期刊
NATURE CHEMICAL BIOLOGY
卷 12, 期 12, 页码 1004-+出版社
NATURE PORTFOLIO
DOI: 10.1038/nchembio.2207
关键词
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资金
- Rainin Foundation
- US National Institutes of Health [U19AI109713, F32 29 AI110029]
Here we present a natural product discovery approach, whereby structures are bioinformatically predicted from primary sequence and produced by chemical synthesis (synthetic-bioinformatic natural products, syn-BNPs), circumventing the need for bacterial culture and gene expression. When we applied the approach to nonribosomal peptide synthetase gene clusters from human-associated bacteria, we identified the humimycins. These antibiotics inhibit lipid II flippase and potentiate beta-lactam activity against methicillin-resistant Staphylococcus aureus in mice, potentially providing a new treatment regimen.
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