期刊
NATURE CHEMICAL BIOLOGY
卷 12, 期 12, 页码 998-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.2180
关键词
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资金
- Deutsche Forschungsgemeinschaft (Cellular Stress Responses in Aging-Associated Diseases) [EXC 229]
- European Union [657501]
- Wellcome Trust [101794]
- European Research Council [281739]
- Marie Curie Actions (MSCA) [657501] Funding Source: Marie Curie Actions (MSCA)
- European Research Council (ERC) [281739] Funding Source: European Research Council (ERC)
ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins. Here we present a proteomic approach for direct in vivo identification and quantification of ADPr sites on histones. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.
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