenges in clinical trials. Efforts are being made to explore multiple antigens and virulence mechanisms to identify suitable candidates for vaccine development.

VACCINES (2022)

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Review Infectious Diseases

Therapeutic Strategies for Emerging Multidrug-Resistant Pseudomonas aeruginosa

Ashlan J. Kunz Coyne et al.

Summary: This review summarizes recent epidemiological, microbiological, and clinical data on the therapeutic management of MDR/XDR-Pseudomonas aeruginosa infections. Conventional antipseudomonal beta-lactam antibiotics are often ineffective due to the remarkable resistance mechanisms of P. aeruginosa. Novel agents with in vitro activity against MDR-P. aeruginosa have been approved, but comparative clinical data is limited, highlighting the need for alternative therapies.

INFECTIOUS DISEASES AND THERAPY (2022)

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Letter Immunology

Invasive Haemophilus influenza Type b in an Infant During the COVID-19 Pandemic: The Return of Diseases We Hoped Never to See Again ...

Christy Tabarani et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2022)

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Review Biotechnology & Applied Microbiology

The clinical progress of mRNA vaccines and immunotherapies

Ann J. Barbier et al.

Summary: The emergency use authorizations (EUAs) of mRNA-based vaccines against SARS-CoV-2 highlight the transformative potential of this nucleic acid technology. Clinical applications of mRNA have mainly focused on vaccines for infectious diseases and cancer, but there are challenges in using mRNA for immunotherapies. The past year has seen significant progress in the clinical development of mRNA therapies for COVID-19, as well as other diseases such as influenza, HIV, and cancer.

NATURE BIOTECHNOLOGY (2022)

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News Item Medicine, General & Internal

Meningitis vaccine could protect against gonorrhoea, studies find

Elisabeth Mahase

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Article Immunology

Development of Klebsiella pneumoniae Capsule Polysaccharide-Conjugated Vaccine Candidates Using Phage Depolymerases

Tzu-Lung Lin et al.

Summary: In this study, researchers successfully retained the immunogenicity of Klebsiella pneumoniae capsule polysaccharide (CPS) by using CPS depolymerases and developed CPS-conjugated vaccines. The vaccines induced anti-CPS antibodies and increased bactericidal activities in mice, providing protection against K. pneumoniae infections.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates

Yixin Wu et al.

Summary: This study compares the immune responses of SARS-CoV-2 mRNA and recombinant protein vaccines, showing that both vaccines can elicit high levels of antibody responses, but with bias towards different IgG subtypes. Additionally, the mRNA vaccine induces stronger cellular immune responses compared to the recombinant protein vaccine.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Designing of a Novel Multi-Antigenic Epitope-Based Vaccine against E. hormaechei: An Intergraded Reverse Vaccinology and Immunoinformatics Approach

Thamer H. Albekairi et al.

Summary: In this study, a multi-epitope-based vaccine against E. hormaechei was designed using reverse vaccinology and immunoinformatic approaches. The vaccine showed potential immune stimulation efficacy and could be a good candidate for future experimental investigations.

VACCINES (2022)

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Article Infectious Diseases

Safety and immunogenicity of VPM1002 versus BCG in South African newborn babies: a randomised, phase 2 non-inferiority double-blind controlled trial

Mark F. Cotton et al.

Summary: This study compared the safety and immunogenicity of VPM1002 and BCG in HIV exposed and unexposed newborn babies, showing that VPM1002 was less reactogenic than BCG, with differences in immunogenic responses.

LANCET INFECTIOUS DISEASES (2022)

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Review Medicine, Research & Experimental

Modern vaccine development via reverse vaccinology to combat antimicrobial resistance

Asuka Joy Tobuse et al.

Summary: With the continuous evolution of bacteria, the global health threat of antimicrobial resistance, which causes millions of deaths annually, is becoming increasingly serious. While relying on antibiotics as the primary treatment method has its advantages, effective alternatives against some drug-resistant bacteria are still lacking in the pharmaceutical market. In recent years, vaccinology has gained significant attention in scientific research, and with the advancement of technology, vaccine research has become faster and more efficient. Although less discussed, bacterial vaccines are a feasible strategy to combat antimicrobial resistance. Some vaccines have shown promising results with good efficacy against numerous multidrug-resistant strains of bacteria. This review aims to discuss the findings from studies utilizing reverse vaccinology for the development of vaccines against multidrug-resistant bacteria, as well as provide a summary of multi-year bacterial vaccine studies in clinical trials. The advantages of reverse vaccinology in generating new bacterial vaccines are also highlighted. Meanwhile, the limitations and future prospects of bacterial vaccines are concluded in this review.

LIFE SCIENCES (2022)

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Article Immunology

120. Safety, Reactogenicity, and Immunogenicity of Three Different Doses of VAC52416 (ExPEC10V) in Adults Aged 60–85 Years in a Randomized, Multicenter, Interventional, First-In-Human, Phase 1/2a Study

Joachim Doua et al.

Open Forum Infectious Diseases (2022)

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Review Microbiology

Paratyphoid Fever A: Infection and Prevention

Lei Xie et al.

Summary: This article reviews the pathogenesis, global burden, infection features, and vaccine development status of paratyphoid fever A, emphasizing the necessity for the development of vaccines against paratyphoid fever A.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Immunology

Immunoinformatics Approach Toward the Introduction of a Novel Multi-Epitope Vaccine Against Clostridium difficile

Caixia Tan et al.

Summary: In this study, a multi-epitope vaccine against Clostridium difficile was designed using computer methods. The vaccine was able to induce immune response against both spore and propagule forms of the pathogen. The structure of the vaccine was predicted and validated, and its interaction with immune receptors was analyzed through docking and simulation. The findings suggest that the formulated vaccine shows promise against C. difficile, but further research is needed for verification.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Pseudomonas aeruginosa: Recent Advances in Vaccine Development

Matthew Killough et al.

Summary: Pseudomonas aeruginosa is an important human pathogen that causes various clinical infections. However, antibiotic resistance has made treating these infections challenging and there is currently no effective vaccine available for clinical use. Despite this, there has been progress in preclinical research, but challenges still remain.

VACCINES (2022)

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Article Immunology

An In-Silico Investigation to Design a Multi-Epitopes Vaccine against Multi-Drug Resistant Hafnia alvei

Fahad M. Alshabrmi et al.

Summary: Antimicrobial resistance is a significant health issue due to antibiotic misuse, leading to high morbidity and mortality rates. This study utilized bacterial pan-genome analysis to develop a vaccine against H. alvei. Various potential vaccine targets were identified and epitope prediction was conducted. The model vaccine construct showed promising results in producing a protective immune response, making it a potential candidate for further research.

VACCINES (2022)

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Article Immunology

Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice

Mohammad Omar Faruk Shaikh et al.

Summary: In this study, the combination vaccine of PopB and OprF/I for P. aeruginosa was evaluated. The results showed that the combination vaccine induced a strong immune response and enhanced protection against acute lethal P. aeruginosa pneumonia.

INFECTION AND IMMUNITY (2022)

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Article Multidisciplinary Sciences

Identification and construction of a multi-epitopes vaccine design against Klebsiella aerogenes: molecular modeling study

Sami I. Alzarea

Summary: This study identified vaccine candidates for Klebsiella aerogene using reverse vaccinology, and confirmed the stable binding between the vaccine and receptors through molecular docking and molecular dynamics simulations. The binding energies of the complex were also calculated.

SCIENTIFIC REPORTS (2022)

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Review Public, Environmental & Occupational Health

Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis

Leonardo Martinez et al.

Summary: This study aimed to investigate the age-specific impact of infant BCG vaccination on tuberculosis development and mortality. Through a systematic review and meta-analysis, the effectiveness of BCG vaccination was found to be significant in preventing tuberculosis in children younger than 5 years, but ineffective in adolescents and adults.

LANCET GLOBAL HEALTH (2022)

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Article Public, Environmental & Occupational Health

Safety and immunogenicity of a typhoid conjugate vaccine among children aged 9 months to 12 years in Malawi: a nested substudy of a double-blind, randomised controlled trial

Nginache Nampota-Nkomba et al.

Lancet Global Health (2022)

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Article Immunology

Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunity

Amir Ghaemi et al.

Summary: This study designed and developed a recombinant vaccine candidate using a formulated combination of recombinant RBD and N proteins. The results showed that the vaccine induced specific immune responses, including the production of neutralizing antibodies and increased T cell response, suggesting its potential as a long-lasting and strong vaccine against SARS-CoV-2.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Immunogenicity and protective efficacy of the recombinant Pastureland multocida lipoproteins VacJ and PlpE, and outer membrane protein H from P. multocida A:1 in ducks

Yajuan Li et al.

Summary: This study successfully cloned and expressed three proteins of the duck cholera pathogen, and formulated subunit and killed vaccines. The results demonstrated that the subunit vaccines generated significant antibody responses and provided varying degrees of protection. These findings indicate the potential of recombinant PlpE or OmpH fusion proteins as vaccine candidates for duck cholera.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Reverse vaccinology approach to design a novel multi-epitope vaccine candidate against COVID-19: an in silico study

Maryam Enayatkhani et al.

Summary: This study utilized bioinformatics approaches to design a novel multi-epitope vaccine against the novel Coronavirus, potentially triggering multiple immune responses. Computational tools were used to validate the biological activities of the vaccine, predict the binding of the protein candidate with Toll-like receptor 4 and HLA-A*11:01, and molecular dynamics simulation was employed to evaluate the stability of the designed fusion protein with the receptors.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Article Infectious Diseases

Safety, immunogenicity, and efficacy of a Clostridioides difficile toxoid vaccine candidate: a phase 3 multicentre, observer-blind, randomised, controlled trial

Guy de Bruyn et al.

Summary: A phase 3 multicentre, observer-blind, randomised, controlled trial was conducted to evaluate the efficacy, immunogenicity, and safety of a toxoid vaccine candidate for Clostridioides difficile infection. However, the study was terminated after showing that the bivalent C difficile toxoid vaccine did not prevent C difficile infection, leading to the discontinuation of its clinical development.

LANCET INFECTIOUS DISEASES (2021)

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Article Medicine, Research & Experimental

A recombinant selective drug-resistant M. bovis BCG enhances the bactericidal activity of a second-line anti-tuberculosis regimen

Gift Chiwala et al.

Summary: The study evaluated the therapeutic efficacy of a recombinant drug-resistant BCG vaccine against drug-resistant tuberculosis, demonstrating the stability, safety, and effectiveness of RdrBCG-I in murine models. Results suggest that the recombinant drug-resistant BCG strategy could be a promising concept for developing therapeutic vaccines against DR-TB.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Biochemistry & Molecular Biology

Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa

Telma de Sousa et al.

Summary: In recent years, the effectiveness of antimicrobials in the treatment of Pseudomonas aeruginosa infections has decreased, with its high pathogenicity, multi-resistance, and biofilm production posing challenges for treatment. Deeper understanding of its pathogenicity factors and development of more targeted therapies are needed for effective treatment against this pathogen.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biotechnology & Applied Microbiology

Safety and immunogenicity of an adjuvanted Escherichia coli adhesin vaccine in healthy women with and without histories of recurrent urinary tract infections: results from a first-in-human phase 1 study

Gary R. Eldridge et al.

Summary: This study focused on developing a vaccine to prevent recurrent urinary tract infections caused by gram-negative bacteria. The phase 1 trial showed good tolerability and immunogenicity of the vaccine, leading to the initiation of a phase 2 trial.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

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Article Microbiology

Performance of a Four-Antigen Staphylococcus aureus Vaccine in Preclinical Models of Invasive S. aureus Disease

Ingrid L. Scully et al.

Summary: The SA4Ag vaccine showed protective effects in experimental animal models against invasive S. aureus infection, reducing bacterial burden in deep tissue infection, bacteremia, and pyelonephritis models, and preventing infection in a model of infectious endocarditis. However, clinical utility of SA4Ag in preventing surgery-associated invasive S. aureus infection was not proven.

MICROORGANISMS (2021)

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Review Pharmacology & Pharmacy

Recombinant protein vaccines, a proven approach against coronavirus pandemics

Jeroen Pollet et al.

Summary: This article points out that recombinant protein vaccines may become a favorable option in the context of the COVID-19 pandemic, despite being overlooked in early development, they may offer an advantage or complement under the current circumstances.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Infectious Diseases

Global Tuberculosis Report 2020-Reflections on the Global TB burden, treatment and prevention efforts

Jeremiah Chakaya et al.

Summary: The global TB report for October 2020 highlights slow progress in TB control efforts and the need to ramp up screening and diagnostic test services. Key drivers of TB, including undernutrition, poverty, diabetes, tobacco smoking, and household air pollution, must be addressed to achieve WHO 2035 TB care and prevention targets. Global focus is needed on the development of new vaccines for TB using new technological methods.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Editorial Material Biotechnology & Applied Microbiology

Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines

S. Moein Moghimi

MOLECULAR THERAPY (2021)

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Review Immunology

Endogenous complement human serum bactericidal assay (enc-hSBA) for vaccine effectiveness assessments against meningococcal serogroup B

Annett Kleinschmidt et al.

Summary: The study evaluated the immunogenicity of vaccines against meningococcal serogroup B, finding that the enc-hSBA method can provide a more accurate estimation of vaccine effectiveness and has been validated for use with a wide range of prevalent strains.

NPJ VACCINES (2021)

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Letter Allergy

Polyethylene glycol (PEG) is a cause of anaphylaxis to the Pfizer/BioNTech mRNA COVID-19 vaccine

Priya Sellaturay et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

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Review Immunology

Effects of SARS-CoV-2 variants on vaccine efficacy and response strategies

Lianlian Bian et al.

Summary: The global spread of the SARS-CoV-2 pandemic has led to the emergence of several variants, posing challenges to vaccine efficacy. However, some vaccines have shown advantages in providing protection against certain variants. Response strategies have been proposed to address the challenges posed by emerging variants, including accelerating the rollout of current vaccines, enhancing vaccine immunogenicity, and developing next-generation vaccines targeting the variants.

EXPERT REVIEW OF VACCINES (2021)

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Review Public, Environmental & Occupational Health

Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects

Tanvir Mahtab Uddin et al.

Summary: Antibiotics have been a crucial tool in treating bacterial infections for over 70 years, but the rise of multidrug-resistant bacteria has posed a significant challenge, necessitating the discovery of innovative medicinal approaches and antimicrobial therapies. Further research and development in combating antibiotic resistance are vital in addressing the emerging threat of antimicrobial resistance.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2021)

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Review Biochemistry & Molecular Biology

Bacterial Membrane Vesicles in Pneumonia: From Mediators of Virulence to Innovative Vaccine Candidates

Felix Behrens et al.

Summary: Respiratory infection-induced pneumonia is the leading cause of death in global infectious diseases, with antibiotics and vaccines helping to reduce the burden. However, lack or refusal of vaccines and antibiotics in some regions, the rise of multidrug-resistant pathogens, and high fatality rates even in patients treated appropriately pose a global threat. Bacteria's secretome contains extracellular vesicles that can trigger inflammatory responses and serve as promising vaccine candidates.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Engineering a Novel Bivalent Oral Vaccine against Enteric Fever

Annelise Soulier et al.

Summary: The study developed a novel bivalent oral vaccine to protect against enteric fever caused by Salmonella serovars Typhi and Paratyphi A. By genetically engineering the attenuated S. Typhi ZH9 strain to introduce S. Paratyphi A immunogenic elements, a new vaccine candidate was created. This new bivalent vaccine is now being tested in a Phase I clinical trial.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Immunology

mRNA vaccines manufacturing: Challenges and bottlenecks

Sara Sousa Rosa et al.

Summary: mRNA vaccines are emerging as a new alternative to conventional vaccines, with their precision, safety profile, and flexible manufacturing. They have been used to combat the Covid-19 pandemic and are being studied for other diseases as well. However, challenges in manufacturing, technology platform, and cost-effective production need to be addressed to fully utilize this new vaccination technology.

VACCINE (2021)

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Article Infectious Diseases

Development of Multi-epitope Subunit Vaccine Against Pseudomonas aeruginosa Using OprF/OprI and PopB Proteins

Fattaneh Sabzehali et al.

Summary: This study developed a potential vaccine against Pseudomonas aeruginosa using reverse vaccinology methods, consisting of OprF/OprI and PopB with multi-epitopes. The vaccine showed optimal physicochemical properties, high expression levels in E. coli, and the ability to induce immune responses against the microorganism. Validation of the efficacy and safety of the vaccine design is required to inhibit Pseudomonas infections experimentally.

ARCHIVES OF CLINICAL INFECTIOUS DISEASES (2021)

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Article Immunology

Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT™ adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice

Chih-Yun Lai et al.

Summary: The rapid development of COVID-19 vaccines has been unprecedented, but ensuring global vaccination coverage remains a challenge. This study examined the immunogenicity of insect-cell expressed SARS-CoV-2 spike protein ectodomain constructs in mice.

VACCINE: X (2021)

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Article Infectious Diseases

Designing multi-epitope vaccine candidates against functional amyloids in Pseudomonas aeruginosa through immunoinformatic and structural bioinformatics approach

Ayesha Z. Beg et al.

Summary: Pseudomonas aeruginosa displays high drug resistance and biofilm-mediated adaptability, making infections difficult to treat. Studying the biofilm component Fap has led to the identification of potential intervention targets, with vaccine candidates showing promising immunostimulation effects.

INFECTION GENETICS AND EVOLUTION (2021)

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Review Medical Laboratory Technology

Analysis of COVID-19 vaccines: Types, thoughts, and application

Xiucui Han et al.

Summary: This article summarizes the efforts made by various countries to deal with COVID-19, discusses the development and application of COVID-19 vaccines, and highlights the issues that need attention in vaccine development.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Immunology

Mucosal Immune Responses Against an Oral Enterotoxigenic Escherichia coli Vaccine Evaluated in Clinical Trials

Ann-Mari Svennerholm et al.

Summary: The ETVAX oral vaccine demonstrated the potential to induce strong mucosal immune responses in a majority of vaccinated Swedish adults and individuals of different age groups, including infants, in Bangladesh, showing promise in combating enterotoxigenic Escherichia coli infections.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Immunology

Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries

Mila Shakya et al.

Summary: Low- and middle-income countries have a high burden of typhoid and paratyphoid fever due to poor water quality and inadequate sanitation. WHO recommends TCV and Gavi supports its introduction, with 2 WHO-prequalified TCVs currently available. Considering disease burden, countries should assess and consider introducing TCV for programmatic use.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Immunology

MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG

Carlos Martin et al.

Summary: BCG has been a key inspiration for the development of numerous new TB vaccine candidates, with MTBVAC as one of them. MTBVAC, based on a live-attenuated Mycobacterium tuberculosis clinical isolate, is set to begin Phase 3 efficacy trials in TB-endemic countries. Recent studies suggest that MTBVAC can induce trained immunity and confer non-specific heterologous protection similar to BCG, showing promising potential for long-term TB eradication programs.

VACCINE (2021)

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Review Immunology

Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

Jonah Clegg et al.

Summary: Staphylococcus aureus is a significant human pathogen with high antibiotic resistance, necessitating the development of new interventions like vaccines and new antibiotics. Current research is focused on discovering novel vaccine formulations and correlates of protection, as well as developing bacteriophages, monoclonal antibodies, centyrins, and new classes of antibiotics. The complex nature of the diseases caused by this pathogen will require a multi-faceted approach using various interventions.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Microbiology

Klebsiella pneumoniae Lipopolysaccharides Serotype O2afg Induce Poor Inflammatory Immune Responses Ex Vivo

Matteo Bulati et al.

Summary: Multidrug resistant Klebsiella pneumoniae with LPS O2afg serotypes are able to evade the initial inflammatory immune response and systematically spread inside the host, resulting in various pathologies associated with this bacterium.

MICROORGANISMS (2021)

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Article Immunology

A Phase 2 Study Evaluating the Safety, Tolerability, and Immunogenicity of Two 3-Dose Regimens of a Clostridium difficile Vaccine in Healthy US Adults Aged 65 to 85 Years

Nicholas Kitchin et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Article Infectious Diseases

Safety and immunogenicity of the oral, inactivated, enterotoxigenic Escherichia coli vaccine ETVAX in Bangladeshi children and infants: a double-blind, randomised, placebo-controlled phase 1/2 trial

Firdausi Qadri et al.

LANCET INFECTIOUS DISEASES (2020)

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Review Biotechnology & Applied Microbiology

Yeast synthetic biology for designed cell factories producing secretory recombinant proteins

Eun Jung Thak et al.

FEMS YEAST RESEARCH (2020)

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Article Multidisciplinary Sciences

Prevention of tuberculosis in macaques after intravenous BCG immunization

Patricia A. Darrah et al.

NATURE (2020)

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Article Microbiology

A live auxotrophic vaccine confers mucosal immunity and protection against lethal pneumonia caused by Pseudomonas aeruginosa

Maria P. Cabral et al.

PLOS PATHOGENS (2020)

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Review Urology & Nephrology

Could sublingual vaccination be a viable option for the prevention of recurrent urinary tract infection in Canada? A systematic review of he current literature and plans for the future

J. Curtis Nickel et al.

CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL (2020)

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Article Multidisciplinary Sciences

Immunogenicity of a DNA vaccine candidate for COVID-19

Trevor R. F. Smith et al.

NATURE COMMUNICATIONS (2020)

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Review Immunology

Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection

Malihe Masomian et al.

VACCINES (2020)

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Review Public, Environmental & Occupational Health

Associations among Water, Sanitation, and Hygiene, and Food Exposures and Typhoid Fever in Case-Control Studies: A Systematic Review and Meta-Analysis

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A D-Alanine auxotrophic live vaccine is effective against lethal infection caused by Staphylococcus aureus

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MTBVAC vaccine is safe, immunogenic and confers protective efficacy against Mycobacterium tuberculosis in newborn mice

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TUBERCULOSIS (2016)

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Safety and immunogenicity of a trivalent recombinant PcpA, PhtD, and PlyD1 pneumococcal protein vaccine in adults, toddlers, and infants: A phase I randomized controlled study

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Cholera Toxin Subunit B as Adjuvant-An Accelerator in Protective Immunity and a Break in Autoimmunity

Thomas Stratmann

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Antibodies for Treatment of Clostridium difficile Infection

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EXPERT REVIEW OF VACCINES (2014)

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VACCINE (2013)

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Sara M. Soto

VIRULENCE (2013)

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A Three-Dose Intramuscular Injection Schedule of Anthrax Vaccine Adsorbed Generates Sustained Humoral and Cellular Immune Responses to Protective Antigen and Provides Long-Term Protection against Inhalation Anthrax in Rhesus Macaques

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EXPERT REVIEW OF VACCINES (2012)

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NDV-3, a recombinant alum-adjuvanted vaccine for Candida and Staphylococcus aureus, is safe and immunogenic in healthy adults

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Annaliesa S. Anderson et al.

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Mycobacterium bovis BCG-Mediated Protection against W-Beijing Strains of Mycobacterium tuberculosis Is Diminished Concomitant with the Emergence of Regulatory T Cells

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CLINICAL AND VACCINE IMMUNOLOGY (2011)

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Refinement of a Human Challenge Model for Evaluation of Enterotoxigenic Escherichia coli Vaccines

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CLINICAL AND VACCINE IMMUNOLOGY (2011)

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Aluminum Vaccine Adjuvants: Are they Safe?

L. Tomljenovic et al.

CURRENT MEDICINAL CHEMISTRY (2011)

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Haemophilus influenzae Infections in the H. influenzae Type b Conjugate Vaccine Era

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VIRULENCE (2011)

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Global Trends in Typhoid and Paratyphoid Fever

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Rationalizing the development of live attenuated virus vaccines

Adam S. Lauring et al.

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Quadrivalent meningococcal ACYW-135 glycoconjugate vaccine for broader protection from infancy

David Pace

EXPERT REVIEW OF VACCINES (2009)

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The type III secretion system of Pseudomonas aeruginosa: infection by injection

Alan R. Hauser

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MVA.85A Boosting of BCG and an Attenuated, phoP Deficient M. tuberculosis Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques

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PLOS ONE (2009)

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Engineering attenuated virus vaccines by controlling replication fidelity

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DNA vaccines: ready for prime time?

Michele A. Kutzler et al.

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BCG vaccination confers poor protection against M-tuberculosis HN878-induced central nervous system disease

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VACCINE (2007)

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The Neisseria meningitidis capsule is important for intracellular survival in human cells

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Effect of aluminum hydroxide adjuvant and formaldehyde in the formulation of rPA anthrax vaccine

S. F. Little et al.

VACCINE (2007)

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Effect of BCG vaccination on childhood tuberculous meningitis and miliarytuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness

BB Trunz et al.

LANCET (2006)

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Typhoid and paratyphoid fever in travellers

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LANCET INFECTIOUS DISEASES (2005)

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Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin

L Grode et al.

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The novel oral typhoid vaccine M01ZH09 is well tolerated and highly immunogenic in 2 vaccine presentations

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JOURNAL OF INFECTIOUS DISEASES (2005)

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Engineering N-linked protein glycosylation with diverse O antigen lipopolysaccharide structures in Escherichia coli

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