☆ 4.7 Article

Chronic Fatigue and Dysautonomia following COVID-19 Vaccination Is Distinguished from Normal Vaccination Response by Altered Blood Markers

VACCINES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Pathology

COVID-19, post-acute COVID-19 syndrome (PACS, long COVID) and post-COVID-19 vaccination syndrome (PCVS, post-COVIDvac-syndrome): Similarities and differences

Felix Scholkmann et al.

Summary: According to the World Health Organization, there have been over 760 million confirmed COVID-19 cases worldwide and more than 13 billion COVID-19 vaccine doses administered as of April 2023. In addition to acute COVID-19, the infection with SARS-CoV-2 can also result in a post-acute COVID-19 syndrome (PACS). The article discusses the side effects of COVID-19 vaccines, proposes new terms (PCVS, ACVS, and PACVS) to refer to these side effects, and emphasizes the importance of distinguishing between acute and post-acute vaccine-related syndromes.

PATHOLOGY RESEARCH AND PRACTICE (2023)

添加到收藏夹

Review Infectious Diseases

Increased interleukin-6 is associated with long COVID-19: a systematic review and meta-analysis

Jing-Xian Yin et al.

Summary: This study found that increased levels of IL-6 are associated with long COVID-19. IL-6 levels were elevated after SARS-CoV-2 infection, and long COVID-19 patients had higher IL-6 levels compared to healthy controls and non-PASC patients.

INFECTIOUS DISEASES OF POVERTY (2023)

添加到收藏夹

Review Clinical Neurology

Neurological side effects of SARS-CoV-2 vaccinations

Josef Finsterer

Summary: This review discusses the neurological side effects of SARS-CoV-2 vaccines, focusing on headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis, which healthcare professionals should be vigilant about.

ACTA NEUROLOGICA SCANDINAVICA (2022)

添加到收藏夹

Article Immunology

Post-HPV-Vaccination Mast Cell Activation Syndrome: Possible Vaccine-Triggered Escalation of Undiagnosed Pre-Existing Mast Cell Disease?

Lawrence B. Afrin et al.

Summary: In recent years, there has been an increase in case reports of dysautonomias, particularly postural orthostatic tachycardia syndrome (POTS), occurring soon after vaccination against human papilloma virus (HPV). This article describes 11 such cases and proposes the hypothesis that vaccination with HPV, specifically the Gardasil product, may trigger or exacerbate mast cell activation syndrome (MCAS) in teenagers. MCAS is increasingly recognized as a prevalent and chronic multisystem disorder, often associated with autonomic disorders such as POTS. Identifying and managing MCAS before vaccination may be a strategy worth investigating to reduce adverse events following HPV vaccination and other types of vaccinations.

VACCINES (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review

Talal Almas et al.

Summary: This review critically evaluates the existing literature on the cardiovascular side effects of different mRNA vaccines and their associated pathophysiology.

BIOMEDICINE & PHARMACOTHERAPY (2022)

添加到收藏夹

Article Rheumatology

Autoimmune post-COVID vaccine syndromes: does the spectrum of autoimmune/inflammatory syndrome expand?

Luis J. Jara et al.

Summary: Around 60% of the global population has been vaccinated against SARS-CoV-2, leading to a significant reduction in the impact of the pandemic and the resumption of social and economic activities. Studies have shown that the vaccines are effective and safe in various populations, including those with risk factors or immunocompromised individuals. While a minority of people may experience adverse events, including autoimmune syndromes, the exact mechanisms for their development are still being studied. Rheumatologists need to be vigilant in monitoring these autoimmune syndromes and investigating their relationship to vaccination timing.

CLINICAL RHEUMATOLOGY (2022)

添加到收藏夹

Review Allergy

Mast Cell Activation Syndromes: Collegium Internationale Allergologicum Update 2022

Peter Valent et al.

Summary: Mast cell activation syndromes (MCASs) are characterized by severe and recurrent mast cell activation, with symptoms such as anaphylaxis, elevated serum tryptase levels, and response to specific drugs. Various genetic conditions, allergies, and related diseases can contribute to the clinical manifestation of MCAS, highlighting the importance of accurate diagnosis and personalized treatment plans.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis?

Stefan R. Bornstein et al.

Summary: Research has found that patients with long COVID syndrome and chronic fatigue syndrome have similar elevation of autoantibodies. Extracorporeal apheresis can effectively reduce these antibodies levels and improve symptoms, providing a promising therapeutic option for patients with post-COVID-19 syndrome. This method may also be effective in cases involving other unknown antibodies and inflammatory mediators.

MOLECULAR PSYCHIATRY (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Implications of Antimuscarinic Autoantibodies in Postural Tachycardia Syndrome

Hongliang Li et al.

Summary: The study found that half of the POTS patients had elevated M2R autoantibody activity, which may affect heart rate by negatively modulating M2R activity and increasing vagal withdrawal during upright posture. This suggests that M2R autoantibodies may play a role in the pathophysiology of POTS.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity

Otavio Cabral-Marques et al.

Summary: The abundance and network signature of autoantibodies targeting G protein-coupled receptors and RAS-related proteins are altered in COVID-19 patients, and the level of disruption marks clinical severity.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Pediatrics

Compensatory Upregulation of Anti-Beta-Adrenergic Receptor Antibody Levels Might Prevent Heart Failure Presentation in Pediatric Myocarditis

Franziska Seidel et al.

Summary: This study described the immunological response in children with myocarditis by analyzing anti-beta-adrenergic receptor antibodies (anti-beta-AR Abs). The levels of anti-beta-AR Abs were found to be increased in myocarditis patients older than 5 years of age, suggesting a compensatory response to prevent further cardiac deterioration. Patients with lower levels of anti-beta-AR Abs had a worse event-free survival, indicating a potential therapeutic target for immunoglobulin substitution in these patients.

FRONTIERS IN PEDIATRICS (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Cardiovascular Complications of COVID-19 Vaccines

Runyu Liu et al.

Summary: Vaccination against COVID-19 has become crucial in controlling the pandemic, but it comes with potential cardiovascular complications such as myocarditis and immune thrombocytopenia. Accurate reporting and monitoring of vaccine safety are essential to address public concerns and ensure effective vaccine administration.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

添加到收藏夹

Article Immunology

A Diagnostic Strategy for Gauging Individual Humoral Ex Vivo Immune Responsiveness Following COVID-19 Vaccination

Anna Sabrina Kuechler et al.

Summary: This study describes a diagnostic procedure for scheduling (re-)vaccination against SARS-CoV-2 based on individual humoral immunization status. The researchers monitored individuals before, during, and six months after vaccination with the Spikevax vaccine. The study found that measuring serum-based SARS-CoV-2 antibody levels could potentially support personalized vaccination schedules.

VACCINES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity

C. Kedor et al.

Summary: Some COVID-19 patients experience long-lasting symptoms, such as fatigue and exertion intolerance, even after recovery. These symptoms are similar to those seen in non-COVID-19 patients and may be related to low-level inflammation and hypoperfusion.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection

Yonghou Jiang et al.

Summary: The study found an association between COVID-19 and AT1R-Ab, highlighting that vascular pathology may be present in individuals with mild COVID-19 as well as those with severe disease.

PLOS ONE (2021)

添加到收藏夹

Article Medicine, General & Internal

Inflammatory Biomarkers in Postural Orthostatic Tachycardia Syndrome with Elevated G-Protein-Coupled Receptor Autoantibodies

William T. Gunning et al.

Summary: The study suggests that POTS may be an autoimmune disorder, with patients exhibiting abnormal plasma concentrations of inflammatory cytokines and platelet dysfunction.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Article Immunology

Delineating the Association Between Soluble CD26 and Autoantibodies Against G-Protein Coupled Receptors, Immunological and Cardiovascular Parameters Identifies Distinct Patterns in Post-Infectious vs. Non-Infection-Triggered Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Marvin Szklarski et al.

Summary: sCD26 is implicated in immunological dysregulation in infection-triggered ME/CFS, while its lower concentrations are associated with autoimmune diseases and dysregulation in infection onset.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Antibodies Against Angiotensin II Receptor Type 1 and Endothelin A Receptor Are Associated With an Unfavorable COVID19 Disease Course

Jelle Miedema et al.

Summary: This study found significantly increased levels of auto-antibodies against AT1R and ETAR in COVID-19 patients with an unfavorable disease course. However, levels of antinuclear antibodies (ANA) in patients with unfavorable disease course did not show significant differences compared to patients with favorable disease course and controls.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Autoantibodies against ACE2 and angiotensin type-1 receptors increase severity of COVID-19

Ana Rodriguez-Perez et al.

Summary: The study found that COVID-19 patients had higher levels of AA-AT1 and AA-ACE2, which were significantly associated with disease severity. Patients with mild disease had lower levels of autoantibodies than those with moderate or severe disease, with no significant differences between males and females.

JOURNAL OF AUTOIMMUNITY (2021)

添加到收藏夹

Article Medicine, General & Internal

Autoantibodies to Vasoregulative G-Protein-Coupled Receptors Correlate with Symptom Severity, Autonomic Dysfunction and Disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Helma Freitag et al.

Summary: The study found that levels of specific AAB were significantly correlated with fatigue and muscle pain symptoms in patients with infection-triggered ME/CFS, while patients with non-infection-triggered ME/CFS showed fewer correlations. This suggests a potential role of AAB or respective receptor pathways in the pathomechanism of the disease.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Article Medicine, General & Internal

Tolerability and Efficacy of s.c. IgG Self-Treatment in ME/CFS Patients with IgG/IgG Subclass Deficiency: A Proof-of-Concept Study

Carmen Scheibenbogen et al.

Summary: An open trial on ME/CFS patients receiving self-administered s.c. IgG therapy showed clinical improvement in a subset of patients. Treatment efficacy was measured through fatigue and physical functioning assessments, with 5 patients showing clinical response at month 12.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Article Immunology

A Long-Term Observation on the Possible Adverse Effects in Japanese Adolescent Girls after Human Papillomavirus Vaccination

Akiyo Hineno et al.

Summary: In Japan, a number of adolescent females experienced unusual symptoms after receiving the HPV vaccination, initially being diagnosed with psychiatric illnesses. However, these symptoms were later attributed to adverse effects of the HPV vaccine, with a causal link not yet proven. A unique post-HPV vaccination disorder combining orthostatic intolerance, chronic pain syndrome, and cognitive dysfunction has been observed in some patients, with the exact pathogenesis remaining unclear.

VACCINES (2021)

添加到收藏夹

Article Medicine, General & Internal

Characterizing long COVID in an international cohort: 7 months of symptoms and their impact

Hannah E. Davis et al.

Summary: Patients with Long COVID report prolonged, multisystem involvement and significant disability. By seven months, many patients have not yet recovered (mainly from systemic and neurological/cognitive symptoms), have not returned to previous levels of work, and continue to experience significant symptom burden.

ECLINICALMEDICINE (2021)

添加到收藏夹

Article Immunology

Functional autoantibodies against G-protein coupled receptors in patients with persistent Long-COVID-19 symptoms

Gerd Wallukat et al.

Summary: Within a sample of long-term COVID-19 recovered patients, various GPCR-fAABs autoantibodies were detected, with some antibodies causing positive chronotropic effects on cardiac cells while affecting the nervous and cardiovascular systems significantly.

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY (2021)

添加到收藏夹

Editorial Material Medicine, General & Internal

Fibromyalgia

Matthew J. Bair et al.

ANNALS OF INTERNAL MEDICINE (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Serum Activity Against G Protein-Coupled Receptors and Severity of Orthostatic Symptoms in Postural Orthostatic Tachycardia Syndrome

Isabella Kharraziha et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Eun-Jin Lim et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G-Protein Coupled Receptor Autoantibodies

William T. Gunning et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)

添加到收藏夹

Review Medicine, General & Internal

Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management

A. Fedorowski

JOURNAL OF INTERNAL MEDICINE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

GPCR-autoantibodies in chronic heart failure

Valerie Boivin-Jahns et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antibodies against GPCR

Carlotta Meyer et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Immunoadsorption to remove β2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME

Carmen Scheibenbogen et al.

PLOS ONE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

Otavio Cabral-Marques et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Immunology

Postural tachycardia syndrome (POTS) with anti-NMDA receptor antibodies after human papillomavirus vaccination

Svetlana Blitshteyn et al.

IMMUNOLOGIC RESEARCH (2017)

添加到收藏夹

Article Psychology, Developmental

Reports of Postural Orthostatic Tachycardia Syndrome After Human Papillomavirus Vaccination in the Vaccine Adverse Event Reporting System

Jorge Arana et al.

JOURNAL OF ADOLESCENT HEALTH (2017)

添加到收藏夹

Review Rheumatology

Functional autoantibodies targeting G protein-coupled receptors in rheumatic diseases

Otavio Cabral-Marques et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

添加到收藏夹

Article Immunology

Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome

Madlen Loebel et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Effects of IL-1β, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity

Janette Bester et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Review Rheumatology

Hypothesis: Human papillomavirus vaccination syndrome-small fiber neuropathy and dysautonomia could be its underlying pathogenesis

Manuel Martinez-Lavin

CLINICAL RHEUMATOLOGY (2015)

添加到收藏夹

Article Immunology

Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine: another angle of the 'autoimmune (auto-inflammatory) syndrome induced by adjuvants' (ASIA)

Nancy Agmon-Levin et al.

IMMUNOLOGIC RESEARCH (2014)

添加到收藏夹

Review Immunology

Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases

Gerd Wallukat et al.

SEMINARS IN IMMUNOPATHOLOGY (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Autoimmune Basis for Postural Tachycardia Syndrome

Hongliang Li et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Impact of human autoantibodies on β1-adrenergic receptor conformation, activity, and internalization

Beatrice Bornholz et al.

CARDIOVASCULAR RESEARCH (2013)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Blockade of platelet alpha2B-adrenergic receptors: A novel antiaggregant mechanism

Maria E. Marketou et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

添加到收藏夹

Review Medicine, General & Internal

Myalgic encephalomyelitis: International Consensus Criteria

B. M. Carruthers et al.

JOURNAL OF INTERNAL MEDICINE (2011)

添加到收藏夹

Review Medicine, General & Internal

Small fiber neuropathy: A burning problem

Jinny Tavee et al.

CLEVELAND CLINIC JOURNAL OF MEDICINE (2009)

添加到收藏夹

Article Medicine, General & Internal

Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection

D Dragun et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.