期刊
VACCINES
卷 11, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/vaccines11111671
关键词
Salmonella; MAPS vaccine; OSP; SseB; quadrivalent; Typhimurium; Enteritidis
Bloodstream infections in low- and middle-income countries are primarily caused by invasive Salmonella disease. A preclinical development of a quadrivalent Salmonella vaccine targeting all four leading serotypes has shown promising results.
Bloodstream infections in low- and middle-income countries (LMICs) are most frequently attributed to invasive Salmonella disease caused by four primary serovars of Salmonella enterica: Typhi, Paratyphi A, Typhimurium, and Enteritidis. We showed previously that a bivalent vaccine targeting S. Typhi and S. Paratyphi A using a Multiple Antigen-Presenting System (MAPS) induced functional antibodies against S. Typhi and S. Paratyphi. In the current study, we describe the preclinical development of a first candidate quadrivalent combination Salmonella vaccine with the potential to cover all four leading invasive Salmonella serotypes. We showed that the quadrivalent Salmonella MAPS vaccine, containing Vi from S. Typhi, O-specific Polysaccharide (OSP) from S. Paratyphi A, S. Enteritidis and S. Typhimurium, combined with the Salmonella-specific protein SseB, elicits robust and functional antibody responses to each of the components of the vaccine. Our data indicates that the application of MAPS technology to the development of vaccines targeting invasive forms of Salmonella is practical and merits additional consideration.
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