Pannexin1 channels in the liver: an open enemy

Pannexin1 proteins form communication channels at the cell plasma membrane surface, which allow the transfer of small molecules and ions between the intracellular compartment and extracellular environment. In this way, pannexin1 channels play an important role in various cellular processes and diseases. Indeed, a plethora of human pathologies is associated with the activation of pannexin1 channels. The present paper reviews and summarizes the structure, life cycle, regulation and (patho)physiological roles of pannexin1 channels, with a particular focus on the relevance of pannexin1 channels in liver diseases.

Automated summary

Pannexin1 proteins form communication channels at the cell membrane surface, facilitating the transfer of molecules and ions. These channels are crucial in cellular processes and can contribute to various diseases. This paper reviews the structure, regulation, and physiological roles of pannexin1 channels, with a focus on their relevance in liver diseases.