☆ 4.7 Review

Nanomedical research and development in Spain: improving the treatment of diseases from the nanoscale

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

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Article Nanoscience & Nanotechnology

Core-Shell Fe3O4@Au Nanorod-Loaded Gels for Tunable and Anisotropic Magneto- and Photothermia

Mikel Rincon-Iglesias et al.

Summary: This study reports on the synthesis of Fe3O4@Au core-shell nanorods and their incorporation into an agarose hydrogel to achieve anisotropic magnetic and optical properties. The results demonstrate the potential application of these materials in magneto- and photothermal therapy.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Biomedical

Our contributions to applications of mesoporous silica nanoparticles

Maria Vallet-Regi

Summary: This article reports our contributions to mesoporous silica materials in biomedicine, demonstrating their potential in drug delivery with high loading capacity and stimuli-responsive features. The research findings suggest that mesoporous silica nanoparticles have promising applications in drug delivery.

ACTA BIOMATERIALIA (2022)

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Article Biochemistry & Molecular Biology

Synthesis of self-assembled hyaluronan based nanoparticles and their applications in targeted imaging and therapy

Kunli Liu et al.

Summary: Hyaluronan nanoparticles (HA-NPs) have gained increasing interest for targeted imaging and therapy. By utilizing the interaction between HA and CD44, as well as the enhanced permeability and retention (EPR) effect, selective accumulation of HA-NPs at disease sites can be achieved. This review focuses on the synthesis strategies of HA-NPs and their applications in therapy and biomedical imaging.

CARBOHYDRATE RESEARCH (2022)

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Article Nanoscience & Nanotechnology

Horseradish Peroxidase-Functionalized Gold Nanoconjugates for Breast Cancer Treatment Based on Enzyme Prodrug Therapy

Gema Vivo-Llorca et al.

Summary: In this study, a novel nanodevice based on enzyme-functionalized gold nanoparticles for enzyme prodrug therapy (EPT) in breast cancer was designed and evaluated. The results showed that the nanodevice was effectively internalized by breast cancer cells and co-treatment with the nanodevice and enzyme prodrug significantly reduced the viability of breast cancer cells. The findings from three-dimensional tumor models also demonstrated the therapeutic effectiveness of this nanodevice.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Materials Science, Biomaterials

Delayed alveolar clearance of nanoparticles through control of coating composition and interaction with lung surfactant protein A

Susana Carregal-Romero et al.

Summary: The coating composition of nanomedicines plays an important role in determining the fate and clearance of the medicines in the body. In this study, two micellar superparamagnetic iron oxide nanoparticles (SPION) with different coatings were compared to understand their impact in pulmonary administration. The results showed that phosphatidylcholine (PC) coating could prolong the retention time of the nanoparticles in the lungs, making it suitable for pulmonary drug delivery. On the other hand, bovine serum albumin (BSA) coated nanoparticles were cleared more rapidly.

BIOMATERIALS ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Engineering pH-Sensitive Stable Nanovesicles for Delivery of MicroRNA Therapeutics

Ariadna Boloix et al.

Summary: The engineering of non-liposomal lipid nanovesicles, known as quatsomes (QS), for delivering miRNAs and other small RNAs into tumor cells' cytosol, triggering a tumor-suppressive response, offers a promising platform for the clinical delivery of miRNA therapeutics.

SMALL (2022)

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Article Engineering, Biomedical

In Vivo Antitumor and Antimetastatic Efficacy of a Polyacetal-Based Paclitaxel Conjugate for Prostate Cancer Therapy

Yolanda Fernandez et al.

Summary: The study demonstrates that tert-Ser-PTX conjugate can provide sustained release of PTX in a pH-responsive manner over 2 weeks, along with epimerization of PTX to 7-epi-PTX. Serum proteins can stabilize tert-Ser-PTX, showing enhanced stability in human serum compared to PBS. While in vitro efficacy assessments in PCa cells showed IC50 values higher than the free form of PTX, in vivo tolerability assays revealed that tert-Ser-PTX significantly reduces systemic toxicities associated with free PTX treatment.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

An Innovative Formulation Based on Nanostructured Lipid Carriers for Imatinib Delivery: Pre-Formulation, Cellular Uptake and Cytotoxicity Studies

Evren Gundogdu et al.

Summary: Imatinib-loaded nanostructured lipid carrier system (F16-IMT) was successfully developed and characterized in this study. The F16-IMT formulation exhibited small particle size, stability, and efficient drug release. It also showed good cellular uptake and cytotoxicity against CRL-1739 cells. These findings suggest that F16-IMT has the potential to be an effective treatment for GIST.

NANOMATERIALS (2022)

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Article Pharmacology & Pharmacy

Combined Therapeutics for Atherosclerosis Treatment Using Polymeric Nanovectors

Baltazar Hiram Leal et al.

Summary: This study reports the development of nanometer-sized polymeric PLGA nanoparticles capable of simultaneously encapsulating and delivering miRNA-124a and the statin atorvastatin. The nanocarriers targeted inflamed cells in atherosclerosis and effectively reduced inflammation levels and prevented the accumulation of low-density lipoproteins inside cells.

PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Development of Peptide Targeted PLGA-PEGylated Nanoparticles Loading Licochalcone-A for Ocular Inflammation

Ruth Galindo et al.

Summary: By incorporating Licochalcone-A into biodegradable nanoparticles and functionalizing PLGA nanoparticles with PEG and cell penetrating peptides, ocular inflammation can be effectively treated. Among them, B6 targeted nanoparticles show better therapeutic efficacy.

PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability

Alexis Alvear-Jimenez et al.

Summary: In this study, a biocompatible hybrid nanosystem for drug delivery purposes was fabricated using the electrospraying technique, combining Ag2S nanoparticles and superparamagnetic iron oxide nanoparticles (SPION). The hybrid nanosystems showed good photoluminescent properties and relatively long decay times. Encapsulation and release capabilities were demonstrated using a model chemotherapeutic drug, and in vitro cytotoxicity assays showed promising results against tumor cell lines.

PHARMACEUTICS (2022)

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Article Biology

Effect of Gold Nanostars Plus Amikacin against Carbapenem-Resistant Klebsiella pneumoniae Biofilms

John Jairo Aguilera-Correa et al.

Summary: Carbapenem-resistant Klebsiella pneumoniae (CR-KP) infection poses a serious challenge due to the lack of effective antibiotics. This study found that the combination of gold nanostars (GNS) and amikacin can inhibit or eradicate CR-KP biofilm and prevent infection in the Galleria mellonella model, showing promise as an anti-CR-KP nanomaterial.

BIOLOGY-BASEL (2022)

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Article Biochemical Research Methods

Clickable Albumin Nanoparticles for Pretargeted Drug Delivery toward PD-L1 Overexpressing Tumors in Combination Immunotherapy

Christoph Gerke et al.

Summary: We present a simple methodology to design a pretargeted drug delivery system based on clickable antibodies and nanoparticles. The system shows high reaction rate constants and bio-orthogonality, making it suitable for in vivo applications.

BIOCONJUGATE CHEMISTRY (2022)

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Article Pharmacology & Pharmacy

In vivo biodistribution of edelfosine-loaded lipid nanoparticles radiolabeled with Technetium-99 m: Comparison of administration routes in mice

Beatriz Lasa-Saracibar et al.

Summary: Nanoencapsulated Edelfosine is effective in various types of tumors, and biodistribution studies revealed that the intraperitoneal route is optimal for sustaining consistent blood levels and avoiding accumulation in RES organs.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular drug delivery

Ruben Varela-Fernandez et al.

Summary: Nanostructured lipid carriers (NLC) with lactoferrin loading have been successfully developed using a double emulsion/solvent evaporation method. The resulting NLC exhibited stable and non-toxic properties, with high encapsulation efficiency and loading capacity of lactoferrin. It has the potential to be a controlled release drug delivery system for the treatment of keratoconus.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

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Article Endocrinology & Metabolism

Endovascular administration of magnetized nanocarriers targeting brain delivery after stroke

Alba Grayston et al.

Summary: This study utilized a new endovascular approach to deliver functionalized polymer nanocapsules to the mouse brain, enabling therapeutic magnetic targeting, magnetic resonance, and fluorescent imaging. The results demonstrated a significant advantage of intraarterial delivery in brain targeting in ischemic mice, with good safety profiles.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2022)

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Article Chemistry, Physical

Iron oxide-manganese oxide nanoparticles with tunable morphology and switchable MRI contrast mode triggered by intracellular conditions

David Garcia-Soriano et al.

Summary: This article describes the preparation of stimuli-responsive nanomaterials that can change their contrast mode in MRI from T-2 to T-1 after internalization by cells. The size and shape of the hybrid nanostructure can be tuned by varying the core size of the magnetic seeds and the concentration of the surfactant. The MnO2 shell can be removed by a redox reaction with glutathione inside the cells, while the iron oxide nanoparticles at the core remain intact and active.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Review Pharmacology & Pharmacy

The Potential of Chitosan in Nanomedicine: An Overview of the Cytotoxicity of Chitosan Based Nanoparticles

Julie Frigaard et al.

Summary: Nanotechnology has found unique applications in drug delivery, cosmetics, fabrics, water treatment, and food packaging. Chitosan, a nanoparticle derived from natural polysaccharide chitin, has gained attention in modern medicine for its unique properties. This review examines the cytotoxicity of chitosan nanoparticles in biomedical research, revealing low cytotoxicity regardless of particle composition or assay method. However, thorough characterization and cytotoxicity assessment are recommended for new chitosan derivatives and compositions before market implementation.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Iron-Gold Nanoflowers: A Promising Tool for Multimodal Imaging and Hyperthermia Therapy

Evangelia Christou et al.

Summary: The development of nanoplatforms capable of multimodal imaging and combined therapies has great potential in improving diagnostic accuracy and therapy success. In this study, a new seed-assisted method was used to synthesize Au@Fe nanoparticles with a flower-like structure, which exhibited excellent features as both MRI and CT Contrast Agents. These nanoparticles also showed considerable energy-to-heat conversion under both Alternating Magnetic Fields and Near-Infrared light. Moreover, they exhibited very low cytotoxicity, confirming their potential for theranostics applications.

PHARMACEUTICS (2022)

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Article Neurosciences

Dual effect of TAT functionalized DHAH lipid nanoparticles with neurotrophic factors in human BBB and microglia cultures

Sara Hernando et al.

Summary: This study successfully demonstrates that the TAT-functionalized DHAH-NLCs can cross the blood-brain barrier and modulate immune responses. The results suggest that DHAH-NLCs have potential therapeutic effects and can serve as a novel drug delivery approach for neurodegenerative diseases.

FLUIDS AND BARRIERS OF THE CNS (2022)

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Article Engineering, Biomedical

Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions

D. Arcos et al.

Summary: The osteogenic capability of mesoporous bioactive nanoparticles in the SiO2 -CaO system was assessed in vivo using an osteoporotic rabbit model. The nanoparticles were found to promote bone regeneration and enhance angiogenesis at the defect site. The incorporation of the anti-osteoporotic drug ipriflavone further increased the presence of osteoblasts.

ACTA BIOMATERIALIA (2022)

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Article Biochemical Research Methods

Role of Common Cell Culture Media Supplements on Citrate-Stabilized Gold Nanoparticle Protein Corona Formation, Aggregation State, and the Consequent Impact on Cellular Uptake

Francesco Barbero et al.

Summary: Sodium citrate-stabilized gold nanoparticles can be destabilized in cell culture media, leading to their aggregation and formation of a protein corona. The presence of certain substances, such as antibiotics, can alter the formation and composition of the corona, resulting in changes in nanoparticle uptake.

BIOCONJUGATE CHEMISTRY (2022)

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Article Pharmacology & Pharmacy

Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid

Aixa Aguilera-Garrido et al.

Summary: Maslinic acid (MA), a low water-soluble compound derived from plants, has been formulated into solid lipid nanoparticles (SLNs) to improve its solubility and bioaccessibility for effective antitumor activity. SLNs can serve as nanocarriers for hydrophobic antitumor compounds and have demonstrated stability and suitability for oral consumption.

DRUG DELIVERY (2022)

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Article Biochemistry & Molecular Biology

Conjugation of the 9-kDa Isoform of Granulysin with Liposomes Potentiates Its Cytotoxicity

Ruth Soler-Agesta et al.

Summary: This study developed lipid nanoparticles that can enhance the cytotoxicity of recombinant granulysin, and demonstrated that the mitochondrial apoptotic pathway is the main mechanism of cell death induced by the nanoparticle.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Microbiology

3D spatial organization and improved antibiotic treatment of a Pseudomonas aeruginosa-Staphylococcus aureus wound biofilm by nanoparticle enzyme delivery

Alba Rubio-Canalejas et al.

Summary: Studied the relationship between P. aeruginosa and S. aureus and its effect on antimicrobial treatment, and found that functionalized silver nanoparticles can improve antibiotic therapy. Proposed a clinical treatment combining antibiofilm enzymes and antibiotics.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Chemistry, Physical

Glutathione-Triggered catalytic response of Copper-Iron mixed oxide Nanoparticles. Leveraging tumor microenvironment conditions for chemodynamic therapy

Javier Bonet-Aleta et al.

Summary: Heterogeneous catalysis is a promising alternative for cancer therapy development, targeting specific chemical features of the tumor microenvironment. This study presents copper-iron oxide spinel nanoparticles that selectively reduce GSH levels while generating ROS, leading to apoptotic cell death in tumor cells. Additionally, a novel analytical protocol is provided to accurately monitor intracellular GSH levels in both tumor and healthy cells.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Biotechnology & Applied Microbiology

Iron oxide and iron oxyhydroxide nanoparticles impair SARS-CoV-2 infection of cultured cells

Marta L. DeDiego et al.

Summary: This study analyzed the potential of using iron oxide nanoparticles to treat and prevent SARS-CoV-2 infection. The nanoparticles were found to impair virus replication and transcription, both before and after infection, and SARS-CoV-2 infection was found to affect cellular iron metabolism. These findings suggest that the nanoparticles may be repurposed as prophylactic or therapeutic treatments for SARS-CoV-2 infection.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Medicine, Research & Experimental

Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation

Jessica Latorre et al.

Summary: This study found that intervention on liver LBP can reduce liver lipid accumulation and oxidative stress, thus reducing the development of obesity-related fatty liver. However, in other circumstances, liver LBP downregulation does not have an impact on liver steatosis.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Article Pharmacology & Pharmacy

Fine Control of In Vivo Magnetic Hyperthermia Using Iron Oxide Nanoparticles with Different Coatings and Degree of Aggregation

Yurena Luengo et al.

Summary: The clinical implementation of magnetic hyperthermia has been slow due to the challenges in producing magnetic nanoparticles with controlled properties and controlling the temperature at the target tissue. This study successfully prepared iron oxide superparamagnetic nanoparticles and demonstrated that the rise in temperature can be controlled by modulating the field intensity during in vivo magnetic hyperthermia protocols. This simple procedure can be easily implemented by researchers or practitioners working in magnetic hyperthermia therapies.

PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Fluorescent PLGA Nanocarriers for Pulmonary Administration: Influence of the Surface Charge

Aina Areny-Balaguero et al.

Summary: Respiratory diseases cause nearly four million deaths every year, and the COVID-19 pandemic has increased the morbidity and mortality rates. Engineered nanocarriers can improve drug delivery while reducing side effects. Poly(lactic-co-glycolic acid) (PLGA), a biodegradable polymer, is being studied as an inhalable drug delivery system. In this study, nanocapsules with positive and negative surface charges were fabricated, and it was found that the nanocapsules with negative charge had faster and greater cell uptake.

PHARMACEUTICS (2022)

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Article Infectious Diseases

A Promising Antifungal and Antiamoebic Effect of Silver Nanorings, a Novel Type of AgNP

Sara Gonzalez-Fernandez et al.

Summary: Silver nanoparticles have potent antimicrobial activity and are investigated as an alternative to antimicrobial drugs. This study analyzed the antifungal and antiamoebic effects of a new type of silver nanoparticles called silver nanorings (AgNRs), and compared them with other types of silver nanoparticles. The results showed that silver nanoparticles have high biocidal effect, with antifungal activity depending on the fungal species involved, and AgNRs and silver nanowires (AgNWs) having an inhibitory effect on the growth of Acanthamoeba castellanii.

ANTIBIOTICS-BASEL (2022)

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Editorial Material Chemistry, Multidisciplinary

What Do We Mean When We Say Nanomedicine?

Luis M. Liz-Marzan et al.

ACS NANO (2022)

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Article Engineering, Biomedical

Antibiotic delivery from bone-targeted mesoporous silica nanoparticles for the treatment of osteomyelitis caused by methicillin-resistant Staphylococcus aureus

J. J. Aguilera-Correa et al.

Summary: This study proposes the use of bone-targeted mesoporous silica nanoparticles for the treatment of Staphylococcus aureus-caused osteomyelitis, providing synergistic therapeutic effects through multidrug delivery. The nanoparticles are engineered with a functional coating that can disaggregate bacterial biofilms, inhibit premature antibiotic release, and protect the intact bone. They effectively target bone tissue both in vitro and in vivo, demonstrating high biocompatibility and significant antibacterial effects.

ACTA BIOMATERIALIA (2022)

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Article Biochemistry & Molecular Biology

Silver Nanoparticles Produced by Laser Ablation and Re-Irradiation Are Effective Preventing Peri-Implantitis Multispecies Biofilm Formation

Ramon Perez-Tanoira et al.

Summary: Silver nanoparticles have antimicrobial effects against various biofilms and may help prevent the development of peri-implantitis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Chemistry, Physical

Design and synthesis of multifunctional polymeric micelles for targeted delivery in Helicobacter pylori infection

Aimen Qaiser et al.

Summary: This study successfully designed a hyaluronic acid-based nanocarrier system that improves the residence time of clarithromycin at the site of H. pylori infection, potentially enhancing the treatment efficacy.

JOURNAL OF MOLECULAR LIQUIDS (2022)

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Article Chemistry, Multidisciplinary

Bioevaluation of magnetic mesoporous silica rods: cytotoxicity, cell uptake and biodistribution in zebrafish and rodents

Jan Grzelak et al.

Summary: This study investigates the potential applications of rod-shaped mesoporous silica nanoparticles (MSR) in liver imaging and therapy. The results demonstrate that these magnetic MSR particles are not cytotoxic and can be successfully taken up by liver cells. The rods can penetrate fibrous tissues or mucus layers more efficiently than spherical particles.

RSC ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Optomagnetic nanofluids for controlled brain hyperthermia: a critical study

Diego Mendez-Gonzalez et al.

Summary: Optomagnetic nanofluids (OMNFs) are colloidal dispersions of nanoparticles with combined magnetic and optical properties, which are suitable for treating difficult-to-reach tumors. Magnetic nanoparticles can generate heating effects under alternating magnetic fields or light irradiation, while luminescent nanoparticles can provide real-time thermal readouts. However, experiments have shown that OMNFs cannot effectively induce heating under alternating magnetic fields and fail to provide reliable temperature readings, while the use of luminescent nanofluids containing only luminescent nanoparticles performs better.

NANOSCALE (2022)

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Article Chemistry, Multidisciplinary

Synergistic immunomodulatory effect in macrophages mediated by magnetic nanoparticles modified with miRNAs

Nuria Lafuente-Gomez et al.

Summary: In this study, magnetic nanoparticles with different coatings were synthesized and their interactions with red blood cells, plasma proteins, and macrophages were investigated. CMD-MNP, chosen for its biosafety profile and ability to promote a pro-inflammatory response in macrophages, was proposed as a smart miRNA delivery system for cancer immunotherapy. It was demonstrated that CMD-MNP-miRNA155 and CMD-MNP-miRNA125b nanoparticles could induce a pro-inflammatory response in human macrophages by increasing the expression of CD80 and the levels of TNF-alpha and IL-6.

NANOSCALE (2022)

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Review Chemistry, Analytical

Gold Nanostars: Synthesis, Optical and SERS Analytical Properties

I. Brian Becerril-Castro et al.

Summary: Gold nanostars are efficient plasmonic nanomaterials for optical sensing, and their importance has been increasing in various fields. Due to their exotic shape and characteristics, these nanoparticles can be used for optical enhancement and catalysis.

ANALYSIS & SENSING (2022)

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Article Biophysics

Mesoporous silica nanoparticles containing silver as novel antimycobacterial agents against Mycobacterium tuberculosis

Sandra Montalvo-Quiros et al.

Summary: Tuberculosis remains a major public health issue with a lack of effective vaccine and the emergence of highly antibiotic-resistant strains of Mycobacterium tuberculosis. Silver nanoparticles show high bactericidal efficacy, but their relatively high toxicity calls for the design of nanocarriers for safe delivery. Mesoporous silica nanoparticles have been used as carriers for silver nanoparticles as antimycobacterial agents, demonstrating good capability against Mtb with different synthetic approaches.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Review Nanoscience & Nanotechnology

Nanoparticle Size Effects in Biomedical Applications

Jayanta Dolai et al.

Summary: The review article focuses on the significance of nanoparticle size in biomedical applications and the optimal size requirement for achieving the best performance in various applications. By discussing the role and properties of nanoparticles of different sizes, the study analyzes their value and impact in biomedical applications.

ACS APPLIED NANO MATERIALS (2021)

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Article Pharmacology & Pharmacy

Improved antileishmanial activity and cytotoxicity of a novel nanotherapy for N-iodomethyl-N,N-dimethyl-N-(6,6-diphenylhex-5-en-1-yl) ammonium iodide

Maritza Fernandez et al.

Summary: The study aimed to develop a suitable oral nano drug delivery system for C6I to enhance its antileishmanial activity. Polymeric and solid lipid nanoparticles were prepared using nanotechnology, showing good biocompatibility and high encapsulation efficiency.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Review Pharmacology & Pharmacy

Mesoporous silica nanoparticles for pulmonary drug delivery

Alba Garcia-Fernandez et al.

Summary: Respiratory diseases have become a major clinical concern worldwide and nanomedicine shows promise in overcoming the limitations of current lung therapies by enhancing drug bioavailability and reducing side effects. However, more efforts are needed to achieve effective pulmonary drug delivery despite the different approaches that have been developed.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Engineering, Biomedical

Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles

Eric Volta-Duran et al.

Summary: The study investigates the potential of conjugating tumor-targeted self-assembling protein nanoparticles with potent microbial toxins and chemically coupled chemotherapeutic drugs, resulting in multifunctional hybrid nanoconjugates with promising applications in oncology. The concept of drug combination proposed in this research could be a feasible strategy for enhancing the effectiveness of multiple drug treatments and overcoming acquired resistance in cancer therapy.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

The Combined Use of Gold Nanoparticles and Infrared Radiation Enables Cytosolic Protein Delivery

Josep Garcia et al.

Summary: By utilizing the unique photothermal properties of gold nanorods, combined with modifications of cell-penetrating peptide and nuclear targeting on proteins and AuNRs, and achieving spatiotemporal control of protein release within the safe biological window through near-infrared laser irradiation, cytosolic protein delivery has been successfully triggered.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Nanotechnology-Based Platforms for Vaginal Delivery of Peptide Microbicides

Elena Sanchez-Lopez et al.

Summary: This review focuses on recent advances in vaginal microbicides, particularly on nanocarriers encapsulating peptide microbicides. The combination of nanotechnology and peptide microbicides has shown promise in improving local drug delivery for prevention and treatment of various vaginal infections.

CURRENT MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Applied

A nanocellulose-based platform towards targeted chemo-photodynamic/photothermal cancer therapy

Thu Thi Anh Do et al.

Summary: The multifunctional rod-like CNCs-based carriers developed in this study have excellent drug-loading capacity and can be used for targeted drug delivery to tumor cells. They also exhibit fluorescence imaging and photodynamic/photothermal treatment capabilities, with pH-sensitive drug release behavior against cervical cancer cells.

CARBOHYDRATE POLYMERS (2021)

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Article Pharmacology & Pharmacy

Sorting hidden patterns in nanoparticle performance for glioblastoma using machine learning algorithms

Joao Basso et al.

Summary: This study focuses on the modulatory effects of cationic compounds on interface and tumor-targeted nanoparticle design, evaluating the efficacy of two novel glycerol-based lipids. Through the use of machine learning techniques, it was discovered that GLY1 outperformed in increasing zeta potential and cytotoxicity, contributing to enhanced uptake by tumor cells.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

Frame-Guided Synthesis of Polymeric Colloidal Discs

Na Qu et al.

Summary: This study presents a novel method for synthesizing polymeric discs by frame-guided droplet shrinkage, resulting in discs with tunable shape parameters. The method is general and has the potential to provide a variety of polymer discs. This approach opens up a new pathway for designing and fabricating colloidal particles.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Chemistry, Multidisciplinary

Photoactivated Nanoscale Temperature Gradient Detection Using X-ray Absorption Spectroscopy as a Direct Nanothermometry Method

Ana Espinosa et al.

Summary: Nanoparticle-mediated thermal treatments have shown high efficacy and versatility as a local anticancer strategy, triggering therapeutic responses at both cell and tissue levels, and potentially reducing toxicity risks.

NANO LETTERS (2021)

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Article Chemistry, Physical

Raltitrexed-Modified Gold and Silver Nanoparticles for Targeted Cancer Therapy: Cytotoxicity Behavior In Vitro on A549 and HCT-116 Human Cancer Cells

Jeroni Morey et al.

Summary: Two different raltitrexed gold and silver nanoparticles were synthesized and evaluated for their delivery of antitumoral drug. The silver nanoparticles strongly inhibited cancer cell viability, while the gold nanoparticles showed no cytotoxic effects. This suggests that silver raltitrexed nanoparticles could be a potential delivery system for certain cancer cells.

MATERIALS (2021)

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Article Engineering, Biomedical

Nanotheranostic Interface Based on Antibiotic-Loaded Conducting Polymer Nanoparticles for Real-Time Monitoring of Bacterial Growth Inhibition

Hamidreza Enshaei et al.

Summary: Conducting polymers have been increasingly used as biologically interfacing electrodes for biomedical applications due to their excellent and fast electrochemical response, reversible doping-dedoping characteristics, high stability, easy processability, and biocompatibility. The smart nanotheranostic electroresponsive platform presented in this study, which consists of chloramphenicol-loaded in poly(3,4-ethylendioxythiophene) nanoparticles for concurrent release of the antibiotic and real-time monitoring of bacterial growth, has great potential for real-time monitoring of the response of bacteria to the released antibiotic, contributing to the evolution of personalized medicine.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Chemistry, Physical

Protein corona modulates interaction of spiky nanoparticles with lipid bilayers

Jean-Baptiste Fleury et al.

Summary: This study investigates how protein corona significantly alters the interaction mode between nanoparticles and lipid bilayers. In the presence of proteins, the length of spikes on the nanoparticle surface exposed to lipid bilayers can be effectively reduced, impacting the dynamics of pore formation. Protein corona is not only crucial for the interaction between NPs and membranes, but may also change their mode of interaction.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Impact of Chemical Composition on the Nanostructure and Biological Activity of α-Galactosidase-Loaded Nanovesicles for Fabry Disease Treatment

Judit Tomsen-Melero et al.

Summary: The incorporation of cationic miristalkonium chloride (MKC) surfactant into RGD nanovesicles has been shown to improve loading capacity and colloidal stability, enhancing the protection and delivery of the enzyme. Using MKC in two different nanosystems increases the stability of enzyme loading, with low concentrations of MKC in hybrid liposomes stabilizing the enzyme without compromising its activity. Hybrid liposomes also show improved efficacy in cell cultures and a good safety profile, ensuring their potential for future preclinical and clinical development.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Critical Parameters to Improve Pancreatic Cancer Treatment Using Magnetic Hyperthermia: Field Conditions, Immune Response, and Particle Biodistribution

Lilianne Beola et al.

Summary: The study utilized magnetic hyperthermia for the treatment of pancreatic cancer, finding that optimal alternating magnetic field conditions can enhance cell viability. In vivo experiments revealed the relationship between the distribution of magnetic nanoparticles within tumor tissue and treatment effectiveness. The conclusion highlights the importance of considering particle biodistribution in improving the efficacy of magnetic hyperthermia for pancreatic cancer treatment.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Ultrafast Directional Janus Pt-Mesoporous Silica Nanomotors for Smart Drug Delivery

Paula Diez et al.

Summary: The development of innovative multifunctional nanomotors presents a promising solution for applications in biomedicine, allowing for rapid drug release and specific targeting. These autonomous motion nanomachines demonstrate efficient propulsion and cargo-towing abilities, making them ideal candidates for controlled drug delivery in biomedical settings.

ACS NANO (2021)

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Article Chemistry, Applied

Effective reduction of biofilm through photothermal therapy by gold core@shell based mesoporous silica nanoparticles

Ana Garcia et al.

Summary: This study developed light-sensitive mesoporous silica nanoparticles with combined photothermal and antimicrobial capabilities for targeting bacterial biofilms. The nanosystems exhibited high therapeutic potential by affecting biofilm architecture and inhibiting its growth. The incorporation of nitrosothiol groups and an antimicrobial molecule such as levofloxacin showed promising results in reducing biofilm dispersion and achieving potent antimicrobial therapy.

MICROPOROUS AND MESOPOROUS MATERIALS (2021)

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Article Pharmacology & Pharmacy

Preparation and evaluation of PEG-coated zein nanoparticles for oral drug delivery purposes

C. Reboredo et al.

Summary: The study aimed to produce PEG-coated nanoparticles with mucus-permeating properties for oral drug delivery using simple procedures and regulatory-approved compounds. The nanoparticles were successfully coated with PEG 35,000, reducing their hydrophobic surface and increasing their hydrophilicity. This coating allowed the nanoparticles to have increased mobility in mucus, potentially enhancing the oral bioavailability of biomacromolecules and other biologically active compounds.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

Antibody cooperative adsorption onto AuNPs and its exploitation to force natural killer cells to kill HIV-infected T cells

Antonio Astorga-Gamaza et al.

Summary: A novel nanotool has been developed to enhance the immune response of natural killer cells against HIV-infected T-cells, showing significant cytotoxic effects in experiments.

NANO TODAY (2021)

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Editorial Material Chemistry, Physical

Whither Magnetic Hyperthermia? A Tentative Roadmap

Irene Rubia-Rodriguez et al.

Summary: The scientific community has put great efforts in advancing magnetic hyperthermia in the past two decades, with fruitful international cooperation and careful analysis of lessons learned providing better guarantees for the future development of this nanotherapy against cancer.

MATERIALS (2021)

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Article Biotechnology & Applied Microbiology

Nanotechnology against human cytomegalovirus in vitro: polyanionic carbosilane dendrimers as antiviral agents

I. Relano-Rodriguez et al.

Summary: Polyanionic carbosilane dendrimers have shown potential application in inhibiting HCMV infection and enhancing the activity of current treatments, representing a low-cost approach to fight HCMV infections.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Instruments & Instrumentation

A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin

Irene Santalices et al.

Summary: The study developed and characterized a novel nanoemulsion for oral delivery of hydrophobically modified insulin. The nanoemulsion showed good stability, miscibility, and mucodiffusive behavior in vitro, as well as high interaction and internalization in cell cultures. Additionally, it demonstrated a moderate hypoglycemic response in both healthy and diabetic rat models.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Instruments & Instrumentation

Zein-based nanocarriers for the oral delivery of insulin. In vivo evaluation in Caenorhabditis elegans

Ana L. Martinez-Lopez et al.

Summary: The study evaluated the potential of nanocarriers for oral insulin delivery, specifically using zein nanoparticles coated with a Gantrez (R) AN-PEG conjugate. Results showed that ZNP-GP had higher diffusion coefficient in pig intestinal mucus compared to ZNP, and both types of nanoparticles displayed similar behavior under simulated intestinal conditions. Furthermore, nanoencapsulated insulin in ZNP-GP showed significantly greater effects on reducing glucose and fat accumulation in Caenorhabditis elegans N2 compared to ZNP or insulin in solution.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Pharmacology & Pharmacy

Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles

Elisa Rojas-Prats et al.

Summary: The study introduced a novel approach to improve TDP-43 proteinopathies by encapsulating PHA-767491 in biodegradable nanoparticles to enhance its permeability to the central nervous system.

PHARMACEUTICS (2021)

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Article Multidisciplinary Sciences

Insulin smart drug delivery nanoparticles of aminophenylboronic acid-POSS molecule at neutral pH

Won Jung Kim et al.

Summary: A glucose-responsive continuous insulin delivery system was developed using novel POSS-APBA nanomicelles, offering rapid insulin release at different glucose concentrations. Interaction between PBA and insulin with diol was investigated, showing potential for controlled insulin delivery in the biomedical field.

SCIENTIFIC REPORTS (2021)

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Article Polymer Science

Polymeric Nanoparticles: Exploring the Current Drug Development and Therapeutic Insight of Breast Cancer Treatment and Recommendations

Ali Sartaj et al.

Summary: This manuscript provides an update on polymeric nanoparticle drug delivery for breast cancer treatment post-2015, highlighting its effectiveness in overcoming issues with conventional chemotherapy and drug resistance.

POLYMERS (2021)

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Article Chemistry, Medicinal

Oral Efficacy of a Diselenide Compound Loaded in Nanostructured Lipid Carriers in a Murine Model of Visceral Leishmaniasis

Mikel Etxebeste-Mitxeltorena et al.

Summary: Leishmaniasis is in urgent need of new oral treatments, and compound 2m loaded in NLC has shown potential as an effective therapy, significantly enhancing its intestinal permeability and demonstrating high efficacy in reducing parasite burden in mice experiments.

ACS INFECTIOUS DISEASES (2021)

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Article Materials Science, Multidisciplinary

Sonochemical route for mesoporous silica-coated magnetic nanoparticles towards pH-triggered drug delivery system

Jesus Antonio Fuentes-Garcia et al.

Summary: This study presents a pH-triggered drug release system based on magnetic nanoparticles, showing different drug release ratios under various pH conditions. Experimental results indicate that the released DOX is highly dependent on pH values, with up to 80% release at pH 5.5. These findings suggest the potential application of the system in targeted drug delivery.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2021)

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Article Biochemistry & Molecular Biology

Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles

Vanesa Nozal et al.

Summary: Phosphodiesterase 7 (PDE7) is an enzyme responsible for degrading cAMP, an important cellular messenger, making the search for potential PDE7 inhibitors a hot topic in treating neurodegenerative and inflammatory diseases. S14, a potential PDE7 inhibitor, has shown promising results in studies, while polymeric nanoparticles loaded with S14 have been developed for targeted drug delivery and controlled release. These advancements aim to improve the pharmacokinetic properties of this interesting PDE7 inhibitor.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Targeting Nanomaterials to Head and Neck Cancer Cells Using a Fragment of the Shiga Toxin as a Potent Natural Ligand

Elena Navarro-Palomares et al.

Summary: This study demonstrates the use of molecular cues from the Shiga toxin to target nanomaterials into head and neck cancer cells. By coating nanoparticles with a recombinant chimera protein, specific cellular responses can be activated predictably. This functionalization strategy can transform inert nanomaterials into hybrid nanosystems capable of identifying specific receptors and triggering specific cellular responses.

CANCERS (2021)

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Article Pharmacology & Pharmacy

Modified Gold Nanoparticles to Overcome the Chemoresistance to Gemcitabine in Mutant p53 Cancer Cells

Eduardo Garcia-Garrido et al.

Summary: This study developed a gold nanoparticle modification technique for efficient delivery of Gapmer targeting mutant p53 proteins. These nanoparticles can effectively reduce mutant p53 protein levels, alter related molecular markers, and show promising results in overcoming chemoresistance to gemcitabine in pancreatic cancer treatment.

PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

Antineoplastic effect of a diphtheria toxin-based nanoparticle targeting acute myeloid leukemia cells overexpressing CXCR4

Victor Pallares et al.

Summary: This study successfully induced apoptosis in CXCR4+ leukemic cells using a self-assembling protein nanoparticle, and in a mouse model, blocked the dissemination of AML cells without inducing toxicity in healthy tissues.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Polyglutamic acid-based crosslinked doxorubicin nanogels as an anti-metastatic treatment for triple negative breast cancer

Aroa Duro-Castano et al.

Summary: The research team utilized poly-amino acid-based nanogels (NGs) as a drug delivery platform to successfully inhibit TNBC lung metastasis and almost completely suppress lymph node metastasis in a mouse model.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Materials Science, Biomaterials

Saccorhiza polyschides used to synthesize gold and silver nanoparticles with enhanced antiproliferative and immunostimulant activity

N. Gonzalez-Ballesteros et al.

Summary: In recent years, there has been a growing trend towards using environmentally friendly processes to synthesize nanomaterials, particularly in nanomedicine where the use of bionanofactories has shown promising potential for preserving properties or reducing toxicity. The study demonstrated that gold and silver nanoparticles synthesized using an aqueous extract of Saccorhiza polyschides exhibited superior immunostimulant and antiproliferative activities on immune and tumor cells, indicating significant therapeutic potential for cancer treatment or immunostimulant therapy.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Biochemistry & Molecular Biology

Improvement of Cell Culture Methods for the Successful Generation of Human Keratinocyte Primary Cell Cultures Using EGF-Loaded Nanostructured Lipid Carriers

Jesus Chato-Astrain et al.

Summary: This study evaluated the use of EGF-loaded nanostructured lipid carriers (NLC) to enhance efficiency of human skin keratinocyte primary cultures, showing that NLC-rhEGF culture medium significantly improved cell growth and gene expression.

BIOMEDICINES (2021)

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Article Biochemistry & Molecular Biology

Two-Sided Antibacterial Cellulose Combining Probiotics and Silver Nanoparticles

Laura Sabio et al.

Summary: The study successfully developed a dual-sided biomaterial combining silver nanoparticles and active probiotics to combat infections caused by pathogens like Pseudomonas aeruginosa.

MOLECULES (2021)

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Article Chemistry, Multidisciplinary

Silver Nanoparticles from Annona muricata Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool

Maria G. Gonzalez-Pedroza et al.

Summary: In this study, silver nanoparticles were successfully synthesized using extracts from Annona muricata, showing a more potent anti-tumor effect in fruit peel extract compared to leaf extract. The nanoparticles demonstrated significant cancer cell destruction capabilities at low concentrations, making them a promising and cost-effective tool for cancer treatment.

NANOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Effects of Ipriflavone-Loaded Mesoporous Nanospheres on the Differentiation of Endothelial Progenitor Cells and Their Modulation by Macrophages

Laura Casarrubios et al.

Summary: This study demonstrated the potential of nanoparticles to enhance VEGFR2 expression and angiogenesis in endothelial progenitor cells (EPCs) by intracellular incorporation through endocytosis mechanisms. The nanospheres showed angiogenic effects on EPCs even in the presence of phagocytic cells, confirming their role in promoting vascularization and tissue regeneration.

NANOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Hard and Soft Protein Corona of Nanomaterials: Analysis and Relevance

Rafaela Garcia-Alvarez et al.

Summary: Upon interaction with biological media, nanomaterials can form a protein corona, altering their bio-identity and impacting their behavior and pharmacological properties. Research has shown that protein coronas can be categorized into hard and soft coronas based on protein-nanoparticle affinity, with implications for medical applications.

NANOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Lipid Nanoparticles as Carriers for Bioactive Delivery

Neerupma Dhiman et al.

Summary: Nanotechnology has significantly impacted industries like pharmaceuticals, biotechnology, food, and cosmetics, especially in improving the solubility and bioavailability of lipophilic drugs. Various nanotechnology-based drug delivery systems, such as solid lipid nanoparticulate drug delivery systems and emulsion-based nanodrug delivery systems, play crucial roles in the targeted delivery of poorly soluble drugs. This review provides a comprehensive overview of lipid nanoparticles as carriers of bioactive molecules, covering aspects like synthesis, characterization, advantages, disadvantages, toxicity, and applications in the medical field. Recent developments in patents and clinical trials related to solid lipid nanoparticles (SLNs) and nanostructure lipid carriers (NLCs) are also discussed.

FRONTIERS IN CHEMISTRY (2021)

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Article Multidisciplinary Sciences

Targeting Alzheimer's disease with multimodal polypeptide-based nanoconjugates

A. Duro-Castano et al.

Summary: This study demonstrates the potential of targeted multimodal polypeptide-based nanoconjugates for Alzheimer's disease treatment, showing neuroprotective and neurotrophic effects in organotypic hippocampal culture. The nanoconjugates effectively reduce neurotoxic beta amyloid aggregate levels and rescue impairments in olfactory memory and object recognition, offering a promising therapeutic strategy for AD.

SCIENCE ADVANCES (2021)

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Article Microbiology

Silver Nanoparticles Conjugated with Contact Lens Solutions May Reduce the Risk of Acanthamoeba Keratitis

Edyta B. Hendiger et al.

Summary: Acanthamoeba keratitis is a severe corneal infection that can be effectively reduced by incorporating silver nanoparticles into contact lens solutions without increasing cytotoxicity.

PATHOGENS (2021)

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Article Nanoscience & Nanotechnology

HAP-Multitag, a PET and Positive MRI Contrast Nanotracer for the Longitudinal Characterization of Vascular Calcifications in Atherosclerosis

Juan Pellico et al.

Summary: Vascular microcalcifications are associated with atherosclerosis plaque instability and increased mortality, with imaging probes such as [F-18]FNa playing a key role in their in vivo identification. The development of HAP-multitag shows promise in early characterization of atherosclerosis, with potential for identifying lesion progression and calcification stages using PET/(T-1)MRI imaging.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

3D Printed Microfluidic Device for Magnetic Trapping and SERS Quantitative Evaluation of Environmental and Biomedical Analytes

Lucio Litti et al.

Summary: Surface-enhanced Raman scattering (SERS) is an ideal technique for environmental and biomedical sensor devices due to its highly informative vibrational features and ultrasensitive nature. The use of Janus magnetic/plasmonic Fe3O4/Au nanostars (JMNSs) as SERS colloidal substrates allows for quantitative determination of analytes with the additional amplification of SERS signals using an external magnetic field, showing promising applications in various fields.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Rumiana Tenchov et al.

Summary: Lipid nanoparticles (LNPs) have become promising vehicles in the pharmaceutical industry for delivering various therapeutics, particularly highlighted in the COVID-19 mRNA vaccines. LNPs exhibit versatility and physical stability, allowing for targeted delivery of therapeutic drugs to specific locations within the body. Liposomes, an early version of LNPs, have already been widely applied in medical practice.

ACS NANO (2021)

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Article Engineering, Biomedical

Coating an adenovirus with functionalized gold nanoparticles favors uptake, intracellular trafficking and anti-cancer therapeutic efficacy

Rebeca Gonzalez-Pastor et al.

Summary: Functionalization of gold nanoparticles enhances uptake and biodistribution of adenoviral vectors, improving transduction efficiency and potential for cancer gene therapy.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Infrared-Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia

Erving Ximendes et al.

Summary: Magnetic hyperthermia therapy involves increasing the temperature within solid tumors by using magnetic nanoparticles, but these nanoparticles lack real-time thermal feedback and accurate localization. This study combines magnetic nanoparticles with infrared luminescent nanothermometers in nanocapsules to provide accurate thermal feedback and multimodal imaging capabilities, representing a milestone towards controlled magnetothermal therapy with minimal side effects.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Nanoparticles for Triple Drug Release for Combined Chemo- and Photodynamic Therapy

Gabriel Martinez-Edo et al.

Summary: The pH-responsive drug delivery system based on mesoporous silica nanoparticles has been developed for delivery of three anticancer drugs with different modes of action. The system combines synergistic chemotherapy and photodynamic therapy, allowing for selective release of drugs in the acidic environment of tumor cells. In vitro studies have shown endocytosis of the system into HeLa and HepG2 cells, with subsequent release of drugs.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Eco-friendly extraction of Mastocarpus stellatus carrageenan for the synthesis of gold nanoparticles with improved biological activity

N. Gonzalez-Ballesteros et al.

Summary: The study investigated the extraction of carrageenan from Mastocarpus stellatus and its application in the green synthesis of gold nanoparticles. The synthesized gold nanoparticles exhibited good stability, negative charge, and higher antioxidant activity in cells.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Nanotechnology-Based Strategies to Overcome Current Barriers in Gene Delivery

Sofia Miron-Barroso et al.

Summary: Nanomaterials are being developed for gene delivery, but challenges such as low efficiency and potential toxicity need to be addressed. Advancements in nanotechnology are crucial for overcoming these limitations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Targeted-lung delivery of dexamethasone using gated mesoporous silica nanoparticles. A new therapeutic approach for acute lung injury treatment

Alba Garcia-Fernandez et al.

Summary: The new mesoporous silica nanoparticles-based nanodevice can target lung inflammation and reduce cytokine levels, showing promising anti-inflammatory effects in an ALI mouse model, which could be used for improving ALI treatment methods.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Selective Magnetic Nanoheating: Combining Iron Oxide Nanoparticles for Multi-Hot-Spot Induction and Sequential Regulation

Jesus G. Ovejero et al.

Summary: The technology proposed in this study utilizes the contactless heating capacity of magnetic nanoparticles to generate multiple local temperatures in a single-pot reactor. By adjusting the conditions of the alternating magnetic fields, selective activation of each population of MNPs can be achieved, paving the way for selective regulation of multienzymatic reactions.

NANO LETTERS (2021)

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Article Nanoscience & Nanotechnology

Albumin-based nanostructures for uveal melanoma treatment

Ana Latorre et al.

Summary: An albumin-based nanostructure containing the mTOR kinase inhibitor AZD8055 was developed for efficient delivery to uveal melanoma cells, showing excellent selectivity and activity. The therapeutic approach induced significant cellular toxicity in melanoma cells and reduced tumor growth in vivo using a much lower dose compared to previous reports.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

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Article Polymer Science

Paclitaxel-Loaded Folate-Targeted Albumin-Alginate Nanoparticles Crosslinked with Ethylenediamine. Synthesis and In Vitro Characterization

Ana Maria Martinez-Relimpio et al.

Summary: Utilizing folate-targeted crosslinked nanoparticles based on BSA and alginate mixtures loaded with paclitaxel (PTX) has shown promising results in cancer treatment by enhancing the drug's antineoplastic activity against solid tumors. The sustained release of PTX from the nanoparticles led to a gradual decrease in cell viability, demonstrating the efficacy of the targeted nanocarriers in delivering the drug to cancer cells with overexpressed folate receptors.

POLYMERS (2021)

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Article Chemistry, Multidisciplinary

Controlled pDNA Release in Gemini Cationic Lipoplexes by Femtosecond Laser Irradiation of Gold Nanostars

Natalia Sanchez-Arribas et al.

Summary: This study demonstrates that the use of AuNSs combined with gemini cationic lipoplexes allows control over pDNA release under ultrafast laser irradiation, showing potential for efficient gene therapy applications.

NANOMATERIALS (2021)

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Article Oncology

Albumin-Based Nanoparticles for the Delivery of Doxorubicin in Breast Cancer

Rama Prajapati et al.

Summary: Albumin-based nanocarriers show great potential in breast cancer therapy, providing safety, biocompatibility, and specific cancer-targeting properties. They can be used to deliver a variety of drugs, representing a revolutionary approach in breast cancer treatment.

CANCERS (2021)

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Review Oncology

Albumin Nanostructures for Nucleic Acid Delivery in Cancer: Current Trend, Emerging Issues, and Possible Solutions

Rama Prajapati et al.

Summary: Nucleic acids show potential in cancer therapy, but delivering them to tumor sites is challenging. Albumin-based nanocarriers offer safe and targeted delivery, with strategies for improving internalization and efficacy.

CANCERS (2021)

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Review Pharmacology & Pharmacy

Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications

Raluca Nicu et al.

Summary: Nanocelluloses are considered one of the most promising green materials with remarkable characteristics, and have been widely utilized in the field of biomedical applications and pharmaceuticals. Research has provided a comprehensive review of the characteristics, functional materials, and applications of NCs, while also assessing their cytotoxicity and challenges related to biodegradability.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil Components: An In Vitro and In Vivo Study

Elisa Poyatos-Racionero et al.

Summary: By specifically controlling the release of essential oil components in the small intestine, the M41-payload-L microdevice may have potential as a hybrid system for protecting and administering bioactive molecules in the small intestine and colon.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

mRNA-Based Nanomedicinal Products to Address Corneal Inflammation by Interleukin-10 Supplementation

Itziar Gomez-Aguado et al.

Summary: Developed mRNA-SLN-based nanosystems showed high transfection efficiency and IL-10 expression in treating corneal inflammation. Nanovectors with a mean particle size between 94 and 348 nm and a positive superficial charge were formulated as eye drops containing 1% PVA. After three days of topical administration to mice, all formulations produced GFP in the corneal epithelium.

PHARMACEUTICS (2021)

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Article Biotechnology & Applied Microbiology

Different Microfluidic Environments for In Vitro Testing of Lipid Nanoparticles against Osteosarcoma

Oihane Mitxelena-Iribarren et al.

Summary: Using lipid nanoparticles as biodegradable shells for controlled drug delivery shows promise for more effective and targeted tumor treatment. The study evaluated the effect of methotrexate encapsulated in different matrices in a dynamic microfluidic platform, showing that MTX-lipid nanoparticles are a promising and more effective therapy for pediatric osteosarcoma treatment than current options.

BIOENGINEERING-BASEL (2021)

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Article Chemistry, Multidisciplinary

A glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic AND logic gate for smart delivery

Beatriz Mayol et al.

Summary: This work presents the assembly of a novel enzyme-controlled nanomachine operated through an AND Boolean logic gate for on-command delivery. The nanodevice uses specific chemical signals to release payloads, and has been successfully employed in cancer cells and macrophage cells.

NANOSCALE (2021)

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Article Chemistry, Multidisciplinary

Assessing the parameters modulating optical losses of iron oxide nanoparticles under near infrared irradiation

Claudia Lozano-Pedraza et al.

Summary: The heating mediated by iron oxide nanoparticles under near infrared irradiation has potential for tumor treatment. Factors such as crystal surface defects, aggregation, concentration, magnetite abundance, excitation wavelength, and power density play key roles in the modulation of photothermal conversion.

NANOSCALE ADVANCES (2021)

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Article Oncology

In silico assessment of collateral eddy current heating in biocompatible implants subjected to magnetic hyperthermia treatments

Irene Rubia-Rodriguez et al.

Summary: This study evaluates the impact of secondary magnetic fields generated by metallic prostheses on the safety and efficiency of magnetic hyperthermia treatments for localized tumors. It proposes using a combination of multi-criteria decision analysis and graphical representation of calculated data as an initial screening tool for preclinical risk assessment. By numerically solving the Maxwell equations and heat exchange problem, the study highlights the need to revise the current exclusion criterion for implant-bearing patients in magnetic hyperthermia procedures.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2021)

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Article Pharmacology & Pharmacy

Nanotechnology-Based Targeted Drug Delivery: An Emerging Tool to Overcome Tuberculosis

Zsuzsa Baranyai et al.

Summary: The emergence and rapid spread of drug resistant strains of tuberculosis pose a serious threat to public health, increasing the demand for more effective therapies. Nanotechnology has emerged as a tool to improve current treatments by using antimicrobial-loaded nanocarriers for targeted drug delivery to Mycobacterium tuberculosis-infected macrophages. This strategy aims to increase local drug concentration and enhance treatment efficacy in order to overcome the challenges in TB treatment.

ADVANCED THERAPEUTICS (2021)

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Article Chemistry, Multidisciplinary

Reversible Control of Protein Corona Formation on Gold Nanoparticles Using Host-Guest Interactions

Jesus Mosquera et al.

ACS NANO (2020)

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Article Engineering, Biomedical

Nanoparticles for multimodal antivascular therapeutics: Dual drug release, photothermal and photodynamic therapy

Juan L. Paris et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Biomedical

Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases

Eleni Samaridou et al.

BIOMATERIALS (2020)

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Article Chemistry, Physical

Synthesis, Characterization, and Evaluation of Superparamagnetic Doped Ferrites as Potential Therapeutic Nanotools

Alberto Pardo et al.

CHEMISTRY OF MATERIALS (2020)

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Review Engineering, Biomedical

Recent progress in biomedical applications of RGD-based ligand: From precise cancer theranostics to biomaterial engineering: A systematic review

Mohsen Alipour et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

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Article Biotechnology & Applied Microbiology

Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers

John J. E. Mulvihill et al.

NANOMEDICINE (2020)

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Article Nanoscience & Nanotechnology

MKC-Quatsomes: a stable nanovesicle platform for bio-imaging and drug-delivery applications

Guillem Vargas-Nadal et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

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Article Chemistry, Multidisciplinary

Janus Magnetic-Plasmonic Nanoparticles for Magnetically Guided and Thermally Activated Cancer Therapy

Ana Espinosa et al.

SMALL (2020)

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Article Instruments & Instrumentation

Technological challenges in the preclinical development of an HIV nanovaccine candidate

Tamara G. Dacoba et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Article Oncology

An Auristatin nanoconjugate targeting CXCR4+leukemic cells blocks acute myeloid leukemia dissemination

Victor Pallares et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Polymeric Nanoparticles that Combine Dexamethasone and Naproxen for the Synergistic Inhibition of Il12b Transcription in Macrophages

Eva Espinosa-Cano et al.

MACROMOLECULAR BIOSCIENCE (2020)

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Article Chemistry, Multidisciplinary

Surfactant-Free Synthesis and Scalable Purification of Triangular Gold Nanoprisms with Low Non-Specific Cellular Uptake

Rafael Ramirez-Jimenez et al.

NANOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

Intercellular Trafficking of Gold Nanostars in Uveal Melanoma Cells for Plasmonic Photothermal Therapy

Ruben Ahijado-Guzman et al.

NANOMATERIALS (2020)

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Article Materials Science, Biomaterials

Glycogen Synthase Kinase 3β Inhibitor Delivered by Chitosan Nanocapsules Promotes Safe, Fast, and Efficient Activation of Wnt Signaling In Vivo

Alfredo Ambrosone et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Oncology

Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells

Ana Lazaro-Carrillo et al.

CANCERS (2020)

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Article Pharmacology & Pharmacy

Crosslinked Hyaluronan Electrospun Nanofibers for Ferulic Acid Ocular Delivery

Maria Aurora Grimaudo et al.

PHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Design of Polymeric Nanocapsules for Intranasal Vaccination against Mycobacterium Tuberculosis: Influence of the Polymeric Shell and Antigen Positioning

Lara Diego-Gonzalez et al.

PHARMACEUTICS (2020)

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Article Microbiology

Silver Nanoparticles as a Novel Potential Preventive Agent against Acanthamoeba Keratitis

Edyta B. Hendiger et al.

PATHOGENS (2020)

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Article Nanoscience & Nanotechnology

Biocompatible Nanovector of siRNA Consisting of Arginine-Based Cationic Lipid for Gene Knockdown in Cancer Cells

Natalia Sanchez-Arribas et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Instruments & Instrumentation

Zein-based nanoparticles for the oral delivery of insulin

Laura Inchaurraga et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Article Pharmacology & Pharmacy

Oral delivery of oleuropein-loaded lipid nanocarriers alleviates inflammation and oxidative stress in acute colitis

Amaia Huguet-Casquero et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Immunology

Arginine-Based Poly(I:C)-Loaded Nanocomplexes for the Polarization of Macrophages Toward M1-Antitumoral Effectors

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FRONTIERS IN IMMUNOLOGY (2020)

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Topical Administration of SLN-Based Gene Therapy for the Treatment of Corneal Inflammation by De Novo IL-10 Production

Monica Vicente-Pascual et al.

PHARMACEUTICS (2020)

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Anti-Inflammatory Polymeric Nanoparticles Based on Ketoprofen and Dexamethasone

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PHARMACEUTICS (2020)

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The Intracellular Number of Magnetic Nanoparticles Modulates the Apoptotic Death Pathway after Magnetic Hyperthermia Treatment

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ACS APPLIED MATERIALS & INTERFACES (2020)

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A refined cocktailing of pro-apoptotic nanoparticles boosts anti-tumor activity

Laura Sanchez-Garcia et al.

ACTA BIOMATERIALIA (2020)

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Combining Ag and γ-Fe2O3 properties to produce effective antibacterial nanocomposites

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COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging

Harrisson D. A. Santos et al.

NATURE COMMUNICATIONS (2020)

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The influence of cation incorporation and leaching in the properties of Mn-doped nanoparticles for biomedical applications

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JOURNAL OF COLLOID AND INTERFACE SCIENCE (2020)

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In vitro and in vivo antimicrobial activity of sodium colistimethate and amikacin-loaded nanostructured lipid carriers (NLC)

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

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Protein Expression Knockdown in Cancer Cells Induced by a Gemini Cationic Lipid Nanovector with Histidine-Based Polar Heads

Natalia Sanchez-Arribas et al.

PHARMACEUTICS (2020)

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Review Biochemistry & Molecular Biology

Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles

Miguel Gisbert-Garzaran et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

Montserrat Colilla et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Newly crocin-coated magnetite nanoparticles induce apoptosis and decrease VEGF expression in breast carcinoma cells

Roya Saravani et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

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Nucleic Acid Delivery by Solid Lipid Nanoparticles Containing Switchable Lipids: Plasmid DNA vs. Messenger RNA

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MOLECULES (2020)

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Ipriflavone-Loaded Mesoporous Nanospheres with Potential Applications for Periodontal Treatment

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NANOMATERIALS (2020)

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Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis

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PHARMACEUTICS (2020)

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Optical nanogap antennas as plasmonic biosensors for the detection of miRNA biomarkers

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JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Selective delivery of T22-PE24-H6 to CXCR4+ diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model

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THERANOSTICS (2020)

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An In Situ Hyaluronic Acid-Fibrin Hydrogel Containing Drug-Loaded Nanocapsules for Intra-Articular Treatment of Inflammatory Joint Diseases

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REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE (2020)

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Plasmonic Cell-Derived Nanocomposites for Light-Controlled Cargo Release inside Living Cells

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ADVANCED BIOSYSTEMS (2020)

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Review Chemistry, Multidisciplinary

Nanoparticles: Properties, applications and toxicities

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ARABIAN JOURNAL OF CHEMISTRY (2019)

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Aqueous Stable Gold Nanostar/ZIF-8 Nanocomposites for Light-Triggered Release of Active Cargo Inside Living Cells

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Co-delivery of RNAi and chemokine by polyarginine nanocapsules enables the modulation of myeloid-derived suppressor cells

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JOURNAL OF CONTROLLED RELEASE (2019)

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Review Chemistry, Multidisciplinary

Clinical cancer nanomedicine

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NANO TODAY (2019)

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Safety and effectiveness of sodium colistimethate-loaded nanostructured lipid carriers (SCM-NLC) against P. aeruginosa: in vitro and in vivo studies following pulmonary and intramuscular administration'

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Biotechnology & Applied Microbiology

Nab-paclitaxel in pretreated metastatic breast cancer: evaluation of activity, safety, and quality of life

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ONCOTARGETS AND THERAPY (2019)

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Solid Lipid Nanoparticles Surface Modification Modulates Cell Internalization and Improves Chemotoxic Treatment in an Oral Carcinoma Cell Line

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NANOMATERIALS (2019)

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Article Chemistry, Multidisciplinary

Polysaccharide Nanoparticles Can Efficiently Modulate the Immune Response against an HIV Peptide Antigen

Tamara G. Dacoba et al.

ACS NANO (2019)

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Article Chemistry, Multidisciplinary

Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Marker Expression for Osteoporosis Treatment

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Janus Gold Nanostars-Mesoporous Silica Nanoparticles for NIR-Light-Triggered Drug Delivery

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CHEMISTRY-A EUROPEAN JOURNAL (2019)

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Mesoporous Silica-Based Materials with Bactericidal Properties

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SMALL (2019)

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MMP-9 Downregulation with Lipid Nanoparticles for Inhibiting Corneal Neovascularization by Gene Silencing

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NANOMATERIALS (2019)

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Article Oncology

Immunotherapeutic effects of intratumoral nanoplexed poly I:C

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JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Review Chemistry, Multidisciplinary

Plasmonic Supercrystals

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ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Flower-like Mn-Doped Magnetic Nanoparticles Functionalized with αvβ3-Integrin-Ligand to Efficiently Induce Intracellular Heat after Alternating Magnetic Field Exposition, Triggering Glioma Cell Death

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ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Engineering, Biomedical

Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment

Marina Martinez-Carmona et al.

ACTA BIOMATERIALIA (2019)

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A novel low molecular weight nanocomposite hydrogel formulation for intra-tumoural delivery of anti-cancer drugs

Ivana Staka et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Review Biochemistry & Molecular Biology

Natural Polysaccharides for siRNA Delivery: Nanocarriers Based on Chitosan, Hyaluronic Acid, and Their Derivatives

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MOLECULES (2019)

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Article Nanoscience & Nanotechnology

Polyethylenimine-coated superparamagnetic iron oxide nanoparticles impair in vitro and in vivo angiogenesis

Vladimir Mulens-Arias et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Nylon-Supported Plasmonic Assay Based on the Aggregation of Silver Nanoparticles: In Situ Determination of Hydrogen Sulfide-like Compounds in Breath Samples as a Proof of Concept

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Article Oncology

Multifunctional Albumin-Stabilized Gold Nanoclusters for the Reduction of Cancer Stem Cells

Ana Latorre et al.

CANCERS (2019)

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Microswimmers with Heat Delivery Capacity for 3D Cell Spheroid Penetration

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Article Engineering, Biomedical

An Ag-loaded photoactive nano-metal organic framework as a promising biofilm treatment

Ana Arenas-Vivo et al.

ACTA BIOMATERIALIA (2019)

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Gold nanoparticles for the in situ polymerization of near-infrared responsive hydrogels based on fibrin

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ACTA BIOMATERIALIA (2019)

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Review Chemistry, Inorganic & Nuclear

Photothermally Active Inorganic Nanoparticles: from Colloidal Solutions to Photothermally Active Printed Surfaces and Polymeric Nanocomposite Materials

Mykola Borzenkov et al.

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2019)

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Review Biochemistry & Molecular Biology

Nanomaterials as Promising Alternative in the Infection Treatment

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Chemistry, Multidisciplinary

In vivo ultrasound-activated delivery of recombinant tissue plasminogen activator from the cavity of sub-micrometric capsules

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JOURNAL OF CONTROLLED RELEASE (2019)

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Article Biotechnology & Applied Microbiology

Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules

Alvaro Casadome-Perales et al.

NANOMEDICINE (2019)

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Article Biotechnology & Applied Microbiology

Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8+ T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes

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JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Immunology

Magnetic Nanoparticles Attached to the NK Cell Surface for Tumor Targeting in Adoptive Transfer Therapies Does Not Affect Cellular Effector Functions

Laura Sanz-Ortega et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Medicine, General & Internal

Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity

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Article Biochemical Research Methods

Dynamic Equilibrium in the Cetyltrimethylammonium Bromide-Au Nanoparticle Bilayer, and the Consequent Impact on the Formation of the Nanoparticle Protein Corona

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BIOCONJUGATE CHEMISTRY (2019)

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Article Materials Science, Biomaterials

Evaluation of cationic core-shell thermoresponsive poly(N-vinylcaprolactam)-based microgels as potential drug delivery nanocarriers

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Cell-Promoted Nanoparticle Aggregation Decreases Nanoparticle-Induced Hyperthermia under an Alternating Magnetic Field Independently of Nanoparticle Coating, Core Size, and Subcellular Localization

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ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Pharmacology & Pharmacy

Triggering antitumoural drug release and gene expression by magnetic hyperthermia

Maria Moros et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Review Pharmacology & Pharmacy

Design strategies for shape-controlled magnetic iron oxide nanoparticles

Alejandro G. Roca et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs

Ana Cadete et al.

SCIENTIFIC REPORTS (2019)

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Article Biotechnology & Applied Microbiology

pH-triggered endosomal escape of pore-forming Listeriolysin O toxin-coated gold nanoparticles

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JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Combination of light-driven co-delivery of chemodrugs and plasmonic-induced heat for cancer therapeutics using hybrid protein nanocapsules

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JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Pharmacology & Pharmacy

Biocompatibility studies of intravenously administered ionic-crosslinked chitosan-BSA nanoparticles as vehicles for antitumour drugs

Nuria Montero et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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A multifunctional drug nanocarrier for efficient anticancer therapy

Carmen Teijeiro-Valino et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Pharmacology & Pharmacy

Engineering polymeric nanocapsules for an efficient drainage and biodistribution in the lymphatic system

Ana Sara Cordeiro et al.

JOURNAL OF DRUG TARGETING (2019)

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Article Biotechnology & Applied Microbiology

In vivo comparison of the biodistribution and long-term fate of colloids - gold nanoprisms and nanorods - with minimum surface modification

Gabriel Alfranca et al.

NANOMEDICINE (2019)

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Article Biotechnology & Applied Microbiology

Design of polymeric nanocapsules to improve their lympho-targeting capacity

Jose Crecente-Campo et al.

NANOMEDICINE (2019)

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Article Biotechnology & Applied Microbiology

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field

Laura Sanz-Ortega et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Review Oncology

Hyperthermia: The Optimal Treatment to Overcome Radiation Resistant Hypoxia

Pernille B. Elming et al.

CANCERS (2019)

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Thermal monitoring during photothermia: hybrid probes for simultaneous plasmonic heating and near-infrared optical nanothermometry

Marta Quintanilla et al.

THERANOSTICS (2019)

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Article Nanoscience & Nanotechnology

Glucose-Responsive Enzyme-Controlled Mesoporous Nanomachine with a Layer-by-Layer Supramolecular Architecture

Sandra Jimenez-Falcao et al.

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Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model

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SCIENTIFIC REPORTS (2019)

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Review Biochemistry & Molecular Biology

Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights

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MOLECULES (2018)

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Article Nanoscience & Nanotechnology

Beyond Traditional Hyperthermia: In Vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers

Eduardo Guisasola et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Nanoscience & Nanotechnology

Effect of Surface Chemistry and Associated Protein Corona on the Long-Term Biodegradation of Iron Oxide Nanoparticles In Vivo

Grazyna Stepien et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Dynamical Magnetic Response of Iron Oxide Nano articles Inside Live Cells

David Cabrera et al.

ACS NANO (2018)

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Article Engineering, Biomedical

Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment

Marina Martinez-Carmona et al.

ACTA BIOMATERIALIA (2018)

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Article Oncology

Oral administration of edelfosine encapsulated lipid nanoparticles causes regression of lung metastases in pre-clinical models of osteosarcoma

Yolanda Gonzalez-Fernandez et al.

CANCER LETTERS (2018)

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Article Engineering, Environmental

New active formulations against M. tuberculosis: Bedaquiline encapsulation in lipid nanoparticles and chitosan nanocapsules

L. De Matteis et al.

CHEMICAL ENGINEERING JOURNAL (2018)

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Article Chemistry, Multidisciplinary

Plasmid-Templated Control of DNA-Cyclodextrin Nanoparticle Morphology through Molecular Vector Design for Effective Gene Delivery

Laura Gallego-Yerga et al.

CHEMISTRY-A EUROPEAN JOURNAL (2018)

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Article Chemistry, Multidisciplinary

Highly Stable and Red-Emitting Nanovesicles Incorporating Lipophilic Diketopyrrolopyrroles for Cell Imaging

Antonio Ardizzone et al.

CHEMISTRY-A EUROPEAN JOURNAL (2018)

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Article Biophysics

RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia

Oihane K. Arriortua et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Article Biophysics

Bacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment

M. L. Cacicedo et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Article Pharmacology & Pharmacy

Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery

Maria C. Llinas et al.

DRUG DELIVERY (2018)

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A versatile drug delivery system targeting senescent cells

Daniel Munoz-Espin et al.

EMBO MOLECULAR MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Lipid Nanoparticles Decorated with TNF-Related Aptosis-Inducing Ligand (TRAIL) Are More Cytotoxic than Soluble Recombinant TRAIL in Sarcoma

Ana Gallego-Lleyda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Nanoscience & Nanotechnology

Cholesteryl oleate-loaded cationic solid lipid nanoparticles as carriers for efficient gene-silencing therapy

Marc Sune-Pou et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Review Respiratory System

The Rationale and Evidence for Use of Inhaled Antibiotics to Control Pseudomonas aeruginosa Infection in Non-cystic Fibrosis Bronchiectasis

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JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2018)

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PEG-PGA enveloped octaarginine-peptide nanocomplexes: An oral peptide delivery strategy

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JOURNAL OF CONTROLLED RELEASE (2018)

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Article Chemistry, Multidisciplinary

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs

Laura Sanchez-Garcia et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Review Engineering, Biomedical

Mesoporous silica nanoparticles in nanomedicine applications

Miguel Manzano et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2018)

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Article Materials Science, Biomaterials

Hybrid folic acid-conjugated gold nanorods-loaded human serum albumin nanoparticles for simultaneous photothermal and chemotherapeutic therapy

David Encinas-Basurto et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Review Biochemistry & Molecular Biology

Nanotechnological Strategies for Protein Delivery

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MOLECULES (2018)

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Article Chemistry, Physical

Targeted Chemo-Photothermal Therapy: A Nanomedicine Approximation to Selective Melanoma Treatment

Gonzalo Villaverde et al.

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (2018)

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Article Chemistry, Multidisciplinary

Nanostructuring Lipophilic Dyes in Water Using Stable Vesicles, Quatsomes, as Scaffolds and Their Use as Probes for Bioimaging

Antonio Ardizzone et al.

SMALL (2018)

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Article Multidisciplinary Sciences

Impact of ConcanavalinA affinity in the intracellular fate of Protein Corona on Glucosamine Au nanoparticles

Desire Di Silvio et al.

SCIENTIFIC REPORTS (2018)

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Article Microbiology

Antibacterial Activity of Glutathione-Stabilized Silver Nanoparticles Against Campylobacter Multidrug-Resistant Strains

Jose M. Silvan et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Article Chemistry, Multidisciplinary

Recent Development of Inorganic Nanoparticles for Biomedical Imaging

Dokyoon Kim et al.

ACS CENTRAL SCIENCE (2018)

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Article Chemistry, Multidisciplinary

Effective in Vitro Photokilling by Cell-Adhesive Gold Nanorods

Alvaro Artiga et al.

FRONTIERS IN CHEMISTRY (2018)

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Article Engineering, Biomedical

Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment

Juan J. Arroyo-Crespo et al.

BIOMATERIALS (2018)

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Review Engineering, Biomedical

Immunomodulatory properties of chitosan polymers

Hannah B. T. Moran et al.

BIOMATERIALS (2018)

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Article Biophysics

Nanoplasmonic biosensor device for the monitoring of acenocoumarol therapeutic drug in plasma

E. Cristina Pelaez et al.

BIOSENSORS & BIOELECTRONICS (2018)

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Review Chemistry, Medicinal

Targeted Drug Delivery Via Human Epidermal Growth Factor Receptor for Sustained Release of Allyl Isothiocyanate

David Encinas-Basurto et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2018)

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Review Biochemistry & Molecular Biology

Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy

Sungmin Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Medicine, Research & Experimental

Design, Characterization, and Biopharmaceutical Behavior of Nanoparticles Loaded with an HIV-1 Fusion Inhibitor Peptide

Martha Ariza-Saenz et al.

MOLECULAR PHARMACEUTICS (2018)

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Article Chemistry, Multidisciplinary

Combining Adhesive Nanostructured Surfaces and Costimulatory Signals to Increase T Cell Activation

Judith Guasch et al.

NANO LETTERS (2018)

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Article Parasitology

Tannic acid-modified silver nanoparticles as a novel therapeutic agent against Acanthamoeba

Marcin Padzik et al.

PARASITOLOGY RESEARCH (2018)

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Article Nanoscience & Nanotechnology

Dual Role of Magnetic Nanoparticles as Intracellular Hotspots and Extracellular Matrix Disruptors Triggered by Magnetic Hyperthermia in 3D Cell Culture Models

Lilianne Beola et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

Protamine nanocapsules as carriers for oral peptide delivery

Lungile Nomcebo Thwala et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Medicine, Research & Experimental

Protamine Nanocapsules for the Development of Thermostable Adjuvanted Nanovaccines

Jose Vicente Gonzalez-Aramundiz et al.

MOLECULAR PHARMACEUTICS (2018)

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Article Chemistry, Multidisciplinary

Gold Nanorod-Based Nanohybrids for Combinatorial Therapeutics

Eva Villar-Alvarez et al.

ACS OMEGA (2018)

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Review Chemistry, Physical

Heating at the Nanoscale through Drug-Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

Eduardo Guisasola et al.

SMALL METHODS (2018)

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Article Engineering, Multidisciplinary

Reprogramming Cells for Synergistic Combination Therapy with Nanotherapeutics against Uveal Melanoma

Paula Milan Rois et al.

BIOMIMETICS (2018)

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Article Chemistry, Multidisciplinary

Multidisciplinary Approach to the Transfection of Plasmid DNA by a Nonviral Nanocarrier Based on a Gemini-Bolaamphiphilic Hybrid Lipid

Maria Martinez-Negro et al.

ACS OMEGA (2018)

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Article Pharmacology & Pharmacy

Penetration of polymeric nanoparticles loaded with an HIV-1 inhibitor peptide derived from GB virus C in a vaginal mucosa model

Martha Ariza-Saenz et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

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Article Pharmacology & Pharmacy

Improved formulation of cationic solid lipid nanoparticles displays cellular uptake and biological activity of nucleic acids

Anna Fabregas et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Review Pharmacology & Pharmacy

The effect of particle shape on cellular interaction and drug delivery applications of micro-and nanoparticles

Anil B. Jindal

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Plasmonic/magnetic nanocomposites: Gold nanorods-functionalized silica coated magnetic nanoparticles

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JOURNAL OF COLLOID AND INTERFACE SCIENCE (2017)

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Rational design of polyarginine nanocapsules intended to help peptides overcoming intestinal barriers

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JOURNAL OF CONTROLLED RELEASE (2017)

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Rational design of protamine nanocapsules as antigen delivery carriers

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JOURNAL OF CONTROLLED RELEASE (2017)

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Gold Suprashells: Enhanced Photothermal Nanoheaters with Multiple Localized Surface Plasmon Resonances for Broadband Surface-Enhanced Raman Scattering

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JOURNAL OF PHYSICAL CHEMISTRY C (2017)

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Correction Biochemistry & Molecular Biology

Design of Poly-l-Glutamate-Based Complexes for pDNA Delivery (vol 10, 1700029, 2017)

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Microencapsulated Solid Lipid Nanoparticles as a Hybrid Platform for Pulmonary Antibiotic Delivery

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An experimental and computational framework for engineering multifunctional nanoparticles: designing selective anticancer therapies

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New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival

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NUCLEIC ACIDS RESEARCH (2017)

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Colloidal Flower-Shaped Iron Oxide Nanoparticles: Synthesis Strategies and Coatings

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PHARMACOLOGICAL RESEARCH (2017)

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Silver nanoparticles in the environment: Sources, detection and ecotoxicology

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SCIENCE OF THE TOTAL ENVIRONMENT (2017)

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Light-Triggered Inactivation of Enzymes with Photothermal Nanoheaters

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Biogenic Synthesis of Metal Nanoparticles Using a Biosurfactant Extracted from Corn and Their Antimicrobial Properties

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Tripalmitin nanoparticle formulations significantly enhance paclitaxel antitumor activity against breast and lung cancer cells in vitro

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SCIENTIFIC REPORTS (2017)

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Targeted Nanoparticles for the Treatment of Alzheimer's Disease

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Benznidazole Nanoformulates: A Chance to Improve Therapeutics for Chagas Disease

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Magnetic hyperthermia enhances cell toxicity with respect to exogenous heating

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In Vivo Subcutaneous Thermal Video Recording by Supersensitive Infrared Nanothermometers

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Gold nanoparticles stabilized by cationic carbosilane dendrons: synthesis and biological properties

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Freeze-dried cylinders carrying chitosan nanoparticles for vaginal peptide delivery

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Effectiveness of nanoencapsulated methotrexate against osteosarcoma cells: in vitro cytotoxicity under dynamic conditions

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In Vivo Deep Tissue Fluorescence and Magnetic Imaging Employing Hybrid Nanostructures

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Subtissue Imaging and Thermal Monitoring of Gold Nanorods through Joined Encapsulation with Nd-Doped Infrared-Emitting Nanoparticles

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Roadmap on biosensing and photonics with advanced nano-optical methods

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Cancer Cell Internalization of Gold Nanostars Impacts Their Photothermal Efficiency In Vitro and In Vivo: Toward a Plasmonic Thermal Fingerprint in Tumoral Environment

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Protein Corona of Nanoparticles: Distinct Proteins Regulate the Cellular Uptake

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(Intra)Cellular Stability of Inorganic Nanoparticles: Effects on Cytotoxicity, Particle Functionality, and Biomedical Applications

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Facile and Sustainable Synthesis of Shaped Iron Oxide Nanoparticles: Effect of Iron Precursor Salts on the Shapes of Iron Oxides

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Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations

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Mechanisms of Silver Nanoparticle Release, Transformation and Toxicity: A Critical Review of Current Knowledge and Recommendations for Future Studies and Applications

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Gold Nanoparticles in Chemical and Biological Sensing

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Design of polymeric nanoparticles for biomedical delivery applications

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Study of Heating Efficiency as a Function of Concentration, Size, and Applied Field in γ-Fe2O3 Nanoparticles

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CLINICA CHIMICA ACTA (2010)

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Tuning Size and Sensing Properties in Colloidal Gold Nanostars

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CHEMICAL SOCIETY REVIEWS (2008)

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Large-Scale Synthesis of Single-Crystalline Iron Oxide Magnetic Nanorings

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

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Large-scale synthesis of Fe3O4 nanosheets at low temperature

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JOURNAL OF PHYSICAL CHEMISTRY C (2007)

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Geomicrobiology of cave ferromanganese deposits: A field and laboratory investigation

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A new property of MCM-41:: Drug delivery system

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CHEMISTRY OF MATERIALS (2001)

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