4.7 Review

Regulation of adult stem cell function by ketone bodies

期刊

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2023.1246998

关键词

adult stem cells; ketone bodies; stem cell function; regenerative medicine; tissue homeostasis; cellular metabolism; beta-hydroxybutyrylation

向作者/读者索取更多资源

Recent evidence suggests that dietary interventions and ketone body supplementation can impact adult stem cell function and have implications for regenerative medicine. This review discusses the mechanisms by which ketone bodies influence adult stem cells, including ketogenesis, uptake and transport, signaling, and cellular metabolism. The exploration of these mechanisms reveals potential therapeutic targets for tissue regeneration and age-related diseases.
Adult stem cells play key roles in tissue homeostasis and regeneration. Recent evidence suggests that dietary interventions can significantly impact adult stem cell function. Some of these effects depend on ketone bodies. Adult stem cells could therefore potentially be manipulated through dietary regimens or exogenous ketone body supplementation, a possibility with significant implications for regenerative medicine. In this review we discuss recent findings of the mechanisms by which ketone bodies could influence adult stem cells, including ketogenesis in adult stem cells, uptake and transport of circulating ketone bodies, receptor-mediated signaling, and changes to cellular metabolism. We also discuss the potential effects of ketone bodies on intracellular processes such as protein acetylation and post-transcriptional control of gene expression. The exploration of mechanisms underlying the effects of ketone bodies on stem cell function reveals potential therapeutic targets for tissue regeneration and age-related diseases and suggests future research directions in the field of ketone bodies and stem cells.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据