ROS induced lipid peroxidation and their role in ferroptosis

Reactive oxygen species (ROS) play a crucial part in the process of cell death, including apoptosis, autophagy, and ferroptosis. ROS involves in the oxidation of lipids and generate 4-hydroxynonenal and other compounds associated with it. Ferroptosis may be facilitated by lipid peroxidation of phospholipid bilayers. In order to offer novel ideas and directions for the investigation of disorders connected to these processes, we evaluate the function of ROS in lipid peroxidation which ultimately leads to ferroptosis as well as proposed crosstalk mechanisms between ferroptosis and other types programmed cell death.

Automated summary

Reactive oxygen species (ROS) are involved in cell death processes, such as apoptosis, autophagy, and ferroptosis. ROS play a role in lipid oxidation and generate compounds like 4-hydroxynonenal. Lipid peroxidation may facilitate ferroptosis. In order to explore disorders related to these processes, we evaluate the function of ROS in lipid peroxidation leading to ferroptosis and propose crosstalk mechanisms between ferroptosis and other types of programmed cell death.