☆ 4.7 Article

Perilipin 3 promotes the formation of membrane domains enriched in diacylglycerol and lipid droplet biogenesis proteins

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting

Maria-Jesus Olarte et al.

Summary: In this review, the two pathways for direct LD protein localization are discussed: the CYTOLD pathway mediates protein targeting from the cytosol to LDs, and the ERTOLD pathway functions in protein targeting from the endoplasmic reticulum to LDs. The emerging principles for each targeting pathway in animal cells are described, along with highlighting open questions in the field.

TRENDS IN BIOCHEMICAL SCIENCES (2022)

添加到收藏夹

Article Cell Biology

The surface of lipid droplets constitutes a barrier for endoplasmic reticulum-resident integral membrane proteins

Rasha Khaddaj et al.

Summary: This study investigates the localization of integral membrane proteins to the surface of lipid droplets (LDs) and confirms that the ER-LD junction acts as a barrier for ER-resident integral membrane proteins. The study also reveals that certain membrane proteins can be targeted to LDs through LD-targeted proteins.

JOURNAL OF CELL SCIENCE (2022)

添加到收藏夹

Article Cell Biology

Seipin collaborates with the ER membrane to control the sites of lipid droplet formation

Roger Schneiter et al.

Summary: Most cells store metabolic energy in lipid droplets (LDs), which consist of a hydrophobic core covered by a phospholipid monolayer. Recent evidence suggests that LD formation occurs in specific subdomains of the endoplasmic reticulum (ER) where proteins gather to initiate LD assembly. The lipodystrophy protein Seipin plays a crucial role in LD biogenesis by forming a large oligomeric toroidal structure that promotes LD nucleation. This article discusses the role of LD biogenesis factors that interact with Seipin to assemble functional LDs.

CURRENT OPINION IN CELL BIOLOGY (2022)

添加到收藏夹

Article Cell Biology

Lipid droplets form a network interconnected by the endoplasmic reticulum through which their proteins equilibrate

Stephanie Cottier et al.

Summary: Lipid droplets (LDs) are intracellular structures for neutral lipid storage, and their protein transfer is influenced by yeast cell fusion and the ER membrane. This transfer is continuous, bidirectional, and the LDs are interconnected through the ER membrane.

JOURNAL OF CELL SCIENCE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane

Xavier Prasanna et al.

Summary: Seipin can trap TAGs in the ER bilayer via its luminal hydrophobic helices, serving as a catalyst for seeding the TAG cluster and generating a favorable promethin binding interface.

PLOS BIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure

Valeria Zoni et al.

Summary: Lipid droplets are intracellular organelles responsible for lipid storage that emerge from the endoplasmic reticulum. Through molecular dynamics simulations, it has been revealed that seipin promotes lipid droplet formation by clustering lipids in its unconventional ring-like oligomeric structure, suggesting a role in priming specific ER sites for LD biogenesis.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Review Cell Biology

Lipid Droplet Nucleation

Abdou Rachid Thiam et al.

Summary: This review focuses on the nucleation step of lipid droplet assembly, discussing how membrane biophysical and physicochemical properties control this process and the role of proteins in orchestrating lipid droplet biogenesis.

TRENDS IN CELL BIOLOGY (2021)

添加到收藏夹

Article Biology

Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets

Valeria Zoni et al.

Summary: The interactions between lipid acyl-chains play a key role in regulating the storage of neutral lipids in lipid droplets, affecting their distribution in cells. Different types of acyl-chains have distinct effects on lipid droplet formation and lipid storage.

ELIFE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

Yoel A. Klug et al.

Summary: The study revealed the mechanism of lipid droplet formation by the coordination of yeast Seipin Sei1 and its partner Ldb16. Sei1 assembles a homooligomeric ring in the ER to concentrate triacylglycerol, promoting Ldb16 stability and lipid droplet assembly.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Biology

Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

Manuel Gimenez-Andres et al.

Summary: This study reveals the mechanism by which Plin4 forms a stable protein layer on the surface of LDs, with the stability of its AHs on LDs being sensitive to the nature and distribution of its polar residues, suggesting a general mechanism of AH stabilization via lateral interactions.

ELIFE (2021)

添加到收藏夹

Review Cell Biology

A Unique Junctional Interface at Contact Sites Between the Endoplasmic Reticulum and Lipid Droplets

Vineet Choudhary et al.

Summary: Lipid droplets (LDs) store metabolic energy in the form of neutral lipids and originate from the endoplasmic reticulum (ER), maintaining contact with it to facilitate protein and lipid exchange. Proper formation of ER-LD junctions is crucial to prevent the formation of aberrant LDs, which can impact lipid homeostasis and lead to lipid storage diseases. The close contacts between LDs, peroxisomes, and mitochondria play a role in metabolic channeling of fatty acids, highlighting the importance of LD contact sites in lipid metabolism.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Cell Biology

Ultrastructural plasma membrane asymmetries in tension and curvature promote yeast cell fusion

Olivia Muriel et al.

Summary: In the process of cell-cell fusion in walled fission yeast, researchers have discovered marked asymmetries between gametes, with the plasma membrane of h- cells protruding into h+ cells. This asymmetry is relaxed upon fusion, with the formation of ramified fusion pores. This suggests that differential turgor pressure and exocytosis/endocytosis ratios between mating types favor cell-cell fusion.

JOURNAL OF CELL BIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Phosphatidate-mediated regulation of lipid synthesis at the nuclear/endoplasmic reticulum membrane

Joanna M. Kwiatek et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Spatial compartmentalization of lipid droplet biogenesis

Mike Henne et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)

添加到收藏夹

Article Cell Biology

Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis

Vineet Choudhary et al.

JOURNAL OF CELL BIOLOGY (2020)

添加到收藏夹

Review Cell Biology

Lipid droplet biogenesis: A mystery unmixing?

Mike F. Renne et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

添加到收藏夹

Article Cell Biology

Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating lipid droplet biogenesis

Hanaa Hariri et al.

JOURNAL OF CELL BIOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain

Zhe Cao et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Cell Biology

Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets

Dalila Ajjaji et al.

MOLECULAR BIOLOGY OF THE CELL (2019)

添加到收藏夹

Review Cell Biology

Dynamics and functions of lipid droplets

James A. Olzmann et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

添加到收藏夹

Article Cell Biology

Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation

Michal Eisenberg-Bord et al.

JOURNAL OF CELL BIOLOGY (2018)

添加到收藏夹

Article Cell Biology

Regulation of lipid droplets by metabolically controlled Ldo isoforms

Vitor Teixeira et al.

JOURNAL OF CELL BIOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lipid droplet proteins and metabolic diseases

Shimeng Xu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Architecture of Lipid Droplets in Endoplasmic Reticulum Is Determined by Phospholipid Intrinsic Curvature

Vineet Choudhary et al.

CURRENT BIOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets

Alenka Copic et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Lipid droplet and peroxisome biogenesis occur at the same ER subdomains

Amit S. Joshi et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum

Sihui Wang et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Many Faces of Amphipathic Helices

Manuel Gimenez-Andres et al.

BIOMOLECULES (2018)

添加到收藏夹

Article Cell Biology

Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly

Qiang Gao et al.

JOURNAL OF CELL BIOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Automated tilt series alignment and tomographic reconstruction in IMOD

David N. Mastronarde et al.

JOURNAL OF STRUCTURAL BIOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Perilipins: a diversity of intracellular lipid droplet proteins

Hiroyuki Itabe et al.

LIPIDS IN HEALTH AND DISEASE (2017)

添加到收藏夹

Review Gastroenterology & Hepatology

Lipid droplets and liver disease: from basic biology to clinical implications

Nina L. Gluchowski et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis

Carole Sztalryd et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2017)

添加到收藏夹

Review Nutrition & Dietetics

The Perilipins: Major Cytosolic Lipid Droplet-Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis

Alan R. Kimmel et al.

ANNUAL REVIEW OF NUTRITION, VOL 36 (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

The physics of lipid droplet nucleation, growth and budding

Abdou Rachid Thiam et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3

Emily R. Rowe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

添加到收藏夹

Article Cell Biology

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

Vineet Choudhary et al.

JOURNAL OF CELL BIOLOGY (2015)

添加到收藏夹

Article Cell Biology

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

Florian Wilfling et al.

DEVELOPMENTAL CELL (2013)

添加到收藏夹

Review Medicine, Research & Experimental

Balancing the fat: lipid droplets and human disease

Natalie Krahmer et al.

EMBO MOLECULAR MEDICINE (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Regulation of the Yeast Triacylglycerol Lipase Tgl3p by Formation of Nonpolar Lipids

Claudia Schmidt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

添加到收藏夹

Article Cell Biology

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

Adam Kassan et al.

JOURNAL OF CELL BIOLOGY (2013)

添加到收藏夹

Article Cell Biology

Expression of oleosin and perilipins in yeast promotes formation of lipid droplets from the endoplasmic reticulum

Nicolas Jacquier et al.

JOURNAL OF CELL SCIENCE (2013)

添加到收藏夹

Article Biochemical Research Methods

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

Susanne A. I. Seidel et al.

METHODS (2013)

添加到收藏夹

Article Cell Biology

The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets

Oludotun Adeyo et al.

JOURNAL OF CELL BIOLOGY (2011)

添加到收藏夹

Article Cell Biology

Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae

Nicolas Jacquier et al.

JOURNAL OF CELL SCIENCE (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Triglyceride Blisters in Lipid Bilayers: Implications for Lipid Droplet Biogenesis and the Mobile Lipid Signal in Cancer Cell Membranes

Himanshu Khandelia et al.

PLOS ONE (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Protein-binding assays in biological liquids using microscale thermophoresis

Christoph J. Wienken et al.

NATURE COMMUNICATIONS (2010)

添加到收藏夹

Review Endocrinology & Metabolism

The genetics of neutral lipid biosynthesis: an evolutionary perspective

Aaron R. Turkish et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Diacylglycerol Enrichment of Endoplasmic Reticulum or Lipid Droplets Recruits Perilipin 3/TIP47 during Lipid Storage and Mobilization

James R. Skinner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

添加到收藏夹

Article Cell Biology

TIP47 functions in the biogenesis of lipid droplets

Anna V. Bulankina et al.

JOURNAL OF CELL BIOLOGY (2009)

添加到收藏夹

Article Cell Biology

Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets

John K. Zehmer et al.

JOURNAL OF CELL SCIENCE (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry

Christer S. Ejsing et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

添加到收藏夹

Review Biochemistry & Molecular Biology

The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis

Dawn L. Brasaemle

JOURNAL OF LIPID RESEARCH (2007)

添加到收藏夹

Review Biochemistry & Molecular Biology

Synthesis, storage and degradation of neutral lipids in yeast

Tibor Czabany et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase

Laura O'Hara et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles

K Athenstaedt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth

H Santos-Rosa et al.

EMBO JOURNAL (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Saccharomyces cerevisiae YLL012/YEH1, YLR020/YEH2, and TGL1 genes encode a novel family of membrane-anchored lipases that are required for steryl ester hydrolysis

R Köffel et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure of a lipid droplet protein: The PAT family member TIP47

SJ Hickenbottom et al.

STRUCTURE (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeast -: art. no. e23

U Gueldener et al.

NUCLEIC ACIDS RESEARCH (2002)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lipid binding-induced conformational change in human apolipoprotein E - Evidence for two lipid-bound states on spherical particles

H Saito et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

添加到收藏夹

Article Biochemistry & Molecular Biology

TIP47 associates with lipid droplets

NE Wolins et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

添加到收藏夹

Article Biochemistry & Molecular Biology

1-acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles

K Athenstaedt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.