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Article
Medicine, General & Internal
Valentina Cossiga et al.
Summary: The low response to vaccines is a well-known problem in cirrhosis. We evaluated the safety and immunogenicity of booster doses in patients with chronic liver disease (CLD), comparing the humoral response in cirrhotic vs. non-cirrhotic patients, and the impact of different factors on immune response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ingmar Schaefer et al.
Summary: Concerns about adverse effects can affect the uptake of COVID-19 vaccination. Research suggests that positive and negative expectations prior to vaccination are associated with systemic adverse effects. Understanding these associations can improve clinician-patient interactions and public vaccine campaigns.
Article
Biochemistry & Molecular Biology
Karolina Wegrzynska et al.
Summary: Accurate and rapid identification of COVID-19 is critical. The GenBody COVID-19 Ag rapid antigen tests showed high sensitivity and specificity, making them suitable for diagnosis and timely isolation and treatment of COVID-19 patients, contributing to the better control of virus spread.
Article
Biochemistry & Molecular Biology
Katharina Roltgen et al.
Summary: During the SARS-CoV-2 pandemic, different vaccines have been used globally. This study compares the antibodies generated by mRNA vaccines, infection, and other types of vaccines. It shows that mRNA vaccines result in a better antibody breadth against viral variants compared to infection. Infection leads to variant-specific antibodies, while mRNA vaccination imprints responses towards the original virus strain. mRNA vaccines also stimulate robust germinal centers in lymph nodes, enhancing the immune response.
Article
Biochemistry & Molecular Biology
Alexandra C. Walls et al.
Summary: Breakthrough infections induce more potent and durable antibody responses compared to those in unvaccinated individuals, providing better protection against spike mutations in variants. Multiple exposures to SARS-CoV-2 antigen enhance the quality of antibody responses. Developing vaccines with broad sarbecovirus immunity is crucial for pandemic preparedness.
Article
Immunology
Timothy A. Bates et al.
Summary: This study found that individuals who previously recovered from COVID-19 and received vaccination (hybrid immunity) have enhanced immune responses. The effects of post-vaccination breakthrough infections on humoral immune response needs further investigation. However, regardless of whether it occurs before or after vaccination, natural infection substantially boosts the quantity, quality, and breadth of humoral immune response.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
John T. Bates et al.
Summary: This study found that BMI did not significantly impact vaccine immunogenicity 50 and 200 days post-vaccination. Additionally, antibody titers had declined by approximately 90% in all groups 200 days post-vaccination.
Article
Immunology
Ioanna Voulgaridi et al.
Summary: The study compared mRNA vaccine BNT162b2 with adenovirus vector-based vaccines in terms of adverse reactions, immunogenicity, and protection against COVID-19. Both types of vaccines caused mild side-effects and induced adequate antibody responses. However, BNT162b2 showed superior intensity of antibody responses and better protection against severe COVID-19.
Review
Urology & Nephrology
Chiara Cantarelli et al.
Summary: People with end-stage kidney disease have a lower rate of response to COVID-19 vaccination, increasing their risk of severe infection. Chronic kidney failure and immunosuppressive therapies impair their immune responses, leading to poor outcomes.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Karolina Wegrzynska et al.
Summary: This study in Poland conducted rapid identification of SARS-CoV-2 variants, revealing the distribution of Alpha, Delta, Kappa, and Omicron variants changed over time, providing insights into the epidemiological trends of the pandemic.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Dagny Lorent et al.
Summary: The study on the seroprevalence of SARS-CoV-2 infection among healthcare workers showed an overall increase in infection rate after vaccination. The antibody levels were correlated with disease severity post-infection and vaccination.
Article
Infectious Diseases
Pnina Shitrit et al.
Summary: An outbreak of SARS-CoV-2 Delta variant in a hospital infected 42 patients, staff, and family members, with 39 being fully vaccinated. The attack rate was relatively high, raising concerns about waning immunity.
Article
Medicine, General & Internal
Sara Y. Tartof et al.
Summary: This study aimed to assess the overall and variant-specific effectiveness of the BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19-related hospital admissions among members of a healthcare system in California. The effectiveness of the vaccine remained high against hospital admissions even up to 6 months after full vaccination, despite a decline in effectiveness against SARS-CoV-2 infections over time, which was likely due to waning immunity rather than the delta variant escaping vaccine protection.
Article
Medicine, General & Internal
Noam Barda et al.
Summary: A study using data from Israel's largest health-care organization showed that a third dose of the BNT162b2 mRNA vaccine is effective in preventing individuals from severe COVID-19-related outcomes, compared to receiving only two doses at least 5 months ago. The effectiveness of the third dose in preventing hospital admission was 93%, severe disease 92%, and COVID-19-related death 81%.
Article
Medicine, General & Internal
Einav G. Levin et al.
Summary: A study in Israel revealed that waning immunity after receiving two doses of the BNT162b2 vaccine led to an increase in the incidence of SARS-CoV-2 infection. Levels of spike-binding IgG and neutralizing antibodies decreased more significantly in men, individuals aged 65 or older, and immunosuppressed individuals in a longitudinal study involving nearly 4000 healthcare workers.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Magdalena Komiazyk et al.
Summary: This study evaluated two RNA extraction methods and four commercial RT-qPCR assays for detecting SARS-CoV-2 in human upper respiratory tract specimens. The results demonstrated the significant impact of laboratory-selected diagnostic methods on the detection of SARS-CoV-2 with low viral loads in clinical specimens.
Article
Medicine, General & Internal
Magdalena Komiazyk et al.
Summary: A double-dose vaccinated woman with COVID-19 experienced all stages of infection, but exhibited mild symptoms. The virus identified in her belonged to the UK SARS-CoV-2 lineage B.1.1.7 (Alpha variant).
Article
Public, Environmental & Occupational Health
Hamad Ali et al.
Summary: Individuals with previous COVID-19 infection showed higher and more sustained levels of SARS-CoV-2 antibodies after COVID-19 vaccination compared to those without previous infection. Vaccinated individuals without previous COVID-19 infection experienced a faster decline in IgG and neutralizing antibodies compared to those with prior infection. Efforts should be made to prioritize vaccination for more individuals, especially those without previous COVID-19 infection, due to inconsistent vaccine supply globally.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Infectious Diseases
Tal Brosh-Nissimov et al.
Summary: A study in Israel showed that a minority of fully vaccinated individuals with significant comorbidities may still develop severe COVID-19, with a high mortality rate. Further research on this vulnerable population may help improve their protection.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Multidisciplinary Sciences
Zijun Wang et al.
Summary: Despite challenges posed by COVID-19 variants, convalescent individuals receiving mRNA vaccines exhibit robust and long-lasting immune responses against circulating SARS-CoV-2 variants, providing hope for effective control of the pandemic.
Article
Medicine, General & Internal
Yinon M. Bar-On et al.
Summary: After receiving a third dose of the BNT162b2 mRNA vaccine, Israeli residents aged 60 and above who had previously received two doses of the vaccine saw significantly lower rates of confirmed Covid-19 infection and severe illness compared to those who did not receive a booster shot, indicating the effectiveness of the booster dose in reducing infection and severe illness.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Moriah Bergwerk et al.
Summary: Among fully vaccinated health care workers, breakthrough infections with SARS-CoV-2 were correlated with neutralizing antibody titers during the peri-infection period. Most breakthrough infections were mild or asymptomatic, although persistent symptoms did occur.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
S. J. Thomas et al.
Summary: BNT162b2 vaccine remains highly effective and safe over the course of 6 months post-vaccination, with efficacy rates ranging from 86% to 100% across different demographics and risk factors for Covid-19. The vaccine also shows a high efficacy against severe disease, with particularly promising results observed in South Africa against the B.1.351 variant.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Giuseppe Lippi et al.
Summary: Although testing for anti-SARS-CoV-2 antibodies in recipients of COVID-19 vaccination can provide benefits such as assessing baseline seroprevalence, identifying non-responders, and detecting antibody decay, challenges like unclear equivalence between antibody titer, neutralizing activity, and vaccine efficiency; lack of cost-effective analyses; and increased laboratory workload remain. A potential solution involves prioritizing testing for high-risk individuals and those with lower vaccine immunogenicity.
Article
Medicine, Research & Experimental
Reid McMurry et al.
Summary: This study analyzed over 1.2 million EHR notes and found that individuals vaccinated with BNT162b2 or mRNA-1273 had a higher rate of return to the clinic after both doses with no increase in emergency department visits. Common adverse effects within seven days post-vaccination included myalgia, headache, and fatigue, while severe events occurred at similar frequencies in vaccinated and unvaccinated individuals.
Article
Immunology
John S. Tregoning et al.
Summary: The development and rollout of vaccines have brought hope for controlling the COVID-19 pandemic, with vaccines proving highly effective in preventing disease. However, challenges remain in ensuring equitable access to vaccines globally, as well as lessons to be learned for controlling pandemics in the future.
NATURE REVIEWS IMMUNOLOGY
(2021)
Review
Microbiology
Petra Zimmermann et al.
CLINICAL MICROBIOLOGY REVIEWS
(2019)
