Effects of clinical medications on male fertility and prospects for stem cell therapy

An increasing number of men require long-term drug therapy for various diseases. However, the effects of long-term drug therapy on male fertility are often not well evaluated in clinical practice. Meanwhile, the development of stem cell therapy and exosomes treatment methods may provide a new sight on treating male infertility. This article reviews the influence and mechanism of small molecule medications on male fertility, as well as progress of stem cell and exosomes therapy for male infertility with the purpose on providing suggestions (recommendations) for evaluating the effect of drugs on male fertility (both positive and negative effect on male fertility) in clinical application and providing strategies for diagnosis and treatment of male infertility.

Automated summary

An increasing number of men requiring long-term drug therapy has raised concerns about its impact on male fertility. However, there is a lack of evaluation in clinical practice. This article reviews the effects of small molecule medications on male fertility and explores the potential of stem cell therapy and exosomes treatment in addressing male infertility, aiming to provide recommendations for evaluating the effects of drugs on male fertility and strategies for diagnosis and treatment.