期刊
NATURE CHEMICAL BIOLOGY
卷 13, 期 1, 页码 9-11出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.2224
关键词
-
资金
- NIH [1DP2GM119162, 1R21A1126239-01]
- Edward Mallinckrodt, Jr. Foundation
- Burroughs Wellcome Fund
- National Science Foundation
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI126239] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [DP2GM119162] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [DP1MH100706] Funding Source: NIH RePORTER
Cas9-based technologies have transformed genome engineering and the interrogation of genomic functions, but methods to control such technologies across numerous dimensions including dose, time, specificity, and mutually exclusive modulation of multiple genes are still lacking. We conferred such multidimensional controls to diverse Cas9 systems by leveraging small-molecule-regulated protein degron domains. Application of our strategy to both Cas9-mediated genome editing and transcriptional activities opens new avenues for systematic genome interrogation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据